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Chapter 29 - The future: new concepts and potential therapies

from Section 7 - The Prognosis of Neuropathic Pain

Published online by Cambridge University Press:  05 December 2013

Cory Toth
Affiliation:
Department of Neurology, University of Calgary
Dwight E. Moulin
Affiliation:
Department of Clinical Neurological Sciences, University of Western Ontario
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Summary

This chapter provides the most up to date information on the current and possible future preventative, intervention, and diagnostic treatments and druggable targets for chronic neuropathic pain sufferers. It introduces new druggable targets that have pharmacological agents with at-minimum Phase I clinical trial data published. Targets discussed within the chapter include, but are not limited to, ion channels, G-protein coupled receptors (GPCRs), neurotrophic factors, and opioid receptors. The chapter discusses the role of certain pharmacological agents such as selective serotonin reuptake inhibitors (SSRIs), whose biological target in neuropathic pain treatment remains uncertain. The development of pain biomarkers is essential in order to develop personalized treatment, and promising examples are discussed. Finally, in light of the clear deficiencies in pharmacological pain treatment an evidence based presentation of non-pharmacologic pain treatments is covered, such as acupuncture and brain stimulation, especially considering their cost-effective nature and efficacy in preclinical and clinical studies.
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Chapter
Information
Neuropathic Pain
Causes, Management and Understanding
, pp. 341 - 356
Publisher: Cambridge University Press
Print publication year: 2013

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