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Section II - Geriatric syndromes

Published online by Cambridge University Press:  05 June 2016

Jan Busby-Whitehead
University of North Carolina
Christine Arenson
Thomas Jefferson University, Philadelphia
Samuel C. Durso
The Johns Hopkins University School of Medicine
Daniel Swagerty
University of Kansas
Laura Mosqueda
University of Southern California
Maria Fiatarone Singh
University of Sydney
William Reichel
Georgetown University, Washington DC
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Reichel's Care of the Elderly
Clinical Aspects of Aging
, pp. 97 - 156
Publisher: Cambridge University Press
Print publication year: 2016

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Fried, LP, Tangen, CM, Walston, J, Newman, AB, Hirsch, C, Gottdiener, J, et al. Frailty in older adults evidence for a phenotype. Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2001;56(3):146–57.CrossRefGoogle ScholarPubMed
Morley, JE, Vellas, B, van Kan, GA, Anker, SD, Bauer, JM, Bernabei, R, et al. Frailty consensus: a call to action. Journal of the American Medical Directors Association. 2013;14(6):392–7.CrossRefGoogle ScholarPubMed
Song, X, Mitnitski, A, Prevalence, Rockwood K. and 10-year outcomes of frailty in older adults in relation to deficit accumulation. Journal of the American Geriatrics Society. 2010;58(4):681–7.CrossRefGoogle ScholarPubMed
Chen, X, Mao, G, Leng, SX. Frailty syndrome: an overview. Clinical Interventions in Aging. 2014;9:433–41.Google ScholarPubMed
Rockwood, K, Andrew, M, Mitnitski, A. A comparison of two approaches to measuring frailty in elderly people. Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2007;62(7):738–43.CrossRefGoogle ScholarPubMed
Rodriguez-Manas, L, Feart, C, Mann, G, Vina, J, Chatterji, S, Chodzko-Zajko, W, et al. Searching for an operational definition of frailty: a Delphi method based consensus statement: the frailty operative definition-consensus conference project. Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2013;68(1):62–7.CrossRefGoogle ScholarPubMed
Bandeen-Roche, K, Xue, QL, Ferrucci, L, Walston, J, Guralnik, JM, Chaves, P, et al. Phenotype of frailty: characterization in the women’s health and aging studies. Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2006;61(3):262–6.CrossRefGoogle ScholarPubMed
Xue, QL. The frailty syndrome: definition and natural history. Clinics in Geriatric Medicine. 2011;27(1):115.CrossRefGoogle ScholarPubMed
Theou, O, Brothers, TD, Mitnitski, A, Rockwood, K. Operationalization of frailty using eight commonly used scales and comparison of their ability to predict all-cause mortality. Journal of the American Geriatrics Society. 2013;61(9):1537–51.CrossRefGoogle ScholarPubMed
Bouillon, K, Kivimaki, M, Hamer, M, Sabia, S, Fransson, EI, Singh-Manoux, A, et al. Measures of frailty in population-based studies: an overview. BMC Geriatrics. 2013;13:64.CrossRefGoogle ScholarPubMed
Abellan van Kan, G, Rolland, Y, Houles, M, Gillette-Guyonnet, S, Soto, M, Vellas, B. The assessment of frailty in older adults. Clinics in Geriatric Medicine. 2010;26(2):275–86.Google ScholarPubMed
Malmstrom, TK, Miller, DK, Morley, JE. A comparison of four frailty models. Journal of the American Geriatrics Society. 2014;62(4):721–6.CrossRefGoogle ScholarPubMed
Shamliyan, T, Talley, KM, Ramakrishnan, R, Kane, RL. Association of frailty with survival: a systematic literature review. Ageing Research Reviews. 2013;12(2):719–36.CrossRefGoogle ScholarPubMed
Cigolle, CT, Ofstedal, MB, Tian, Z, Blaum, CS. Comparing models of frailty: the Health and Retirement Study. Journal of the American Geriatrics Society. 2009;57(5):830–9.CrossRefGoogle ScholarPubMed
Bowles, J, Brooks, T, Hayes-Reams, P, Butts, T, Myers, H, Allen, W, et al. Frailty, family, and church support among urban African American elderly. Journal of Health Care for the Poor and Underserved. 2000;11(1):8799.CrossRefGoogle ScholarPubMed
Ottenbacher, KJ, Ostir, GV, Peek, MK, Snih, SA, Raji, MA, Markides, KS. Frailty in older Mexican Americans. Journal of the American Geriatrics Society. 2005;53(9):1524–31.CrossRefGoogle ScholarPubMed
Gill, TM, Gahbauer, EA, Han, L, Allore, HG. Trajectories of disability in the last year of life. New England Journal of Medicine. 2010;362(13):1173–80.CrossRefGoogle ScholarPubMed
Robertson, DA, Savva, GM, Kenny, RA. Frailty and cognitive impairment–a review of the evidence and causal mechanisms. Ageing Research Reviews. 2013;12(4):840–51.CrossRefGoogle ScholarPubMed
Afilalo, J, Alexander, KP, Mack, MJ, Maurer, MS, Green, P, Allen, LA, et al. Frailty assessment in the cardiovascular care of older adults. Journal of the American College of Cardiology. 2014;63(8):747–62.CrossRefGoogle ScholarPubMed
Xue, QL, Bandeen-Roche, K, Varadhan, R, Zhou, J, Fried, LP. Initial manifestations of frailty criteria and the development of frailty phenotype in the Women’s Health and Aging Study II. Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2008;63(9):984–90.CrossRefGoogle ScholarPubMed
Gill, TM, Gahbauer, EA, Allore, HG, Han, L. Transitions between frailty states among community-living older persons. Archives of Internal Medicine. 2006;166(4):418–23.CrossRefGoogle ScholarPubMed
Leng, S, Chaves, P, Koenig, K, Walston, J. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study. Journal of the American Geriatrics Society. 2002;50(7):1268–71.CrossRefGoogle ScholarPubMed
Mohler, MJ, Fain, MJ, Wertheimer, AM, Najafi, B, Nikolich-Žugich, J. The Frailty Syndrome: Clinical measurements and basic underpinnings in humans and animals. Experimental Gerontology. 2014;54:613.CrossRefGoogle ScholarPubMed
Ershler, WB, Keller, ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annual Review of Medicine. 2000;51:245–70.CrossRefGoogle ScholarPubMed
Leng, SX, Xue, QL, Tian, J, Huang, Y, Yeh, SH, Fried, LP. Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: results from the Women’s Health and Aging Studies I. Experimental Gerontology. 2009;44(8):511–6.CrossRefGoogle ScholarPubMed
Leng, SX, Cappola, AR, Andersen, RE, Blackman, MR, Koenig, K, Blair, M, et al. Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty. Aging Clinical and Experimental Research. 2004;16(2):153–7.CrossRefGoogle Scholar
Travison, TG, Nguyen, AH, Naganathan, V, Stanaway, FF, Blyth, FM, Cumming, RG, et al. Changes in reproductive hormone concentrations predict the prevalence and progression of the frailty syndrome in older men: the concord health and ageing in men project. Journal of Clinical Endocrinology and Metabolism. 2011;96(8):2464–74.CrossRefGoogle ScholarPubMed
Poehlman, ET, Toth, MJ, Fishman, PS, Vaitkevicius, P, Gottlieb, SS, Fisher, ML, et al. Sarcopenia in aging humans: the impact of menopause and disease. Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 1995;50(Spec No):73–7.Google ScholarPubMed
Clegg, A, Young, J, Iliffe, S, Rikkert, MO, Rockwood, K. Frailty in elderly people. Lancet. 2013;381(9868):752–62.CrossRefGoogle ScholarPubMed
Varadhan, R, Walston, J, Cappola, AR, Carlson, MC, Wand, GS, Fried, LP. Higher levels and blunted diurnal variation of cortisol in frail older women. Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2008;63(2):190–5.CrossRefGoogle ScholarPubMed
Ko, FC. The clinical care of frail, older adults. Clinics in Geriatric Medicine. 2011;27(1):89100.CrossRefGoogle ScholarPubMed
Cruz-Jentoft, AJ, Baeyens, JP, Bauer, JM, Boirie, Y, Cederholm, T, Landi, F, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age and Ageing. 2010;39(4):412–23.CrossRefGoogle ScholarPubMed
Makary, MA, Segev, DL, Pronovost, PJ, Syin, D, Bandeen-Roche, K, Patel, P, et al. Frailty as a predictor of surgical outcomes in older patients. Journal of the American College of Surgeons. 2010;210(6):901–8.CrossRefGoogle ScholarPubMed
Yao, X, Hamilton, RG, Weng, NP, Xue, QL, Bream, JH, Li, H, et al. Frailty is associated with impairment of vaccine-induced antibody response and increase in post-vaccination influenza infection in community-dwelling older adults. Vaccine. 2011;29(31):5015–21.CrossRefGoogle ScholarPubMed
Ridda, I, Macintyre, CR, Lindley, R, Gao, Z, Sullivan, JS, Yuan, FF, et al. Immunological responses to pneumococcal vaccine in frail older people. Vaccine. 2009;27(10):1628–36.CrossRefGoogle ScholarPubMed
Studenski, SA, Peters, KW, Alley, DE, Cawthon, PM, McLean, RR, Harris, TB, et al. The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2014;69(5):547–58.CrossRefGoogle ScholarPubMed
Bales, CW, Ritchie, CS. Sarcopenia, weight loss, and nutritional frailty in the elderly. Annual Review of Nutrition. 2002;22:309–23.CrossRefGoogle ScholarPubMed
White, JV, Guenter, P, Jensen, G, Malone, A, Schofield, M. Consensus statement of the Academy of Nutrition and Dietetics/American Society for Parenteral and Enteral Nutrition: characteristics recommended for the identification and documentation of adult malnutrition (undernutrition). Journal of the Academy of Nutrition and Dietetics. 2012;112(5):730–8.CrossRefGoogle Scholar
Weening-Dijksterhuis, E, de Greef, MH, Scherder, EJ, Slaets, JP, van der Schans, CP. Frail institutionalized older persons: A comprehensive review on physical exercise, physical fitness, activities of daily living, and quality-of-life. American Journal of Physical Medicine & Rehabilitation / Association of Academic Physiatrists. 2011;90(2):156–68.Google ScholarPubMed
Theou, O, Stathokostas, L, Roland, KP, Jakobi, JM, Patterson, C, Vandervoort, AA, et al. The effectiveness of exercise interventions for the management of frailty: a systematic review. Journal of Aging Research. 2011;2011:569194.CrossRefGoogle ScholarPubMed
De Vries, NM, van Ravensberg, CD, Hobbelen, JS, Olde Rikkert, MG, Staal, JB, Nijhuis-van der Sanden, MW. Effects of physical exercise therapy on mobility, physical functioning, physical activity and quality of life in community-dwelling older adults with impaired mobility, physical disability and/or multi-morbidity: a meta-analysis. Ageing Research Reviews. 2012;11(1):136–49.CrossRefGoogle ScholarPubMed
Peterson, MJ, Giuliani, C, Morey, MC, Pieper, CF, Evenson, KR, Mercer, V, et al. Physical activity as a preventative factor for frailty: the health, aging, and body composition study. Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2009;64(1):61–8.Google ScholarPubMed
Gill, TM, Baker, DI, Gottschalk, M, Peduzzi, PN, Allore, H, Byers, A. A program to prevent functional decline in physically frail, elderly persons who live at home. New England Journal of Medicine. 2002;347(14):1068–74.CrossRefGoogle ScholarPubMed
Milne, AC, Potter, J, Vivanti, A, Avenell, A. Protein and energy supplementation in elderly people at risk from malnutrition. Cochrane Database of Systematic Reviews. 2009;2:CD003288.Google Scholar
Cawood, AL, Elia, M, Stratton, RJ. Systematic review and meta-analysis of the effects of high protein oral nutritional supplements. Ageing Research Reviews. 2012;11(2):278–96.CrossRefGoogle ScholarPubMed
Morley, JE. Should frailty be treated with testosterone? Aging Male: the Official Journal of the International Society for the Study of the Aging Male. 2011;14(1):13.CrossRefGoogle ScholarPubMed
Muir, SW, Montero-Odasso, M. Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis. Journal of the American Geriatrics Society. 2011;59(12):2291–300.CrossRefGoogle ScholarPubMed
Wong, YY, McCaul, KA, Yeap, BB, Hankey, GJ, Flicker, L. Low vitamin D status is an independent predictor of increased frailty and all-cause mortality in older men: the Health in Men Study. Journal of Clinical Endocrinology and Metabolism. 2013;98(9):3821–8.CrossRefGoogle ScholarPubMed
Lamberts, SW. The somatopause: to treat or not to treat? Hormone Research. 2000;53(Suppl 3):42–3.Google ScholarPubMed
Gallagher, P, Ryan, C, Byrne, S, Kennedy, J, O’Mahony, D. STOPP (Screening Tool of Older Person’s Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. International Journal of Clinical Pharmacology and Therapeutics. 2008;46(2):7283.CrossRefGoogle ScholarPubMed
Onder, G, Penninx, BW, Balkrishnan, R, Fried, LP, Chaves, PH, Williamson, J, et al. Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study. Lancet. 2002;359(9310):926–30.CrossRefGoogle ScholarPubMed
Ellis, G, Whitehead, MA, Robinson, D, O’Neill, D, Langhorne, P. Comprehensive geriatric assessment for older adults admitted to hospital: meta-analysis of randomised controlled trials. BMJ (Clinical research ed). 2011;343:d6553.CrossRefGoogle ScholarPubMed
Kawryshanker, S, Raymond, W, Ingram, K. Effect of frailty on functional gain, resource utilisation, and discharge destination: an observational prospective study in a GEM ward. Current Gerontology and Geriatric Research. 2014;2014:357857.CrossRefGoogle Scholar
Villareal, DT, Chode, S, Parimi, N, Sinacore, DR, et al. Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med. 2011;364:1218–29.CrossRefGoogle ScholarPubMed
Janssen, I, Shepard, DS, Katzmarzyk, PT, Roubenoff, R. The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc. 2004;52(1):80–5.CrossRefGoogle ScholarPubMed
Kim, SW. Multidimensional frailty score for the prediction of post-operative mortality risk. JAMA Surgery. 2014;149(7):633–40.CrossRefGoogle ScholarPubMed
Joseph, B, Pandit, V, Zangbar, B, Kulvatunyou, N, Hashmi, A, et al. Superiority of frailty over age in predicting outcomes among geriatric trauma patients. JAMA Surg. 2014;149(8):766–72.CrossRefGoogle ScholarPubMed
Lord, S, Sherrington, C, Menz, H, et al. Falls in Older People: Risk Factors and Strategies for Prevention. Cambridge: Cambridge University Press; 2007.CrossRefGoogle Scholar
Close, J, Ellis, M, Hooper, R, et al. Prevention of falls in the elderly trial (PROFET): a randomised controlled trial. Lancet 1999;353:93–7.CrossRefGoogle ScholarPubMed
Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Web -based Injury Statistics Query and Reporting System (WISQARS) [online]. Accessed September 2, 2014.
Campbell, AJ, Borrie, MJ, Spears, GF, et al. Circumstances and consequences of falls experienced by a community population 70 years and over during a prospective study. Age Ageing 1990;19:136–41.CrossRefGoogle ScholarPubMed
Berg, WP, Alessio, HM, Mills, EM, et al. Circumstances and consequences of falls in independent community-dwelling older adults. Age Ageing 1997;26:261–8.CrossRefGoogle ScholarPubMed
Cali, CM, Kiel, DP. An epidemiologic study of fall-related fractures among institutionalized older people. JAGS 1995;43:1336–40.CrossRefGoogle ScholarPubMed
Lord, SR, Ward, JA, Williams, P, et al. An epidemiological study of falls in older community-dwelling women: the Randwick falls and fractures study. Aust J Public Health 1993;17:240–5.Google ScholarPubMed
Ganz, DA, Bao, Y, Shekelle, PG, et al. Will my patient fall? JAMA 2007;297:7786.CrossRefGoogle ScholarPubMed
Brault, MW, Hootman, J, Helmick, CG, et al. Prevalence and most common causes of disability among adults, United States, 2005. MMWR 2009;58:421–6.Google Scholar
Verghese, J, LeValley, A, Hall, CB, et al. Epidemiology of gait disorders in community-residing older adults. J Am Geriatr Soc 2006;54:255–61.CrossRefGoogle ScholarPubMed
Salzman, B. Gait and balance disorders in older adults. Am Fam Physician 2010;82:61–8.Google ScholarPubMed
Waite, LM, Grayson, DA, Piguet, O, et al. Gait slowing as a predictor of incident dementia: 6-year longitudinal data from the Sydney Older Persons Study. J Neurol Sci 2005;229–230:8993.CrossRefGoogle ScholarPubMed
Bloem, BR, Haan, J, Lagaay, AM, et al. Investigation of gait in elderly subjects over 88 years of age. J Geriatr Psychiatry Neurol 1992;5:7884.Google ScholarPubMed
Verghese, J, Lipton, RB, Hall, CB, et al. Abnormality of gait as a predictor of non-Alzheimer’s dementia. N Engl J Med 2002;347:1761–8.CrossRefGoogle ScholarPubMed
Ashburn, A, Stack, E, Pickering, RM, et al. A community-dwelling sample of people with Parkinson’s disease: characteristics of fallers and non-fallers. Age Ageing 2001;30:4752.CrossRefGoogle ScholarPubMed
Burns, R. Falling and getting up again. Parkinson Report 1994;XV:18.Google Scholar
Koller, WC, Glatt, S, Vetere-Overfield, B, et al. Falls and Parkinson’s disease. Clin Neuropharmacol 1989;12:98105.Google ScholarPubMed
Paulson, GW, Schaefer, K, Hallum, B. Avoiding mental changes and falls in older Parkinsons’ patients. Geriatrics 1986;41:5962.Google ScholarPubMed
Paul, SS, Sherrington, C, Canning, CG, et al. The relative contribution of physical and cognitive fall risk factors in people with Parkinson’s disease: a large prospective cohort study. Neurorehabil Neural Repair 2014;28:282–90.CrossRefGoogle ScholarPubMed
Salgado, R, Lord, SR, Packer, J, et al. Factors associated with falling in elderly hospital patients. Gerontology 1994;40:325–31.CrossRefGoogle ScholarPubMed
O’Loughlin, JL, Robitaille, Y, Boivin, JF, et al. Incidence of and risk factors for falls and injurious falls among the community-dwelling elderly. Am J Epidemiol 1993;137:342–54.Google ScholarPubMed
Herndon, JG, Helmick, CG, Sattin, RW, et al. Chronic medical conditions and risk of fall injury events at home in older adults. JAGS 1997;45:739–43.CrossRefGoogle ScholarPubMed
Dolinis, J, Harrison, JE. Factors associated with falling in older Adelaide residents. Aust N Z J Public Health 1997;21:462–8.CrossRefGoogle ScholarPubMed
Campbell, AJ, Borrie, MJ, Spears, GF. Risk factors for falls in a community-based prospective study of people 70 years and older. J Gerontol 1989;44:M112–7.CrossRefGoogle Scholar
Nevitt, MC, Cummings, SR, Kidd, S, et al. Risk factors for recurrent nonsyncopal falls: a prospective study. JAMA 1989;261:2663–8.CrossRefGoogle ScholarPubMed
Prudham, D, Evans, JG. Factors associated with falls in the elderly: a community study. Age Ageing 1981;10:141–6.CrossRefGoogle ScholarPubMed
Hyndman, D, Ashburn, A, Stack, E. Fall events among people with stroke living in the community: Circumstances of falls and characteristics of fallers. Arch Phys Med Rehabil 2002;83:165–70.CrossRefGoogle ScholarPubMed
Mitoma, H, Hayashi, R, Yanagisawa, N, et al. Gait disturbances in patients with pontine medial tegmental lesions: clinical characteristics and gait analysis. Arch Neurol 2000;57:1048–57.CrossRefGoogle ScholarPubMed
Moseley, A, Wales, A, Herbert, R, et al. Observation and analysis of hemiplegic gait: stance phase. Aust J Physiother 1993;39:259–67.CrossRefGoogle ScholarPubMed
Moore, S, Schurr, K, Wales, A, et al. Observation and analysis of hemiplegic gait: swing phase. Aust J Physiother 1993;39:271–8.CrossRefGoogle ScholarPubMed
Pijnappels, M, Bobbert, MF, van Dieen, JH. Contribution of the support limb in control of angular momentum after tripping. J Biomech 2004;37:1811–18.CrossRefGoogle ScholarPubMed
Taylor, ME, Delbaere, K, Mikolaizak, AS, et al. Gait parameter risk factors for falls under simple and dual task conditions in cognitively impaired older people. Gait Posture 2013;37:126–30.CrossRefGoogle ScholarPubMed
Verghese, J, Robbins, M, Holtzer, R, et al. Gait dysfunction in mild cognitive impairment syndromes. JAGS 2008;56:1244–51.CrossRefGoogle ScholarPubMed
Montero-Odasso, M, Verghese, J, Beauchet, O, et al. Gait and cognition: a complementary approach to understanding brain function and the risk of falling. JAGS 2012;60:2127–36.CrossRefGoogle ScholarPubMed
Herman, T, Mirelman, A, Giladi, N, et al. Executive control deficits as a prodrome to falls in healthy older adults: a prospective study linking thinking, walking, and falling. J Gerontol 2010;65:1086–92.Google ScholarPubMed
Holtzer, R, Friedman, R, Lipton, RB, et al. The relationship between specific cognitive functions and falls in aging. Neuropsychology 2007;21:540–8.CrossRefGoogle Scholar
Tinetti, ME, Speechley, M, Ginter, SF. Risk factors for falls among elderly persons living in the community. N Engl J Med 1988;319:1701–7.CrossRefGoogle ScholarPubMed
Morris, JC, Rubin, EH, Morris, EJ, et al. Senile dementia of the Alzheimer’s type: an important risk factor for serious falls. J Gerontol 1987;42:412–17.CrossRefGoogle ScholarPubMed
Laird, RD, Studenski, S, Perera, S, et al. Fall history is an independent predictor of adverse health outcomes and utilization in the elderly. Am J Manag Care 2001;7:1133–8.Google ScholarPubMed
Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation–United States, 2010–2012. MMWR 2013;62:869–73.
Baan, H, Dubbeldam, R, Nene, AV, et al. Gait analysis of the lower limb in patients with rheumatoid arthritis: a systematic review. Semin Arthritis Rheum 2012;41:768–88 e8.CrossRefGoogle ScholarPubMed
Broström, EW, Esbjörnsson, A-C, von Heideken, J, et al. Gait deviations in individuals with inflammatory joint diseases and osteoarthritis and the usage of three-dimensional gait analysis. Best Pract Res Clin Rheumatol 2012;26:409–22.CrossRefGoogle ScholarPubMed
Blake, A, Morgan, K, Bendall, M, et al. Falls by elderly people at home – prevalence and associated factors. Age Ageing 1988;17:365–72.CrossRefGoogle ScholarPubMed
Buchner, DM, Larson, EB. Falls and fractures in patients with Alzheimer-type dementia. JAMA 1987;257:1492–5.CrossRefGoogle ScholarPubMed
Robbins, AS, Rubenstein, LZ, Josephson, KR, et al. Predictors of falls among elderly people – results of two population-based studies. Arch Int Med 1989;149:1628–33.CrossRefGoogle ScholarPubMed
Tinetti, ME, Williams, TF, Mayewski, R. Fall risk index for elderly patients based on number of chronic disabilities Am J Med 1986;80:429–34.CrossRefGoogle ScholarPubMed
Torgerson, DJ, Garton, MJ, Reid, DM. Falling and perimenopausal women. Age Ageing 1993;22:5964.CrossRefGoogle ScholarPubMed
Barbour, KE, Stevens, JA, Helmick, CG, et al. Falls and fall injuries among adults with arthritis – United States, 2012. MMWR 2014;63:379–83.Google ScholarPubMed
Gabell, A, Simons, MA, Nayak, USL. Falls in the healthy elderly: predisposing causes. Ergonomics 1985;28:965–75.CrossRefGoogle ScholarPubMed
Thomas, MJ, Roddy, E, Zhang, W, et al. The population prevalence of foot and ankle pain in middle and old age: a systematic review. Pain 2011;152:2870–80.CrossRefGoogle ScholarPubMed
Hung, L, Ho, Y, Leung, P. Survey of foot deformities among 166 geriatric inpatients. Foot Ankle 1985;5:156–64.CrossRefGoogle ScholarPubMed
Helfand, AE, Cooke, HL, Walinsky, MD, et al. Foot problems associated with older patients – a focused podogeriatric study. J Am Podiatr Med Assoc 1998;88:237–41.CrossRefGoogle ScholarPubMed
Black, JR, Hale, WE. Prevalence of foot complaints in the elderly. J Am Podiatr Med Assoc 1987;77:308–11.CrossRefGoogle ScholarPubMed
Guralnik, J, Simonsick, E, Ferrucci, L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994;49:M8594.CrossRefGoogle Scholar
Benvenuti, F, Ferrucci, L, Guralnik, JM, et al. Foot pain and disability in older persons: an epidemiologic survey. JAGS 1995;43:479–84.CrossRefGoogle Scholar
Menz, HB, Lord, SR. Gait instability in older people with hallux valgus. Foot Ankle Int 2005;26:483–9.CrossRefGoogle ScholarPubMed
Menz, HB, Morris, ME, Lord, SR. Foot and ankle risk factors for falls in older people: a prospective study. J Gerontol 2006;61:866–70.CrossRefGoogle ScholarPubMed
Mickle, KJ, Munro, BJ, Lord, SR, et al. Foot pain, plantar pressures, and falls in older people: a prospective study. JAGS 2010;58:1936–40.CrossRefGoogle ScholarPubMed
Tinetti, ME. Performance-oriented assessment of mobility problems in elderly patients. JAGS 1986;34:119–26.CrossRefGoogle ScholarPubMed
Winter, DA. The Biomechanics and Motor Control of Human Gait: Normal, Elderly and Pathological. Waterloo, Ontario: University of Waterloo Press; 1991.Google Scholar
Kemoun, G, Thoumie, P, Boisson, D, et al. Ankle dorsiflexion delay can predict falls in the elderly. J Rehabil Med 2002;34:278–83.CrossRefGoogle ScholarPubMed
Al-Yahya, E, Dawes, H, Smith, L, et al. Cognitive motor interference while walking: a systematic review and meta-analysis. Neurosci Biobehav Rev 2011;35:715–28.CrossRefGoogle ScholarPubMed
Owings, TM, Grabiner, MD. Variability of step kinematics in young and older adults. Gait Posture 2004;20:26–9.CrossRefGoogle ScholarPubMed
Hausdorff, J, Rios, D, Edelberg, H. Gait variability and fall risk in community-living older adults: a 1-year prospective study. Arch Phys Med Rehabi 2001;82:1050–6.CrossRefGoogle ScholarPubMed
Di Fabio, RP, Kurszewski, WM, Jorgenson, EE, et al. Footlift asymmetry during obstacle avoidance in high-risk elderly. JAGS 2004;52:2088–93.CrossRefGoogle ScholarPubMed
Verghese, J, Holtzer, R, Lipton, RB, et al. Quantitative gait markers and incident fall risk in older adults. J Gerontol 2009;64:896901.CrossRefGoogle ScholarPubMed
Abellan van Kan, G, Rolland, Y, Andrieu, S, et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force. J Nutr Health Aging 2009;13:881–9.CrossRefGoogle Scholar
Hardy, SE, Perera, S, Roumani, YF, et al. Improvement in usual gait speed predicts better survival in older adults. JAGS 2007;55:1727–34.CrossRefGoogle ScholarPubMed
Studenski, S, Perera, S, Patel, K, et al. Gait speed and survival in older adults. JAMA 2011;305:50–8.CrossRefGoogle ScholarPubMed
Murray, MP, Kory, RC, Clarkson, BH. Walking patterns in healthy old men. J Gerontol 1969;24:169–78.CrossRefGoogle ScholarPubMed
Crowinshield, RD, Brand, RA, Johnston, RC. The effects of walking velocity and age on hip kinematics and kinetics. Clin Orthop Rel Res 1978;132:140–4.Google Scholar
Elble, RJ, Thomas, SS, Higgins, C, et al. Stride-dependent changes in gait of older people. J Neurol 1991;238:15.CrossRefGoogle ScholarPubMed
Kerrigan, DC, Todd, MK, Croce, UD, et al. Biomechanical gait alterations independent of speed in the healthy elderly: evidence for specific limiting impairments. Arch Phys Med Rehabil 1998;79:317–22.CrossRefGoogle ScholarPubMed
Hageman, PA, Blanke, DJ. Comparison of gait of young women and elderly women. Phys Ther 1986;66:1382–7.CrossRefGoogle ScholarPubMed
Winter, DA, Patla, AE, Frank, JS, et al. Biomechanical walking pattern changes in the fit and healthy elderly. Phys Ther 1990;70:340–7.CrossRefGoogle ScholarPubMed
Judge, JO, Davis, RB, 3rd, Ounpuu, S. Step length reductions in advanced age: the role of ankle and hip kinetics. J Gerontol 1996;51:M30312.CrossRefGoogle ScholarPubMed
McGibbon, C, Krebs, D. Age-related changes in lower trunk coordination and energy transfer during gait. J Neurophysiol 2001;85:1923–31.CrossRefGoogle ScholarPubMed
McGibbon, C, Puniello, M, Krebs, D. Mechanical energy transfer during gait in relation to strength impairment and pathology in elderly women. Clin Biomech 2001;16:324–33.CrossRefGoogle ScholarPubMed
McGibbon, CA, Krebs, DE, Puniello, MS. Mechanical energy analysis identifies compensatory strategies in disabled elders’ gait. J Biomech 2001;34:481–90.CrossRefGoogle ScholarPubMed
Mills, PM, Barrett, RS. Swing phase mechanics of healthy young and elderly men. Hum Mov Sci 2001;20:427–46.CrossRefGoogle Scholar
Murray, MP, Drought, AB, Kory, RC. Walking patterns of normal men. Journal of Bone and Joint Surgery 1964;46A:335–60.Google Scholar
Lockhart, TE, Woldstad, JC, Smith, JL. Effects of age-related gait changes on the biomechanics of slips and falls. Ergonomics 2003;46:1136–60.CrossRefGoogle ScholarPubMed
Kerrigan, DC, Lee, LW, Collins, JJ, et al. Reduced hip extension during walking: Healthy elderly and fallers versus young adults. Arch Phys Med Rehabil 2001;82:2630.CrossRefGoogle ScholarPubMed
Lee, LW, Kerrigan, DC. Identification of kinetic differences between fallers and nonfallers in the elderly. Am J Phys Med Rehabil 1999;78:242–6.CrossRefGoogle ScholarPubMed
Campbell, AJ, Reinken, J, Allan, BC, et al. Falls in old age: a study of frequency and related clinical factors. Age and ageing 1981;10:264–70.CrossRefGoogle ScholarPubMed
Tinetti, ME, Speechley, M, Ginter, SF. Risk factors for falls among elderly persons living in the community. N Engl J Med 1988;319:1701–7.CrossRefGoogle ScholarPubMed
Lord, SR, Ward, JA, Williams, P, et al. An epidemiological study of falls in older community-dwelling women: the Randwick falls and fractures study. Aust J Pub Health 1993;17:240–54.Google ScholarPubMed
Van Dieen, JH, Pijnappels, M, Bobbert, MF. Age-related intrinsic limitations in preventing a trip and regaining balance after a trip. Safety Science 2005;43:437–53.CrossRefGoogle Scholar
Pavol, MJ, Owings, TM, Foley, KT, et al. Gait characteristics as risk factors for falling from trips induced in older adults. J Gerontol 1999;54:M583–90.CrossRefGoogle ScholarPubMed
Pavol, MJ, Owings, TM, Foley, KT, et al. Mechanisms leading to a fall from an induced trip in healthy older adults. J Gerontol 2001;56:M428–37.CrossRefGoogle ScholarPubMed
Grabiner, MD, Koh, TJ, Lundin, TM, et al. Kinematics of recovery from a stumble. J Gerontol 1993;48:M97102.CrossRefGoogle ScholarPubMed
Cao, C, Ashton-Miller, JA, Schultz, AB, et al. Abilities to turn suddenly while walking: effects of age, gender, and available response time. J Gerontol 1997;52:M8893.CrossRefGoogle ScholarPubMed
Lockhart, TE, Smith, JL, Woldstad, JC. Effects of aging on the biomechanics of slips and falls. Hum Factors 2005;47:708–29.CrossRefGoogle ScholarPubMed
Brady, RA, Pavol, MJ, Owings, TM, et al. Foot displacement but not velocity predicts the outcome of a slip induced in young subjects while walking. J Biomech 2000;33:803–8.CrossRefGoogle ScholarPubMed
Gillespie, LD, Robertson, MC, Gillespie, WJ, et al. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev 2012;9:CD007146.Google Scholar
Sherrington, C, Tiedemann, A, Fairhall, N, et al. Exercise to prevent falls in older adults: an updated meta-analysis and best practice recommendations. NSW Public Health Bull 2011;22:7883.CrossRefGoogle ScholarPubMed
Tomlinson, CL, Patel, S, Meek, C, et al. Physiotherapy versus placebo or no intervention in Parkinson’s disease. Cochrane Database Syst Rev 2013. DOI: 10.1002/14651858.CD002817.pub4.CrossRef
Mehrholz, J, Friis, R, Kugler, J, et al. Treadmill training for patients with Parkinson’s disease. Cochrane Database Syst Rev 2010. DOI: 10.1002/14651858.CD007830.pub2.CrossRef
English, C, Hillier, SL.Circuit class therapy for improving mobility after stroke. Cochrane Database Syst Rev 2010. DOI: 10.1002/14651858.CD007513.pub2.CrossRef
Handoll, HHG, Sherrington, C, Mak, JCS. Interventions for improving mobility after hip fracture surgery in adults. Cochrane Database Syst Rev 2011. DOI: 10.1002/14651858.CD001704.pub4.CrossRef
States, RA, Pappas, E, Salem, Y. Overground physical therapy gait training for chronic stroke patients with mobility deficits. Cochrane Database Syst Rev 2009. DOI: 10.1002/14651858.CD006075.pub2.CrossRef
Dean, CM, Rissel, C, Sherrington, C, et al. Exercise to enhance mobility and prevent falls after stroke: the Community Stroke Club Randomized Trial. Neurorehabil Neural Repair 2012;26:1046–57.CrossRefGoogle ScholarPubMed
Binder, EF, Brown, M, Sinacore, DR, et al. Effects of extended outpatient rehabilitation after hip fracture: a randomized controlled trial. JAMA 2004;292:837–46.CrossRefGoogle ScholarPubMed
Robertson, MC, Campbell, AJ, Gardner, MM, et al. Preventing injuries in older people by preventing falls: a meta-analysis of individual-level data. JAGS 2002;50:905–11.CrossRefGoogle ScholarPubMed
Campbell, A, Robertson, M, La Grow, S, et al. Randomised controlled trial of prevention of falls in people aged 75 with severe visual impairment: the VIP trial. BMJ 2005;331:817925.CrossRefGoogle ScholarPubMed
Fairhall, N, Sherrington, C, Lord, SR, et al. Effect of a multifactorial, interdisciplinary intervention on risk factors for falls and fall rate in frail older people: a randomised controlled trial. Age Ageing 2014;43:616–22.CrossRefGoogle ScholarPubMed
Sherrington, C, Lord, SR, Vogler, CM, et al. A post-hospital home exercise program improved mobility but increased falls in older people: a randomised controlled trial. PloS one 2014;9:e104412.CrossRefGoogle ScholarPubMed
Canning, C, Sherrington, C, Lord, S, et al. Exercise for falls prevention in Parkinson’s disease: a randomized controlled trial. Neurology 2015 Jan 20;84(3):304–12.CrossRefGoogle ScholarPubMed
Bisdorff, A, Von Brevern, M, Lempert, T, Newman-Toker, DE. Classification of vestibular symptoms: towards an international classification of vestibular disorders. J Vestib Res. 2009;19(1–2):113.Google ScholarPubMed
Newman-Toker, DE, Cannon, LM, Stofferahn, ME, Rothman, RE, Hsieh, YH, Zee, DS. Imprecision in patient reports of dizziness symptom quality: a cross-sectional study conducted in an acute care setting. Mayo Clin Proc. 2007 Nov;82(11):1329–40.CrossRefGoogle Scholar
Sloane, PD. Dizziness in primary care: results from the National Ambulatory Medical Care Survey. J Fam Pract. 1989;29(1):33–8.Google ScholarPubMed
Kroenke, K, Mangelsdorff, AD. Common symptoms in ambulatory care: incidence, evaluation, therapy, and outcome. Am J Med. 1989;86(3):262–6.CrossRefGoogle ScholarPubMed
Jonsson, R, Sixt, E, Landahl, S, Rosenhall, U. Prevalence of dizziness and vertigo in an urban elderly population. J Vestib Res. 2004;14(1):4752.Google Scholar
Wolinsky, FD, Fitzgerald, JF. The risk of hip fracture among noninstitutionalized older adults. J Gerontol. 1994;49(4):165–75.CrossRefGoogle ScholarPubMed
Wolinsky, FD, Fitzgerald, JF. Subsequent hip fracture among older adults. Am J Public Health. 1994;84(8):1316–18.CrossRefGoogle ScholarPubMed
Kao, AC, Nanda, A, Williams, CS, Tinetti, ME. Validation of dizziness as a possible geriatric syndrome. J Am Geriatr Soc. 2001;49(1):72–5.CrossRefGoogle ScholarPubMed
Newman-Toker, DE. Diagnosing Dizziness in the Emergency Department – Why “What do you mean by ‘dizzy’?” Should Not Be the First Question You Ask. [Doctoral Dissertation, Clinical Investigation, Bloomberg School of Public Health] [PhD Clinical Investigation]. Baltimore, MD: The Johns Hopkins University; 2007.
Drachman, DA. A 69-year-old man with chronic dizziness. JAMA. 1998;280(24):2111–8.CrossRefGoogle ScholarPubMed
Newman-Toker, DE. Symptoms and signs of neuro-otologic disorders. Continuum (Minneap Minn). 2012 Oct;18(5 Neuro-otology):1016–40.CrossRef
Newman-Toker, DE, Dy, FJ, Stanton, VA, Zee, DS, Calkins, H, Robinson, KA. Primary cardiovascular disease causes true vertigo – a systematic review. Abstracts of the Bárány Society XXV International Congress, Kyoto, Japan, Mar 31–Apr 3, 2008. J Vestib Res. 2008.
Paul, NL, Simoni, M, Rothwell, PM. Transient isolated brainstem symptoms preceding posterior circulation stroke: a population-based study. Lancet Neurology. 2013 Jan;12(1):6571.CrossRefGoogle ScholarPubMed
Newman-Toker, DE, Dy, FJ, Stanton, VA, Zee, DS, Calkins, H, Robinson, KA. How often is dizziness from primary cardiovascular disease true vertigo? A systematic review. J Gen Intern Med. 2008 Dec;23(12):2087–94.CrossRefGoogle ScholarPubMed
Fife, TD, Iverson, DJ, Lempert, T, Furman, JM, Baloh, RW, Tusa, RJ, et al. Practice parameter: therapies for benign paroxysmal positional vertigo (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2008;70(22):2067–74.CrossRefGoogle ScholarPubMed
Lempert, T, Neuhauser, H, Daroff, RB. Vertigo as a symptom of migraine. Annals of the New York Academy of Sciences. 2009 May;1164:242–51.CrossRefGoogle ScholarPubMed
Kattah, JC, Talkad, AV, Wang, DZ, Hsieh, YH, Newman-Toker, DE. HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging. Stroke. 2009 Nov;40(11):3504–10.CrossRefGoogle ScholarPubMed
Chalela, JA, Kidwell, CS, Nentwich, LM, Luby, M, Butman, JA, Demchuk, AM, et al. Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison. Lancet. 2007;369(9558):293–8.CrossRefGoogle ScholarPubMed
Edlow, JA, Newman-Toker, DE, Savitz, SI. Diagnosis and initial management of cerebellar infarction. Lancet Neurol. 2008 Oct;7(10):951–64.CrossRefGoogle ScholarPubMed
Newman-Toker, DE, Kerber, KA, Hsieh, YH, Pula, JH, Omron, R, Saber Tehrani, AS, et al. HINTS outperforms ABCD2 to screen for stroke in acute continuous vertigo and dizziness. Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine. 2013 Oct;20(10):986–96.CrossRefGoogle ScholarPubMed
Saber Tehrani, AS, Kattah, JC, Mantokoudis, G, Pula, JH, Nair, D, Blitz, A, et al. Small strokes causing severe vertigo: frequency of false-negative MRIs and nonlacunar mechanisms. Neurology. 2014 Jul 8;83(2):169–73.CrossRefGoogle ScholarPubMed
Tarnutzer, AA, Berkowitz, AL, Robinson, KA, Hsieh, YH, Newman-Toker, DE. Does my dizzy patient have a stroke? A systematic review of bedside diagnosis in acute vestibular syndrome. CMAJ: Canadian Medical Association Journal [Journal de l’Association medicale canadienne]. [Research Support, Non-US Gov’t Research Support, US Gov’t, PHS Review]. 2011 Jun 14;183(9):E571–92.CrossRefGoogle ScholarPubMed
Newman-Toker, DE, Saber Tehrani, AS, Mantokoudis, G, Pula, JH, Guede, CI, Kerber, KA, et al. Quantitative video-oculography to help diagnose stroke in acute vertigo and dizziness: toward an ECG for the eyes. Stroke: A Journal of Cerebral Circulation. [Research Support, N.I.H., Extramural Research Support, Non-US Gov’t Research Support, US Gov’t, PHS]. 2013 Apr;44(4):1158–61.CrossRefGoogle ScholarPubMed
Newman-Toker, DE. Vertigo and dizziness. In: Aminoff, MJ, Daroff, RB, editors. Encyclopedia of the Neurological Sciences. 2nd ed. Oxford: Elsevier; 2014: 629–37.Google Scholar
Parnes, LS, Agrawal, SK, Atlas, J. Diagnosis and management of benign paroxysmal positional vertigo (BPPV). CMAJ. 2003;169(7):681–93.Google Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013.
Alzheimer’s Association. 2014 Alzheimer’s disease facts and figures. Alzheimer’s & Dementia. 2014;146.
Elliott, AF, Burgio, LD, Decoster, J. Enhancing caregiver health: findings from the resources for enhancing Alzheimer’s caregiver health II intervention. J Am Geriatr Soc. 2010;58:30–7.CrossRefGoogle ScholarPubMed
Corrada, MM, Brookmeyer, R, Paganini-Hill, A, et al. Dementia incidence continues to increase with age in the oldest old: the 90+ study. Ann Neurol. 2010; 67:114–21.CrossRefGoogle ScholarPubMed
Vincent, GK, Velkoff, VA. The next four decades: The older population in the united sates: 2010–2050. Current Population Reports. Washington, DC: US Department of Commerce Economics and Statistics Administration. 2010.Google Scholar
Llewellyn, DJ, Lang, IA, Langa, KM, et al. Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med. 2010;170:1135–41.CrossRefGoogle ScholarPubMed
Norton, MC, Smith, KR, Ostbye, T, et al. Greater risk of dementia when spouse has dementia? The cache county study. J Am Geriatr Soc. 2010;58:895900.CrossRefGoogle ScholarPubMed
Fratiglioni, L, Paillard-Borg, S, Winblad, B. An active and socially integrated lifestyle in late life might protect against dementia. Lancet Neurol. 2004;3:343–53.CrossRefGoogle ScholarPubMed
Simonsick, EM. Fitness and cognition: encouraging findings and methodological considerations for future work. J Am Geriatr Soc. 2003;51:570–1.CrossRefGoogle ScholarPubMed
Coyle, JT. Use it or lose it – do effortful mental activities protect against dementia? NEJM. 2003;348:2489–90.CrossRefGoogle ScholarPubMed
Buchman, AS, Boyle, PA, Yu, L, et al. Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology. 2012;78:1323–9.CrossRefGoogle ScholarPubMed
Yaffe, K, Fiocco, AJ, Lindquist, K, et al. Predictors of maintaining cognitive function in older adults: the health ABC study. Neurology. 2009;72:2029–35CrossRefGoogle ScholarPubMed
Jellinger, KA. Morphologic diagnosis of “vascular dementia” – a critical update. Journal of the Neurological Sciences.2008;270: 112.CrossRefGoogle ScholarPubMed
Knopman, DS, Boeve, BF, Petersen, RC. Essential of the proper diagnoses of mild cognitive impairment, dementia, and major subtypes of dementia. Mayo Clin Proc. 2003;78:12901308.CrossRefGoogle Scholar
Snowden, JS. Semantic dysfunction in frontotemporal lobar degeneration. Dement Geriatr Cogn Disord. 1999;10(Suppl 1):33–6.CrossRefGoogle ScholarPubMed
Morris, JC. Dementia update 2005. Alzheimer Dis Assoc Disord. 2005;19:100–17.CrossRefGoogle ScholarPubMed
Jack, CR Jr, Albert, MS, Knopman, DS, et al. Introduction to the recommendations from the national institute on aging – Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7:257–62.CrossRefGoogle ScholarPubMed
Hebert, LE, Weuve, J, Scherr, PA, Evans, DA. Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Neurology. 2013;80:1778–83.CrossRefGoogle ScholarPubMed
Barnes, DE, Yaffe, K, Byers, AL, et al. Midlife vs late-life depressive symptoms and risk of dementia: Differential effects for Alzheimer disease and vascular dementia. Arch Gen Psychiatry. 2012;69:493–8.Google ScholarPubMed
Querfurth, HW, Laferla, FM. Mechanisms of disease: Alzheimer’s disease. NEJM. 2010;362:1844–5.CrossRefGoogle Scholar
Cummings, JL, Vinters, HV, Cole, GM, et al. Alzheimer’s disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology. 1998;51(Suppl 1):S2S17.CrossRefGoogle ScholarPubMed
Mash, DC, Flynn, DD, Potter, LT. Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer’s disease and experimental cholinergic degeneration. Science. 1985;228:1115–17.CrossRefGoogle Scholar
Cummings, JL. Alzheimer’s disease. NEJM. 2004;351:5667.CrossRefGoogle ScholarPubMed
Gandy, S. The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease. J Clin Invest. 2005;115(5):1121–9.Google ScholarPubMed
Tanzi, RE. Tangles and neurodegenerative disease – a surprising twist. NEJM. 2005;353:1853–5.CrossRefGoogle ScholarPubMed
Santacruz, K, Lewis, J, Spires, T, et al. Tau suppression in a neuro-degenerative mouse model improves memory function. Science. 2005;309:476–81.CrossRefGoogle Scholar
Gorelick, PB, Scuteri, A, Black, SE, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke. Stroke. 2011;42:2672–713.CrossRefGoogle ScholarPubMed
Larson, EB, Shadlen, MF, Wang, L, et al. Survival after initial diagnosis of Alzheimer disease. Ann Intern Med. 2004;140:501–9.CrossRefGoogle ScholarPubMed
Román, GC. Vascular neurocognitive disorder. In: Gabbard’s Treatments of Psychiatric Disorders, 5th ed. Arlington, VA: American Psychiatric Publishing; 2014Google Scholar
Duthie, EH, Glatt, SL. Understanding and treating multi-infarct dementia. Clin Geriatr Med. 1988;4:749–66.CrossRefGoogle ScholarPubMed
Moorhouse, P, Rockwood, K. Vascular cognitive impairment: current concepts and clinical developments. Lancet Neurol. 2008;7:246–55.CrossRefGoogle ScholarPubMed
Rincon, F, Wright, CB. Vascular cognitive impairment. Curr Opin Neurol. 2013;26:2936.CrossRefGoogle ScholarPubMed
Dichgans, M, Zietemann, V. Prevention of vascular cognitive impairment. Stroke. 2012;43:3137–46.CrossRefGoogle ScholarPubMed
The Lund and Manchester Groups. Clinical and neuropathological criteria for frontotemporal dementia. J Neurol Neurosurg Psychiatry. 1994;57:416–18.
Whitwell, JL, Jack, CR Jr, Senjem, ML, Josephs, KA. Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration. Neurology. 2006;66:102–4.CrossRefGoogle ScholarPubMed
Rabinovici, GD, Miller, BL. Frontotemporal lobar degeneration epidemiology, pathophysiology, diagnosis and management. CNS Drugs. 2010;24:375–98.CrossRefGoogle ScholarPubMed
McMurtray, AM, Chen, AK, Shapira, JS, et al. Variations in regional SPECT hypoperfusion and clinical features in frontotemporal dementia. Neurology.2006;66:517–22.CrossRefGoogle ScholarPubMed
Mendez, MF, McMurtray, A, Chen, AK, et al. Functional neuroimaging and presenting psychiatric features in frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2006;77:47.CrossRefGoogle ScholarPubMed
Vanderzee, J, Rademakers, R, Engelborghs, S, et al. A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLD. Brain. 2006;129:841–52.Google Scholar
Mackenzie, IR, Baker, M, West, G, et al. A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17. Brain. 2006;129:853–67.CrossRefGoogle ScholarPubMed
Huey, ED, Putnam, KT, Grafman, J. A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia. Neurology. 2006;66:1722.CrossRefGoogle ScholarPubMed
McKhann, GM, Albert, MS, Grossman, M, et al. Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick’s Disease. Arch Neurol. 2001;58:1803–9.CrossRefGoogle Scholar
Neary, D, Snowden, JS, Northen, B, et al. Dementia of frontal lobe type. J Neurol Neurosurg Psychiatry. 1988;51:353–61.CrossRefGoogle ScholarPubMed
Chare, L, Hodges, JR, Leyton, CE, et al. New criteria for frontotemporal dementia syndromes: Clinical and pathological diagnostic implications. Journal of Neurology, Neurosurgery & Psychiatry. 2014;85:865–70.CrossRefGoogle ScholarPubMed
Hodges, JR, Davies, RR, Xuereb, JH, et al. Clinicopathological correlates in frontotemporal dementia. Ann Neurol. 2004;56:399406.CrossRefGoogle ScholarPubMed
Eslinger, PJ, Dennis, K, Moore, P, et al. Metacognitive deficits in frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2005;76:1630–5.CrossRefGoogle ScholarPubMed
Bonner, MF, Ash, S, Grossman, M. The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants. Current Neurology & Neuroscience Reports. 2010;10:484–90.CrossRefGoogle ScholarPubMed
Campbell, S, Stephens, S, Ballard, C. Dementia with Lewy bodies: clinical features and treatment. Drugs Aging. 2001;18:397407.CrossRefGoogle ScholarPubMed
McKeith, IG. Spectrum of Parkinson’s disease, Parkinson’s dementia, and Lewy body dementia. Neurol Clin. 2000;18:865902.CrossRefGoogle ScholarPubMed
Savica, R, Grossardt, BR, Bower, JH, et al. Incidence of dementia with Lewy bodies and Parkinson disease dementia. JAMA Neurology. 2013;70:1396–402.CrossRefGoogle ScholarPubMed
Halliday, GM, Song, YJ, Harding, AJ. Striatal beta-amyloid in dementia with Lewy bodies but not parkinson’s disease. J Neural Transm. 2011;118:713–9.CrossRefGoogle Scholar
Kalaitzakis, ME, Walls, AJ, Pearce, RK, et al. Striatal abeta peptide deposition mirrors dementia and differentiates DLB and PDD from other parkinsonian syndromes. Neurobiol Dis. 2011;41:377–84.CrossRefGoogle ScholarPubMed
Kantarci, K, Lowe, VJ, Boeve, BF, et al. Multimodality imaging characteristics of dementia with Lewy bodies. Neurobiol Aging. 2012;33:2091–105.CrossRefGoogle ScholarPubMed
Klein, JC, Eggers, C, Kalbe, E, et al. Neurotransmitter changes in dementia with Lewy bodies and parkinson disease dementia in vivo. Neurology. 2010;74:885–92.CrossRefGoogle ScholarPubMed
Shimada, H, Shinotoh, H, Hirano, S, et al. Beta-amyloid in Lewy body disease is related to Alzheimer’s disease-like atrophy. Movement Disorders. 2013;28:169–75.CrossRefGoogle ScholarPubMed
Kupsch, AR, Bajaj, N, Weiland, F, et al. Impact of DaTscan SPECT imaging on clinical management, diagnosis, confidence of diagnosis, quality of life, health resource use and safety in patients with clinically uncertain parkinsonian syndromes: A prospective 1-year follow-up of an open-label controlled study. J Neurol Neurosurg Psychiatry. 2012;83:620–8.CrossRefGoogle ScholarPubMed
Lim, SM, Katsifis, A, Villemagne, VL, et al. The 18 F-FDG PET cingulate island sign and comparison to 123I-beta-CIT SPECT for diagnosis of dementia with Lewy bodies. Journal of Nuclear Medicine. 2009;50:1638–45.CrossRefGoogle ScholarPubMed
O’Brien, JT, McKeith, IG, Walker, Z, et al. Diagnostic accuracy of 123I-FP-CIT SPECT in possible dementia with Lewy bodies. British Journal of Psychiatry. 2009;194:34–9.Google ScholarPubMed
Ferman, TJ, Boeve, BF, Smith, GE, et al. Inclusion of RBD improves the diagnostic classification of dementia with Lewy bodies. Neurology. 2011;77:875–82.CrossRefGoogle ScholarPubMed
Aarsland, D, Andersen, K, Larsen, JP, et al. Risk of dementia in Parkinson’s disease: a community-based, prospective study. Neurology. 2001;56:730–6.CrossRefGoogle ScholarPubMed
Stern, Y, Marder, K, Tang, MX, Mayeux, R. Antecedent clinical features associated with dementia in Parkinson’s disease. Neurology.1993;43:1690–2.CrossRefGoogle ScholarPubMed
Emre, M. Dementia in Parkinson’s disease: cause and treatment. Curr Opin Neurol. 2004;17:399404.CrossRefGoogle ScholarPubMed
Aarsland, D, Perry, R, Brown, A, et al. Neuropathology of dementia in Parkinson’s disease: a prospective, community-based study. Ann Neurol. 2005;58:773–6.CrossRefGoogle ScholarPubMed
Quinn, N. Parkinsonism–recognition and differential diagnosis. BMJ. 1995; 310:447–52.CrossRefGoogle ScholarPubMed
Litvan, I, Campbell, G, Mangone, CA, et al. Which clinical features differentiate progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) from related disorders? A clinicopathological study. Brain. 1997;120(Pt 1):6574.CrossRefGoogle ScholarPubMed
Verny, M, Jellinger, KA, Hauw, JJ, et al. Progressive supranuclear palsy: a clinicopathological study of 21 cases. Acta Neuropathol (Berl). 1996;91:427–31.CrossRefGoogle ScholarPubMed
Maher, ER, Lees, AJ. The clinical features and natural history of the Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). Neurology. 1986;36:1005–8.CrossRefGoogle Scholar
Centers for Disease Control. Creutzfeldt-Jakob disease (CJD). Available at: (accessed April 28, 2015).
World Health Organization (WHO). WHO manual for surveillance of human transmissible spongiform encephalopathies including variant Creutzfeldt-Jakob disease, 2003. Available at: (accessed December 2, 2015).
Rinne, ML, McGinnis, SM, Samuels, MA, et al. Clinical problem-solving: a startling decline. N Engl J Med. 2012;366:836–42.CrossRefGoogle ScholarPubMed
Chohan, G, Pennington, C, Mackenzie, JM, et al. The role of cerebrospinal fluid 14–3-3 and other proteins in the diagnosis of sporadic Creutzfeldt-Jakob disease in the UK: a 10-year review. Journal of Neurology, Neurosurgery & Psychiatry. 2010;81: 1243–8.CrossRefGoogle Scholar
Heath, CA, Cooper, SA, Murray, K, et al. Validation of diagnostic criteria for variant Creutzfeldt-Jakob disease. Ann Neurol. 2010;67:761–70.Google ScholarPubMed
Vitali, P, Maccagnano, E, Caverzasi, E, et al. Diffusion-weighted MRI hyperintensity patterns differentiate CJD from other rapid dementias. Neurology. 2011 May;76:1711–19.CrossRefGoogle ScholarPubMed
Chapman, DP, Williams, SM, Strine, TW, et al. Dementia and its implications for public health. Available at: (accessed May 25, 2008).
Wivel, ME. NIMH report: NIH consensus conference stresses need to identify reversible causes of dementia. Hosp Community Psychiatry. 1988;39:22–3.Google Scholar
Clarfield, AM. The decreasing prevalence of reversible dementias: an updated meta-analysis. Arch Intern Med. 2003;163:2219–29.CrossRefGoogle ScholarPubMed
Clarfield, AM. The reversible dementias: do they reverse? Ann Intern Med. 1988;109:476–86.CrossRefGoogle ScholarPubMed
Williams, MA, Relkin, NR. Diagnosis and management of idiopathic normal-pressure hydrocephalus. Neurol Clin Pract. 2013;3:375–85.CrossRefGoogle ScholarPubMed
Kiefer, M, Unterberg, A. The differential diagnosis and treatment of normal-pressure hydrocephalus. Dtsch Arztebl Int. 2012;109:1525.Google ScholarPubMed
Tueth, MJ, Cheong, JA. Delirium: diagnosis and treatment in the older patient. Geriatrics. 1993;48:7580.Google ScholarPubMed
Inouye, SK, Westendorp, RG, Saczynski, JS. Delirium in elderly people. Lancet. 2014;8(383):911–22.Google Scholar
Petersen, RC, Roberts, RO, Knopman, DS, et al. Prevalence of mild cognitive impairment is higher in men: the Mayo Clinic study of aging. Neurology. 2010;75:889–97.CrossRefGoogle ScholarPubMed
Sachdev, PS, Lipnicki, DM, Crawford, J, et al. Risk profiles of subtypes of mild cognitive impairment: the Sydney memory and ageing study. J Am Geriatr Soc. 2012;60:2433.CrossRefGoogle ScholarPubMed
Roberts, RO, Geda, YE, Knopman, DS, et al. The incidence of MCI differs by subtype and is higher in men: the Mayo Clinic study of aging. Neurology. 2012;78:342–51.CrossRefGoogle ScholarPubMed
Roberts, RO, Geda, YE, Knopman, DS, et al. Cardiac disease associated with increased risk of nonamnestic cognitive impairment: stronger effect on women. JAMA Neurology. 2013;70:374–82.CrossRefGoogle ScholarPubMed
Mitchell, AJ, Shiri-Feshki, M. Rate of progression of mild cognitive impairment to dementia – meta-analysis of 41 robust inception cohort studies. Acta Psychiatr Scand. 2009;119:252–65.CrossRefGoogle ScholarPubMed
Boyle, PA, Buchman, AS, Wilson, RS, et al. The APOE epsilon4 allele is associated with incident mild cognitive impairment among community-dwelling older persons. Neuroepidemiology. 2010;34:43–9.CrossRefGoogle ScholarPubMed
De Meyer, G, Shapiro, F, Vanderstichele, H, et al. Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal elderly people. Arch Neurol. 2010;67:949–56.CrossRefGoogle ScholarPubMed
Heister, D, Brewer, JB, Magda, S, et al. for the Alzheimer’s Disease Neuroimaging Initiative. Predicting MCI outcome with clinically available MRI and CSF biomarkers. Neurology. 2011;77:1619–28.CrossRefGoogle Scholar
Landau, SM, Harvey, D, Madison, CM, et al. Comparing predictors of conversion and decline in mild cognitive impairment. Neurology. 2010;75:230–8.CrossRefGoogle ScholarPubMed
Lo, RY, Hubbard, AE, Shaw, LM, et al. Longitudinal change of biomarkers in cognitive decline. Arch Neurol. 2011;68:1257–66.CrossRefGoogle ScholarPubMed
Van Rossum, IA, Vos, SJ, Burns, L, et al. Injury markers predict time to dementia in subjects with MCI and amyloid pathology. Neurology. 2012;79:1809–16.CrossRefGoogle ScholarPubMed
Vemuri, P, Wiste, HJ, Weigand, SD, et al. Serial MRI and CSF biomarkers in normal aging, MCI, and AD. Neurology. 2010;75:143–51.CrossRefGoogle ScholarPubMed
Small, GW, Rabins, PV, Barry, PP, et al. Diagnosis and treatment of Alzheimer’s disease and related disorders. JAMA. 1997;278:1363–71.Google Scholar
Auer, S, Reisberg, B. The GDS/FAST system. Int Psychogeriatr. 1997;9:167–71.CrossRefGoogle Scholar
Folstein, M, Anthony, JC, Parchad, I, et al. The meaning of cognitive impairment in the elderly. J Am Geriatr Soc. 1985;33:228–35.CrossRefGoogle ScholarPubMed
Hancock, P, Larner, AJ. Test your memory test: diagnostic utility in a memory clinic population. Int J Geriatr Psychiatry. 2011;26:976–80.CrossRefGoogle Scholar
Grigoletto, F, Zappala, G, Anderson, DW, et al. Norms for the mini-mental state examination in a healthy population. Neurology. 1999;53:315–20.CrossRefGoogle Scholar
Dufouil, C, Clayton, D, Brayne, C, et al. Population norms for the MMSE in the very old: estimates based on longitudinal data. Neurology. 2000;55:1609–13.CrossRefGoogle ScholarPubMed
Karlawish, JH, Casarett, DJ, James, BD, et al. The ability of persons with Alzheimer disease (AD) to make a decision about taking an AD treatment. Neurology. 2005;64:1514–19.CrossRefGoogle ScholarPubMed
Pruchno, RA, Smyer, MA, Rose, MS, et al. Competence of long-term care residents to participate in decisions about their medical care: a brief, objective assessment. Gerontologist. 1995;35: 622–9.CrossRefGoogle ScholarPubMed
Stahelin, HB, Monsch, AU, Spiegel, R. Early diagnosis of dementia via a two-step screening and diagnostic procedure. Int Pyschogeriatr. 1997;9:123–30.Google Scholar
Powlishta, KK, Von Dras, DD, Stanford, A, et al. The clock drawing test is a poor screen for very mild dementia. Neurology. 2002;59:898903.CrossRefGoogle ScholarPubMed
Borson, S, Scanlan, J, Brush, M, et al. The Mini-Cog: a cognitive “vital signs” measure for dementia screening in multi-lingual elderly. Int J Geriatr Psychiatry. 2000;15:1021–7.3.0.CO;2-6>CrossRefGoogle Scholar
Borson, S, Scanlan, J, Chen, P, et al. The Mini-Cog as a screen for dementia: validation in a population-based sample. J Am Geriatr Soc. 2003;51:1451–4.CrossRefGoogle Scholar
Nasreddine, Z, Phillips, N, Bédirian, V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005; 53:695–9.CrossRefGoogle ScholarPubMed
Fujiwara, Y, Suzuki, H, Yasunaga, M, et al. Brief screening tool for mild cognitive impairment in older Japanese: validation of the Japanese version of the Montreal Cognitive Assessment. Geriatrics & Gerontology International. 2010;10:225–32.CrossRefGoogle ScholarPubMed
Larner, AJ. Screening utility of the Montreal Cognitive Assessment (MoCA): in place of – or as well as – the MMSE? International Psychogeriatrics. 2012;24:391–6.CrossRefGoogle ScholarPubMed
Dong, Y, Sharma, VK, Venketasubramanian, N, et al. The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke. J. Neurol. Sci. 2010;299:1518.CrossRefGoogle ScholarPubMed
Godefroy, O, Fickl, A, Roussel, M, et al. Is the Montreal Cognitive Assessment superior to the Mini-Mental State Examination to detect poststroke cognitive impairment? A study with neuropsychological evaluation. Stroke. 2011;42:1712–16.Google ScholarPubMed
Pendlebury, ST, Cuthbertson, FC, Welch, SJ, et al. Underestimation of cognitive impairment by Mini-Mental State Examination versus the Montreal Cognitive Assessment in patients with transient ischemic attack and stroke: a population-based study. Stroke. 2010;41:1290–3.CrossRefGoogle ScholarPubMed
Petersen, RC, Smith, GE, Ivnik, RJ, et al. Apolipoprotein E status as a predictor of the development of Alzheimer’s disease in memory-impaired individuals. JAMA. 1995;273:1274–8.CrossRefGoogle ScholarPubMed
Chandler, MJ, Lacritz, LH, Hynan, LS, et al. A total score for the CERAD neuropsychological battery. Neurology. 2005;65:102–6.CrossRefGoogle ScholarPubMed
McGurn, B, Starr, JM, Topfer, JA, et al. Pronunciation of irregular words is preserved in dementia, validating premorbid IQ estimation. Neurology. 2004;62:1184–6CrossRefGoogle ScholarPubMed
Weyting, MD, Bossuyt, PM, van Crevel, H. Reversible dementia: more than 10% or less than 1%? A quantitative review. J Neurol. 1995;242:466–71.Google Scholar
Mapstone, M, Cheema, AK, Fiandaca, MS, et al. Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. 2014;20:415–18.CrossRefGoogle ScholarPubMed
Goldman, JS, Hahn, SE, Catania, JW, et al. Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors. Genet Med. 2011;13:597605.CrossRefGoogle ScholarPubMed
Henderson, AS, Easteal, S, Jorm, AF. Apolipoprotein E allele epsilon 4, dementia, and cognitive decline in a population sample. Lancet. 1995;346:1387–90.CrossRefGoogle Scholar
Galasko, D. Cerebrospinal fluid biomarkers in Alzheimer disease: a fractional improvement? Arch Neurol. 2003;60:1195–6.CrossRefGoogle ScholarPubMed
Albert, M, DeCarli, C, DeKosky, S, et al. The use of MRI and PET for the clinical diagnosis of dementia and investigation of cognitive impairment: consensus report. Available at: (accessed May 25, 2008).
Killiany, RJ, Gomez-Isla, T, Moss, M, et al. Use of structural magnetic resonance imaging to predict who will get Alzheimer’s disease. Ann Neurol. 2000;47:430–9.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Adak, S, Illouz, K, Gorman, W, et al. Predicting the rate of cognitive decline in aging and early Alzheimer disease. Neurology. 2004;63:108–14.CrossRefGoogle ScholarPubMed
Weiner, MW, Veitch, DP, Aisen, PS, et al. The Alzheimer’s disease neuroimaging initiative: a review of papers published since its inception. Alzheimer’s & Dementia. 2012;8(1 Suppl):S168.CrossRefGoogle Scholar
Wu, X, Chen, K, Yao, L, et al. Assessing the reliability to detect cerebral hypometabolism in probable Alzheimer’s disease and amnestic mild cognitive impairment. J Neurosci Methods. 2010;192:277–85.CrossRefGoogle ScholarPubMed
McKhann, GM, Knopman, DS, Chertkow, H, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging – Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7:263–9.CrossRefGoogle Scholar
Klunk, WE, Engler, H, Nordberg, A, et al. Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B. Ann Neurol. 2004;55:306–19.CrossRefGoogle ScholarPubMed
Jack, CR Jr, Lowe, VJ, Weigand, SD, et al. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer’s disease: implications for sequence of pathological events in Alzheimer’s disease. Brain. 2009;132:1355–65.CrossRefGoogle ScholarPubMed
Cordell, CB, Borson, S, Boustani, M, et al. Alzheimer’s Association recommendations for operationalizing the detection of cognitive impairment during the Medicare annual wellness visit in a primary care setting. Alzheimers Dement. 2013;9:141–50.CrossRefGoogle Scholar
Lin, JS, O’Connor, E, Rossom, RC, et al. Screening for cognitive impairment in older adults: a systematic review for the US Preventive Services Task Force. Annals of Internal Medicine. 2013;159(9)601–12.Google Scholar
Trinh, NH, Hoblyn, J, Mohanty, S, et al. Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis. JAMA. 2003;289(2):210–16.CrossRefGoogle ScholarPubMed
Kaduszkiewicz, H, Zimmermann, T, Beck-Bornhold, HP, et al. Cholinesterase inhibitors for patients with Alzheimer’s disease: systematic review of randomised clinical trials. BMJ. 2005;331:321–7.CrossRefGoogle ScholarPubMed
Doody, RS, Stevens, JC, Beck, C, et al. Practice parameter: management of dementia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001;56:1154–66.CrossRefGoogle ScholarPubMed
Geldmacher, DS, Provenzano, G, McRae, T, et al. Donepezil is associated with delayed nursing home placement in patients with Alzheimer’s disease. J Am Geriatr Soc. 2003;51:937–44.CrossRefGoogle ScholarPubMed
Grossberg, GT. The ABC of Alzheimer’s disease: behavioral symptoms and their treatment. Int Psychogeriatr. 2002;14(Suppl 1):2749.CrossRefGoogle ScholarPubMed
Courtney, C, Farrell, D, Gray, R, et al. Long-term donepezil treatment in 565 patients with Alzheimer’s disease (AD2000): randomized double-blind trial. Lancet. 2004;363:2105–15.Google Scholar
Gill, SS, Anderson, GM, Fischer, HD, et al. Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort study. Arch Intern Med. 2009;169:867–73.CrossRefGoogle ScholarPubMed
Schneider, LS, Dagerman, KS, Higgins, JP, et al. Lack of evidence for the efficacy of memantine in mild Alzheimer disease. Arch Neurol. 2011;68:991–8.CrossRefGoogle ScholarPubMed
McShane, R, Areosa Sastre, A, Miakaran, N. Memantine for dementia. Cochrane Database Syst Rev. 2006;2:CD003154.Google Scholar
Ridha, BH, Josephs, KA, Rossor, MN. Delusions and hallucinations in dementia with Lewy bodies: worsening with memantine. Neurology. 2005;65:481–2.CrossRefGoogle ScholarPubMed
Reisberg, B, Doody, R, Stoffler, A, et al. Memantine in moderate-to-severe Alzheimer’s disease. NEJM. 2003;348:1333–41.CrossRefGoogle ScholarPubMed
Doody, RS, Farlow, M, Aisen, PS, Alzheimer’s Disease Cooperative Study Data Analysis and Publication Committee. Phase 3 trials of solanezumab and bapineuzumab for Alzheimer’s disease. N Engl J Med. 2014;370:1460.CrossRefGoogle ScholarPubMed
Salloway, S, Sperling, R, Fox, NC, et al. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer’s disease. N Engl J Med. 2014;370:322–33.CrossRefGoogle ScholarPubMed
Miller, ER, Pastor-Barriuso, R, Dalal, D, et al. Meta-analysis: high dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142:3746.CrossRefGoogle ScholarPubMed
Dysken, MW, Sano, M, Asthana, S, et al. Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial. JAMA. 2014;1;311:3344.CrossRefGoogle Scholar
Aisen, PS, Saumier, D, Briand, R, et al. A phase II study targeting amyloid-B with 3-APS in mild-to-moderate Alzheimer disease. Neurology. 2006;67:1757–63.CrossRefGoogle Scholar
Scharf, S, Mander, A, Ugoni, A, et al. A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer’s disease. Neurology. 1999;53:197201.CrossRefGoogle ScholarPubMed
Rich, JB, Rasmusson, DX, Folstein, MF, et al. Nonsteroidal anti-inflammatory drugs in Alzheimer’s disease. Neurology. 1995;45:51–5.CrossRefGoogle ScholarPubMed
Coker, LH, Espeland, MA, Hogan, PE, et al. Change in brain and lesion after CEE therapies: the WHIMS-MRI studies. Neurology. 2014;82:427–34.CrossRefGoogle ScholarPubMed
Coker, LH, Espeland, MA, Rapp, SR, et al. Postmenopausal hormone therapy and cognitive outcomes: the Women’s Health Initiative Memory Study (WHIMS). J Steroid Biochem Mol Biol. 2010;118:304–10.CrossRefGoogle Scholar
Birks, J, Grimley, EV, Van Dongen, M. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev. 2002;CD003120.CrossRef
Snitz, BE, O’Meara, ES, Carlson, MC, et al. Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial. JAMA. 2009;302:2663–70.CrossRefGoogle ScholarPubMed
Angell, M, Kassirer, JP. Alternative medicine – the risks of untested and unregulated remedies. NEJM. 1998;339:839–41.CrossRefGoogle ScholarPubMed
Briones, TL, Darwish, H. Decrease in age-related tau hyperphosphorylation and cognitive improvement following vitamin D supplementation are associated with modulation of brain energy metabolism and redox state. Neuroscience. 2014;262:143–55.CrossRefGoogle ScholarPubMed
Briones, TL, Darwish, H. Vitamin D mitigates age-related cognitive decline through the modulation of pro-inflammatory state and decrease in amyloid burden. J Neuroinflammation. 2012;9:244.CrossRefGoogle ScholarPubMed
Craft, S, Baker, LD, Montine, TJ, et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol. 2012;69:2938.CrossRefGoogle ScholarPubMed
Newhouse, P, Kellar, K, Aisen, P, et al. Nicotine treatment of mild cognitive impairment: A 6-month double-blind pilot clinical trial. Neurology. 2012;78:91101.CrossRefGoogle ScholarPubMed
Salloway, S, Sperling, R, Brashear, HR. Phase 3 trials of solanezumab and bapineuzumab for Alzheimer’s disease. N Engl J Med. 2014;370:1459–60.CrossRefGoogle ScholarPubMed
Blennow, K, Zetterberg, H, Rinne, JO, et al. AAB-001 201/202 Investigators: effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease. Arch Neurol. 2012;69:1002–10.Google ScholarPubMed
Farlow, M, Arnold, SE, van Dyck, CH, et al. Safety and biomarker effects of solanezumab in patients with Alzheimer’s disease. Alzheimer’s & Dementia. 2012;8:261–71.CrossRefGoogle ScholarPubMed
Dodel, R, Rominger, A, Bartenstein, P, et al. Intravenous immunoglobulin for treatment of mild-to-moderate Alzheimer’s disease: a phase 2, randomised, double-blind, placebo-controlled, dose-finding trial. Lancet Neurology. 2013;12:233–43.CrossRefGoogle ScholarPubMed
Shah, S, Federoff, HJ. Therapeutic potential of vaccines for Alzheimer’s disease. Immunotherapy. 2011;3:287–98.CrossRefGoogle ScholarPubMed
Wiessner, C, Wiederhold, KH, Tissot, AC, et al. The second-generation active abeta immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects. Journal of Neuroscience. 2011;31:9323–31.CrossRefGoogle ScholarPubMed
Winblad, B, Andreasen, N, Minthon, L, et al. Safety, tolerability, and antibody response of active abeta immunotherapy with CAD106 in patients with alzheimer’s disease: Randomised, double-blind, placebo-controlled, first-in-human study. Lancet Neurology. 2012;11:597604.CrossRefGoogle ScholarPubMed
Wilson, RS, Mendes De Leon, CF, Barnes, LL, et al. Participation in cognitively stimulating activities and risk of incident Alzheimer disease. JAMA. 2002;287:742–8.CrossRefGoogle ScholarPubMed
Wilson, RS, Bennett, DA, Bienias, JL, et al. Cognitive activity and incident AD in a population-based sample of older persons. Neurology. 2002;59:1910–14.CrossRefGoogle Scholar
Verghese, J, Lipton, RB, Katz, MJ, et al. Leisure activities and the risk of dementia in the elderly. NEJM. 2003;348:2508–16.CrossRefGoogle ScholarPubMed
Weuve, J, Kang, JH, Manson, JE, et al. Physical activity, including walking, and cognitive function in older women. JAMA. 2004;292:1454–61.CrossRefGoogle ScholarPubMed
Van Gelder, BM, Tijhuis, MAR, Kalmijn, S, et al. Physical activity in relation to cognitive decline in elderly men; the FINE study. Neurology. 2004;63:2316–21.CrossRefGoogle ScholarPubMed
Teri, L, Gibbons, LE, McCurry, SM, et al. Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial. JAMA. 2003;290:2015–22.CrossRefGoogle ScholarPubMed
Rolland, Y, Rival, L, Pillard, F, et al. Feasibility of regular physical exercise for patients with moderate to severe Alzheimer disease. J Nutr Health Aging. 2000;4:109–13.Google ScholarPubMed
Dvorak, RV, Poehlman, ET. Appendicular skeletal muscle mass, physical activity, and cognitive status in patients with Alzheimer’s disease. Neurology. 1998;51:1386–90.CrossRefGoogle ScholarPubMed
Lauque, S, Arnaud-Battandier, F, Gillette, S, et al. Improvement of weight and fat-free mass with oral nutritional supplementation in patients with Alzheimer’s disease at risk of malnutrition: a prospective randomized study. J Am Geriatr Soc. 2004;52:1702–7.CrossRefGoogle ScholarPubMed
Scarmeas, N, Luchsinger, JA, Schupf, N, et al. Physical activity, diet, and risk of Alzheimer disease. JAMA. 2009;302:627–37.Google ScholarPubMed
Ngandu, T, Lehtisalo, J, Solomon, A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385(9984):2255–63.CrossRefGoogle ScholarPubMed
Mohamed, S, Rosenheck, R, Lyketsos, CG, et al. Caregiver burden in Alzheimer disease: cross-sectional and longitudinal patient correlates. Am J Geriatr Psychiatry. 2010;18: 917–27.CrossRefGoogle ScholarPubMed
Okura, T, Langa, KM. Caregiver burden and neuropsychiatric symptoms in older adults with cognitive impairment: the aging, demographics, and memory study (ADAMS). Alzheimer Dis Assoc Disord. 2011;25: 116–21.CrossRefGoogle Scholar
Okura, T, Plassman, BL, Steffens, DC, et al. Prevalence of neuropsychiatric symptoms and their association with functional limitations in older adults in the United States: the aging, demographics, and memory study. J Am Geriatr Soc. 2010;58: 330–7.CrossRefGoogle ScholarPubMed
Brodaty, H, Arasaratnam, C. Meta-analysis of nonpharmacological interventions for neuropsychiatric symptoms of dementia. Am J Psychiatry. 2012;169:946–53.CrossRefGoogle ScholarPubMed
Teri, L, Rabins, P, Whitehourse, P, et al. Management of behavior disturbance in Alzheimer disease: current knowledge and future directions. Alzheimer Dis Assoc Disord. 1992;6:7788.CrossRefGoogle ScholarPubMed
Roca, RP. Managing the behavioral complications of dementia. In: Cobbs, EL, Duthie, EH, Murphy, JB, eds. Geriatric Review Syllabus: A Core Curriculum in Geriatric Medicine. 4th ed., Iowa: Kendall/Hunt; 1999:183–6.Google Scholar
Gitlin, LN, Winter, L, Dennis, MP, Hodgson, N, Hauck, WW. Targeting and managing behavioral symptoms in individuals with dementia: a randomized trial of a nonpharmacological intervention. J Am Geriatr Soc. 2010;58:1465–74.CrossRefGoogle ScholarPubMed
Lyketsos, CG, Steinberg, M, Tschanz, JT, et al. Mental and behavioral disturbances in dementia. Am J Psychiatry. 2000;157:708–14.CrossRefGoogle ScholarPubMed
Khachiyants, N, Trinkle, D, Son, SJ, et al. Sundown syndrome in persons with dementia: an update. Psychiatry Investig. 2011;4:275–87.Google Scholar
Cohen-Mansfield, J, Werner, P. Management of verbally disruptive behaviors in nursing home residents. J Gerontol Med Sci. 1996;52:M369–77.Google Scholar
Sloane, PD, Hoeffer, B, Mitchell, CM, et al. Effect of person-centered showering and the towel bath on bathing-associated aggression, agitation, and discomfort in nursing home residents with dementia: a randomized, controlled trial. J Am Geriatr Soc. 2004;52:17951804.CrossRefGoogle ScholarPubMed
Porsteinsson, AP, Drye, LT, Pollock, BG, et al. Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA. 2014;311:682–91.CrossRefGoogle ScholarPubMed
Lonergan, E, Luxenberg, J, Colford, J. Haloperidol for agitation in dementia. Cochrane Database Syst Rev. 2002;CD0003154.CrossRef
Wilson, MP, Pepper, D, Currier, GW, et al. The psychopharmacology of agitation: consensus statement of the American Association for Emergency Psychiatry Project Beta psychopharmacology workgroup. West J Emerg Med. 2012;13:2634.CrossRefGoogle Scholar
Schneider, LS, Tariot, PN, Dagerman, KS, et al. for the CATIE-AD Study Group. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer’s disease. NEJM. 2006;355:15251538.CrossRefGoogle ScholarPubMed
Sink, KM, Holden, KF, Yaffe, K. Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence. JAMA. 2005;293:596608.CrossRefGoogle Scholar
Lee, PE, Gill, SS, Freedman, M, et al. Atypical antipsychotic drugs in the treatment of behavioural and psychological symptoms of dementia: systematic review. BMJ. 2004;329:75.CrossRefGoogle ScholarPubMed
Kuehn, BM. FDA warns antipsychotic drugs may be risky for elderly. JAMA. 2005;293:2462.Google ScholarPubMed
Schneider, LS, Dagerman, KS, Insel, P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA. 2005;294:1934–42.CrossRefGoogle ScholarPubMed
Wang, PS, Schneeweiss, S, Avorn, J, et al. Risk of death in elderly users of conventional vs. atypical antipsychotic medications. NEJM. 2005;353:2335–41.CrossRefGoogle ScholarPubMed
Nelson, JC, Devanand, DP. A systematic review and meta-analysis of placebo-controlled antidepressant studies in people with depression and dementia. J Am Geriatr Soc. 2011;59:577–85.CrossRefGoogle ScholarPubMed
Weintraub, D, Rosenberg, PB, Drye, LT, et al. Sertraline for the treatment of depression in Alzheimer disease: week-24 outcomes. Am J Geriatr Psychiatry. 2010;18:332–40.CrossRefGoogle ScholarPubMed
Banerjee, S, Hellier, J, Dewey, M et al. Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial. Lancet. 2011 Jul 30;378(9789):403–11.CrossRefGoogle ScholarPubMed
Banerjee, S, Hellier, J, Romeo, R, et al. Study of the use of antidepressants for depression in dementia: the HTA-SADD trial – a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine. Health Technol Assess. 2013;17:1166.CrossRefGoogle Scholar
Coupland, C, Dhiman, P, Morriss, R, et al. Antidepressant use and risk of adverse outcomes in older people: population based cohort study. BMJ. 2011;343:d4551.CrossRefGoogle ScholarPubMed
Burrows, G, Kremer, C. Mirtazipine: clinical advantages in the treatment of depression. Psychopharmacology. 1997;17(Suppl): 34S39S.Google Scholar
Camargos, E, Louzado, L, Quintas, J. Trazodone improves sleep parameters in Alzheimer disease patients: a randomized, double-blind, and placebo-controlled study. Am J Geriatr Psychiatry. 2014 Dec;22(12):1565–74.CrossRefGoogle ScholarPubMed
Drachman, DA, Swearer, JM. Driving and Alzheimer’s disease: the risk of crashes [published erratum appears in Neurology. 1994;44:4]. Neurology. 1993;43:2448–56.Google Scholar
Iverson, DJ, Gronseth, GS, Reger, MA, et al. Practice parameter update: evaluation and management of driving risk in dementia. Report of the quality standards subcommittee of the American Academy of Neurology. Neurology. 2010;74:1316–24.CrossRefGoogle ScholarPubMed
American Geriatric Society Ethics Committee and Clinical Practice and Models of Care Committee. American Geriatrics Society feeding tubes in advance dementia position statement. J Am Geriatr Soc. 2014;62:1590–3.
Mitchell, SL, Teno, JM, Kiely, DK, et al. The clinical course of advanced dementia. N Engl J Med. 2009;361:1529–38.CrossRefGoogle ScholarPubMed
Gillick, MR. Rethinking the role of tube feeding in patients with advanced dementia. NEJM. 2000;342:206–10.CrossRefGoogle ScholarPubMed
Arai, Y, Sugiura, M, Washio, M, Miura, H, Kudo, K. Caregiver depression predicts early discontinuation of care for disabled elderly at home. Psychiatry Clin Neurosci. 2001;55:379–82.CrossRefGoogle ScholarPubMed
Belle, SH, Burgio, L, Burns, R, et al. Enhancing the quality of life of dementia caregivers from different ethnic or racial groups. Ann Intern Med. 2006;145:727–38.CrossRefGoogle ScholarPubMed
Newcomer, R, Yordi, C, DuNah, R, Fox, P, Wilkinson, A. Effects of the Medicare Alzheimer’s Disease Demonstration on caregiver burden and depression. Health Serv Res. 1999;34:669–89.Google ScholarPubMed
Gaugler, JE, Jarrott, SE, Zarit, SH, Stephens, MA, Townsend, A, Greene, R. Respite for dementia caregivers: the effects of adult day service use on caregiving hours and care demands. Int Psychogeriatr. 2003;15:3758.CrossRefGoogle ScholarPubMed
Kennedy, GJ. Dementia. In: Cassel, CK, Leipzig, R, Cohen, HJ, Larson, EB, Meier, DE. eds. Geriatric Medicine: An Evidence-Based Approach. 4th ed. New York: Springer-Verlag; 2003:1074–93.Google Scholar
Ryan, DJ, O’Regan, NA, Caoimh, RO, et al. Delirium in an adult acute hospital population: predictors, prevalence and detection.BMJ Open 2013 Jan 7;3(1):pii: e001772. DOI: 10.1136/bmjopen-2012-001772.CrossRefGoogle Scholar
Dasgupta, M. Prognosis of delirium in hospitalized elderly: worse than we thought.Geriatric Psychiatry 2013 May;29(5):497505.CrossRefGoogle ScholarPubMed
Kiely, DK, Marcantonio, ER, Inouye, SK, et al. Persistent delirium predicts greater mortality. J Am Geriatr Soc 2009 Jan;57(1):5561.CrossRefGoogle ScholarPubMed
George, J, Bleasdale, S, Singleton, S. Causes and prognosis of delirium in elderly patients admitted to a district general hospital. Age Ageing 1997 Nov 26(6):423–7.CrossRefGoogle ScholarPubMed
Leslie, DL, Inouye, SK. The importance of delirium: economic and societal costs. J Am Geriatr Soc 2011 Nov;59(2):241–3.CrossRefGoogle ScholarPubMed
Inouye, SK, Westendorp, RG, Saczynski, JS. Delirium in elderly people. Lancet 2014 Mar 8;383(9920):911–22.Google ScholarPubMed
Williams, ST. Pathophysiology of encephalopathy and delirium. Journal of Clinical Neurophysiology 2013;30(5):435–7.CrossRefGoogle ScholarPubMed
Morrison, RS1, Magaziner, J, Gilbert, M, et al. Relationship between pain and opioid analgesics on the development of delirium following hip fracture. J Gerontol A Biol Sci Med Sci. 2003 Jan;58(1):7681.CrossRefGoogle ScholarPubMed
Inouye, SK. Delirium in older persons. NEJM 2006 Mar;354:1157–65.CrossRefGoogle ScholarPubMed
Rudolph, JL, Jones, RN, Levkoff, SE, et al. Derivation and validation of a preoperative prediction rule for delirium after cardiac surgery. Circulation 2009 Jan 20;119(2):229–36.CrossRefGoogle ScholarPubMed
Kennedy, M, Enander, RA, Tadiri, SP, Wolfe, RE, Shapiro, NI, Marcantonio, ER. Delirium risk prediction, healthcare use and mortality of elderly adults in the emergency department. J Am Geriatr Soc 2014 Mar;62(3):462–69.CrossRefGoogle ScholarPubMed
Inouye, SK, Zhang, Y, Jones, RN, Kiely, DK, Yang, F, Marcantonio, ER. Risk factors for delirium at discharge: development and validation of a predictive model. Arch Intern Med 2007 Jul 9;167(13):1406–13.CrossRefGoogle ScholarPubMed
Inouye, SK. A multicomponent intervention to prevent delirium in hospitalized older patients. NEJM 1999 Mar 4;340(9):669–76.CrossRefGoogle ScholarPubMed
Inouye, SK, Rubin, FH, Wierman, HR, Supiano, MA, Fenlon, K. No shortcuts for delirium prevention. J Am Geriatr Soc 2010 May;58(5):998–9.CrossRefGoogle ScholarPubMed
Marcantonio, ER. Reducing delirium after hip fracture: a randomized trial. J Am Geriatr Soc 2001 May;49(5):516–22.CrossRefGoogle ScholarPubMed
Gorsch, M, Nicholas, JA. Pharmacologic prevention of postoperative delirium. Z Gerontol Geriatri 2014;47(2):105.CrossRefGoogle Scholar
Inouye, SK, van Dyck, CH, Alessi, CA, Balkin, S, Siegal, AP, Horwitz, RI. Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med 1990 Dec 15;113(12):941–8.CrossRefGoogle Scholar
Flaherty, JH, Little, MO. Matching the environment to patients with delirium: lessons learned from the delirium room, a restraint-free environment for older hospitalized adults with delirium. J Am Geriatr Soc 2013;59:295300.CrossRefGoogle Scholar
Lonergan, E, Britton, AM, Luxenberg, J, Wyller, T. Antipsychotics for delirium. Cochrane Database Syst Rev 2007 Apr 18;2:CD005594.Google Scholar