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Chapter 9 - Systemic Pharmacologic Analgesia

Published online by Cambridge University Press:  08 March 2019

Tauqeer Husain
Affiliation:
Ashford and St Peter’s NHS Foundation Trust, Surrey
Roshan Fernando
Affiliation:
Womens Wellness and Research Centre, Hamad Medical Corporation, Qatar
Scott Segal
Affiliation:
Wake Forest University, North Carolina
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Summary

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Chapter
Information
Obstetric Anesthesiology
An Illustrated Case-Based Approach
, pp. 39 - 45
Publisher: Cambridge University Press
Print publication year: 2019

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References

Melzach, R. The myth of painless childbirth. Pain 1984; 19:321–27.Google Scholar
Anim-Somuah, M, Smyth, R, Howell, C. Epidural versus non-epidural or no analgesia in labour. Cochrane Database Syst Rev 2005; (4):CD000331.CrossRefGoogle Scholar
Rosen, MA. Nitrous oxide for relief of labor pain: a systematic review. Am J Obstet Gynecol 2002; 186:S110–26.CrossRefGoogle ScholarPubMed
Olofsson, C, Ekblom, A, Ekman-Ordeberg, G, Hjelm, A, Irestedt, L. Lack of analgesic effect of systemically administered morphine or pethidine on labour pain. BJOG 1996; 103:968–72.CrossRefGoogle ScholarPubMed
Carstoniu, J, Levytam, S, Norman, P, et al. Nitrous oxide in early labor: safety and analgesic efficacy assessed by a double-blind, placebo-controlled study. Anesthesiology 1994; 80:3035.CrossRefGoogle ScholarPubMed
Yentis, SM. The use of Entonox for labour pain should be abandoned (Proposer). Int J Obstet Anesth 2001; 10(1):2529.CrossRefGoogle Scholar
Clyburn, P. The use of Entonox for labour pain should be abandoned (Opposer). Int J Obstet Anesth 2001; 10:2539.CrossRefGoogle Scholar
Wong, CA. Epidural and spinal analgesia/anesthesia for labor and vaginal delivery, in Chestnut, DH, Polley, LS, Tsen, LC, Wong, CA (eds.), Chestnut’s Obstetric Anesthesia: Principles and Practice. Philadelphia, PA: Mosby Elsevier; 2009, pp. 429–92.Google Scholar
Westling, F, Milsom, I, Zetterstrom, H, Ekstorom-Jodal, B. Effects of nitrous oxide oxygen inhalation on the maternal circulation during vaginal delivery. Acta Anaesthesiol Scand 1992; 36(2):175–81.CrossRefGoogle ScholarPubMed
Lucas, DN, Siemaszko, O, Yentis, SM. Maternal hypoxemia associated with the use of Entonox in labour. Int J Obstet Anesth 2000; 9(4):270–72.CrossRefGoogle ScholarPubMed
McAneny, T, Doughty, AG. Self-administration of nitrous oxide/oxygen in obstetrics. Anaesthesia 1963; 18:488–97.CrossRefGoogle Scholar
Stefani, S, Hughes, S, Shnider, S, et al. Neonatal neurobehavioral effects of inhalation analgesia for vaginal delivery. Anesthesiology 1982; 56(5):351–55.CrossRefGoogle ScholarPubMed
Griffin, RP, Reynolds, F. Maternal hypoxemia during labour and delivery: the influence of analgesia and effect on neonatal outcome. Anaesthesia 1995; 50(2):151–56.CrossRefGoogle ScholarPubMed
Malaise, O, Bruyere, O, Jean-Yves, R. Intravenous paracetamol: a review of efficacy and safety in therapeutic use. Future Neurol 2007; 2(6):673–88.CrossRefGoogle Scholar
Graham, GG, Scott, KF, Day, RO. Tolerability of paracetamol. Drug Saf 2005; 28(3):227–40.CrossRefGoogle ScholarPubMed
Elbohoty, AEH, Abd-Elrazek, H, Abd-El-Gawad, M, et al. Intravenous infusion of paracetamol versus intravenous pethidine as an intrapartum analgesic in the first stage of labor. Int J Gynaecol Obstet 2012; 118(1):710.CrossRefGoogle ScholarPubMed
Hyllested, M, Jones, S, Pedersen, JL, Kehlet, H. Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review. Br J Anaesth 2002; 88(2):199214.CrossRefGoogle ScholarPubMed
Othman, M, Jones, L, Neilson, JP. Non-opioid drugs for pain management in labour (review). Cochrane Database Syst Rev 2012; (11):CD009223.Google Scholar
Ostensen, ME. Safety of non-steroidal anti-inflammatory drugs during pregnancy and lactation. Inflammopharmacology 1996; 4:3141.CrossRefGoogle Scholar
Elbourne, D, Wiseman, RA. Types of intra-muscular opioids for maternal pain relief in labour. Cochrane Database Syst Rev 1998; (4):CD001237.CrossRefGoogle Scholar
Benyamin, R, Trescot, AM, Datta, A, et al. Opioid complications and side effects. Pain Physician 2008; 11:S105–20.Google ScholarPubMed
Yentis, SM, Hirsch, NP, Smith, GP. Anaesthesia and Intensive Care A–Z: An encyclopedia of Principles and Practice, 3rd edn. London: Elsevier; 2004.Google Scholar
Wee, M. Analgesia in labour: inhalational and parenteral. Anaesth Intensive Care Med 2004; 5(7):233–34.CrossRefGoogle Scholar
Fortescue, C, Wee, M. Analgesia in labour: non-regional techniques. Continuing Education in Anaesthesia Critical Care and Pain 2005; 5(1):913.CrossRefGoogle Scholar
Husslein, P, Kubista, E, Egarter, C. Obstetrical analgesia with tramadol: results of a prospective randomized comparative study with pethidine. Z Geburtshilfe Perinatol 1987; 191(6):234–37.Google ScholarPubMed
Viegas, OAC, Khaw, B, Ratnam, SS. Tramadol in labor pain in primiparous patients: a prospective comparative clinical trial. Eur J Obstet Gynaecol Reprod Biol 1993; 49(3):131–35.CrossRefGoogle ScholarPubMed
Wee, MYK, Tuckey, JP, Thomas, PW, Burnard, S. A comparison of intramuscular diamorphine and intramuscular pethidine for labour analgesia: a two-centre randomized blinded controlled trial. BJOG 2013; 121(4): 447–56.Google Scholar
Thomson, AM, Hillier, VF. A re-evaluation of the effect of pethidine on the length of labour. J Adv Nurs 1994; 19(3):448–56.CrossRefGoogle ScholarPubMed
Bailey, PL, Egan, TD, Stanley, TH. Intravenous opioid anesthetics, in Miller, RD (ed.), Anesthesia, 5th edn, vol. 1. Philadelphia, PA: Churchill Livingstone; 2000, pp. 273376.Google Scholar
Ala-Kokko, T, Vähäkangas, K, Pelkonen, O. Placental function and principles of drug transfer. Acta Anaesthesiol Scand 1993; 37:4749.CrossRefGoogle Scholar
Littleford, J. Effects on the fetus and newborn of maternal analgesia and anesthesia: a review. Can J Anaesth 2004; 51(6):586609.CrossRefGoogle ScholarPubMed
Jones, L, Othman, JL, Dowswell, T, et al. Pain management for women in labour: an overview of systematic reviews. Cochrane Database Syst Rev 2012; (3):CD009234Google Scholar
Ullman, R, Smith, LA, Burns, E, Mori, R, Dowswell, T. Parenteral opioid for maternal pain relief in labour. Cochrane Database Syst Rev 2010; (9):CD007396.Google Scholar
Maguie, W, Fowlie, PW. Naloxone for narcotic exposed newborn infants. Cochrane Database Syst Rev 2002; (4):CD003483.Google Scholar
Medicines and Healthcare products Regulatory Agency (MHRA). Codeine: restricted use as analgesic in children and adolescents after European safety review, June 2013. Available at www.mhra.gov.uk/safetyinformation/drugsafetyupdate/CON287006 (accessed January 10, 2014).
Egan, TD. Pharmacokinetics and pharmacodynamics of remifentanil: an update in the year 2000. Curr Opin Anesthesiol 2000; 13(4):449–55.CrossRefGoogle ScholarPubMed
Babenco, HD, Conard, PF, Gross, JB. The pharmacodynamics effect of a remifentanil bolus on ventilatory control. Anesthesiology 2000; 92(2):393–98.CrossRefGoogle ScholarPubMed
Volmanen, P, Alahuhta, S. Will remifentanil be a labour analgesic? Int J Obstet Anaesth 2004; 13(1):14.CrossRefGoogle ScholarPubMed
Dhileepan, S, Stacey, RG. A preliminary investigation of remifentanil as a labor analgesic. Anesth Analg 2001; 92(5):1358–59.Google ScholarPubMed
Caldero-Barcia, R, Poseiro, JJ. Physiology of the uterine contraction. Clin Obstet Gynecol 1960; 3:386408.CrossRefGoogle Scholar
Volikas, I, Butwick, A, Wilkinson, C, Pleming, A, Nicholson, G. Maternal and neonatal side effects of remifentanil patient-controlled analgesia in labour. Br J Anaesth 2005; 95(4):504–9.CrossRefGoogle ScholarPubMed
Balki, M, Kasodekar, S, Dhumne, S, Bernstein, P, Carvalho, JC. Remifentanil patient-controlled analgesia for labour: optimizing drug delivery regimens. Can J Anaesth, 2007; 54(8):626–33.CrossRefGoogle ScholarPubMed
Tveit, TO, Halvorsen, A, Seiler, S, Rosland, JH. Efficacy and side effects of intravenous remifentanil patient controlled analgesia used in a stepwise approach for labour: an observational study. Int J Obstet Anaesth 2013; 22(1):1925.CrossRefGoogle Scholar
Schnabel, A, Hahn, N, Broscheit, J, et al. Remifentanil for labour analgesia: a meta-analysis of randomised controlled trials. Eur J Anaesthesiol 2012; 29(4):177–85.CrossRefGoogle ScholarPubMed
Stourac, P, Suchomelova, H, Stodulkova, M, et al. Comparison of parturient – controlled remifentanil with epidural bupivacaine and sufentanil for labour analgesia: randomised controlled trial. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic, 2012.
Douma, MR, Middledorp, JM, Verwey, RA, Dahan, A, Stienstra, R. A randomised comparison of intravenous remifentanil patient-controlled analgesia with epidural ropivicaine/sufentanil during labour. Int J Obstet Anaesth 2011; 20(2):118–23.CrossRefGoogle Scholar
Volmanen, P, Sarvela, J, Akural, EL, et al. Intravenous remifentanil vs epidural levobupivicaine with fentanyl for pain relief in early labour: a randomised, controlled, double-blinded study. Acta Anaesthesiol Scand 2008; 52(2):249–55.CrossRefGoogle Scholar
Marwah, R, Hassan, S, Carvalho, JC, Balki, M. Remifentanil versus fentanyl for intravenous patient-controlled labour analgesia: an observational study. Can J Anaesth 2012; 59(3):246–54.CrossRefGoogle Scholar
Stocki, D, Matot, I, Einav, S, et al. A randomized controlled trial of the efficacy and respiratory effects of patient-controlled intravenous remifentanil analgesia and patient-controlled epidural analgesia in laboring women. Anesth Analg 2013; 118(3):589–97.Google Scholar
Sneyd, R. Remifentanil on the labour ward. Anaesthesia 2012; 67(9):1045–46.CrossRefGoogle ScholarPubMed
Kan, RE, Hughes, SC, Rosen, MA, et al. Intravenous remifentanil: placental transfer, maternal and neonatal effects. Anesthesiology 1998; 88(6):1467–74.CrossRefGoogle ScholarPubMed
Hinova, A, Fernando, R. Systemic remifentanil for labour analgesia. Int Anaesth Res Soc 2009; 109(6):1925–29.Google Scholar
Bonner, JC, McClymont, W. Respiratory arrest in an obstetric patient using remifentanil patient-controlled analgesia. Anaesthesia 2012; 67(5):538–40.CrossRefGoogle Scholar
Pruefer, C, Bewlay, A. Respiratory arrest with remifentanil patient-controlled analgesia: another case. Anaesthesia 2012; 67(9):1044–45.CrossRefGoogle ScholarPubMed
Marr, R, Hyams, J, Bythell, V. Cardiac arrest in an obstetric patient using remifentanil patient-controlled analgesia. Anaesthesia 2013; 34(2):123–24.Google Scholar
Kinney, MA, Rose, CH, Traynor, KD, et al. Emergency bedside cesarean delivery: lessons learned in teamwork and patient safety. BMC Res Notes 2012; 5:412.CrossRefGoogle ScholarPubMed
Volmanen, P, Akural, EI, Raudaskoski, T, Alahuhta, S. Remifentanil in obstetric analgesia: a dose- finding study. Anesth Analg 2002; 94(4):913–17.CrossRefGoogle ScholarPubMed
McMackin, P, Hodgkinson, P, Foley, P, et al. Remifentanil PCA for labour: completing the audit cycle. Abstracts of free papers presented at the Annual Congress of the AAGBI, Edinburgh. Anaesthesia 2011; 66:S1.Google Scholar
Machatuta, NA, Kinsella, SM. Remifentanil for labour analgesia: time to draw breath? Anaesthesia 2013; 68(3):231–35.Google Scholar
Kranke, P, Girard, T, Lavand’homme, P, et al. Must we press on until a young mother dies? Remifentanil patient-controlled analgesia in labour may not be suited as a “poor man’s epidural.” BMC Pregnancy and Childbirth 2013; 13:139.CrossRefGoogle Scholar
Ross, AK, Davis, PJ, Dear, GL, et al. Pharmacokinetics of remifentanil in anesthetized pediatric patients undergoing elective surgery or diagnostic procedures. Anesth Analg 2001; 93(6):1393–401.CrossRefGoogle ScholarPubMed
Thurlow, JA, Laxton, CH, Dick, A, et al. Remifentanil by patient controlled analgesia compared with intramuscular meperidine for pain relief in labour. Br J Anaesth 2002; 88(3):374–78.CrossRefGoogle ScholarPubMed
Evron, S, Glezerman, M, Sadan, O, Boaz, M, Ezri, T. Remifentanil: a novel systemic analgesic for labor pain. Anesth Analg 2005; 100(1):233–38.CrossRefGoogle ScholarPubMed
Griffin, RP, Reynolds, F. Maternal hypoxemia during labour and delivery: the influence of analgesia and effect on neonatal outcome. Anaesthesia 1995; 50(2):151–56.CrossRefGoogle ScholarPubMed

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