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Chapter 1 - Chemical and Behavioral Addictions

New Perspectives and Challenges

Published online by Cambridge University Press:  01 February 2024

Andrea Fiorillo
University of Campania “L. Vanvitelli”, Naples
Peter Falkai
Ludwig-Maximilians-Universität München
Philip Gorwood
Sainte-Anne Hospital, Paris
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Substance use and substance use disorders (SUD) are highly (and increasing) prevalent both as single disorders and within the context of complex psychiatric and somatic comorbidities. In parallel with the impact of these disorders, research on addictive processes has significantly expanded in recent decades. However, several challenges remain to be addressed on multiple levels. Within the context of continuing evolution of new (illicit and prescription) drugs of abuse and changes in the growing field of behavioral (nonchemical) addictions (gambling, gaming), the epidemiological situation is rapidly changing. On the level of disorder conceptualization and underlying pathogenetic mechanisms many challenges remain to be addressed, impacting a broad spectrum from legislation and public mental health issues to underlying neurobiological processes such as neuroimmune mechanisms and microbiome, and cognitive dimensions. These provide new targets of therapeutic approaches such as neuromodulation, personalized pharmacotherapy, and contingency management.

Mental Health Research and Practice
From Evidence to Experience
, pp. 1 - 18
Publisher: Cambridge University Press
Print publication year: 2024

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Rehm, J, Manthey, J, Shield, KD, et al. Trends in substance use and in the attributable burden of disease and mortality in the WHO European Region, 2010–16. Eur J Public Health 2019;29(4):723728. Scholar
Rehm, J, Shield, KD. Global burden of disease and the impact of mental and addictive disorders. Curr Psychiatry Rep 2019;21(2):10. ScholarPubMed
Boyd, J, Sexton, O, Angus, C, et al. Causal mechanisms proposed for the alcohol harm paradox: A systematic review. Addiction 2021;117(1):3356. ScholarPubMed
Zangani, C, Schifano, F, Napoletano, F, et al. The e-psychonauts’ “spiced” world: Assessment of the synthetic cannabinoids’ information available online. Curr Neuropharmacol 2020;18(10):9661051. ScholarPubMed
Schifano, F, Chiappini, S, Corkery, JM, et al. The e-psychonaut drugs’ psychopharmacology. Curr Opin Pharmacol 2021;57:165174. ScholarPubMed
Dias da Silva, D, Ferreira, B, Roque Bravo, R, et al. The new psychoactive substance 3-methylmethcathinone (3-MMC or metaphedrone) induces oxidative stress, apoptosis, and autophagy in primary rat hepatocytes at human-relevant concentrations. Arch Toxicol 2019;93(9):26172634. ScholarPubMed
van Schalkwyk, MCI, Petticrew, M, Cassidy, R, et al. A public health approach to gambling regulation: Countering powerful influences. Lancet Public Health 2021;6(8):e614e619. ScholarPubMed
Stevens, MW, Dorstyn, D, Delfabbro, PH, et al. Global prevalence of gaming disorder: A systematic review and meta-analysis. Aust N Z J Psychiatry 2021;55(6):553568. ScholarPubMed
Fauth-Bühler, M, Mann, K. Neurobiological correlates of internet gaming disorder: Similarities to pathological gambling. Addict Behav 2017;64:349356. ScholarPubMed
Mann, K, Fauth-Bühler, M, Higuchi, S, et al. Pathological gambling: A behavioral addiction. World Psychiatry 2016;15 (3):297298. ScholarPubMed
Petry, NM, Blanco, C, Auriacombe, M, et al. An overview of and rationale for changes proposed for pathological gambling in DSM-5. J Gambl Stud 2014;30(2):493502. ScholarPubMed
Billieux, J, Stein, DJ, Castro-Calvo, J, et al. Rationale for and usefulness of the inclusion of gaming disorder in the ICD-11. World Psychiatry 2021;20(2):198199. ScholarPubMed
Pierce, M, van Amsterdam, J, Kalkman, GA, et al. Is Europe facing an opioid crisis like the United States? An analysis of opioid use and related adverse effects in 19 European countries between 2010 and 2018. Eur Psychiatry 2021;64(1):e47. Scholar
van Amsterdam, J, Pierce, M, van den Brink, W Is Europe facing an emerging opioid crisis comparable to the US? Ther Drug Monit 2021;43(1):4251. Scholar
Häuser, W, Buchser, E, Finn, DP, et al. Is Europe also facing an opioid crisis? – A survey of European Pain Federation chapters. Eur J Pain 2021;25(8):17601769. ScholarPubMed
Häuser, W, Morlion, B, Vowles, KE, et al. European* clinical practice recommendations on opioids for chronic noncancer pain – Part 1: Role of opioids in the management of chronic noncancer pain. Eur J Pain 2021;25(5):949968. ScholarPubMed
Krčevski Škvarč, N, Morlion, B, Vowles, KE, et al. European clinical practice recommendations on opioids for chronic noncancer pain – Part 2: Special situations. Eur J Pain 2021;25(5):969985. ScholarPubMed
Heilig, M, MacKillop, J, Martinez, D, et al. Addiction as a brain disease revised: Why it still matters, and the need for consilience. Neuropsychopharmacology 2021;46(10):17151723. ScholarPubMed
Donovan, DM, Bigelow, GE, Brigha, GS, et al. Primary outcome indices in illicit drug dependence treatment research: Systematic approach to selection and measurement of drug use end-points in clinical trials. Addiction 2012;107(4):694708. ScholarPubMed
Sliedrecht, W, de Waart, R, Witkiewitz, K, et al. Alcohol use disorder relapse factors: A systematic review. Psychiatry Res 2019;278:97115. ScholarPubMed
European Medicines Agency. Guidelines on the development of medicinal products for the treatment of alcohol dependence. 2010. Scholar
López-Pelayo, H, Matrai, S, Balcells-Olivero, M, et al. Standard units for cannabis dose: Why is it important to standardize cannabis dose for drug policy and how can we enhance its place on the public health agenda? Int J Drug Policy 2021;97:103350. ScholarPubMed
López-Pelayo, H, Matrai, S, Balcells-Olivero, M, et al. Supporting future cannabis policy – developing a standard joint unit: A brief back-casting exercise. Front Psychiatry 2021;12:675033. ScholarPubMed
Morie, KP, Potenza, MN. A mini-review of relationships between cannabis use and neural foundations of reward processing, inhibitory control and working memory. Front Psychiatry 2021;12:657371. ScholarPubMed
Morie, KP, Wu, J, Potenza, MN, et al. Daily cannabis use in adolescents who smoke tobacco is associated with altered late-stage feedback processing: A high-density electrical mapping study. J Psychiatr Res 2021;139:8290. ScholarPubMed
Schauer, GL, King, BA, Bunnell, RE, et al. Toking, vaping, and eating for health or fun: Marijuana use patterns in adults, US, 2014. Am J Prev Med 2016;50(1):18. ScholarPubMed
Solowij, N. Peering through the haze of smoked vs vaporized cannabis: To vape or not to vape? JAMA Netw Open 2018;1(7):e184838. ScholarPubMed
Volkow, ND, Swanson, JM, Evins, AE, et al. Effects of cannabis use on human behavior, including cognition, motivation, and psychosis: A review. JAMA Psychiatry 2016;73(3):292297. ScholarPubMed
Wang, L, Wang, Q, Davis, PB, et al. Increased risk for COVID-19 breakthrough infection in fully vaccinated patients with substance use disorders in the United States between December 2020 and August 2021. World Psychiatry 2021;21:124132. ScholarPubMed
López-Pelayo, H, Aubin, HJ, Drummond, C, et al. “The post-COVID era”: Challenges in the treatment of substance use disorder (SUD) after the pandemic. BMC Med 2020;18(1):241. Scholar
Mark, TL, Treiman, K, Padwa, H, et al. Addiction treatment and telehealth: Review of efficacy and provider insights during the COVID-19 pandemic. Psychiatr Serv 2021;appips202100088. Scholar
Koob, GF, Volkow, ND. Neurocircuitry of addiction. Neuropsychopharmacology 2010;35(1): 217238. ScholarPubMed
Koob, GF, Volkow, ND. Neurobiology of addiction: A neurocircuitry analysis. Lancet Psychiatry 2016;3(8):760773. ScholarPubMed
Namba, MD, Leyrer-Jackson, JM, Nagy, EK, et al. Neuroimmune mechanisms as novel treatment targets for substance use disorders and associated comorbidities. Front Neurosci 2021;15:650785. ScholarPubMed
Salavrakos, M, Leclercq, S, De Timary, P, et al. Microbiome and substances of abuse. Prog Neuropsychopharmacol Biol Psychiatry 2021;105:110113. ScholarPubMed
Levin, SG, Godukhin, OV. Modulating effect of cytokines on mechanisms of synaptic plasticity in the brain. Biochemistry (Mosc) 2017;82(3):264274. ScholarPubMed
Coppens, V, Morrens, M, Destoop, M, et al. The interplay of inflammatory processes and cognition in alcohol use disorders – a systematic review. Front Psychiatry 2019;10:632. ScholarPubMed
Goossens, J, Morrens, M, Coppens, V. The potential use of peripheral blood mononuclear cells as biomarkers for treatment response and outcome prediction in psychiatry: A systematic review. Mol Diagn Ther 2021;25(3):283299. ScholarPubMed
Heitmann, J, van Hemel-Ruiter, ME, Huisman, M, et al. Effectiveness of attentional bias modification training as add-on to regular treatment in alcohol and cannabis use disorder: A multicenter randomized control trial. PLoS One 2021;16(6):e0252494. ScholarPubMed
Verdejo-Garcia, A, Garcia-Fernandez, G, Dom, G. Cognition and addiction. Dialogues Clin Neurosci 2019;21(3):281290. ScholarPubMed
Yucel, M, Oldenhof, E, Ahmed, SH, et al. A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: An international Delphi consensus study. Addiction 2019;114(6):10951109. ScholarPubMed
Hildebrandt, MK, Dieterich, R, Endrass, T. Neural correlates of inhibitory control in relation to the degree of substance use and substance-related problems – A systematic review and perspective. Neurosci Biobehav Rev 2021;128:111. Scholar
Anderson, AC, Youssef, GJ, Robinson, AH, et al. Cognitive boosting interventions for impulsivity in addiction: a systematic review and meta-analysis of cognitive training, remediation and pharmacological enhancement. Addiction 2021;116(12):33043319. ScholarPubMed
Rinck, M, Wiers, RW, Becker, ES. , et al. Relapse prevention in abstinent alcoholics by cognitive bias modification: Clinical effects of combining approach bias modification and attention bias modification. J Consult Clin Psychol 2018;86(12): 10051016. ScholarPubMed
Boffo, M, Zerhouni, O, Gronau, QF, et al. Cognitive bias modification for behavior change in alcohol and smoking addiction: Bayesian meta-analysis of individual participant data. Neuropsychol Rev 2019;29(1):5278. ScholarPubMed
Heitmann, J, Bennik, EC, van Hemel-Ruiter, ME. , et al. The effectiveness of attentional bias modification for substance use disorder symptoms in adults: A systematic review. Syst Rev 2018;7(1):160. ScholarPubMed
Manning, V, Garfield, JBB, Staiger, PK. , et al. Effect of cognitive bias modification on early relapse among adults undergoing inpatient alcohol withdrawal treatment: A randomized clinical trial. JAMA Psychiatry 2021;78(2):133140. ScholarPubMed
Loijen, A, Vrijsen, JN, Egger, JIM, et al. Biased approach-avoidance tendencies in psychopathology: A systematic review of their assessment and modification. Clin Psychol Rev 2020;77:101825. ScholarPubMed
Verdejo-Garcia, A, Tiego, J, Kakoschke, N, et al. A unified online test battery for cognitive impulsivity reveals relationships with real-world impulsive behaviours. Nat Hum Behav 2021;5:15621577. ScholarPubMed
Bach, P, Reinhard, I, Koopmann, A, et al. Test-retest reliability of neural alcohol cue-reactivity: Is there light at the end of the magnetic resonance imaging tube? Addict Biol 2021. Scholar
Ekhtiari, H, Tavakoli, H, Addolorato, G, et al. Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead. Neurosci Biobehav Rev 2019;104:118140. ScholarPubMed
Abdellaoui, A, Smit, DJA, van den Brin, W, et al. Genomic relationships across psychiatric disorders including substance use disorders. Drug Alcohol Depend 2021;220:108535. ScholarPubMed
Bolivar, HA, Klemperer, EM, Coleman, SRM, et al. Contingency management for patients receiving medication for opioid use disorder: A systematic review and meta-analysis. JAMA Psychiatry 2021. Scholar
Destoop, M, Docx, L, Morrens, M., et al. Meta-analysis on the effect of contingency management for patients with both psychotic disorders and substance use disorders. J Clin Med 2021;10(4). ScholarPubMed
McClintock, SM, Reti, IM, Carpenter, LL, et al. Consensus recommendations for the clinical application of repetitive transcranial magnetic stimulation (RTMS) in the treatment of depression. J Clin Psychiatry 2018;79:3548. ScholarPubMed
Chervyakov, AV, Chernyavsky, AY, Sinitsyn, DO, et al. Possible mechanisms underlying the therapeutic effects of transcranial magnetic stimulation. Front Hum Neurosci 2015;9:114. ScholarPubMed
Stagg, CJ, Antal, A, Nitsche, MA. Physiology of transcranial direct current stimulation. The Journal of ECT 2018;34:144152. ScholarPubMed
de Boer, NS, Schluter, RS, Daams, JG, et al. The effect of non-invasive brain stimulation on executive functioning in healthy controls: A systematic review and meta-analysis. Neurosci Biobehav Rev 2021;125:122147. ScholarPubMed
Patel, R, Silla, F, Pierce, S, et al. Cognitive functioning before and after repetitive transcranial magnetic stimulation (rTMS): A quantitative meta-analysis in healthy adults. Neuropsychologia 2020;141:107395. ScholarPubMed
Strobach, T, Antonenko, D. tDCS-induced effects on executive functioning and their cognitive mechanisms: A review. J Cogn Enhanc 2017;1:4964. Scholar
Bikson, M, Grossman, P, Thoma, C, et al. Safety of transcranial direct current stimulation: Evidence based update 2016. Brain Stimul 2016;9:641661. Scholar
Matsumoto, H, Ugawa, Y. Adverse events of tDCS and tACS: A review. Clin Neurophysiol Pract 2017;2:1925. ScholarPubMed
Nikolin, S, Huggins, C, Martin, D, et al. Safety of repeated sessions of transcranial direct current stimulation: A systematic review. Brain Stimul 2018;11:278288. ScholarPubMed
Rossi, S, Hallett, M, Rossini, PM, et al. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin Neurophysiol 2009;120:20082039. ScholarPubMed
Coles, AS, Kozak, K, Georg, TP. A review of brain stimulation methods to treat substance use disorders. Am J Addict 2018;27:7191. ScholarPubMed
Fregni, F, El-Hagrassy, MM, Pacheco-Barrios, K, et al. Evidence-based guidelines and secondary meta-analysis for the use of transcranial direct current stimulation in neurological and psychiatric disorders. Int J Neuropsychopharmacol 2021;24:256313. ScholarPubMed
Hanlon, CA, Dowdle, LT. , Henderson, JS. Modulating neural circuits with transcranial magnetic stimulation: Implications for addiction treatment development. Pharmacol Rev 2018;70:661683. ScholarPubMed
Hone-Blanchet, A, Ciraulo, DA. , Pascual-Leone, A, et al. Noninvasive brain stimulation to suppress craving in substance use disorders: Review of human evidence and methodological considerations for future wor Neurosci Biobehav Rev 2015;59:184200. Scholar
Jansen, JM, Daams, JG, Koeter, MW, et al. Effects of non-invasive neurostimulation on craving: A meta-analysis. Neurosci Biobehav Rev 2013;37(10):24722480. ScholarPubMed
Lefaucheur, JP, Antal, A, Ayache, SS, et al. Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). Clin Neurophysiol 2017;128:5692. ScholarPubMed
Lupi, M, Martinotti, G, Santacroce, R, et al. Transcranial direct current stimulation in substance use disorders. J ECT 2017;33:203209. ScholarPubMed
Maiti, R, Mishra, BR, Hota, D Effect of high-frequency transcranial magnetic stimulation on craving in substance use disorder: A meta-analysis. J Neuropsych Clin Neurosci 2017;29:160171. ScholarPubMed
Salling, MC, Martinez, D. Brain stimulation in addiction. Neuropsychopharmacol 2016;41:27982809. ScholarPubMed
Zhang, JJQ, Fong, KNK, Ouyang, RG, et al. Effects of repetitive transcranial magnetic stimulation (rTMS) on craving and substance consumption in patients with substance dependence: A systematic review and meta-analysis. Addiction 2019;114:21372149. ScholarPubMed
Mostafavi, SA, Khaleghi, A, Mohammadi, MR. Noninvasive brain stimulation in alcohol craving: A systematic review and meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 2020;101:109938. ScholarPubMed
Philip, NS, Sorensen, DO, McCalley, DM, et al. Non-invasive brain stimulation for alcohol use disorders: State of the art and future directions. Neurother 2020;17:116126. ScholarPubMed
Kang, N, Kim, RK, Kim, HJ. Effects of transcranial direct current stimulation on symptoms of nicotine dependence: A systematic review and meta-analysis. Addict Behav 2019;96:133139. ScholarPubMed
Tseng, PT, Jeng, JS, Zeng, BS, et al. Efficacy of non-invasive brain stimulation interventions in reducing smoking frequency in patients with nicotine dependence: a systematic review and network meta-analysis of randomized controlled trials. Addiction 2021. Scholar
Wing, VC, Barr, MS, Wass, CE, et al. Brain stimulation methods to treat tobacco addiction. Brain Stimul 2013;6:221230. ScholarPubMed
Ma, T, Sun, Y, Ku, Y Effects of non-invasive brain stimulation on stimulant craving in users of cocaine, amphetamine, or methamphetamine: A systematic review and meta-analysis. Front Neurosci 2019;13:19. ScholarPubMed
Young, JR, Smani, SA, Mischel, NA, et al. Non-invasive brain stimulation modalities for the treatment and prevention of opioid use disorder: A systematic review of the literature. J Addict Dis 2020;38:186199. ScholarPubMed
Pettorruso, M, Miuli, A, Di Natale, C, et al. Non-invasive brain stimulation targets and approaches to modulate gambling-related decisions: A systematic review. Addict Behav 2021;112:106657. ScholarPubMed
Zucchella, C, Mantovani, E, Federico, A, et al. Non-invasive brain stimulation for gambling disorder: A systematic review. Front Neurosci 2020;14:729. ScholarPubMed
Hall, PA, Vincent, CM, Burhan, AM. Non-invasive brain stimulation for food cravings, consumption, and disorders of eating: A review of methods, findings and controversies. Appetite 2018;124:7888. ScholarPubMed
Sauvaget, A, Trojak, B, Bulteau, S, et al. Transcranial direct current stimulation (tDCS) in behavioral and food addiction: a systematic review of efficacy, technical, and methodological issues. Front Neurosci 2015;9:349 ScholarPubMed
Spagnolo, PA, Goldman, D. Neuromodulation interventions for addictive disorders: Challenges, promise, and roadmap for future research. Brain 2017;140:11831203. ScholarPubMed
Song, S, Zilverstand, A, Gui, W, et al. Effects of single-session versus multi-session non-invasive brain stimulation on craving and consumption in individuals with drug addiction, eating disorders or obesity: A meta-analysis. Brain Stimul 2019;12:606618. ScholarPubMed
Hanlon, CA, Dowdle, LT, Austelle, CW, et al. What goes up, can come down: Novel brain stimulation paradigms may attenuate craving and craving-related neural circuitry in substance dependent individuals. Brain Res 2015;1628:199209. ScholarPubMed
Lapenta, OM, Marques, LM, Rego, GG, et al. TDCS in addiction and impulse control disorders. J ECT 2018;34:182192. ScholarPubMed
Horvath, JC, Carter, O, Forte, JD. Transcranial direct current stimulation: Five important issues we aren’t discussing (but probably should be). Front Syst Neurosci 2014;8:2. ScholarPubMed
Dubreuil-Vall, L, Chau, P, Ruffini, G, et al. tDCS to the left DLPFC modulates cognitive and physiological correlates of executive function in a state-dependent manner. Brain Stimul 2019;12:14561463. Scholar
Chase, HW, Boudewyn, MA, Carter, CS, et al. Transcranial direct current stimulation: A roadmap for research, from mechanism of action to clinical implementation. Mol Psychiatry 2020;25:397407. ScholarPubMed
Dedoncker, J, Baeken, C, De Raedt, R, et al. Combined transcranial direct current stimulation and psychological interventions: State of the art and promising perspectives for clinical psychology. Biol Psychol 2021;158:107991. ScholarPubMed
Dinur-Klein, L, Dannon, P, Hadar, A, et al. Smoking cessation induced by deep repetitive transcranial magnetic stimulation of the prefrontal and insular cortices: A prospective, randomized controlled trial. Biol Psychiatry 2014;76:742749. ScholarPubMed
Claus, ED, Klimaj, SD, Chavez, R, et al. A randomized trial of combined tdcs over right inferior frontal cortex and cognitive bias modification: Null effects on drinking and alcohol approach bias. Alcohol Clin Exp Res 2019;43(7):15911599. ScholarPubMed
den Uyl, TE, Gladwin, TE, Lindenmeyer, J, et al. A clinical trial with combined transcranial direct current stimulation and attentional bias modification in alcohol-dependent patients. Alcohol Clin Exp Res 2018;42(10):19611969. ScholarPubMed
den Uyl, TE, Gladwin, TE, Rinck, M, et al. A clinical trial with combined transcranial direct current stimulation and alcohol approach bias retraining. Addict Biol 2017;22:16321640. ScholarPubMed
den Uyl, TE, Gladwin, TE, Wiers, RW. Electrophysiological and behavioral effects of combined transcranial direct current stimulation and alcohol approach bias retraining in hazardous drinkers. Alcohol Clin Exp Res 2016;40(10):21242133. ScholarPubMed
Spagnolo, PA, Montemitro, C, Pettorruso, M, et al. Better together? Coupling pharmacotherapies and cognitive interventions with non-invasive brain stimulation for the treatment of addictive disorders. Front Neurosci 2020;13:15. ScholarPubMed
Wing, VC, Bacher, I, Wu, BS, et al. High frequency repetitive transcranial magnetic stimulation reduces tobacco craving in schizophrenia. Schizophr Res 2012;139:264266. ScholarPubMed
Duecker, F, Sack, AT. Rethinking the role of sham TMS. Front Psychol 2015;6:15. ScholarPubMed
Fonteneau, C, Mondino, M, Arns, M, et al. Sham tDCS: A hidden source of variability? Reflections for further blinded, controlled trials. Brain Stimul 2019;12:668673. ScholarPubMed
Villamar, MF, Volz, MS, Bikson, M, et al. Technique and considerations in the use of 4x1 ring high-definition transcranial direct current stimulation (HD-tDCS). J Vis Exp 2013;(77):e50309. Scholar
Daughters, SB, Yi, JY, Phillips, RD, et al. Alpha-tACS effect on inhibitory control and feasibility of administration in community outpatient substance use treatment. Drug Alcohol Depend 2020;213:108132. ScholarPubMed
Charvet, LE, Shaw, MT, Bikson, M, et al. Supervised transcranial direct current stimulation (tDCS) at home: A guide for clinical research and practice. Brain Stimul 2020;13:686693. Scholar
Palm, U, Kumpf, U, Behler, N, et al. Home use, remotely supervised, and remotely controlled transcranial direct current stimulation: A systematic review of the available evidence. Neuromodulation 2018;21:323333. ScholarPubMed
Shaw, MT, Kasschau, M, Dobbs, B, et al. Remotely supervised transcranial direct current stimulation: An update on safety and tolerability. J Vis Exp 2017;(128):56211. Scholar
Volkow, ND. Addiction should be treated, not penalized. Neuropsychopharmacology 2021;46(12):20482050. Scholar
Volkow, ND, Poznyak, V, Saxena, S, et al. Drug use disorders: Impact of a public health rather than a criminal justice approach. World Psychiatry 2017;16(2):213214. ScholarPubMed
Moeller, SJ. and Paulus, MP. Toward biomarkers of the addicted human brain: Using neuroimaging to predict relapse and sustained abstinence in substance use disorder. Prog Neuropsychopharmacol Biol Psychiatry 2018;80(Pt B):143154. ScholarPubMed
Yip, SW, Scheinost, D, Potenza, MN, et al. Connectome-based prediction of cocaine abstinence. Am J Psychiatry 2019;176(2):156164. ScholarPubMed
Yip, SW, Kiluk, B, Scheinost, D. Toward addiction prediction: An overview of cross-validated predictive modeling findings and considerations for future neuroimaging research. Biol Psychiatry Cogn Neurosci Neuroimaging 2020;5(8):748758. ScholarPubMed
Scarpazza, C, Ha, M, Baecker, L, et al. Translating research findings into clinical practice: A systematic and critical review of neuroimaging-based clinical tools for brain disorders. Transl Psychiatry 2020;10(1):107. ScholarPubMed
El-Boraie, A, Tyndale, RF. The role of pharmacogenetics in smoking. Clin Pharmacol Ther 2021;110(3):599606. ScholarPubMed
Hartwell, EE, Feinn, R, Morris, PE, et al. Systematic review and meta-analysis of the moderating effect of rs1799971 in OPRM1, the mu-opioid receptor gene, on response to naltrexone treatment of alcohol use disorder. Addiction 2020;115(8):14261437. ScholarPubMed
Schacht, JP, Hoffman, M, Chen, BH, et al. Epigenetic moderators of naltrexone efficacy in reducing heavy drinking in alcohol use disorder: A randomized trial. Pharmacogenomics J 2021;22:18. ScholarPubMed
Mann, K, Roos, CR, Hoffmann, S, et al. Precision medicine in alcohol dependence: A controlled trial testing pharmacotherapy response among reward and relief drinking phenotypes. Neuropsychopharmacology 2018;43(4):891899. ScholarPubMed
Witkiewitz, K, Roos, CR, Mann, K, et al. Advancing precision medicine for alcohol use disorder: Replication and extension of reward drinking as a predictor of naltrexone response. Alcohol Clin Exp Res 2019;43(11):23952405. ScholarPubMed
Bach, P, Weil, G, Pompili, E, et al. FMRI-based prediction of naltrexone response in alcohol use disorder: A replication study. Eur Arch Psychiatry Clin Neurosci 2021;271(5):915927. ScholarPubMed
Bach, P, Weil, G, Pompili, E, et al. Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone. Addict Biol 2020;25(1):e12717. ScholarPubMed

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