Skip to main content Accessibility help
Hostname: page-component-59b7f5684b-9m8n8 Total loading time: 2.212 Render date: 2022-10-01T04:16:28.917Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "displayNetworkTab": true, "displayNetworkMapGraph": false, "useSa": true } hasContentIssue true

Part 1 - Basic Science and General Principles

Published online by Cambridge University Press:  29 May 2020

Peter M. Haddad
Hamad Medical Corporation, Qatar
David J. Nutt
Centre for Neuropsychopharmacology, Division of Psychiatry, Department of Brain Sciences, Imperial College London
Get access
Publisher: Cambridge University Press
Print publication year: 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)


Primary Sources

Abrahamsson, T, Chou, CYC, Li, SY, et al. (2017). Differential regulation and evoked spontaneous release by presynaptic NMDA receptors. Neuron, 96, 839855.CrossRefGoogle ScholarPubMed
Berger, M, Gray, JA, Roth, BL (2009). The expanded biology of serotonin. Ann Rev Med, 60, 355366.CrossRefGoogle ScholarPubMed
Chandler, CM, Overton, JS, Rüedi-Bettschen, D, Platt, DM (2018). GABA receptor subtype mechanisms and abuse-related effects of ethanol: genetic and pharmacological evidence. Handb Exp Pharmacol, 248, 327. doi:10.1007/164_2017_80.CrossRefGoogle ScholarPubMed
Chen, XX, Zhang, JH, Pan, BH, et al. (2017). The atypical antipsychotic olanzapine causes weight gain by targeting 5HT2 receptors. Life Sci, 187, 6473.CrossRefGoogle Scholar
Cortes-Altamirano, JL, Olmos-Hernandez, A, Bonilla-Jaime, H, et al. (2017). Review: 5HT1, 5HT2, 5HT3 and 5HT7 receptors and their role in the modulation of pain response in the central nervous system. Curr Neuropharmacol, 16, 210221. doi:10.2174/1570159x15666170911121027.Google Scholar
Di Menna, L, Joffe, ME, Iacovelli, L, et al. (2018). Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system. Neuropharmacology, 128, 301313.CrossRefGoogle ScholarPubMed
Doly, S, Quentin, E, Eddine, R, et al. (2017). Serotonin 2B receptors in mesoaccumbens dopaminergic pathway regulate dopaminergic responses. J Neurosci, 37, 1037210388.CrossRefGoogle Scholar
Glasgow, NG, Povysheva, NV, Azoleifa, AM, Johnson, JW (2017). Memantine and ketamine differentially alter NMDA receptor desensitization. J Neurosci, 37, 96869704.CrossRefGoogle ScholarPubMed
Huang, X, Yang, J, Yang, S, et al. (2017). Role of tandospirone, a 5HT1A receptor partial agonist, in the treatment of CNS disorders and the underlying mechanisms. Oncotarget, 8, 102705102720.CrossRefGoogle Scholar
Kaushik, V, Smith, ST, Mikobi, E, Kaji, MA (2018). Acetylcholinesterase inhibitors: beneficial effects on co-morbidities in patients with Alzheimer’s disease. Am J Alzheimers Dis Other Dement, 33, 7385.CrossRefGoogle Scholar
Li, D-J, Fu, H, Tong, B, et al. (2018). Cholinergic anti-inflammatory pathway inhibits neointimal hyperplasia by suppressing inflammation and oxidative stress. Redox Biol, 15, 2233.CrossRefGoogle ScholarPubMed
Makera, C, Dondio, G, Braida, D, et al. (2018). Effects of the antidepressant mirtazepine and zinc on nicotinic acetylcholine receptors. Eur J Pharmacol, 820, 265273.Google Scholar
Niswender, CM, Conn, PJ (2010). Metabotropic glutamate receptors: physiology, pharmacology and disease. Ann Rev Pharmacol Toxicol, 50, 295322.CrossRefGoogle ScholarPubMed
Overden, ES, McGregor, NW, Emsley, RA, Warnick, L (2018). DNA methylation and antipsychotic treatment in schizophrenia: progress and future directions. Prog Neuropsychopharmacol Biol Psychiatry, 81, 3849.CrossRefGoogle Scholar
Palma, E, Ruffolo, G, Cifelli, P, et al. (2017). Modulation of GABA-A receptors in the treatment of epilepsy. Curr Pharm Des, 23, 55635568. doi.2174/1381612823666170809100230.CrossRefGoogle ScholarPubMed
Pytliak, M, Vargova, V, Mechirova, V, Felsoci, M (2011). Serotonin receptors – from molecular biology to clinical applications. Physiol Rev, 60, 1525.Google ScholarPubMed
Viana, GSDB, Xanvier, CC, Costa, RD, Neves, KRT (2018). The monoaminergic pathways and inhibition of monoamine transporters interfere with the antidepressant-like behavior of ketamine. IBRO Rep, 4, 713.CrossRefGoogle Scholar
Vizi, ES, Lendvai, B (1999). Modulatory role of presynaptic nicotinic receptors in synaptic and non synaptic chemical communication in the central nervous system. Brain Res Rev, 30, 219235.CrossRefGoogle ScholarPubMed
Williams, DJ, Sidaway, P, Cunnane, TV, Brain, KL (2011). Mechanisms involved in nicotinic acetylcholine receptor induced neurotransmitter release from sympathetic nerve terminals. PLoS One, 6, e29209. doi:1371/journal.pone 0029209.CrossRefGoogle ScholarPubMed
Xiao, X, Shang, X, Zhai, B, et al. (2018). Nicotine alleviates chronic stress induced anxiety in patients with Alzheimer’s disease. Neurochem Int, 114, 5870.CrossRefGoogle Scholar

Secondary Sources

Ahmadi-Soleimani, SM, Azizi, H, Gompf, HS, Semnanian, S (2017). Role of orexin type-1 receptors in the paragiganto-coerulear modulation of opioid withdrawal and tolerance; a site specific focus. Neuropharmacology, 126, 2537.CrossRefGoogle ScholarPubMed
Andrabi, SS, Parvez, S, Tabassum, H (2017). Neurosteroids and ischaemic stroke: progesterone as a promising agent in reducing brain injury in ischemic stroke. J Environ Pathol Toxicol Oncol, 36, 191205.CrossRefGoogle ScholarPubMed
Balthazart, J, Choleris, E, Remage-Healey, L (2018). Steroids and the brain: 50 years of research, conceptual shifts and the ascent of non-classical and membrane initiated actions. Horm Behav, 99, 18.CrossRefGoogle Scholar
Bodnar, RJ (2017). Endogenous opiates and behavior: 2015. Peptides, 88, 126188.CrossRefGoogle ScholarPubMed
D’Souza, DC, Sewell, RA, Ranganathan, M (2009). Cannabis and psychosis/schizophrenia: human studies. Eur Arch Psychiatry Clin Neurosci, 259, 413431.CrossRefGoogle ScholarPubMed
Fantegrosse, WE, Wilson, CD, Berquist, MD (2018). Pro-psychotic effects of synthetic cannabinoids: interactions with central dopamine, serotonin and glutamate receptors. Drug Metab Rev, 50, 6578. doi:10.1080/03602532.2018.1428343.CrossRefGoogle Scholar
Grund, T, Goyon, S, Li, Y, et al. (2007). Neuropeptide S activates paraventricular oxytocin neurons to induce anxiolysis. J Neurosci, 37, 1221412225.CrossRefGoogle Scholar
Henry, MS, Gendron, L, Tremblay, ME, Drolet, G (2017). Enkephalins: endogenous analgesics with an emerging role in stress resilience. Neural Plast, 2017, 1546125.CrossRefGoogle ScholarPubMed
Smith, AS, Tabbaa, M, Lei, K, et al. (2016). Local oxytocin tempers anxiety by activating GABAA receptors in the hypothalamic paraventricular nucleus. Psychoneuroendocrinology, 63, 5058.CrossRefGoogle ScholarPubMed
Starwicz, K, Finn, DP (2017). Cannabinoids and pain: sites and mechanisms of action. Adv Pharmacol, 80, 437475.CrossRefGoogle Scholar

Save book to Kindle

To save this book to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the or variations. ‘’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats