Published online by Cambridge University Press: 18 June 2020
Up to 43 per cent of women and 18 per cent of men are affected by migraine at some time in their lives . This sex difference is accounted for by the influence of reproductive hormones in women, with notable effects of menarche, menstruation, pregnancy, lactation, menopause and hormonal contraception on migraine. In particular, the perimenopause is a time of worsening migraine [2–4]. Despite this, migraine is significantly under-reported by women seeking management of menopause who should routinely be asked about headache .