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11 - Skin

Published online by Cambridge University Press:  20 August 2009

Shirley Hodgson
Affiliation:
St George's Hospital Medical School, London
William Foulkes
Affiliation:
McGill University, Montréal
Charis Eng
Affiliation:
Cleveland Clinic Foundation
Eamonn Maher
Affiliation:
University of Birmingham
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Summary

Genetic predisposition to skin cancer may involve a variety of mechanisms. Firstly, there is a group of genetic disorders associated with a predisposition to specific skin cancers, and in which the premalignant lesions are primarily confined to the skin (see Table 11.1). These disorders are discussed below under the specific skin cancer involved. A second group comprises hereditary skin disorders which (possibly by virtue of chronic inflammation) predispose to skin cancers (see Table 11.1). These are described after the specific skin cancers (p. 139). The final group includes genetic disorders which (i) predispose to both skin and systemic neoplasms, or (ii) predispose to systemic neoplasia but are associated with cutaneous stigmata. These conditions are discussed in part three and include the chromosome breakage disorders (Bloom syndrome (p. 174), Fanconi anaemia (p. 193), ataxia telangiectasia (p. 167), xeroderma pigmentosum (p. 259), Cowden syndrome (p. 179), dermatitis herpetiformis/coeliac disease (p. 178), Di George syndrome, familial hyperglucagonaemia, Gardner syndrome (p. 184), Gorlin syndrome (p. 196), haemochromatosis, multiple endocrine neoplasia type 2 (MEN2B, p. 224), neurofibromatosis type 1 (NF1, p. 230), porphyria (p. 243), tuberose sclerosis (p. 246) and tylosis (p. 252).

Specific skin cancers

With Julia A Newton-Bishop

Melanoma is a relatively uncommon cancer, with an incidence in most of Northern Europe of around 10 per 100 000 per annum (Parkin et al., 1997). In many countries, and particularly in the UK, it is more common in women.

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Publisher: Cambridge University Press
Print publication year: 2006

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  • Skin
  • Shirley Hodgson, St George's Hospital Medical School, London, William Foulkes, McGill University, Montréal, Charis Eng, Cleveland Clinic Foundation, Eamonn Maher, University of Birmingham
  • Book: A Practical Guide to Human Cancer Genetics
  • Online publication: 20 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511545832.013
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  • Skin
  • Shirley Hodgson, St George's Hospital Medical School, London, William Foulkes, McGill University, Montréal, Charis Eng, Cleveland Clinic Foundation, Eamonn Maher, University of Birmingham
  • Book: A Practical Guide to Human Cancer Genetics
  • Online publication: 20 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511545832.013
Available formats
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Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Skin
  • Shirley Hodgson, St George's Hospital Medical School, London, William Foulkes, McGill University, Montréal, Charis Eng, Cleveland Clinic Foundation, Eamonn Maher, University of Birmingham
  • Book: A Practical Guide to Human Cancer Genetics
  • Online publication: 20 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511545832.013
Available formats
×