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Chapter Thirty - Louis Caplan

from Some Key Physicians

Published online by Cambridge University Press:  13 December 2022

Louis R. Caplan
Beth Israel Deaconess Medical Centre
Aishwarya Aggarwal
John F. Kennedy Medical Center
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Call me Ishmael …

… and I only am escaped alone to tell thee.

—Herman Melville, Moby-Dick
Although my contributions to the history of stroke are meager, I (Louis R. Caplan) decided to include my autobiography in this volume. I have functioned mostly like Ishmael: as a scribe, witness, simplifier, disseminator, and describer of the stroke-related ideas and events that have transpired during the last 50 years or so when the most changes occurred. My story includes a glimpse into medicine, neurology, and stroke as it changed during the twentieth century. It is an autobiographical sketch that has not appeared elsewhere. It seemed awkward to write the memoir in anything but the first person, although that is discouraged by publishers.

Stories of Stroke
Key Individuals and the Evolution of Ideas
, pp. 280 - 294
Publisher: Cambridge University Press
Print publication year: 2022

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Notes and References

A longer account of the fellowship and Fisher’s career and contributions is found in Caplan, LR. C. Miller Fisher: Stroke in the 20th Century. New York: Oxford University Press, 2020.CrossRefGoogle Scholar
Bleich, HL. The computer as a consultant. New England Journal of Medicine 1971;284:141147.Google ScholarPubMed
Mohr, J, Caplan, L, Melski, J, Duncan, G, Goldstein, R, Kistler, J, Pessin, M, Bleich, H. The Harvard Cooperative Stroke Registry: A prospective registry. Neurology 1978;28:754762.CrossRefGoogle ScholarPubMed
Caplan, LR. Occlusion of the vertebral or basilar artery: Follow-up analysis of some patients with benign outcome. Stroke 1979;10:277282.Google ScholarGoogle Scholar
Caplan, L, Hier, D, D’Cruz, I. Cerebral embolism in the Michael Reese Stroke Registry. Stroke 1983;14:530540.Google ScholarGoogle Scholar
The Stroke Data Bank published many reports, among which were Foulkes, MA, Wolf, PA, Priced, TR, Mohr, JP, Hier, DB. The Stroke Data Bank: Design, methods, and baseline characteristics. Stroke 1988;19:547554.Google ScholarGoogle Scholar
Caplan, LR, Stein, RW. Stroke: A Clinical Approach. Boston: Butterworth, 1986.Google Scholar
Caplan, L, Banks, G, Thomas, C. Central nervous system complications of addiction of “T’s and Blues.” Neurology 1982;32:623628.Google ScholarGoogle Scholar
Jones, HR, Caplan, L, Come, P, et al. Cerebral emboli of paradoxical origin. Annals of Neurology 1983;13:314319.CrossRefGoogle ScholarPubMed
Representative reports from the NEMC-P Circulation Registry include Caplan, LR, Chung, C-S, Wityk, RJ, et al. New England Medical Center posterior circulation stroke registry: I. Methods, data base, distribution of brain lesions, stroke mechanisms, and outcomes. Journal of Clinical Neurology 2005;1:1430.Google ScholarGoogle ScholarGoogle ScholarGoogle Scholar
Representative descriptions and reviews of brain infarcts: Caplan, LR, DeWitt, LD, Pessin, MS, Gorelick, PB, Adelman, LS. Lateral thalamic infarcts. Archives of Neurology 1988;45:959964.Google ScholarGoogle ScholarGoogle ScholarGoogle ScholarGoogle ScholarGoogle ScholarGoogle ScholarGoogle ScholarGoogle ScholarGoogle Scholar
The early investigations of thrombolytic therapy are reviewed in del Zoppo, GJ, Poeck, K, Pessin, MS, et al. Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke. Annals of Neurology 1992;32:7886.Google ScholarGoogle ScholarGoogle Scholar
Barbut, D, Caplan, LR. Brain complications of cardiac surgery. Current Problems in Cardiology 1997;22(9):449480.Google ScholarGoogle ScholarGoogle Scholar
Savitz, SI, Dinsmore, J, Wu, J, Henderson, GV, Stieg, P, Caplan, L. Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: A preliminary safety and feasibility study. Cerebrovascular Diseases 2005;20:101107.Google ScholarGoogle Scholar
Caplan, LR. Posterior Circulation Disease: Clinical Findings, Diagnosis, and Management. Boston: Blackwell Scientific, 1996.Google ScholarGoogle Scholar
Caplan, L. Posterior circulation ischemia: Then, now, and tomorrow. The Thomas Willis Lecture – 2000. Stroke 2000;31:20112013.Google ScholarGoogle Scholar
Gorelick, P, Caplan, L, Hier, D, Patel, D, Parker, S. Racial differences in the distribution of anterior circulation occlusive cerebrovascular disease. Neurology 1984;34:5459.Google ScholarGoogle ScholarGoogle ScholarGoogle Scholar
Caplan, L, Schoene, W. Clinical features of subcortical atherosclerotic encephalopathy (Binswanger disease). Neurology 1978;28:12061215.Google ScholarGoogle ScholarGoogle ScholarGoogle Scholar
Fisher, C.M. Basilar artery branch occlusion: A cause of pontine infarction. Neurology 1971;21:900905.Google ScholarGoogle Scholar
Caplan, LR, Hennerici, M. (Hypothesis) Impaired clearance of emboli (washout) is an important link between hypoperfusion, embolism, and ischemic stroke. Archives of Neurology 1998;55:14751482.CrossRefGoogle Scholar
Caplan, LR. Cardiac encephalopathy. (Current Treatment Options in) Cardiovascular Medicine 2004;6:171178.Google ScholarGoogle Scholar
Caplan, LR, Baquis, GD, Pessin, MS, et al. Dissection of the intracranial vertebral artery. Neurology 1988;38:867877.Google ScholarGoogle ScholarGoogle ScholarGoogle ScholarGoogle Scholar
Hinchey, JA, Chaves, CJ, Appignani, B, Breen, JC, Pao, L, Wang, A, Pessin, MS, Lamy, C, Mas, J-L, Caplan, LR. A reversible posterior leukoencephalopathy syndrome. New England Journal of Medicine 1996;334:494500.CrossRefGoogle ScholarPubMed
Albers, G, Caplan, LR, Easton, JD, et al. Transient ischemic attack. Proposal for a new definition. New England Journal of Medicine 2002;347:17131716.Google ScholarGoogle ScholarGoogle ScholarGoogle Scholar
Editorial. TIAs: We need to return to the question, What is wrong with Mr. Jones? Neurology 1988;38:791793;Google ScholarGoogle ScholarGoogle ScholarGoogle Scholar
Siderov, E, Feng, W, Caplan, LR. Stroke in pregnant and postpartum women. Expert Reviews in Cardiovascular Therapy 2011;9:12351247.Google ScholarGoogle ScholarGoogle Scholar
Caplan, L, Kleeman, F, Berg, S. Urinary retention probably secondary to herpes genitalis. New England Journal of Medicine 1977;297:920921.Google ScholarGoogle Scholar

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