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Section III - Care of the elderly by organ system

Published online by Cambridge University Press:  05 June 2016

Jan Busby-Whitehead
University of North Carolina
Christine Arenson
Thomas Jefferson University, Philadelphia
Samuel C. Durso
The Johns Hopkins University School of Medicine
Daniel Swagerty
University of Kansas
Laura Mosqueda
University of Southern California
Maria Fiatarone Singh
University of Sydney
William Reichel
Georgetown University, Washington DC
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Reichel's Care of the Elderly
Clinical Aspects of Aging
, pp. 157 - 606
Publisher: Cambridge University Press
Print publication year: 2016

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Moran, AE, Forouzanfar, MH, Roth, GA, et al. Temporal trends in ischemic heart disease mortality in 21 world regions, 1980–2010: the Global Burden of Disease 2010 Study. Circulation 2014;129:14831492.CrossRefGoogle Scholar
Lozano, R, Naghavi, M, Foreman, K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:20952128.Google ScholarPubMed
Go, AS, Mozaffarian, D, Roger, VL, et al. Heart disease and stroke statistics – 2014 update: a report from the American Heart Association. Circulation 2014;129(3):399410.CrossRefGoogle ScholarPubMed
Lakatta, EG. Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons. Heart Failure Reviews 2002;7:2949.CrossRefGoogle ScholarPubMed
Rich, MW. Heart disease in the elderly. In: Rosendorff, C, ed. Essential Cardiology: Principles and Practice, Third Edition. New York: Springer, 2013:669686.CrossRefGoogle Scholar
D’Agostino, RB, Vasan, RS, Pencina, MJ, et al. General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 2008;117:743753.CrossRefGoogle ScholarPubMed
Haffner, SM, Lehto, S, Ronnemaa, T, et al. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. New Engl J Med 1998;339:229234.CrossRefGoogle ScholarPubMed
Kuller, LH, Arnold, AM, Psaty, BM, et al. Ten-year follow-up of subclinical cardiovascular disease and risk of coronary heart disease in the Cardiovascular Health Study. Arch Int Med 2006;166:7178.CrossRefGoogle Scholar
White, HD, Barbash, GI, Califf, RM, et al. Age and outcome with contemporary thrombolytic therapy: results from the GUSTO-I trial. Circulation 1996;94:18261833.CrossRefGoogle ScholarPubMed
Scirica, BM. Acute coronary syndrome: emerging tools for diagnosis and risk assessment. J Am Coll Cardiol 2010;55:14031415.CrossRefGoogle ScholarPubMed
Eggers, KM, Venge, P, Lindahl, B, Lind, L. Cardiac troponin I levels measured with a high-sensitivity assay increase over time and are strong predictors of mortality in an elderly population. J Am Coll Cardiol 2013;61:19061913.CrossRefGoogle Scholar
Thygesen, K, Alpert, JS, Jaffe, AS, et al. Third universal definition of myocardial infarction. J Am Coll Cardiol 2012;60:15811598.CrossRefGoogle ScholarPubMed
O’Gara, PT, Kushner, FG, Ascheim, DD, et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction. J Am Coll Cardiol 2013;61:e78140.Google ScholarPubMed
Amsterdam, EA, Wenger, NK, Brindis, RG, et al. 2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes. J Am Coll Cardiol 2014;64(24):e139e228.CrossRefGoogle ScholarPubMed
ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 1988;332: 349360.CrossRef
The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001;345: 494502.CrossRef
Wiviott, SD, Braunwald, E, McCabe, CH, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007;357:20012015.CrossRefGoogle ScholarPubMed
Wallentin, L, Becker, RC, Budaj, A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2009;361:10451057.CrossRefGoogle ScholarPubMed
Steen, H, James, S, Becker, RC, et al. Ticagrelor versus clopidogrel in elderly patients with acute coronary syndromes: a substudy from the Prospective Randomized PLATelet Inhibition and Patient Outcomes (PLATO) trial. Circ Cardiovasc Qual Outcomes 2012;680688.CrossRef
Mauri, L, Kereiakes, DJ, Yeh, RW, et al. Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. N Engl J Med 2014;371:21552166.CrossRefGoogle ScholarPubMed
Morrow, DA, Braunwald, E, Bonaca, MP, et al. Vorapaxar in the secondary prevention of atherothrombotic events. N Engl J Med 2012;366:14041413.CrossRefGoogle ScholarPubMed
The PURSUIT Trial Investigators. Inhibition of platelet glycoprotein IIb/IIIa with eptifibatide in patients with acute coronary syndromes. N Engl J Med 1998;339: 436443.CrossRef
Antman, EM, Cohen, M, Radley, D, et al. Assessment of the treatment effect of enoxaparin for unstable angina/non-Q-wave myocardial infarction: TIMI 11B-ESSENCE meta-analysis. Circulation 1999;100:16021608.CrossRefGoogle ScholarPubMed
FRagmin and Fast Revascularization during InStability in Coronary artery disease (FRISC II) Investigators. Long-term low-molecular-mass heparin in unstable coronary-artery disease: FRISC II prospective randomised multicentre study. Lancet 1999;354: 701707.CrossRef
Dewilde, WJ, Oirbans, T, Verheugt, FW, et al. Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomized, controlled trial. Lancet 2013;381:11071115.CrossRefGoogle ScholarPubMed
COMMIT Collaborative Group. Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet 2005;366:16221632.CrossRef
ACE Inhibitor Myocardial Infarction Collaborative Group. Indications for ACE inhibitors in the early treatment of acute myocardial infarction: systematic overview of individual data from 100,000 patients in randomized trials. Circulation 1998;97:22022212.CrossRef
Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico. GISSI-3: effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction. Lancet 1994;343:11151122.
Ambrosioni, E, Borghi, C, Magnani, B, for the Survival of Myocardial Infarction Long-Term Evaluation (SMILE) Study Investigators. The effect of the angiotensin-converting-enzyme inhibitor zofenopril on mortality and morbidity after anterior myocardial infarction. N Engl J Med 1995;332:8085.CrossRefGoogle ScholarPubMed
The Acute Infarction Ramipril Efficacy (AIRE) Study Investigators. Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet 1993;342:821828.
Dickstein, K, Kjekshus, J. Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial. Lancet 2002;360:752760.CrossRefGoogle ScholarPubMed
Pitt, B, Remme, W, Zannad, F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003;348:13091321.CrossRefGoogle ScholarPubMed
Miettinen, TA, Pyorala, K, Olsson, AG, et al. Cholesterol-lowering therapy in women and elderly patients with myocardial infarction or angina pectoris: findings from the Scandinavian Simvastatin Survival Study (4S). Circulation 1997;96:42114218.CrossRefGoogle Scholar
Lewis, SJ, Moye, LA, Sacks, FM, et al. Effect of pravastatin on cardiovascular events in older patients with myocardial infarction and cholesterol levels in the average range: results of the Cholesterol and Recurrent Events (CARE) trial. Ann Intern Med 1998;129:681689.CrossRefGoogle ScholarPubMed
The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998;339:13491357.CrossRef
Shepherd, J, Blauw, GJ, Murphy, MB, et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 2002;360:16231630.CrossRefGoogle ScholarPubMed
Stone, NJ, Intwala, S, Katz, D. Statins in very elderly adults. J Am Geriatr Soc 2014;62:943945.CrossRefGoogle ScholarPubMed
Rich, MW. Aggressive lipid management in very elderly adults: less is more. J Am Geriatr Soc 2014;62:945947.CrossRefGoogle ScholarPubMed
Sathasivam, S. Statin induced myopathy. BMJ 2008;337:a2286.CrossRefGoogle ScholarPubMed
Lee, DS, Markwardt, S, Goeres, L, et al. Statins and physical activity in older men: the osteoporotic fractures in men study. JAMA Intern Med 2014;174:12631270.Google ScholarPubMed
Golomb, BA, Evans, MA, Dimsdale, JE, et al. Effects of statins on energy and fatigue with exertion: Results from a randomized controlled trial. Arch Intern Med 2012;172:11801182.CrossRefGoogle ScholarPubMed
Evans, MA, Golomb, BA. Statin-associated adverse cognitive effects: survey results from 171 patients. Pharmacotherapy 2009;29:800811.CrossRefGoogle ScholarPubMed
The Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO IIb) Angioplasty Substudy Investigators. A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction. N Engl J Med 1997;336:16211628.CrossRef
De Boer, MJ, Ottervanger, JP, van’t Hof, AW, et al. Reperfusion therapy in elderly patients with acute myocardial infarction: a randomized comparison of primary angioplasty and thrombolytic therapy. J Am Coll Cardiol 2002;39:17231728.CrossRefGoogle ScholarPubMed
Antman, EM, Cohen, M, Bernink, PJLM, et al. The TIMI Risk Score for unstable angina/non-ST elevation MI: a method for prognostication and therapeutic decision making. JAMA 2000;284:835842.CrossRefGoogle ScholarPubMed
Granger, CB, Goldberg, RJ, Dabbous, O, et al. Predictors of hospital mortality in the Global Registry of Acute Coronary Events (GRACE). Arch Intern Med 2003;163:23452353.CrossRefGoogle Scholar
FRagmin and Fast Revascularization during InStability in Coronary artery disease (FRISC II) Investigators. Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study. Lancet 1999;354: 708715.CrossRef
Hochman, JS. Cardiogenic shock complicating acute myocardial infarction: expanding the paradigm. Circulation 2003;107:29983002.CrossRefGoogle ScholarPubMed
Hochman, JS, Sleeper, LA, White, HD, et al. for the SHOCK Investigators. One-year survival following early revascularization for cardiogenic shock. JAMA 2001;285:190192.CrossRefGoogle ScholarPubMed
Dzavik, V, Sleeper, LA, Cocke, TP, et al. for the SHOCK Investigators. Early revascularization is associated with improved survival in elderly patients with acute myocardial infarction complicated by cardiogenic shock: a report from the SHOCK Trial Registry. Eur Heart J 2003;24:828837.CrossRefGoogle ScholarPubMed
Bueno, H, Lopez-Palop, R, Perez-David, E, et al. Combined effect of age and right ventricular involvement on acute inferior myocardial infarction prognosis. Circulation 1998;98:17141720.CrossRefGoogle ScholarPubMed
Hasdai, D, Topol, EJ, Califf, RM, et al. Cardiogenic shock complicating acute coronary syndromes. Lancet 2000;356:749756.CrossRefGoogle ScholarPubMed
Fihn, SD, Gardin, JM, Abrams, J, et al. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease. J Am Coll Cardiol 2012;60:e44e164.CrossRefGoogle ScholarPubMed
James, PA, Oparil, S, Carter, BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults. JAMA 2014;311:507520.CrossRefGoogle ScholarPubMed
Stone, NJ, Robinson, JG, Lichtenstein, AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults. J Am Coll Cardiol 2014;63:28892934.CrossRefGoogle ScholarPubMed
American Geriatrics Society Expert Panel on the Care of Older Adults with Diabetes Mellitus. Guidelines abstracted from the American Geriatrics Society guidelines for improving the care of older adults with diabetes mellitus: 2013 update. J Am Geriatrc Soc 2013;61:20202026.CrossRef
Witt, BJ, Jacobsen, SJ, Weston, SA, et al. Cardiac rehabilitation after myocardial infarction in the community. J Am Coll Cardiol 2004;44:988996.CrossRefGoogle Scholar
American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). ACC/AHA 2002 guidelines update for exercise testing. Circulation 2002;106:18831892.
The TIME Investigators. Trial of invasive versus medical therapy in elderly patients with chronic symptomatic coronary-artery disease (TIME): a randomised trial. Lancet 2001;358:951957.CrossRef
Boden, WE, O’Rourke, RA, Teo, KK, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med 2007;356:15031516.CrossRefGoogle ScholarPubMed
Weintraub, WS, Veledar, E, Thompson, T, Burnette, J, Jurkovitz, C, Mahoney, E. Percutaneous coronary intervention outcomes in octogenarians during the stent era (National Cardiovascular Network). Am J Cardiol 2001;88:14071410.CrossRefGoogle Scholar
Alexander, KP, Anstrom, KJ, Muhlbaier, LH, et al. Outcomes of cardiac surgery in patients ≥80 years: results from the National Cardiovascular Network. J Am Coll Cardiol 2000;35:731738.CrossRefGoogle Scholar
Newman, MF, Kirchner, JL, Phillips-Bute, B, et al. for the Neurological Outcome Research Groups and the Cardiothoracic Anesthesiology Research Endeavors Investigators. Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. N Engl J Med 2001;344:395402.CrossRefGoogle ScholarPubMed
Yancy, CW, Jessup, M, Bozkurt, B, et al. 2013 ACCF/AHA guideline for the management of heart failure. Circulation 2013;128:e240e327.Google ScholarPubMed
The ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker versus diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002;288:29812997.CrossRef
Moser, M, Hebert, PR. Prevention of disease progression, left ventricular hypertrophy and congestive heart failure in hypertension treatment trials. J Am Coll Cardiol 1996;27:12141218.CrossRefGoogle ScholarPubMed
Okin, PM, Devereux, RB, Jern, S, et al. Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and the prediction of major cardiovascular events. JAMA 2004;292:23432349.CrossRefGoogle ScholarPubMed
Goldman, L, Hashimoto, B, Cook, EF, Loscalzo, A. Comparative reproducibility and validity of systems for assessing cardiovascular functional class: advantages of a new specific activity scale. Circulation 1981;64:12271234.CrossRefGoogle ScholarPubMed
Maisel, AS, Krishnaswamy, P, Nowak, RM, et al. for the Breathing Not Properly Multinational Study Investigators. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med 2002;347:161167.CrossRefGoogle ScholarPubMed
Gaggin, HK, Mohammed, AA, Bhardwaj, A, et al. Heart failure outcomes and benefits of NT-proBNP-guided management in the elderly: Results from the Prospective, Randomized ProBNP Outpatient Tailored Chronic Heart Failure Therapy (PROTECT Study). J Cardiac Fail 2012;18:626634.CrossRefGoogle Scholar
Redfield, MM, Rodeheffer, RJ, Jacobsen, SJ, et al. Plasma brain natriuretic peptide concentration: impact of age and gender. J Am Coll Cardiol 2002;40:976982.CrossRefGoogle ScholarPubMed
Wang, TJ, Larson, MG, Levy, D, et al. Impact of age and sex on plasma natriuretic peptide levels in healthy adults. Am J Cardiol 2002;90:254258.CrossRefGoogle ScholarPubMed
Heiat, A, Gross, CP, Krumholz, HM. Representation of the elderly, women, and minorities in heart failure clinical trials. Arch Intern Med 2002;162:16821688.CrossRefGoogle ScholarPubMed
Rich, MW, Beckham, V, Wittenberg, C, et al. A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl J Med 1995;333:11901195.CrossRefGoogle ScholarPubMed
Whellan, DJ, Hasselblad, V, Peterson, E, O’Connor, CM, Schulman, KA. Meta-analysis and review of heart failure disease management randomized controlled clinical trials. Am Heart J 2005;149:722729.CrossRefGoogle ScholarPubMed
Ades, PA, Keteyian, SJ, Balady, GJ, et al. Cardiac rehabilitation exercise and self-care for chronic heart failure. J Am Coll Cardiol HF 2013;1(6):540547.Google ScholarPubMed
Faris, R, Flather, M, Purcell, H, et al. Current evidence supporting the role of diuretics in heart failure: a meta analysis of randomised controlled trials. Int J Cardiol 2002;82:149158.CrossRefGoogle ScholarPubMed
Domanski, M, Norman, J, Pitt, B, et al. Diuretic use, progressive heart failure, and death in patients in the Studies of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol 2003;42:705708.CrossRefGoogle Scholar
Neuberg, GW, Miller, AB, O’Connor, CM, et al. Diuretic resistance predicts mortality in patients with advanced heart failure. Am Heart J 2002;144:3138.CrossRefGoogle ScholarPubMed
Gheorghiade, M, Zannad, F, Sopko, G, et al. Acute heart failure syndromes: current state and framework for future research. Circulation 2005;112:39583968.CrossRefGoogle ScholarPubMed
Gupta, D, Georgiopoulou, VV, Kalogeropoulos, AP, et al. Dietary sodium intake in heart failure. Circulation 2012;126:479485.CrossRefGoogle ScholarPubMed
Flather, MD, Yusuf, S, Kober, L, et al. for the ACEI-Inhibitor Myocardial Infarction Collaborative Group. Long-term ACEI-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients. Lancet 2000;355:15751581.CrossRefGoogle ScholarPubMed
Garg, R, Yusuf, S for the Collaborative Group on ACE Inhibitor Trials. Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. JAMA 1995;273:14501456.CrossRefGoogle ScholarPubMed
The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fraction. N Engl J Med 1992;327:685691.CrossRef
Maggioni, AP, Anand, I, Gottlieb, SO, et al. Effects of valsartan on morbidity and mortality in patients with heart failure not receiving angiotensin-converting enzyme inhibitors. J Am Coll Cardiol 2002;40:14141421.CrossRefGoogle Scholar
Granger, CB, McMurray, JJV, Yusuf, S, et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial. Lancet 2003;362:772776.CrossRefGoogle ScholarPubMed
Pfeffer, MA, Swedberg, K, Granger, CB, et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet 2003;362:759766.CrossRefGoogle ScholarPubMed
Kuenzli, A, Bucher, HC, Anand, I, et al. Meta-analysis of combined therapy with angiotensin receptor antagonists versus ACE inhibitors alone in patients with heart failure. PloS One 2010;5:e9946.CrossRefGoogle ScholarPubMed
Cohn, JN, Archibald, DG, Ziesche, S, et al. Effect of vasodilator therapy on mortality in chronic congestive heart failure: results of a Veterans Administration Cooperative Study. N Engl J Med 1986;314:15471552.CrossRefGoogle ScholarPubMed
Cohn, JN, Johnson, G, Ziesche, S, et al. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med 1991;325:303310.CrossRefGoogle ScholarPubMed
Taylor, AL, Ziesche, S, Yancy, C, et al. for the African-American Heart Failure Trial Investigators. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med 2004;351:20492057.CrossRefGoogle ScholarPubMed
MERIT-HF Study Group. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet 1999;353:20012007.CrossRef
Packer, M, Coats, AJS, Fowler, MB, et al. for the Carvedilol Prospective Randomized Cumulative Survival Study Group. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 2001;344:16511658.CrossRefGoogle ScholarPubMed
Deedwania, PC, Gottlieb, S, Ghali, JK, et al. Efficacy, safety and tolerability of beta-adrenergic blockade with metoprolol CR/XL in elderly patients with heart failure. Eur Heart J 2004;25:13001309.CrossRefGoogle ScholarPubMed
Pitt, B, Zannad, F, Remme, WJ, et al. for the Randomized Aldactone Evaluation Study Investigators. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999;341:709717.CrossRefGoogle ScholarPubMed
Zannad, F, McMurray, JJV, Krum, H, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med 2011;364:1121.CrossRefGoogle ScholarPubMed
Juurlink, DN, Mamdani, MM, Lee, DS, et al. Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study. N Engl J Med 2004;351:543551.CrossRefGoogle ScholarPubMed
The Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 1997;336:525533.CrossRef
Rich, MW, McSherry, F, Williford, WO, Yusuf, S, for the Digitalis Investigation Group. Effect of age on mortality, hospitalizations and response to digoxin in patients with heart failure: the DIG study. J Am Coll Cardiol 2001;38:806813.CrossRefGoogle ScholarPubMed
Ahmed, A, Rich, MW, Love, TE, et al. Digoxin and reduction in mortality and hospitalization in heart failure: a comprehensive post hoc analysis of the DIG trial. Eur Heart J 2006;27:178186.CrossRefGoogle ScholarPubMed
Massie, BN, Collins, JF, Ammon, SE, et al. Randomized trial of warfarin, aspirin, and clopidogrel in patients with chronic heart failure: the Warfarin and Antiplatelet Therapy in Chronic Heart Failure (WATCH) Trial. Circulation 2009;119:16161624.CrossRefGoogle ScholarPubMed
Homma, S, Thompson, JLP, Pullicino, PM, et al. Warfarin and aspirin in patients with heart failure and sinus rhythm. N Engl J Med 2012;366:18591869.CrossRefGoogle ScholarPubMed
O’Connor, CM, Gattis, WA, Uretsky, BF, et al. Continuous intravenous dobutamine is associated with an increased risk of death in patients with advanced heart failure: Insights from the Flolan International Randomized Survival Trial (FIRST). Am Heart J 1999;138:7886.CrossRefGoogle Scholar
Cuffe, MS, Califf, RM, Adams, KFJ, et al. Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial. JAMA 2002;287:15411547.CrossRefGoogle ScholarPubMed
Publication Committee for the VMAC Investigators (Vasodilation in the Management of Acute CHF). Intravenous nesiritide vs nitroglycerin for treatment of decompensated congestive heart failure: a randomized controlled trial. JAMA 2002;287:15311540.
O’Connor, CM, Starling, RC, Hernandez, AF, et al. Effect of nesiritide in patients with acute decompensated heart failure. N Engl J Med 2011;365:3243.CrossRefGoogle ScholarPubMed
Daneshvar, DA, Czer, LS, Phan, A, Trento, A, Schwarz, ER. Heart transplantation in the elderly: why cardiac transplantation does not need to be limited to younger patients but can be safely performed in patients above 65 years of age. Ann Transplant 2010;15:110119.Google Scholar
Atluri, P, Goldstone, AB, Kobrin, DM, et al. Ventricular assist device implant in the elderly is associated with increased, but respectable risk: A multi-institutional study. Ann Thorac Surg 2013;96:141147.CrossRefGoogle ScholarPubMed
Kitzman, DW, Gardin, JM, Gottdiener, JS, et al. for the Cardiovascular Health Study Research Group. Importance of heart failure with preserved systolic function in patients > or = 65 years of age. Am J Cardiol 2001;87:413419.CrossRefGoogle ScholarPubMed
Owan, TE, Hodge, DO, Herges, RM, Jacobsen, SJ, Roger, VL, Redfield, MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 2006;355:251259.CrossRefGoogle ScholarPubMed
Bhatia, RS, Tu, JV, Lee, DS, et al. Outcome of heart failure with preserved ejection fraction in a population-based study. New Engl J Med 2006;355:260269.CrossRefGoogle ScholarPubMed
Owan, TE, Hodge, DO, Herges, RM, et al. Trends in prevalence and outcome of heart failure with preserved ejection fraction. New Engl J Med 2006;355:251259.CrossRefGoogle ScholarPubMed
Meta-analysis Global Group in Chronic Heart Failure (MAGGIC). The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis. Eur Heart J 2011; doi:10.1093/eurheartj/ehr254.CrossRef
Yusuf, S, Pfeffer, MA, Swedberg, K, et al. for the CHARM investigators and Committees. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet 2003;362:777781.CrossRefGoogle ScholarPubMed
Ahmed, A, Rich, MW, Fleg, JL, et al. Effects of digoxin on morbidity and mortality in diastolic heart failure: the Ancillary Digitalis Investigation Group Trial. Circulation 2006;114:397403.CrossRefGoogle ScholarPubMed
Cleland, JGF, Tendera, M, Adamus, J, et al. The perindopril in elderly people with chronic heart failure (PEP-CHF) study. Eur Heart J 2006;27:23382345.CrossRefGoogle ScholarPubMed
Massie, BM, Carson, PE, McMurray, JJ, et al. Irbesartan in patients with heart failure and preserved ejection fraction. N Engl J Med 2008;359:24562467.CrossRefGoogle ScholarPubMed
Van Veldhuisen, DJ, Cohen-Solal, A, Bohm, M, et al. Beta-blockade with nebivolol in elderly heart failure patients with impaired and preserved left ventricular ejection fraction. J Am Coll Cardiol 2009;53:21502158.CrossRefGoogle ScholarPubMed
Pitt, B, Pfeffer, MA, Assmann, SF, et al. Spironolactone for heart failure with preserved ejection fraction. N Engl J Med 2014;370:13831392.CrossRefGoogle ScholarPubMed
Edelmann, F, Wachter, R, Schmidt, AG, et al. Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial. JAMA 2013;309:781791.CrossRefGoogle ScholarPubMed
Redfield, MM, Chen, HH, Borlaug, BA, et al. Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial. JAMA 2013;309:12681277.CrossRefGoogle ScholarPubMed
Zile, MR, Bourge, RC, Redfield, MM, Zhou, D, Baicu, CF, Little, WC. Randomized, double-blind, placebo-controlled study of sitaxsentan to improve impaired exercise tolerance in patients with heart failure and a preserved ejection fraction. J Am Coll Cardiol HF 2014;2:123130.Google Scholar
Conraads, VM, Metra, M, Kamp, O, et al. Effects of long-term administration of nebivolol on the clinical symptoms, exercise capacity, and left ventricular function of patients with diastolic dysfunction: results of the ELANDD study. Eur J Heart Fail 2012;14:219225.CrossRefGoogle ScholarPubMed
Bristow, MR, Saxon, LA, Boehmer, J, et al. for the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med 2004;350:21402150.CrossRefGoogle ScholarPubMed
Cleland, JGF, Daubert, JC, Erdmann, E, et al. for the Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators. The effect of cardiac resynchronization on morbidity and mortality in heart failure. New Engl J Med 2005;352:15391549.CrossRefGoogle ScholarPubMed
Tracy, CM, Epstein, AE, Darbar, D, et al. 2012 ACCF/AHA/HRS Focused update incorporated into the ACCF/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities. Circulation 2013;127:e283e352.Google Scholar
Cheng, YJ, Zhang, J, Li, WJ, et al. More favorable response to cardiac resynchronization therapy in women than in men. Circ Arrhythm Electrophysiol 2014;7(5):807815.CrossRefGoogle ScholarPubMed
Zusterzeel, R, Selzman, KA, Sanders, WE, et al. Cardiac resynchronization therapy in women: US Food and Drug Administration meta-analysis of patient-level data. JAMA Intern Med 2014;174:13401348.CrossRefGoogle ScholarPubMed
Verbrugge, FH, Dupont, M, De Vusser, P, et al. Response to cardiac resynchronization therapy in elderly patients (≥70 years) and octogenarians. Eur J Heart Fail 2013;15:203210.CrossRefGoogle ScholarPubMed
Moss, AJ, Zareba, W, Hall, WJ, et al. for the Multicenter Automatic Defibrillator Implantation Trial II Investigators. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 2002;346:877883.CrossRefGoogle ScholarPubMed
Bardy, GH, Lee, KL, Mark, DB, et al. for the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 2005;352:225237.CrossRefGoogle ScholarPubMed
Santangeli, P, Di Biase, L, Dello Russo, A, et al. Meta-analysis: age and effectiveness of prophylactic implantable cardioverter-defibrillators. Ann Intern Med 2010;153:592599.CrossRefGoogle ScholarPubMed
Lampert, R, Hayes, DL, Annas, GJ, et al. HRS Expert Consensus Statement on the Management of Cardiovascular Implantable Electronic Devices (CIEDs) in patients nearing end of life or requesting withdrawal of therapy. Heart Rhythm 2010;7:10081026.CrossRefGoogle ScholarPubMed
Feltner, C, Jones, CD, Cene, CW, et al. Transitional care interventions to reduce readmissions for persons with heart failure: a systematic review and meta-analysis. Ann Intern Med 2014;160:774784.CrossRefGoogle ScholarPubMed
Huynh, BC, Rovner, A, Rich, MW. Long-term survival in elderly patients hospitalized for heart failure: 14 year follow-up from a prospective randomized trial. Arch Intern Med 2006;166:18921898.CrossRefGoogle ScholarPubMed
Whellan, DJ, Goodlin, SJ, Dickinson, MG, et al. End-of-life care in patients with heart failure. J Cardiac Failure 2014;20:121134.CrossRefGoogle ScholarPubMed
Otto, CM, Prendergast, B. Aortic-valve stenosis – from patients at risk to severe valve obstruction. N Engl J Med 2014;371:744756.CrossRefGoogle ScholarPubMed
Nishimura, RA, Otto, CM, Bonow, RO, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease. J Am Coll Cardiol 2014;63:e57e185.CrossRefGoogle ScholarPubMed
Leon, MB, Smith, CR, Mack, M, et al. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med 2010;363:15971607.CrossRefGoogle ScholarPubMed
Smith, CR, Leon, MB, Mack, MJ, et al. Transcatheter versus surgical aortic-valve replacement in high-risk patients. N Engl J Med 2011;364:21872198.CrossRefGoogle ScholarPubMed
Kodali, SK, Williams, MR, Smith, CR, et al. Two-year outcomes after transcatheter or surgical aortic-valve replacement. N Engl J Med 2012;366:16861695.CrossRefGoogle ScholarPubMed
Reynolds, MR, Magnuson, EA, Lei, Y, et al. Health-related quality of life after transcatheter aortic valve replacement in inoperable patients with severe aortic stenosis. Circulation 2011;124:19641972.CrossRefGoogle ScholarPubMed
Lindman, BR, Alexander, KP, O’Gara, PT, Afilalo, J. Futility, benefit, and transcatheter aortic valve replacement. J Am Coll Cardiol Cardiovasc Intervent; 2014;7:707716.CrossRefGoogle ScholarPubMed
Scognamiglio, R, Rahimtoola, SH, Fasoli, G, et al. Nifedipine in asymptomatic patients with severe aortic regurgitation and normal left ventricular function. N Engl J Med 1994;331:689694.CrossRefGoogle ScholarPubMed
Evangelista, A, Tornos, P, Sambola, A, et al. Long-term vasodilator therapy in patients with severe aortic regurgitation. N Engl J Med 2005;353:13421349.CrossRefGoogle ScholarPubMed
Mathew, JP, Fontes, ML, Tudor, IC, et al. A multicenter risk index for atrial fibrillation after cardiac surgery. JAMA 2004;291:17201729.CrossRefGoogle ScholarPubMed
Crystal, E, Connolly, SJ, Sleik, K, et al. Interventions on prevention of postoperative atrial fibrillation in patients undergoing heart surgery: a meta-analysis. Circulation 2002;106:7580.CrossRefGoogle ScholarPubMed
Mitchell, LB, Exner, DV, Wyse, DG, et al. Prophylactic oral amiodarone for the prevention of arrhythmias that begin early after revascularization, valve replacement, or repair – PAPABEAR: a randomized controlled trial. JAMA 2005;294:30933100.CrossRefGoogle ScholarPubMed
Enriquez-Sarano, M, Avierinos, JF, Messika-Zeitoun, D, et al. Quantitative determinants of the outcome of asymptomatic mitral regurgitation. N Engl J Med 2005;352:875883.CrossRefGoogle ScholarPubMed
Feldman, T, Foster, E, Glower, DD, et al. Percutaneous repair or surgery for mitral regurgitation. N Engl J Med 2011;364:13951406.CrossRefGoogle ScholarPubMed
Wan, B, Rahnvavardi, M, Tian, DH, et al. A meta-analysis of MitraClip system versus surgery for treatment of severe mitral regurgitation. Ann Cardiothorac Surg 2013;2:683692.Google ScholarPubMed
Lamas, GA, Lee, KL, Silverman, R, et al. Ventricular pacing or dual-chamber pacing for sinus-node dysfunction. N Engl J Med 2002;346:18541862.CrossRefGoogle ScholarPubMed
Go, AS, Hylek, EM, Phillips, KA, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk factors In Atrial fibrillation (ATRIA) study. JAMA 2001;285:23702375.CrossRefGoogle ScholarPubMed
January, CT, Wann, LS, Alpert, JS, et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation. J Am Coll Cardiol 2014;64(21):e1e76.CrossRefGoogle ScholarPubMed
Coleman, CI, Perkerson, KA, Gillespie, EL, et al. Impact of prophylactic beta blockade on post-cardiothoracic surgery length of stay and atrial fibrillation. Ann Phamacother 2004;38:20122016.CrossRefGoogle ScholarPubMed
Kluger, J, White, CM. Amiodarone prevents symptomatic atrial fibrillation and reduces the risk of cerebrovascular events and ventricular tachycardia after open heart surgery: results of the Atrial Fibrillation Suppression Trial (AFIST). Card Electrophysiol Rev 2003;7:165167.CrossRefGoogle Scholar
Wyse, DG, Waldo, AL, DiMarco, JP, et al. A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med 2002;347:18251833.Google ScholarPubMed
The AFFIRM Investigators. Quality of life in atrial fibrillation: the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. Am Heart J 2005;149:112120.CrossRef
Wolf, PA, Abbott, RD, Kannel, WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke 1991;22:983988.CrossRefGoogle ScholarPubMed
Gage, BF, Waterman, AD, Shannon, W, et al. Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation. JAMA 2001;285:28642870.CrossRefGoogle Scholar
Lip, GY, Nieuwlaat, R, Pisters, R, Lane, DA, Crijns, HJ. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the Euro Heart Survey on Atrial Fibrillation. Chest. 2010;137:263–72.CrossRefGoogle ScholarPubMed
Connolly, SJ, Ezekowitz, MD, Yusuf, S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009;361:11391151.CrossRefGoogle ScholarPubMed
Patel, MR, Mahaffey, KW, Garg, J, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011;365:883891.CrossRefGoogle ScholarPubMed
Granger, CB, Alexander, JH, McMurray, JJV, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011;365:981992.CrossRefGoogle ScholarPubMed
Pisters, R, Lane, DA, Nieuwlaat, R, Vos, CB, Crijns, HJ, Lip, GY. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. Chest 2010;138:10931100.CrossRefGoogle ScholarPubMed
Lane, DA, Lip, GYH. Clinician update: use of the CHA2DS2-VASc and HAS-BLED scores to aid decision making for thromboprophylaxis in nonvalvular atrial fibrillation. Circulation 2012;126:860865.CrossRefGoogle Scholar
Gage, BF, Birman-Deych, E, Kerzner, R, Radford, MJ, Nilasena, DS, Rich, MW. Incidence of intracranial hemorrhage in patients with atrial fibrillation who are prone to fall. Am J Med 2005;118:612617.CrossRefGoogle ScholarPubMed
Donze, J, Clair, C, Hug, B, et al. Risk of falls and major bleeds in patients on oral anticoagulation therapy. Am J Med 2012;125:773778.CrossRefGoogle ScholarPubMed
Sardar, P, Chatterjee, S, Chaudhari, S, Lip, GY. New oral anticoagulants in elderly adults: evidence from a meta-analysis of randomized trials. J Am Geriatr Soc 2014;62:857864.CrossRefGoogle ScholarPubMed
Buxton, AE, Lee, KL, Fisher, JD, et al. for the Multicenter Unsustained Tachycardia Trial Investigators. A randomized study of the prevention of sudden death in patients with coronary artery disease. N Engl J Med 1999;341:18821890.CrossRefGoogle ScholarPubMed
US Census Bureau, Statistical Abstract of the United States: 2012. Table 169. Visits to Office-Based Physicians and Hospital Outpatient Departments by Diagnosis: 2003 and 2008. Health and Nutrition, page 117. Available at: (accessed August 15, 2014).
Gillespie, CD, Hurvitz, KA, National Center for Chronic Disease Prevention and Health Promotion, National Center for Health Statistics. Prevalence of hypertension and controlled hypertension – United States, 2007–2010. CDC Health Disparities and Inequalities Report – United States, 2013. MMWR Supplement. 2013;62(3):144–8.Google Scholar
Vasan, RS, Larson, MG, Leip, EP, et al. Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med. 2001;345:1291–7.CrossRefGoogle ScholarPubMed
James, PA, Oparil, S, Carter, BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth joint national committee (JNC 8). JAMA. 2014;311(5):507–20.CrossRefGoogle Scholar
Perry, HM Jr, Davis, BR, Price, TR, et al. Effect of treating isolated systolic hypertension on the risk of developing various types and subtypes of stroke: The systolic hypertension in the elderly program (SHEP). JAMA. 2000;824:465–71.Google Scholar
Beckett, NS, Peters, R, Fletcher, AE, et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008;358:1887–98.CrossRefGoogle ScholarPubMed
Laubscher, T, Regier, L, Stone, S. Hypertension in the elderly: new blood pressure targets and prescribing tips. Canadian Family Physician. 2014;60(5):453–6.Google ScholarPubMed
Sica, D. Assessment of the role of ACE inhibitors in the elderly. In: Prisant, LM, ed. Hypertension in the Elderly. Totowa, NJ: Humana Press, 2005: 321–48.Google Scholar
JNC7 Express: The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Bethesda, MD: National High Blood Pressure Education Program, Department of Health and Human Services, 2003:3 (table 1).
McDermott, M, Hoff, F, Ferrucci, L, et al. Lower extremity ischemia, calf skeletal muscle characteristics, and functional impairment in peripheral arterial disease. J Am Ger Soc. 2007;55(3):400406.CrossRefGoogle ScholarPubMed
Parmenter, B, Baker, M, Barry, B, et al. Muscle strength is impaired in peripheral arterial disease and predicts over ground walking ability. Submitted to J Gerontol. 30 Jun 2014.CrossRef
Parmenter, BJ, Raymond, J, Fiatarone Singh, M. The effect of exercise on fitness and functional outcomes in intermittent claudication: a systematic review of randomized controlled trials. Sports Med. 2013;43(6):513552.CrossRefGoogle Scholar
McDermott, M, Greenland, P, Liu, K, et al. Leg symptoms in peripheral arterial disease. Associated clinical characteristics and functional impairment. JAMA. 2001;286(13):1599.CrossRefGoogle ScholarPubMed
Long, J, Modrall, J, Parker, B, Swann, A, Welborn III, M, Anthony, T. Correlation between ankle-brachial index, symptoms, and health-related quality of life in patients with peripheral vascular disease. J Vasc Surg. 2004;39:723727.CrossRefGoogle ScholarPubMed
Caro, J, Migliaccio-Walle, K, Ishak, K, Proskorovsky, I. The morbidity and mortality following a diagnosis of peripheral arterial disease: long-term follow-up of a large database. BMC Cardiovascular Disorders. 2005;5(14):18.CrossRefGoogle ScholarPubMed
Criqui, M, Deneberg, J, Langer, R, Fronek, A. The epidemiology of peripheral arterial disease: importance of identifying the population at risk. Vasc Med. 1997;2(3):221226.CrossRefGoogle ScholarPubMed
Kannel, W, Shurtleff, D. The Framingham Study: cigarettes and the development of intermittent claudication. Geriatrics. 1973;28(2):6168.Google ScholarPubMed
Smith, G, Shipley, M, Rose, G. Intermittent claudication, heart disease risk factors, and mortality: the Whitehall Study. Circulation. 1990;82(6):19251931.CrossRefGoogle ScholarPubMed
Anderson, J, Halperin, J, Albert, N, et al. Management of patients with peripheral artery disease ACC/AHA 2005 and 2011 guidelines. Circulation. 2013;127. doi: 10.1161/CIR.1160b1013e31828b31882aa.CrossRefGoogle Scholar
Pradhan, A, Shrivastava, S, Cook, N, Rifai, N, Creager, M, Ridker, P. Symptomatic peripheral arterial disease in women: nontraditional biomarkers of elevated risk. Circulation. 2008;117:823831.CrossRefGoogle ScholarPubMed
Fowkes, F, Housley, E, Riemersma, R, et al. Smoking, lipids, glucose intolerance, and blood pressure as risk factors for peripheral atherosclerosis compared with ischemic heart disease in the Edinburgh Artery Study. Am J Epidemiol. 1992;135:331340.CrossRefGoogle ScholarPubMed
Subherwal, S, Patel, M, Kober, L, et al. Peripheral artery disease is a coronary heart disease risk equivalent among both men and women: results from a nationwide study. Eur J Prev Cardiol. 2014;22(3). doi: 10.1177/2047487313519344.Google ScholarPubMed
McDermott, M, Mehta, S, Ahn, H, Greenland, P. Atherosclerotic risk factors are less intensively treated in patients with peripheral arterial disease than in patients with coronary artery disease. J Gen Intern Med. 1997;12(4):209215.CrossRefGoogle ScholarPubMed
Criqui, M, Langer, R, Fronek, A, et al. Mortality over a period of 10 years in patients with peripheral arterial disease. N Engl J Med. 1992;326:381386.CrossRefGoogle Scholar
Rooke, T, Hirsch, A, Misra, S, et al. ACCF/AHA focused update of the Guideline for the Management of Patients with Peripheral Artery Disease (updating the 2005 guideline). J Am Coll Cardiol. 2011;58(19):20202045.CrossRefGoogle Scholar
Allison, M, Ho, E, Denenberg, J, et al. Ethnic-specific prevalence of peripheral arterial disease in the United States. Am J Prev Med. 2007;32:328333.CrossRefGoogle ScholarPubMed
Go, A, Mozaffarian, D, Roger, V, et al. Heart Disease and Stroke Statistics 2013 Update: a report from the American Heart Association. Circulation. 2013;127(2):e6e245.Google ScholarPubMed
Norgren, L, Hiatt, WR, Dormandy, JA, Nehler, MR, Harris, KA, Fowkes, FGR. Inter-society consensus for the management of peripheral arterial disease. J Vasc Surg. 2007;45(1):S5S67.CrossRefGoogle ScholarPubMed
Eraso, L, Fukaya, E, Mohler, E, Xie, D, Sha, D, Berger, J. Peripheral arterial disease, prevalence and cumulative risk factor profile analysis. Eur J Prev Cardiol. 2014;21:704711.CrossRefGoogle ScholarPubMed
Hirsch, AT, Criqui, MH, Treat-Jacobson, D. Peripheral arterial disease detection, awareness, and treatment in primary care. JAMA. 2001;286(11):13171324.CrossRefGoogle ScholarPubMed
Centers for Disease Control and Prevention (CDC). Lower extremity disease among persons aged > or =40 years with and without diabetes: United States, 1999–2002. MMWR. 2005;54:11581160.
Heald, C, Fowkes, F, Murray, G, Price, J, Ankle Brachial Index Collaboration. Risk of mortality and cardiovascular disease associated with the ankle-brachial index: systematic review. Atherosclerosis. 2006;189:6169.CrossRefGoogle ScholarPubMed
Ankle Brachial Index Collaboration, Fowkes, FG, Murray, GD, et al. Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis. JAMA. 2008;300(2):197208.Google ScholarPubMed
Criqui, M, Ninomiya, J, Fronek, A. Progression of peripheral arterial disease predicts cardiovascular disease morbidity and mortality. J Am Coll Cardiol. 2008;52(21):17361742.CrossRefGoogle ScholarPubMed
Garcia, L. Epidemiology and pathophysiology of lower extremity peripheral arterial disease. J Endovasc Surg. 2006;13(S2):113119.Google ScholarPubMed
Kroger, K, Buss, C, Renzing-Kohler, K, Santosa, F, Rudofsky, G. Segmental manifestation of peripheral atherosclerosis and its association to risk factors. VASA. 2000;29(3):199203.Google ScholarPubMed
Van Zitteren, M, Vriens, P, Heyligers, J, et al. Self-reported symptoms on questionnaires and anatomic lesions on duplex ultrasound examinations in patients with peripheral arterial disease. J Vasc Surg. 2012;55:10251034.CrossRefGoogle ScholarPubMed
Gutstein, D, Fuster, V. Pathophysiology and clinical significance of atherosclerotic plaque rupture. Cardiovasc Res. 1999;41:323333.CrossRefGoogle ScholarPubMed
Okura, H, Asawa, K, Kubo, T, et al. Incidence and predictors of plaque rupture in the peripheral arteries. Circ Cardiovasc Interv. 2010;3:6370.CrossRefGoogle ScholarPubMed
Chen, Q, Shi, Y, Wang, Y, Li, X. Patterns of disease distribution of lower extremity peripheral arterial disease. Angiology. 2015 Mar 19;66(3):211218.CrossRefGoogle ScholarPubMed
Brevetti, G, Schiano, V, Chiariello, M. Endothelial dysfunction: a key to the pathophysiology and natural history of peripheral arterial disease? Atherosclerosis. 2008;197:111.CrossRefGoogle ScholarPubMed
O’hare, A. Management of peripheral arterial disease in chronic kidney disease. Cardiol Clin. 2005;23(3):225236.CrossRefGoogle ScholarPubMed
Graham, I, Daly, L, Refsum, H, et al. Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project. JAMA. 1997;277(22):17751781.CrossRefGoogle ScholarPubMed
McDermott, M, Greenland, P, Guralnik, J, et al. Inflammatory markers, D-dimer, pro-thrombotic factors, and physical activity levels in patients with peripheral arterial disease. Vascular Medicine. 2004;9(2):107115.CrossRefGoogle ScholarPubMed
Hirsch, A, Allison, M, Gomes, A, et al. A call to action: women and peripheral artery disease: a scientific statement from the American Heart Association. Circulation. 2012;125:14491472.CrossRefGoogle Scholar
Rose, G. The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. Bulletin of the World Health Organisation. 1962;27:645658.Google Scholar
Schorr, E, Treat-Jacobson, D. Methods of symptom evaluation and their impact on peripheral artery disease (PAD) symptom prevalence: a review. Vasc Med. 2013;18:95111.CrossRefGoogle ScholarPubMed
McDermott, M, Mehta, S, Greenland, P. Exertional leg symptoms other than intermittent claudication are common in peripheral arterial disease. Arch Intern Med. 1999;159:387392.CrossRefGoogle ScholarPubMed
Au, T, Golledge, J, Walker, P, Haigh, K, Nelson, M. Peripheral arterial disease – diagnosis and management in general practice. Aust Fam Physician. 2013;42(6):397400.Google ScholarPubMed
Haigh, K, Bingley, J, Golledge, J, Walker, P. Peripheral arterial disease – screening in general practice. Aust Fam Physician. 2013;42(6):391395.Google ScholarPubMed
Golledge, J. Lower-limb arterial disease. Lancet. 1997;350(9089):14591465.CrossRefGoogle ScholarPubMed
McDermott, M, Applegate, W, Bonds, D, et al. Ankle brachial index values, leg symptoms, and functional performance among community-dwelling older men and women in the lifestyle interventions and independence for elders study. J Am Heart Assoc. 2013;2(6):e0000257.CrossRefGoogle ScholarPubMed
Fowkes, F, Murray, G, Butcher, I, et al. Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events. Eur J Prev Cardiol. 2014;21(3):310320.CrossRefGoogle ScholarPubMed
Hirsch, A, Haskal, Z, Hertzer, N, et al. ACC/AHA 2005 guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): executive summary a collaborative report. J Am Coll Cardiol. 2006;47(6):12391312.CrossRefGoogle ScholarPubMed
Haigh, K, Bingley, J, Golledge, J, Walker, P. Barriers to screening and diagnosis of peripheral artery disease by general practitioners. Vasc Med. 2013;18(6):325330.CrossRefGoogle ScholarPubMed
Jens, S, Koelemay, M, Reekers, J, Bipat, S. Diagnostic performance of computed tomography angiography and contrast-enhanced magnetic resonance angiography in patients with critical limb ischaemia and intermittent claudication: systematic review and meta-analysis. Eur Radiol. 2013;23(11):31043114.CrossRefGoogle ScholarPubMed
Gardner, A, Afaq, A. Management of lower extremity peripheral arterial disease. J Cardiopulm Rehabil Prev. 2008;28(6):349357.CrossRefGoogle ScholarPubMed
Li, Y, Burrows, N, Gregg, E, Albright, A, Geiss, L. Declining rates of hospitalization for nontraumatic lower-extremity amputation in the diabetic population aged 40 years or older: US, 1988–2008. Diabetes Care. 2012;35(2):273277.CrossRefGoogle ScholarPubMed
Stratton, I, AI, A, Neil, H, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321(7258):405412.CrossRefGoogle ScholarPubMed
Askew, CD, Parmenter, BJ, Leight, AS, Walker, PJ, Golledge, J. Exercise prescription for patients with peripheral arterial disease and intermittent claudication: a position statement from Exercise and Sports Science Australia. Journal of Science and Medicine in Sport. 2013;
Parmenter, BJ, Raymond, J, Dinnen, PJ, Fiatarone Singh, MA. Systematic, A Review of randomized controlled trials: walking versus alternative exercise prescription as treatment for intermittent claudication. Atherosclerosis 2011;218(1):112.CrossRefGoogle ScholarPubMed
Lauret, G, Fakhry, F, Fokkenrood, H, Hunink, M, Teijink, J, Spronk, S. Modes of exercise training for intermittent claudication. Cochrane Database Syst Rev. 2014;7;CD009638.Google Scholar
Parmenter, B, Dieberg, G, Smart, N. Meta, A Analysis of exercise training to improve health related quality of life in peripheral arterial disease. Accepted for publication in Vascular Medicine 18 Oct 2014.
McDermott, M, Criqui, M, Greenland, P, et al. Leg strength in peripheral arterial disease: associations with disease severity and lower-extremity performance. J Vasc Surg. 2004;39(3):523530.CrossRefGoogle ScholarPubMed
McDermott, M, Greenland, P, Liu, K, et al. The ankle brachial index is associated with leg function and physical activity: the Walking and Leg Circulation Study. Ann Intern Med. 2002;136(12):873883.CrossRefGoogle ScholarPubMed
McDermott, M, Guralnik, J, Albay, M, Bandinelli, S, Miniati, B, Ferrucci, L. Impairments of muscles and nerves associated with peripheral arterial disease and their relationship with lower extremity functioning: the InCHIANTI Study. J Am Ger Soc. 2004;52(3):405410.CrossRefGoogle ScholarPubMed
Gardner, A, Montgomery, P, Parker, D. Physical activity is a predictor of all-cause mortality in patients with intermittent claudication. J Vasc Surg. 2008;47(1):117122.CrossRefGoogle ScholarPubMed
Gardner, AW, Katzel, LI, Sorkin, JD, et al. Exercise rehabilitation improves functional outcomes and peripheral circulation in patients with intermittent claudication: a randomized controlled trial. J Americ Geriatrics Soc. 2001;49(6):755762.CrossRefGoogle ScholarPubMed
Leeper, N, Myers, J, Zhou, M, et al. Exercise capacity is the strongest predictor of mortality in patients with peripheral arterial disease. J Vasc Surg. 2013;57(3):728733.CrossRefGoogle ScholarPubMed
Askew, C, Green, S, Walker, P, et al. Skeletal muscle phenotype is associated with exercise tolerance in patients with peripheral arterial disease. J Vasc Surg. 2005;41:802807.CrossRefGoogle ScholarPubMed
Hiatt, W. Medical treatment of peripheral arterial disease and claudication. N Engl J Med. 2001;344:16081621.CrossRefGoogle ScholarPubMed
Garg, P, Liu, K, Tian, L, et al. Physical activity during daily life and functional decline in peripheral arterial disease. Circulation. 2009;119:251260.CrossRefGoogle ScholarPubMed
Garg, P, Tian, L, Criqui, M, et al. Physical activity during daily life and mortality in patients with peripheral arterial disease. Circulation. 2006;114:242248.CrossRefGoogle ScholarPubMed
Kurvers, H, van der Graaf, Y, Blankensteijn, J, Visseren, F, Eikelboom, B, SMART Study Group. Screening for asymptomatic internal carotid artery stenosis and aneurysm of the abdominal aorta: comparing the yield between patients with manifest atherosclerosis and patients with risk factors for atherosclerosis only. J Vasc Surg. 2003;37(6):12261233.CrossRefGoogle ScholarPubMed
Drachman, D.A., Swearer, J.M.. Neurological Evaluation of the Elderly Patient. In: Albert, M.L., Knoefel, J.E., eds. Clinical Neurology of Aging. 3rd Edition. New York, Oxford University Press, 2011; 4153.Google Scholar
Sirven, J.I., Mancall, E.L.. Neurological Examination of the Older Adult. In: Sirven, J.I., Malamut, B.L., eds. Clinical Neurology of the Older Adult. 2nd Edition. Philadelphia, Lippincott Williams and Wilkins, 2008; 57.Google Scholar
Manini, T.M., Hong, S.L., Clark, B.C.. Aging and muscle: a neuron’s perspective. Curr Opin Clini Nutr Metab Care 2013; 16(1): 110.Google ScholarPubMed
Chitnus, T., Weiner, H.L.. Multiple Sclerosis in the Elderly. In: Albert, M.L., Knoefel, J.E., eds. Clinical Neurology of Aging. 3rd Edition. New York, Oxford University Press, 2011; 536543.Google Scholar
Scalfari, A., Knappertz, V., Cutter, G., et al. Mortality in patients with multiple sclerosis. Neurology 2013; 81: 184192.CrossRefGoogle ScholarPubMed
Hughes, R.A., Rees, J.H.. Clinical and epidemiologic features of Guillain-Barré syndrome. The Journal of Infectious Diseases 1997; 176: S92–8.CrossRefGoogle ScholarPubMed
Yuki, N., Hartung, H.P.. Guillain-Barré syndrome. N Engl J Med 2012; 366: 22942304.CrossRefGoogle ScholarPubMed
Worms, P.M.. The epidemiology of motor neuron disease: a review of recent studies. Journal of the Neurological Sciences 2001; 191: 39.CrossRefGoogle ScholarPubMed
Rowland, L.P., Shneider, N.A.. Amyotrophic lateral sclerosis. N Engl J Med 2001; 344: 16881700.CrossRefGoogle ScholarPubMed
Donaghy, M.. Classification and clinical features of motor neurone diseases and motor neuropathies in adults. J. Neurol 1999; 246: 331333CrossRefGoogle ScholarPubMed
Sieb, J.P.. Myasthenia gravis: an update for the clinician. Clinical and Experimental Immunology 2013; 175: 408418.CrossRefGoogle Scholar
Drachman, D.B.. Myasthenia gravis. N Engl J Med 1994; 330: 17971810.CrossRefGoogle ScholarPubMed
Bitzur, R., Cohen, H., Kamai, Y., Harats, D.. Intolerance to statins: mechanisms and management. Diabetes Care 2013; 36: S325S330.CrossRefGoogle ScholarPubMed
Macedo, A.F., Taylor, F.C., Casas, J.P., et al. Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis. BMC Medicine 2014; 12: 5164.CrossRefGoogle ScholarPubMed
Mold, J.W., Vesely, S.K., Keyl, B.A.. The prevalence, predictors, and consequences of peripheral sensory neuropathy in older patients. J Am Board Fam Pract 2004; 17: 309318.CrossRefGoogle ScholarPubMed
Hreib, K.K., Jones, H.R.. Clinical Neurologic Evaluation. In: Jones, H.R., ed. Netter’s Neurology. New Jersey, Icon Learning Systems, 2005; 239.Google Scholar
Hoffman Snyder, C.R., Smith, B.E.. Common Peripheral Neuropathies in the Older Adult. In: Sirven, J.I., Malamut, B.L., eds. Clinical Neurology of the Older Adult. 2nd Edition. Philadelphia, Lippincott Williams and Wilkins, 2008; 402419.Google Scholar
Zawora, M., Liang, T.W., Jarra, H.. Neurological Problems in the Elderly. In: Arenson, S., Busby-Whitehead, J., Brummel-Smith, K., et al., eds. Reichel’s Care of the Elderly: Clinical Aspects of Aging. 6th Edition. New York, Cambridge University Press, 2009; 140170.Google Scholar
Centers for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014. Atlanta, GA: US Department of Health and Human Services; 2014. Available at: (accessed August 3, 2014).
Charnogursky, G., Lee, H., Lopez, N.. Diabetic neuropathy. Handbook of Clinical Neurology 2014; 120: 773785.CrossRefGoogle ScholarPubMed
Schmader, K.E.. Epidemiology and impact on quality of life of postherpetic neuralgia and painful diabetic neuropathy. Clinical Journal of Pain 2002; 18: 350354.CrossRefGoogle ScholarPubMed
Lacomis, D.. Small-fiber neuropathy. Muscle and Nerve 2002; 26: 173188.CrossRefGoogle ScholarPubMed
Brannagan, T.H., Weimer, L.H., Latov, N.. Acquired Neuropathies. In: Rowland, L.P., ed. Merritt’s Neurology. 11th Edition. Philadelphia, Lippincott Williams and Wilkins, 2005; 748767.Google Scholar
Ghaznawi, N., Virdi, A., Dayan, A., et al. Herpes zoster ophthalmicus: comparison of disease in patients 60 years and older versus younger than 60 years. Ophthalmology 2011; 118: 22422250.CrossRefGoogle ScholarPubMed
Gnann, J.W., Whitley, R.J.. Herpes zoster. N Engl J Med 2002; 347: 340346.CrossRefGoogle ScholarPubMed
Eldar, A.H., Chapman, J.. Guillain-Barré syndrome and other immune mediated neuropathies: diagnosis and classification. Autoimmunity Reviews 2014; 13: 525530.CrossRefGoogle ScholarPubMed
Mahdi-Rogers, M., Hughes, R.A.. Epidemiology of chronic inflammatory neuropathies in southeast England. European Journal of Neurology 2014; 21: 2833.CrossRefGoogle Scholar
Lijima, M., Koike, H., Nattori, N., et al. Prevalence and incidence rates of chronic inflammatory demyelinating polyneuropathy in the Japanese population. J Neurol Neurosurgery Psychiatry 2008; 79(9): 10401043.Google Scholar
Rigler, S.K.. Alcoholism in the elderly. American Family Physician 2000; 61: 17101716.Google ScholarPubMed
Mellion, M., Gilchrist, J.M., De La Monte, S.. Alcohol-related peripheral neuropathy: nutritional, toxic, or both? Muscle and Nerve 2011; 43: 309316.CrossRefGoogle ScholarPubMed
Kumar, N.. Neurologic aspects of cobalamin (B12) deficiency. Handbook of Clinical Neurology 2014; 120: 915926.CrossRefGoogle ScholarPubMed
Nemni, R., Gerosa, E., Piccolo, G., Merlinii, G.. Neuropathies associated with monoclonal Gammopathies. Haematologica 1994; 79: 557566.Google Scholar
Pop-Busui, R., Roberts, L., Pennathur, S., et al. The management of diabetic neuropathy in CKD. Am J Kidney Dis 2010; 55: 365385CrossRefGoogle ScholarPubMed
Dworkin, R.H., O’Connor, A.B., Backonja, M., et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 2007; 132: 237251.CrossRefGoogle ScholarPubMed
Laccheo, I., Ablah, E., Heinrichs, R., et al. Assessment of quality of life among the elderly with epilepsy. Epilepsy Behav 2008; 12: 257261.CrossRefGoogle ScholarPubMed
Stephen, L.J., Brodie, M.J.. Epilepsy in elderly people. Lancet 2000; 355: 14411446.CrossRefGoogle ScholarPubMed
Leppik, I.E., Birnbaum, A.K.. Epilepsy in the elderly. Annals of the New York Academy of Sciences 2010; 1184: 208224.CrossRefGoogle ScholarPubMed
Ramsay, R.E., Rowan, A.J., Pryor, F.M.. Special considerations in treating the elderly patient with epilepsy. Neurology 2004; 62: S24–9.CrossRefGoogle ScholarPubMed
Huying, F., Limpe, S., Werhahn, K.J.. Antiepileptic drug use in nursing home residents: a cross-sectional, regional study. Seizure 2006; 15: 194197CrossRefGoogle ScholarPubMed
Hardie, N.A., Garrard, J., Gross, C.R., et al. The validity of epilepsy or seizure documentation in nursing homes. Epilepsy Research 2007; 74: 171175.CrossRefGoogle ScholarPubMed
Brodie, M.J., Kelly, K., Stephen, L.J.. Prospective adults with new antiepileptic drugs in focal epilepsy: insights into population responses? Epilepsy and Behavior 2014; 31: 7376.CrossRefGoogle ScholarPubMed
Wallace, H., Shorwon, S., Tallis, R.. Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2,052,922 and age-specific fertility rates of women with epilepsy. Lancet 1998; 352: 1970–73.CrossRefGoogle Scholar
Bladin, C.F., Alexandrov, A.V., Bellavance, A., et al. Seizures after stroke: a prospective multicenter study. Arch Neurol 2000; 57: 16171622.CrossRefGoogle ScholarPubMed
Brodie, M.J., Elder, A.T., Kwan, P.. Epilepsy in later life. Lancet Neurol 2009; 8: 1019–30.CrossRefGoogle ScholarPubMed
Imfeld, P., Bodmer, M., Schuerch, M., et al. Seizures in patients with Alzheimer’s disease or vascular dementia: a population-based nested case control analysis. Epilepsia 2013; 54: 700707.CrossRefGoogle ScholarPubMed
Irizarry, M.C., Jin, S., He, F., et al. Incidence of new-onset seizures in mild to moderate Alzheimer disease. Arch Neurol 2012; 69: 368372.CrossRefGoogle ScholarPubMed
Sherzai, D., Losey, T., Vega, S., Sherzai, A.. Seizures and dementia in the elderly: nationwide inpatient sample 1999–2008. Epilepsy and Behavior 2014; 36: 5356.CrossRefGoogle ScholarPubMed
Vossel, K.A., Beagle, A.J., Rabinovici, G.D., et al. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol 2013; 70: 11581166.CrossRefGoogle ScholarPubMed
Meierkord, H., Holtkamp, M.. Non-convulsive status epilepticus in adults: clinical forms and treatment. Lancet Neurol 2007; 6: 329339.CrossRefGoogle ScholarPubMed
Jirsch, J., Hirsch, L.J.. Nonconvulsive seizures: developing a rational approach to the diagnosis and management in the critically ill population. Clinical Neurophysiology 2007; 118: 16601670.CrossRefGoogle ScholarPubMed
McBride, A.E., Shih, T.T., Hirsch, L.J.. Video-EEG monitoring in the elderly: a review of 94 patients. Epilepsia 2002; 43: 165.CrossRefGoogle ScholarPubMed
Rowan, A.J., Ramsay, R.E., Collins, J.F., et al. New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology 2005; 64: 18681873.CrossRefGoogle ScholarPubMed
Cumbo, E., Ligori, L.D.. Levitiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer’s disease. Epilepsy Behavior 2010; 17: 461.CrossRefGoogle Scholar
Glauser, T., Ben-Menachem, E., Bourgeois, B., et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2006; 47: 10941120.CrossRefGoogle ScholarPubMed
Glauser, T., Ben-Menachem, E., Bourgeois, B., et al. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2013; 54: 551563.CrossRefGoogle ScholarPubMed
Speechio, L.M., Tramacere, L., La Neve, A., Beghi, E.. Discontinuing antiepileptic drugs in patients who are seizure free on monotherapy. J Neurol, Neurosurg Psychiatry 2002; 72: 2225.CrossRefGoogle Scholar
Robbins, M.S., Lipton, R.B.. Management of headache in the elderly. Drugs Aging 2010; 27: 377398.CrossRefGoogle ScholarPubMed
Schwaiger, J., Kiechl, S., Seppi, K., et al. Prevalence of primary headaches and cranial neuralgias in men and women aged 55–94 years (Bruneck Study). Cephalagia 2009; 29: 179187.CrossRefGoogle Scholar
Walker, R.A., Wadman, M.C.. Headache in the elderly. Clin Geriatr Med 2007; 23: 291305.CrossRefGoogle ScholarPubMed
Prencipe, M., Casini, A., Ferretti, C., et al. Prevalence of headache in an elderly population: attack frequency, disability and use of medication. J Neurol Neurosurg Psychiatry 2001; 70: 377–81.CrossRefGoogle Scholar
Pringsheim, T., Davenport, J., Becker, W.. Prophylaxis of migraine headache. CMAJ 2010; 182: E269276.CrossRefGoogle ScholarPubMed
Charles, A.. The evolution of a migraine attack – a review of recent evidence. Headache 2013; 53: 413419.CrossRefGoogle ScholarPubMed
Bamford, C.C., Mays, M., Tepper, S.J.. Unusual headaches in the elderly. Curr Pain Headache Rep 2011; 15: 295301.CrossRefGoogle ScholarPubMed
Özge, A.. Chronic daily headache in the elderly. Curr Pain Headache Rep 2013; 17: 382389.CrossRefGoogle ScholarPubMed
Weyand, C.M., Goronzy, J.J.. Giant-cell arteritis and polymalgia rheumatica. N Engl J Med 2014; 371: 5057CrossRefGoogle Scholar
Kermani, T.A., Schmidt, J.S., Crowson, C.S., et al. Utility of erythrocyte sedimentation rate and C-reactive protein for the diagnosis of giant cell arteritis. Semin Arthritis Rheum 2012; 41: 866871.CrossRefGoogle Scholar
Kristoffersen, E.S., Lundqvist, C.. Medication-overuse headache: epidemiology, diagnosis and treatment. TherAdv Drug Saf. 2014; 5: 8799.CrossRefGoogle Scholar
Dodick, D.W., Capobianco, D.J.. Headaches. In: Sirven, J.I., Malamut, B.L., eds. Clinical Neurology of the Older Adult. 2nd Edition. Philadelphia, Lippincott Williams and Wilkins, 2008; 197212.Google Scholar
Feigin, VL, Lawes, CM, Bennett, DA, Anderson, CS. Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol 2003 Jan;2(1):4353.CrossRefGoogle ScholarPubMed
Koton, S, Schneider, AL, Rosamond, WD, et al. Stroke incidence and mortality trends in US communities, 1987 to 2011. JAMA 2014 Jul 16;312(3):259268.CrossRefGoogle ScholarPubMed
Go, AS, Mozaffarian, D, Roger, VL, et al. Executive summary: heart disease and stroke statistics–2014 update: a report from the American Heart Association. Circulation 2014 Jan 21;129(3):399410.CrossRefGoogle ScholarPubMed
Yusuf, S, Rangarajan, S, Teo, K, et al. Cardiovascular risk and events in 17 low-, middle-, and high-income countries. N Engl J Med 2014 Aug 28;371(9):818827.CrossRefGoogle ScholarPubMed
Sacco, RL, Kasner, SE, Broderick, JP, et al. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2013 Jul;44(7):20642089.CrossRefGoogle ScholarPubMed
Marini, C, Baldassarre, M, Russo, T, et al. Burden of first-ever ischemic stroke in the oldest old: evidence from a population-based study. Neurology 2004 Jan 13;62(1):7781.CrossRefGoogle ScholarPubMed
Burke, JF, Freedman, VA, Lisabeth, LD, et al. Racial differences in disability after stroke: results from a nationwide study. Neurology 2014 Jul 29;83(5):390397.CrossRefGoogle ScholarPubMed
Kelly, AG, Hoskins, KD, Holloway, RG. Early stroke mortality, patient preferences, and the withdrawal of care bias. Neurology 2012 Aug 28;79(9):941944.CrossRefGoogle ScholarPubMed
Qureshi, AI, Chaudhry, SA, Connelly, B, et al. Impact of advanced healthcare directives on treatment decisions by physicians in patients with acute stroke. Crit Care Med 2013 Jun;41(6):14681475.CrossRefGoogle ScholarPubMed
Silveira, MJ, Wiitala, W, Piette, J. Advance directive completion by elderly Americans: a decade of change. J Am Geriatr Soc 2014 Apr;62(4):706710.CrossRefGoogle Scholar
Barber, PA, Kleinig, TJ. INTERACT2: a reason for optimism with spontaneous intracerebral hemorrhage? Int J Stroke 2014 Jan;9(1):5960.CrossRefGoogle ScholarPubMed
McArdle, PF, Kittner, SJ, Ay, H, et al. Agreement between TOAST and CCS ischemic stroke classification: The NINDS SIGN Study. Neurology 2014 Oct 28;83(18):16531660. Epub 2014 Sep 26.CrossRefGoogle Scholar
Adams, HP Jr, Bendixen, BH, Kappelle, LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993 Jan;24(1):3541.CrossRefGoogle Scholar
Arsava, EM, Ballabio, E, Benner, T, et al. The Causative Classification of Stroke system: an international reliability and optimization study. Neurology 2010 Oct 5;75(14):12771284.CrossRefGoogle ScholarPubMed
Asimos, AW, Johnson, AM, Rosamond, WD, et al. A multicenter evaluation of the ABCD2 score’s accuracy for predicting early ischemic stroke in admitted patients with transient ischemic attack. Ann Emerg Med 2010 Feb;55(2):201210.e5.CrossRefGoogle ScholarPubMed
Easton, JD, Saver, JL, Albers, GW, et al. Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists. Stroke 2009 Jun;40(6):22762293.CrossRefGoogle ScholarPubMed
Giles, MF, Albers, GW, Amarenco, P, et al. Early stroke risk and ABCD2 score performance in tissue- vs time-defined TIA: a multicenter study. Neurology 2011 Sep 27;77(13):12221228.CrossRefGoogle ScholarPubMed
Kleindorfer, D, Panagos, P, Pancioli, A, et al. Incidence and short-term prognosis of transient ischemic attack in a population-based study. Stroke 2005 Apr;36(4):720723.CrossRefGoogle ScholarPubMed
Johnston, SC, Gress, DR, Browner, WS, Sidney, S. Short-term prognosis after emergency department diagnosis of TIA. JAMA 2000 Dec 13;284(22):29012906.CrossRefGoogle ScholarPubMed
Rojas, JI, Zurru, MC, Romano, M, et al. Acute ischemic stroke in patients aged 80 or older. Medicina (B Aires) 2007;67(6 Pt 2):701704.Google ScholarPubMed
Agyemang, C, van Oeffelen, AA, Norredam, M, et al. Ethnic disparities in ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage incidence in the Netherlands. Stroke 2014 Sep 30;45(11):32363242.CrossRefGoogle ScholarPubMed
Talahma, M, Strbian, D, Sundararajan, S. Sickle cell disease and stroke. Stroke 2014 Jun;45(6):e98e100.CrossRefGoogle ScholarPubMed
Gueguen, A, Mahevas, M, Nzouakou, R, et al. Sickle-cell disease stroke throughout life: a retrospective study in an adult referral center. Am J Hematol 2014 Mar;89(3):267272.CrossRefGoogle Scholar
Tinetti, ME, Han, L, Lee, DS, et al. Antihypertensive medications and serious fall injuries in a nationally representative sample of older adults. JAMA Intern Med 2014 Apr;174(4):588595.CrossRefGoogle Scholar
Aronow, WS, Fleg, JL, Pepine, CJ, et al. ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents developed in collaboration with the American Academy of Neurology, American Geriatrics Society, American Society for Preventive Cardiology, American Society of Hypertension, American Society of Nephrology, Association of Black Cardiologists, and European Society of Hypertension. J Am Soc Hypertens 2011 Jul–Aug;5(4):259352.CrossRefGoogle Scholar
Gouya, G, Arrich, J, Wolzt, M, et al. Antiplatelet treatment for prevention of cerebrovascular events in patients with vascular diseases: a systematic review and meta-analysis. Stroke 2014 Feb;45(2):492503.CrossRefGoogle ScholarPubMed
Kernan, WN, Ovbiagele, B, Black, HR, et al. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2014 Jul;45(7):21602236.CrossRefGoogle ScholarPubMed
Shin, JY, Choi, NK, Jung, SY, et al. Risk of ischemic stroke with the use of risperidone, quetiapine and olanzapine in elderly patients: a population-based, case-crossover study. J Psychopharmacol 2013 Jul;27(7):638644.CrossRefGoogle ScholarPubMed
Everson-Rose, SA, Roetker, NS, Lutsey, PL, et al. Chronic stress, depressive symptoms, anger, hostility, and risk of stroke and transient ischemic attack in the multi-ethnic study of atherosclerosis. Stroke 2014 Aug;45(8):23182323.CrossRefGoogle ScholarPubMed
Lambiase, MJ, Kubzansky, LD, Thurston, RC. Prospective study of anxiety and incident stroke. Stroke 2014 Feb;45(2):438443.CrossRefGoogle ScholarPubMed
Helms, TM, Duong, G, Zippel-Schultz, B, et al. Prediction and personalised treatment of atrial fibrillation-stroke prevention: consolidated position paper of CVD professionals. EPMA J 2014 Sep 2;5(1):15.CrossRefGoogle ScholarPubMed
Coppens, M, Hart, RG, Eikelboom, JW. Stroke prevention in older adults with atrial fibrillation. CMAJ 2013 Nov 19;185(17):14791480.CrossRefGoogle ScholarPubMed
Quinn, GR, Fang, MC. Atrial fibrillation: stroke prevention in older adults. Clin Geriatr Med 2012 Nov;28(4):617634.CrossRefGoogle ScholarPubMed
Moran, PS, Flattery, MJ, Teljeur, C, et al. Effectiveness of systematic screening for the detection of atrial fibrillation. Cochrane Database Syst Rev 2013 Apr 30;4:CD009586.Google Scholar
Sanna, T, Diener, HC, Passman, RS, et al. Cryptogenic stroke and underlying atrial fibrillation. N Engl J Med 2014 Jun 26;370(26):24782486.CrossRefGoogle ScholarPubMed
Gladstone, DJ, Spring, M, Dorian, P, et al. Atrial fibrillation in patients with cryptogenic stroke. N Engl J Med 2014 Jun 26;370(26):24672477.CrossRefGoogle ScholarPubMed
Weber-Kruger, M, Gelbrich, G, Stahrenberg, R, et al. Finding atrial fibrillation in stroke patients: randomized evaluation of enhanced and prolonged Holter monitoring – Find-AFRANDOMISED – rationale and design. Am Heart J 2014 Oct;168(4):438445.e1.CrossRefGoogle ScholarPubMed
Halperin, JL, Hankey, GJ, Wojdyla, DM, et al. Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF). Circulation 2014 Jul 8;130(2):138146.CrossRefGoogle Scholar
Sardar, P, Chatterjee, S, Chaudhari, S, Lip, GY. New oral anticoagulants in elderly adults: evidence from a meta-analysis of randomized trials. J Am Geriatr Soc 2014 May;62(5):857864.CrossRefGoogle ScholarPubMed
Dzik, WS. Reversal of drug-induced anticoagulation: old solutions and new problems. Transfusion 2012 May;52 Suppl 1:45S55S.CrossRefGoogle ScholarPubMed
Salvi, F, Marchetti, A, D’Angelo, F, et al. Adverse drug events as a cause of hospitalization in older adults. Drug Saf 2012 Jan;35 Suppl 1:2945.CrossRefGoogle ScholarPubMed
Wang, C, Yi, X, Zhang, B, et al. Clopidogrel plus aspirin prevents early neurologic deterioration and improves 6-month outcome in patients with acute large artery atherosclerosis stroke. Clin Appl Thromb Hemost 2015 Jul;21(5):453461. Epub 2014 Sep 23.CrossRefGoogle ScholarPubMed
Wong, KS, Chen, C, Fu, J, et al. Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial. Lancet Neurol 2010 May;9(5):489497.CrossRefGoogle ScholarPubMed
Markus, HS, Droste, DW, Kaps, M, et al. Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the clopidogrel and aspirin for reduction of emboli in symptomatic carotid stenosis (CARESS) trial. Circulation 2005 May 3;111(17):22332240.CrossRefGoogle ScholarPubMed
Boan, AD, Lackland, DT, Ovbiagele, B. Lowering of blood pressure for recurrent stroke prevention. Stroke 2014 Aug;45(8):25062513.CrossRefGoogle ScholarPubMed
De Lima, LG, Saconato, H, Atallah, AN, da Silva, EM. Beta-blockers for preventing stroke recurrence. Cochrane Database Syst Rev 2014 Oct 15;10:CD007890.Google Scholar
Udell, JA, Opotowsky, AR, Khairy, P, et al. Patent foramen ovale closure vs medical therapy for stroke prevention: meta-analysis of randomized trials and review of heterogeneity in meta-analyses. Can J Cardiol 2014 Oct;30(10):12161224.CrossRefGoogle ScholarPubMed
Kmietowicz, Z. Geriatrician questions prescribing for stroke prevention in people over 80. BMJ 2014 Feb 26;348:g1788.CrossRefGoogle ScholarPubMed
Byatt, K. Overenthusiastic stroke risk factor modification in the over-80s: are we being disingenuous to ourselves, and to our oldest patients? Evid Based Med 2014 Aug;19(4):121122.CrossRefGoogle ScholarPubMed
Manocha, D, Bansal, N, Gumaste, P, Brangman, S. Safety profile of high-dose statin therapy in geriatric patients with stroke. South Med J 2013 Dec;106(12):658664.CrossRefGoogle ScholarPubMed
Raley, KA, Hutchison, AM. Statin use and cognitive changes in elderly patients with dementia. Consult Pharm 2014;29(7):487489.CrossRefGoogle ScholarPubMed
Mandas, A, Congiu, MG, Abete, C, et al. Cognitive decline and depressive symptoms in late-life are associated with statin use: evidence from a population-based study of Sardinian old people living in their own home. Neurol Res 2014 Mar;36(3):247254.CrossRefGoogle ScholarPubMed
Tapia-Perez, JH, Gehring, S, Zilke, R, Schneider, T. Effect of increased glucose levels on short-term outcome in hypertensive spontaneous intracerebral hemorrhage. Clin Neurol Neurosurg 2014 Mar;118:3743.CrossRefGoogle ScholarPubMed
Tanaka, R, Ueno, Y, Miyamoto, N, et al. Impact of diabetes and prediabetes on the short-term prognosis in patients with acute ischemic stroke. J Neurol Sci 2013 Sep 15;332(1–2):4550.CrossRefGoogle ScholarPubMed
Nardi, K, Milia, P, Eusebi, P, et al. Predictive value of admission blood glucose level on short-term mortality in acute cerebral ischemia. J Diabetes Complications 2012 Mar–Apr;26(2):7076.CrossRefGoogle ScholarPubMed
Murphy, RA, Patel, KV, Kritchevsky, SB, et al. Weight change, body composition, and risk of mobility disability and mortality in older adults: a population-based cohort study. J Am Geriatr Soc 2014 Aug;62(8):14761483.CrossRefGoogle ScholarPubMed
Alamowitch, S, Eliasziw, M, Algra, A, et al. Risk, causes, and prevention of ischaemic stroke in elderly patients with symptomatic internal-carotid-artery stenosis. Lancet 2001 Apr 14;357(9263):11541160.CrossRefGoogle ScholarPubMed
Brott, TG, Hobson, RW 2nd, Howard, G, et al. Stenting versus endarterectomy for treatment of carotid-artery stenosis. N Engl J Med 2010 Jul 1;363(1):1123.CrossRefGoogle ScholarPubMed
Gonzales, NR, Demaerschalk, BM, Voeks, JH, et al. Complication rates and center enrollment volume in the carotid revascularization endarterectomy versus stenting trial. Stroke 2014 Sep 25.CrossRef
Rerkasem, K, Rothwell, PM. Carotid endarterectomy for symptomatic carotid stenosis. Cochrane Database Syst Rev 2011 Apr 13;(4):CD001081.Google ScholarPubMed
Antoniou, GA, Georgiadis, GS, Georgakarakos, EI, et al. Meta-analysis and meta-regression analysis of outcomes of carotid endarterectomy and stenting in the elderly. JAMA Surg 2013 Dec;148(12):11401152.CrossRefGoogle ScholarPubMed
Kasner, SE, Lynn, MJ, Chimowitz, MI, et al. Warfarin vs aspirin for symptomatic intracranial stenosis: subgroup analyses from WASID. Neurology 2006 Oct 10;67(7):12751278.CrossRefGoogle ScholarPubMed
Birkbak, J, Clark, AJ, Rod, NH. The effect of sleep disordered breathing on the outcome of stroke and transient ischemic attack: a systematic review. J Clin Sleep Med 2014 Jan 15;10(1):103108.Google ScholarPubMed
Petrov, ME, Howard, VJ, Kleindorfer, D, et al. Over-the-counter and Prescription Sleep Medication and Incident Stroke: The REasons for Geographic And Racial Differences in Stroke Study. J Stroke Cerebrovasc Dis 2014 Sep;23(8):21102116.CrossRefGoogle ScholarPubMed
Birkbak, J, Clark, AJ, Rod, NH. The effect of sleep disordered breathing on the outcome of stroke and transient ischemic attack: a systematic review. J Clin Sleep Med 2014 Jan 15;10(1):103108.Google ScholarPubMed
Diaz, KM, Booth, JN 3rd, Calhoun, DA, et al. Healthy lifestyle factors and risk of cardiovascular events and mortality in treatment-resistant hypertension: the reasons for geographic and racial differences in stroke study. Hypertension 2014 Sep;64(3):465471.CrossRefGoogle ScholarPubMed
Marler, JR. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995 Dec 14;333(24):15811588.Google Scholar
Yayan, J. Effectiveness of alteplase in the very elderly after acute ischemic stroke. Clin Interv Aging 2013;8:963974.CrossRefGoogle ScholarPubMed
Gomez-Choco, M, Obach, V, Urra, X, et al. The response to IV rt-PA in very old stroke patients. Eur J Neurol 2008 Mar;15(3):253256.CrossRefGoogle ScholarPubMed
Engelter, ST, Bonati, LH, Lyrer, PA. Intravenous thrombolysis in stroke patients of > or = 80 versus < 80 years of age – a systematic review across cohort studies. Age Ageing 2006 Nov;35(6):572580.CrossRefGoogle ScholarPubMed
Jonsson, AC, Delavaran, H, Iwarsson, S, et al. Functional status and patient-reported outcome 10 years after stroke: the Lund Stroke Register. Stroke 2014 Jun;45(6):17841790.CrossRefGoogle ScholarPubMed
Camara-Lemarroy, CR, Ibarra-Yruegas, BE, Gongora-Rivera, F. Gastrointestinal complications after ischemic stroke. J Neurol Sci 2014 Aug 28.CrossRef
Martino, R, Foley, N, Bhogal, S, et al. Dysphagia after stroke: incidence, diagnosis, and pulmonary complications. Stroke 2005 Dec;36(12):27562763.CrossRefGoogle ScholarPubMed
Lin, CJ, Hung, JW, Cho, CY, et al. Poststroke constipation in the rehabilitation ward: incidence, clinical course and associated factors. Singapore Med J 2013 Nov;54(11):624629.CrossRefGoogle ScholarPubMed
Douds, GL, Hellkamp, AS, Olson, DM, et al. Venous thromboembolism in the Get with the Guidelines-Stroke acute ischemic stroke population: incidence and patterns of prophylaxis. J Stroke Cerebrovasc Dis 2014 Jan;23(1):123129.CrossRefGoogle ScholarPubMed
Naccarato, M, Chiodo Grandi, F, Dennis, M, Sandercock, PA. Physical methods for preventing deep vein thrombosis in stroke. Cochrane Database Syst Rev 2010 Aug 4;8:CD001922.Google Scholar
Drury, P, Levi, C, McInnes, E, et al. Management of fever, hyperglycemia, and swallowing dysfunction following hospital admission for acute stroke in New South Wales, Australia. Int J Stroke 2014 Jan;9(1):2331.CrossRefGoogle ScholarPubMed
Allan, LM, Rowan, EN, Thomas, AJ, et al. Long-term incidence of depression and predictors of depressive symptoms in older stroke survivors. Br J Psychiatry 2013 Dec;203(6):453460.CrossRefGoogle ScholarPubMed
Tang, WK, Caeiro, L, Lau, CG, et al. Apathy and suicide-related ideation 3 months after stroke: a cross-sectional study. BMC Neurol 2015 Apr 23;15(1):60.CrossRefGoogle ScholarPubMed
Santos, CO, Caeiro, L, Ferro, JM, Figueira, ML. A study of suicidal thoughts in acute stroke patients. J Stroke Cerebrovasc Dis 2012 Nov;21(8):749754.CrossRefGoogle ScholarPubMed
Vallury, KD, Jones, M, Gray, R. Do family-oriented interventions reduce poststroke depression? A systematic review and recommendations for practice. Top Stroke Rehabil 2015 Dec;22(6):459465. doi: 10/1179/1074935715Z00000000061. Epub 2015 Mar 28.CrossRefGoogle ScholarPubMed
Cai, W, Wang, J, Wang, L, et al. Prevalence and risk factors of urinary incontinence for post-stroke inpatients in Southern China. Neurourol Urodyn 2015;34(3):231235.CrossRefGoogle ScholarPubMed
Gregory, P, Edwards, L, Faurot, K, et al. Patient preferences for stroke rehabilitation. Top Stroke Rehabil 2010 Sep–Oct;17(5):394400.CrossRefGoogle ScholarPubMed
DuGoff, EH, Canudas-Romo, V, Buttorff, C, et al. Multiple chronic conditions and life expectancy: a life table analysis. Med Care 2014 Aug;52(8):688694.CrossRefGoogle ScholarPubMed
Bilbao, G, Garibi, J, Pomposo, I, et al. A prospective study of a series of 356 patients with supratentorial spontaneous intracerebral haematomas treated in a neurosurgical department. Acta Neurochir (Wien) 2005 Aug;147(8):823829.CrossRefGoogle Scholar
Bhatia, R, Singh, H, Singh, S, et al. A prospective study of in-hospital mortality and discharge outcome in spontaneous intracerebral hemorrhage. Neurol India 2013 May–Jun;61(3):244248.CrossRefGoogle ScholarPubMed
Flemming, KD, Wijdicks, EF, Li, H. Can we predict poor outcome at presentation in patients with lobar hemorrhage? Cerebrovasc Dis 2001;11(3):183189.CrossRefGoogle ScholarPubMed
Schneider, SA, Deuschl, G. The treatment of tremor. Neurotherapeutics 2014; 11: 128–38.CrossRefGoogle ScholarPubMed
Zesiewicz, TA, Elble, R, Louis, ED, et al. Practice parameter: therapies for essential tremor: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2005; 64:2008–20.CrossRefGoogle ScholarPubMed
Koller, W, Pahwa, R, Busenbark, K, et al. High-frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor. Ann Neurol 1997; 42:292–9.CrossRefGoogle ScholarPubMed
Schuurman, PR, Bosch, DA, Bossuyt, PM, et al. A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor. N Engl J Med 2000; 342:461–8.CrossRefGoogle ScholarPubMed
Deuschl, G, Bain, P, Brin, M. Consensus statement of the Movement Disorder Society on Tremor: ad hoc scientific committee. Mov Disord 1998; 13(Suppl 3):223.CrossRefGoogle ScholarPubMed
Tyrer, P, Alexander, MS, Regan, A, Lee, I. An extrapyramidal syndrome after lithium therapy. Br J Psychiatry 1980; 136:191–4.CrossRefGoogle ScholarPubMed
Niethammer, M, Ford, B. Permanent lithium-induced cerebellar toxicity: three cases and review of literature. Mov Disord 2007; 22:570–3.CrossRefGoogle ScholarPubMed
Baumann, C. Epidemiology, diagnosis and differential diagnosis in Parkinson’s disease tremor. Parkinsonism and Related Disorders 2012; 18(Suppl 1):S9092.CrossRefGoogle ScholarPubMed
Hughes, AJ, Daniel, SE, Blankson, S, Lees, AJ. A clinicopathologic study of 100 cases of Parkinson’s disease. Arch Neurol 1993; 50:140–8.CrossRefGoogle ScholarPubMed
Respondek, G, Stamelou, M, Kurz, C, et al. The phenotypic spectrum of progressive supranuclear palsy: a retrospective multicenter study of 100 definite cases. Mov Disord. 2014 Dec;29(14):1758–66.CrossRefGoogle ScholarPubMed
Cummings, JL. Reconsidering diagnostic criteria for dementia with lewy bodies. Highlights from the Third International Workshop on Dementia with Lewy Bodies and Parkinson’s Disease Dementia, September 17–20, 2003, Newcastle Upon Tyne, United Kingdom. Rev Neurol Dis 2004 Winter;1(1):31–4.Google ScholarPubMed
Wenning, GK, Geser, F, Krismer, F, et al. The natural history of multiple system atrophy: a prospective European cohort study. Lancet Neurol 2013 Mar;12(3):264–74.CrossRefGoogle ScholarPubMed
Armstrong, MJ, Litvan, I, Lang, AE, et al. Criteria for the diagnosis of corticobasal degeneration. Neurology 2013 Jan 29;80(5):496503.CrossRefGoogle Scholar
Winikates, J, Jankovic, J. Clinical correlates of vascular parkinsonism. Arch Neurol 1999; 56:98102.CrossRefGoogle ScholarPubMed
Langston, JW, Ballard, P. Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): implications for treatment and the pathogenesis of Parkinson’s disease. Can J Neurol Sci 1984; 11:160–5.Google ScholarPubMed
Olanow, CW. Manganese-induced parkinsonism and Parkinson’s disease. Ann N Y Acad Sci 2004; 1012:209–23.CrossRefGoogle ScholarPubMed
Klawans, HL, Stein, RW, Tanner, CM, Goetz, CG. A pure parkinsonian syndrome following acute carbon monoxide intoxication. Arch Neurol 1982; 39:302–4.CrossRefGoogle ScholarPubMed
Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson’s disease. N Engl J Med 1993; 328:176–83.
Shults, CW, Oakes, D, Kieburtz, K, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002; 59:1541–50.CrossRefGoogle ScholarPubMed
Whone, AL, Watts, RL, Stoessl, AJ, et al. Slower progression of Parkinson’s disease with ropinirole versus levodopa: the REAL-PET study. Ann Neurol 2003; 54:93101.CrossRefGoogle ScholarPubMed
Parkinson Study Group. Dopamine transporter brain imaging to assess the effects of pramipexole vs. levodopa on Parkinson disease progression. JAMA 2002; 287:1653–61.
Parkinson Study Group. A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study. Arch Neurol 2002; 59:1937–43.
Calne, DB. The role of various forms of treatment in the management of Parkinson’s disease. Clin Neuropharmacol 1982; 5(Suppl 1):S3843.CrossRefGoogle ScholarPubMed
Pritchett, AM, Morrison, JF, Edwards, WD, et al. Valvular heart disease in patients taking pergolide. Mayo Clin Proc 2002; 77:1280–6.CrossRefGoogle ScholarPubMed
Voon, V, Sohr, M, Lang, AE, et al. Impulse control disorders in Parkinson disease: a multicenter case–control study. Ann Neurol. 2011 Jun;69(6):986–96.CrossRefGoogle ScholarPubMed
Rascol, O, Brooks, DJ, Korczyn, AD, et al. A five-year study of the incidence of dyskinesia in patients with early Parkinson’s disease who were treated with ropinirole or levodopa: 056 study group. N Engl J Med 2000; 342: 1484–91.CrossRefGoogle ScholarPubMed
Parkinson Study Group. Pramipexole vs levodopa as initial treatment for Parkinson disease: a randomized controlled trial. Parkinson Study Group. JAMA 2000; 284:1931–8.
Cilia, R, Akpalu, A, Sarfo, FS, et al. “The modern pre-levodopa era of Parkinson’s disease: insights into motor complications from sub-Saharan Africa.” Brain 137 2014;10:2731–42.Google Scholar
Stowe, RL, Ives, NJ, Clarke, C, et al. Dopamine agonist therapy in early Parkinson’s disease. Cochrane Database Syst Rev 2008;2:CD006564.Google Scholar
PD MED Collaborative Group. Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson’s disease (PD MED): a large, open-label, pragmatic randomised trial.The Lancet 2014;384(9949):1196–205.
Hauser, RA, Hsu, A, Kell, S, et al. Extended-release carbidopa-levodopa (IPX066) compared with immediate-release carbidopa-levodopa in patients with Parkinson’s disease and motor fluctuations: a phase 3 randomised, double-blind trial. Lancet Neurol 2013;12(4):346–56.CrossRefGoogle ScholarPubMed
Fernandez, HH, Standaert, DG, Hauser, RA, et al. Levodopa-carbidopa intestinal gel in advanced Parkinson’s disease: final 12-month, open-label results. Mov Disord 2015 Apr;30(4):500–9.CrossRefGoogle ScholarPubMed
Zibetti, M, Merola, A, Artusi, CA, et al. Levodopa/carbidopa intestinal gel infusion in advanced Parkinson’s disease: a 7-year experience. Eur J Neurol 2014 Feb;21(2):312–18.CrossRefGoogle ScholarPubMed
Uncini, A, Eleopra, R, Onofrj, M. Polyneuropathy associated with duodenal infusion of levodopa in Parkinson’s disease: features, pathogenesis and management. J Neurol Neurosurg Psychiatry 2015 May;86(5):490–5.CrossRefGoogle ScholarPubMed
Rinne, UK, Rinne, JO, Rinne, JK, et al. Brain receptor changes in Parkinson’s disease in relation to the disease process and treatment. J Neural Transm Suppl 1983; 18:279–86.Google ScholarPubMed
Lew, MF, Kricorian, G. Results from a 2-year centralized tolcapone liver enzyme monitoring program. Clin Neuropharmacol 2007 Sep–Oct;30(5):281–6.CrossRefGoogle ScholarPubMed
Martinez-Ramirez, D, Okun, MS. Rationale and clinical pearls for primary care doctors referring patients for deep brain stimulation. Gerontology 2014;60(1):3848.CrossRefGoogle ScholarPubMed
Perestelo-Pérez, L, Rivero-Santana, A, Pérez-Ramos, J, et al. Deep brain stimulation in Parkinson’s disease: meta-analysis of randomized controlled trials. J Neurol 2014 Nov;261(11):2051–60.CrossRefGoogle ScholarPubMed
Mouradian, MM, Heuser, IJ, Baronti, F, Chase, TN. Modification of central dopaminergic mechanisms by continuous levodopa therapy for advanced Parkinson’s disease. Ann Neurol 1990; 27:1823.CrossRefGoogle ScholarPubMed
Block, G, Liss, C, Reines, S, et al. Comparison of immediate-release and controlled release carbidopa/levodopa in Parkinson’s disease: a multicenter 5-year study. The CR First Study Group. Eur Neurol 1997;37:23–7.CrossRefGoogle Scholar
Nutt, JG, Woodward, WR, Beckner, RM, et al. Effect of peripheral catechol-O-methyltransferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients. Neurology 1994;44:913–9.CrossRefGoogle ScholarPubMed
Parkinson Study Group. Entacapone improves motor fluctuations in levodopa-treated Parkinson’s disease patients. Ann Neurol 1997;42:747–55.
Rajput, AH, Martin, W, Saint-Hilaire, MH, Dorflinger, E, Pedder, S. Tolcapone improves motor function in parkinsonian patients with the “wearing-off” phenomenon: a double-blind, placebo-controlled, multicenter trial. Neurology 1997;49:1066–71.CrossRefGoogle ScholarPubMed
Pourfar, M, Feigin, A, Eidelberg, D. Natural history. In: Factor, SA, Weiner, WJ, editors, Parkinson’s Disease: Diagnosis and Clinical Management. 2nd ed. New York: Demos; 2008: 127–33.Google Scholar
Ostergaard, K, Aa Sunde, N. Evolution of Parkinson’s disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus. Mov Disord 2006;21:624631.CrossRefGoogle ScholarPubMed
Marras, C, McDermott, MP, Rochon, PA, et al. Survival in Parkinson disease: thirteen-year follow-up of the DATATOP cohort. Neurology 2005;64(1):8793.CrossRefGoogle ScholarPubMed
Tuck, K, Brod, L, Nutt, J, Fromme, EK. Preferences of patients with Parkinson. American Journal of Hospice & Palliative Medicine 2015;32(1):6877.CrossRefGoogle Scholar
Verghese, J, Le Valley, A, Hall, CB, et al. Epidemiology of gait disorders in community-residing older adults. Journal of American Geriatric Society 2006;54:255–61.CrossRefGoogle ScholarPubMed
Sudarsky, LR. Gait impairment and falls. In: Samuels, S and Feske, S, eds. Office Practice of Neurology. Philadelphia: Churchill Livingstone; 2003: 25.CrossRefGoogle Scholar
Marmarou, A, Black, P, Bergsneider, M, et al. Guidelines for management of idiopathic normal pressure hydrocephalus: progress to date. Acta Neurochir Suppl 2005;95:237–40.CrossRefGoogle ScholarPubMed
Perlman, SL. Ataxias. Clin Geriatr Med 2006; 22:859–77.CrossRefGoogle ScholarPubMed
Zesiewicz, TA, Sullivan, KL, Arnulf, I, et al. Practice parameter: treatment of nonmotor symptoms of Parkinson disease: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2010;74(11):924–31.CrossRefGoogle ScholarPubMed
Ruzicka, E, Jankovic, JJ. Disorders of gait. In: Jankovic, J and Tolosa, E, eds. Parkinsons Disease and Movement Disorders. Philadelphia: Lippincott Williams & Wilkins; 2007: 409.Google Scholar
Mouton, CP, Espino, DV. Health screening in older women. Am Fam Physician 1999;59(7):1835–42.Google ScholarPubMed
Barak, Y, Wagenaar, RC, Holt, KG. Gait characteristic of elderly people with a history of falls: a dynamic approach. Phys Ther 2006 86:1501–10.CrossRefGoogle Scholar
Gilman, S. Merritt’s Neurology. 10th ed. Philadelphia: Lippincott Williams & Wilkins, 2000.Google Scholar
Ondo, W. Gait and balance disorders. Med Clin N Am 2003;87(4): 793801.CrossRefGoogle ScholarPubMed
Hyndman, D, Ashburn, A, Yardley, L, Stack, E. Interference between balance, gait, and cognitive task performance among people with stroke living in the community. Disability and Rehabilitation. 2006;28(13–14):849–56.CrossRefGoogle ScholarPubMed
Nutt, JG. Abnormalities of posture and movement. In: Cassel, CK, Cohen, HJ, Larson, EB, et al. (eds). Geriatric Medicine. 3rd ed. New York: Spring-Verlag; 1997: 939–48.Google Scholar
Factora, R, Luciano, M. Normal pressure hydrocephalus: diagnosis and new approaches to treatment. Clin Geriatr Med 2006;22:645–57.CrossRefGoogle Scholar
Kanade, RV, van Deursen, RWM, Harding, K, Price, P. Walking performance in people with diabetic neuropathy: benefits and threats. Diabetologia 2006;49:1747–54.CrossRefGoogle ScholarPubMed
Foley, DJ, Monjan, AA, Brown, SL, et al. Sleep complaints among elderly persons: an epidemiological study of 3 communities. Sleep. 1995;18:425432.CrossRefGoogle Scholar
Mellinger, GD, Balter, MB, Uhlenhuth, EH. Insomnia and its treatment: prevalence and correlates. Arch Gen Psychiatry. 1985;42:225232.CrossRefGoogle ScholarPubMed
Morgan, K. Sleep and aging. In: Lichstein, K, Morin, C, eds. Treatment of Late Life Insomnia. Thousand Oaks, CA: Sage Publications, 2000.Google Scholar
Floyd, JA, Medler, SM, Ager, JW, et al. Age-related changes in initiation and maintenance of sleep: a meta-analysis. Res Nurs Health. 2000;23:106117.3.0.CO;2-A>CrossRefGoogle ScholarPubMed
Diagnostic Classification Steering Committee TMJC. International Classification of Sleep Disorders, 3rd edition. Rochester, NY: American Academy of Sleep Medicine, 2014.
Ford, DE, Kamerow, DB. Epidemiological study of the sleep disturbances and psychiatric disorders. JAMA. 1989;262:14791484.CrossRefGoogle Scholar
Vitiello, MV, Moe, KE, Prinz, PN. Sleep complaints cosegregate with illness in older adults: clinical research informed by and informing epidemiological studies of sleep. J Psychosom Res. 2002;53:555559.CrossRefGoogle Scholar
Bloom, HG, Ahmed, I, Alessi, CA, et al. Evidence-based recommendations for the assessment and management of sleep disorders in older persons. J Am Geriatr Soc. 2009;57:761789.CrossRefGoogle ScholarPubMed
Rodriguez, JC, Dzierzewski, JM, Alessi, CA. Sleep problems in the elderly. Med Clin North Am. 2015;99:431439.CrossRefGoogle ScholarPubMed
Insomnia, Roth T.: Definition, prevalence, etiology, and consequences. J Clin Sleep Med. 2007;3:S7S10.Google Scholar
Dzierzewski, JM, O’Brien, E, Kay, DB, et al. Tackling sleeplessness: psychological treatment options for insomnia in older adults. Nat Sci Sleep. 2010;2:4761.Google ScholarPubMed
Spielman, AJ, Caruso, LS, Glovinsky, PB. A behavioral perspective on insomnia treatment. Psychiat Clinics of N Amer. 1987;10:541553.CrossRefGoogle ScholarPubMed
Bastien, CH, Vallieres, A, Morin, CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001;2:297307.CrossRefGoogle ScholarPubMed
Buysse, DJ, Reynolds, CFI, Monk, TH, et al. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193213.CrossRefGoogle ScholarPubMed
Morin, CM, Colecchi, C, Stone, J, et al. Behavioral and pharmacological therapies for late life insomnia: a randomized controlled trial. JAMA. 1999;281:991999.CrossRefGoogle ScholarPubMed
Sivertsen, B, Omvik, S, Pallesen, S, et al. Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults. JAMA. 2006;295:28512858.CrossRefGoogle ScholarPubMed
McCurry, SM, Logsdon, RG, Teri, L, et al. Evidence-based psychological treatments for insomnia in older adults. Psychol Aging. 2007;22:1827.CrossRefGoogle ScholarPubMed
Morgenthaler, T, Kramer, M, Alessi, CA, et al. Practice parameters for the psychological and behavioral treatment of insomnia: an update. An American Academy of Sleep Medicine report. Sleep. 2006;29:14151419.Google ScholarPubMed
Siebern, AT, Manber, R. New developments in cognitive behavioral therapy as the first-line treatment of insomnia. Psychol Res Behav Manag. 2011;4:2128.CrossRefGoogle ScholarPubMed
Stewart, R, Besset, A, Bebbington, P, et al. Insomnia comorbidity and impact and hypnotic use by age group in a national survey population aged 16 to 74 years. Sleep. 2006;29:13911397.CrossRefGoogle Scholar
Alessi, CA. Sleep problems. In: Durso, SC, Sullivan, GM, eds. Geriatrics Review Syllabus: A Core Curriculum in Geriatric Medicine, 8th edition. New York: American Geriatrics Society, 2013: 316339.Google Scholar
Young, T, Peppard, PE, Gottlieb, DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med. 2002;165:12171239.CrossRefGoogle ScholarPubMed
George, CFP. Sleep apnea, alertness, and motor vehicle crashes. American Journal of Respiratory and Critical Care Medicine. 2007;176(10):954956.CrossRefGoogle ScholarPubMed
Punjabi, NM, Caffo, BS, Goodwin, JL, et al. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Medicine. 2009;6(8):e1000132.CrossRefGoogle ScholarPubMed
Kales, A, Cadieux, RJ, Bixler, EO, et al. Severe obstructive sleep apnea – I: onset, clinical course, and characteristics. Journal of Chronic Diseases. 1985;38(5):419425.CrossRefGoogle ScholarPubMed
Cowan, DC, Allardice, G, MacFarlane, D, et al. Predicting sleep disordered breathing in outpatients with suspected OSA. BMJ Open. 2014;4:e004519.CrossRefGoogle ScholarPubMed
Epstein, LJ, Kristo, D, Strollo, PJ Jr, et al. Clinical guidelines for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med. 2009;15:263276.Google Scholar
Qaseem, A, Holty, JE, Owens, DK, et al. Management of obstructive sleep apnea in adults: a clinical practice guideline from the American College of Physicians. Annals of Internal Medicine. 2013;159(7):471483.CrossRefGoogle ScholarPubMed
Strohl, KP, Brown, DB, Collop, N, et al. An official American Thoracic Society Clinical Practice Guideline: sleep apnea, sleepiness, and driving risk in noncommercial drivers. An update of a 1994 Statement. American Journal of Respiratory and Critical Care Medicine. 2013;187(11):12591266.CrossRefGoogle ScholarPubMed
Campos-Rodriguez, F, Pena-Grinan, N, Reyes-Nuñez, N, et al. Mortality in obstructive sleep apnea-hypopnea patients treated with positive airway pressure. Chest. 2005;128:624633.CrossRefGoogle ScholarPubMed
Giles, TL, Lasserson, TJ, Smith, BJ, et al. Continuous positive airway pressure for obstructive sleep apnoea in adults. Cochrane Database Syst Rev. 2006;25:CD001106.Google Scholar
Rosenthal, L, Gerhardstein, R, Lumley, A, et al. CPAP therapy in patients with mild OSA: implementation and treatment outcome. Sleep Medicine. 2000;1(3);215220.CrossRefGoogle ScholarPubMed
Krahn, LE, Lin, SC, Wisbey, J, et al. Assessing sleep in psychiatric inpatients: nurse and patient reports versus wrist actigraphy. Ann Clin Psychiatry. 1997;9:203210.CrossRefGoogle ScholarPubMed
Venkateshiah, SB, Collop, NA. Sleep and sleep disorders in the hospital. Chest. 2012;141:13371345.CrossRefGoogle ScholarPubMed
Iranzo, A, Santamaria, J, Bereguer, J, et al. Prevalence and clinical importance of sleep apnea in the first night after cerebral infarction. Neurology. 2002;58:911916.CrossRefGoogle ScholarPubMed
Kaw, R, Chung, F, Pasupuleti, V, et al. Meta-analysis of the association between obstructive sleep apnoea and postoperative outcome. British Journal of Anaesthesia. 2012;109;897906.CrossRefGoogle ScholarPubMed
D’Apuzzo, MR, Browne, JA. Obstructive sleep apnea as a risk factor for postoperative complications after revision joint arthroplasty. The Journal of Arthroplasty. 2012;27(8):9598.CrossRefGoogle ScholarPubMed
Koch, S, Haesler, E, Tiziani, A, Wilson, J. Effectiveness of sleep management strategies for residents of aged care facilities: findings of a systematic review. Journal of Clinical Nursing. 2006;15(10):12671275.CrossRefGoogle ScholarPubMed
Ancoli-Israel, S, Klauber, MR, Kripke, DF, et al. Sleep apnea in female patients in a nursing home. Increased risk of mortality. CHEST. 1989;96(5):10541058.CrossRefGoogle Scholar
Alessi, CA, Martin, JL, Webber, AP, et al. Randomized, controlled trial of a nonpharmacological intervention to improve abnormal sleep/wake patterns in nursing home residents. J Am Geriatr Soc. 2005;53:803810.CrossRefGoogle ScholarPubMed
Koch, S, Haesler, E, Tiziani, A, et al. Effectiveness of sleep management strategies for residents of aged care facilities: findings of a systematic review. J Clin Nurs. 2006;15:12671275.CrossRefGoogle ScholarPubMed
Roth, HL. Dementia and sleep. Neurol Clin. 2012;30:12131248.CrossRefGoogle ScholarPubMed
McCleery, J, Cohen, DA, Sharpley, AL. Pharmacotherapies for sleep disturbances in Alzheimer’s disease. Cochrane Database Syst Rev. 2014;3:CD009178.Google Scholar
Stahl, S. 2013. Stahl’s Essential Psychopharmacology. 4th ed. Cambridge: Cambridge University Press.Google Scholar
Institute of Medicine. 2012. The Mental Health Workforce for Geriatric Population. Washington, DC: IOM Press.
Inouye, SK, Bogardus, ST, Charpentier, PA, et al. 1999. A multicomponent intervention to prevent delirium in hospitalized patients. NEJM. 340:669–74.CrossRefGoogle Scholar
Rovner, BW, Kalonek, S, Filipp, L, et al. 1986. Prevalence of mental illness in a community nursing home. Am J Psychiatry. 143:14461449.Google Scholar
Blazer, DG. 2001. Depression in Late Life. 3rd ed. St. Louis: Mosby-Year Book.Google Scholar
Blazer, DG. 1994. Is depression more frequent in late life? J Geriatr Psychiatry. 2:193199.CrossRefGoogle ScholarPubMed
Lipsey, JR, Robinson, RG, Pearlson, GD, et al. 1985. The dexamethasone suppression test and mood following stroke. Am J Psychiatry. 142:318323.Google ScholarPubMed
Jorm, A. 2000. Does old age reduce the risk of anxiety and depression? Psychol Med. 30:1122.CrossRefGoogle ScholarPubMed
Philibert, RA, Richards, L, Lynch, CF, et al. 1995. Effect of ECT on mortality and clinical outcome in geriatric unipolar depression. J Clin Psychiatry. 56:390394.Google ScholarPubMed
Stoppe, A, Louza, M, Moacyr, R, et al. 2006. Fixed high-dose ECT in the elderly with depression. J ECT. 22:9299.CrossRefGoogle ScholarPubMed
Lehmann, SW, Rabins, PV. 2006. Factors related to hospitalization in elderly manic patients with early and late onset bipolar disorder. Int J Geri Psych. 21: 10601064.CrossRefGoogle ScholarPubMed
Blazer, D, Hughes, DC, George, LK. 1987. The epidemiology of depression in an elderly community population. Gerontologist. 27:281287.CrossRefGoogle Scholar
Bruce, ML, Kim, K, Leaf, PJ. 1990. Depressive episodes and dysphoria resulting from conjugal bereavement in a prospective community sample. Am J Psychiatry. 147:608611.Google Scholar
Meehan, PJ, Saltzman, LE, Sattin, RW. 1991. Suicides among older United States residents: epidemiologic characteristics and trends. Am J Public Health. 81:11981200.CrossRefGoogle ScholarPubMed
Howard, R, Rabins, PV, Seeman, MV, et al. 2000. Late- onset schizophrenia and very-late-onset schizophrenia-like psychosis: an international consensus. Am J Psychiatry. 157:172178.CrossRefGoogle Scholar
Holroyd, S, Rabins, PV, Finkelstein, D, et al. 1994. Visual hallucinations in patients from an ophthalmology clinic and medical clinic population. J Nerv Ment Dis. 182:272276.CrossRefGoogle ScholarPubMed
Myers, WA. 1991. New Techniques in the Psychotherapy of Older Patients. Washington, DC: American Psychiatry Press.Google Scholar
US Census Bureau. Population profile of the United States. 2012.
Kerr, WC, Greenfield, TK, Bond, J, et al. Age-period-cohort modelling of alcohol volume and heavy drinking days in the US National Alcohol Surveys: divergence in younger and older adult trends. Addiction. 2009 Jan;104(1):2737. doi: 10.1111/j.1360-0443.2008.02391.x.CrossRefGoogle ScholarPubMed
Substance Abuse and Mental Health Services Administration. Results from the 2012 National Survey on Drug Use and Health: Summary of national findings. NSDUH Series H-46, HHS Publication No. (SMA) 13–4795. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2013.
Duncan, DF, Nicholson, T, White, JB, et al. The baby boomer effect: changing patterns of substance abuse among adults ages 55 and older. J Aging Soc Policy. 2010 Jul;22(3):237248. doi: 10.1080/08959420.2010.485511.CrossRefGoogle ScholarPubMed
Cummings, SM, Bride, B, Rawlins-Shaw, AM. Alcohol abuse treatment for older adults: a review of recent empirical research. Journal of Evidence-Based Social Work. 2006;3(1):7999.CrossRefGoogle Scholar
Saitz, R. Unhealthy alcohol use. New Eng J Med. 2005;352(6):596607.CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013.
Moore, AA, Karno, MP, Grella, CE, et al. Alcohol, tobacco, and nonmedical drug use in older US adults: Data from the 2001/02 National Epidemiologic Survey of Alcohol and Related Conditions. Journal of the American Geriatrics Society. 2009;57(12):22752281.CrossRefGoogle Scholar
Arndt, S, Clayton, R, Schultz, S. Trends in substance abuse treatment 1998–2008: Increasing older adult first time admissions for illicit drugs. American Journal of Geriatric Psychiatry. 2011;19:704711.CrossRefGoogle ScholarPubMed
Moos, RH, Schutte, KK, Brennan, PL, Moos, BS. Older adults’ alcohol consumption and late-life drinking problems: a 20-year perspective. Addiction. 2009;104:12931302.CrossRefGoogle ScholarPubMed
Kirchner, J, Zubritsky, C, Cody, M, et al. Alcohol consumption among older adults in primary care. Journal of General Internal Medicine. 2007;22:9297.CrossRefGoogle ScholarPubMed
Center for Substance Abuse Treatment. Substance Abuse among Older Adults: Treatment Improvement Protocol (TIP) Series 26. Rockville, MD: Substance Abuse and Mental Health Services Administration; 1998.
Moore, AA, Gould, R, Reuben, DB, et al. Longitudinal patterns and predictors of alcohol consumption in the United States. American Journal of Public Health. 2005;95(3):458465.CrossRefGoogle ScholarPubMed
Blazer, DG, Wu, L. The epidemiology of at risk and binge drinking among middle-aged and elderly community adults: National Survey on Drug Use and Health. Am J Psychiat. 2009;166:11621169.CrossRefGoogle ScholarPubMed
National Institute on Alcohol Abuse and Alcoholism. Rethinking Drinking. NIH Publication No. 13–3770. Bethesda, MD: NIH; 2010.
Grant, BF, Dawson, DA, Stinson, FS, et al. The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991–1992 and 2001–2002. Drug Alcohol Depen. 2004;74:223234.CrossRef