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9 - Blood and lymph

Published online by Cambridge University Press:  20 August 2009

Shirley Hodgson
Affiliation:
St George's Hospital Medical School, London
William Foulkes
Affiliation:
McGill University, Montréal
Charis Eng
Affiliation:
Cleveland Clinic Foundation
Eamonn Maher
Affiliation:
University of Birmingham
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Summary

Leukaemia

Leukaemia is responsible for approximately 2 per cent of all cancers, with an incidence of about 8 per 100 000 in the UK. Acute myeloid and lymphoblastic leukaemias (AML and ALL) account for about 1 per cent of all cancers and 1.5 per cent of cancer deaths. The age incidence of leukaemia shows two peaks, in childhood and in the elderly. Genetic factors are not considered to have a prominent role in the pathogenesis of acute leukaemias or in chronic myeloid leukaemia, but have been implicated in chronic lymphocytic leukaemia (CLL). Gunz et al. (1975) studied the incidence of leukaemia in relatives of 909 patients with leukaemia. The overall incidence of leukaemia in first-degree relatives was three times higher than expected although only 2 per cent of patients had a first-degree relative with leukaemia. Among the main subtypes of leukaemia, an increased risk to relatives was most marked in chronic lymphocytic leukaemia, less so in acute leukaemias and absent in chronic myeloid leukaemia. When familial clusters of leukaemia have been reported, the type of leukaemia in individual relatives is not always concordant (Lee et al., 1987). Familial leukaemia does not necessarily indicate a genetic cause, and shared exposure to an environmental leukaemogen also needs to be considered, particularly in childhood acute leukaemias. Genetic disorders that have been associated with a predisposition to leukaemia are shown in Table 9.1 and discussed in detail in part three. Genetic disorders are thought to account for only 3 per cent of childhood leukaemia.

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Publisher: Cambridge University Press
Print publication year: 2006

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  • Blood and lymph
  • Shirley Hodgson, St George's Hospital Medical School, London, William Foulkes, McGill University, Montréal, Charis Eng, Cleveland Clinic Foundation, Eamonn Maher, University of Birmingham
  • Book: A Practical Guide to Human Cancer Genetics
  • Online publication: 20 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511545832.011
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  • Blood and lymph
  • Shirley Hodgson, St George's Hospital Medical School, London, William Foulkes, McGill University, Montréal, Charis Eng, Cleveland Clinic Foundation, Eamonn Maher, University of Birmingham
  • Book: A Practical Guide to Human Cancer Genetics
  • Online publication: 20 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511545832.011
Available formats
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Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Blood and lymph
  • Shirley Hodgson, St George's Hospital Medical School, London, William Foulkes, McGill University, Montréal, Charis Eng, Cleveland Clinic Foundation, Eamonn Maher, University of Birmingham
  • Book: A Practical Guide to Human Cancer Genetics
  • Online publication: 20 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511545832.011
Available formats
×