Skip to main content Accessibility help
×
Home
Hostname: page-component-7f7b94f6bd-vvt5l Total loading time: 0.37 Render date: 2022-06-28T13:59:53.282Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "useNewApi": true } hasContentIssue true

6 - Angioplasty: Catheters, Guidewires, and Balloons

Published online by Cambridge University Press:  19 January 2018

Philip A. Rea
Affiliation:
University of Pennsylvania
Mark V. Pauly
Affiliation:
University of Pennsylvania
Lawton R. Burns
Affiliation:
University of Pennsylvania
Get access

Summary

This volume focuses primarily on managing the discovery of new chemically- and biologically-based therapeutics to treat disease. The management of discovery in the life sciences also encompasses therapeutic medical devices, which are rooted in a different set of disciplines: materials science, mechanical engineering, and (increasingly) electrical engineering. Beyond the different sciences, the medical device sector features an entirely different model of innovation to the pharmaceutical sector. Rather than moving from bench to bedside, device innovation more frequently proceeds from bedside to bench and back again to bedside. In this process, clinicians rather than lab researchers are often the innovators. Physicians identify unmet needs in their patients, attempt to address these needs through product prototypes that they themselves often develop, and then engage outsiders with capital and engineering skills to refine the invention.

Thus, the development of novel medical devices involves the engagement of end users and external firms in an open-source and iterative process of innovation. The process is characterized by rapid prototyping, iterative and incremental changes, and close interaction between clinicians and product companies. This chapter examines one set of medical devices (catheters, guidewires, and balloons) and the procedure to insert them into the human body: percutaneous transluminal coronary angioplasty (PTCA), more commonly known as balloon angioplasty (Figure 6.1 – for a more detailed account of PTCA see “Description of Percutaneous Transluminal Coronary Angioplasty (PTCA)” in the Appendix at the end of this chapter).

Balloon angioplasty has been heralded as one of the 10 greatest discoveries in the field of cardiology during the twentieth century, and one of the most successful examples of translational medicine. Building upon research into transluminal angioplasty from the 1960s conducted by Charles Dotter, Andreas Grüntzig in the 1970s developed a procedure that applied Dotter's research to the treatment of patients with coronary artery disease. The procedure successfully treated stenosis of the femoral arteries using a balloon-tipped catheter to open them up, thereby diminishing the need for more invasive procedures such as coronary artery bypass with graft (CABG) surgery. Within two decades, the technique had become not only the treatment of choice for patients with acute myocardial infarction or occluded leg arteries (who could now avoid amputation), but one of the most widely used medical procedures, and it ushered in the era of interventional cardiology.

Type
Chapter
Information
Managing Discovery in the Life Sciences
Harnessing Creativity to Drive Biomedical Innovation
, pp. 160 - 190
Publisher: Cambridge University Press
Print publication year: 2018

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats No formats are currently available for this content.
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats No formats are currently available for this content.
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats No formats are currently available for this content.
×