Book contents
- Frontmatter
- Contents
- Acknowledgments
- Manual of Stem Cell and Bone Marrow Transplantation
- 1 Rationale for Transplantation
- 2 Types of Transplantation
- 3 HLA Matching in Allogeneic Transplantation
- 4 Stem Cell Source
- 5 Pretransplant Evaluation and Counseling of Patient and Donor
- 6 Conditioning Regimens
- 7 Stem Cell Infusion
- 8 ABO Compatibility
- 9 Engraftment
- 10 Preventative Care
- 11 Transplant-Related Complications
- 12 Graft-Versus-Host Disease – Prophylaxis and Acute
- 13 Graft-Versus-Host Disease – Chronic
- 14 Engraftment Syndrome
- 15 Infectious Disease
- 16 Graft Rejection And Failure
- 17 Gastrointestinal Complications
- 18 Pulmonary Complications
- 19 Veno-Occlusive Disease
- 20 Special Transfusion-Related Situations
- 21 Cardiovascular Complications
- 22 Neurologic Complications
- 23 Cystitis
- 24 Donor Lymphocyte Infusion
- 25 Transplantation: Regulation And Accreditation
- Appendix
- Index
11 - Transplant-Related Complications
Published online by Cambridge University Press: 23 November 2009
- Frontmatter
- Contents
- Acknowledgments
- Manual of Stem Cell and Bone Marrow Transplantation
- 1 Rationale for Transplantation
- 2 Types of Transplantation
- 3 HLA Matching in Allogeneic Transplantation
- 4 Stem Cell Source
- 5 Pretransplant Evaluation and Counseling of Patient and Donor
- 6 Conditioning Regimens
- 7 Stem Cell Infusion
- 8 ABO Compatibility
- 9 Engraftment
- 10 Preventative Care
- 11 Transplant-Related Complications
- 12 Graft-Versus-Host Disease – Prophylaxis and Acute
- 13 Graft-Versus-Host Disease – Chronic
- 14 Engraftment Syndrome
- 15 Infectious Disease
- 16 Graft Rejection And Failure
- 17 Gastrointestinal Complications
- 18 Pulmonary Complications
- 19 Veno-Occlusive Disease
- 20 Special Transfusion-Related Situations
- 21 Cardiovascular Complications
- 22 Neurologic Complications
- 23 Cystitis
- 24 Donor Lymphocyte Infusion
- 25 Transplantation: Regulation And Accreditation
- Appendix
- Index
Summary
When making a differential diagnosis in a patient who has undergone hematopoietic stem cell transplantation (HSCT), it is critical to have a solid understanding of the entire course of treatment. This includes transplant type (autologous or allogeneic) stem cell source (marrow, peripheral blood [PB], or cord blood), donor match (related or unrelated, matched or mismatched), interval post-HSCT (early or late), graft-versus-host disease (GVHD) prophylaxis, infectious prophylaxis, current immune suppressive medications, conditioning regimen (ablative or nonmyeloablative), and length of granulocytopenia. Transplant-related toxicities can include treatment-related organ damage, infection, GVHD, or any other combination. Time course is generally thought of as follows: early – first 30 days when pancytopenia and the direct effect of chemotherapy is the greatest; mid – day 15 to roughly 100; and late – after day 100. There is often an overlap in timing of complications.
In the remainder of the book you will find information on the following transplant-related complications:
GVHD – prevention, acute and chronic
Engraftment syndrome
Infectious disease
Graft rejection and Graft failure
Gastrointestinal complications
Pulmonary complications
Veno-occlusive disease
Special transfusion-related situations
Cardiovascular complications
Neurological complications
Cystitis
Donor lymphocyte infusion
- Type
- Chapter
- Information
- Publisher: Cambridge University PressPrint publication year: 2009