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Section V - Other Considerations and Issues in Pediatric Hepatology

Published online by Cambridge University Press:  19 January 2021

Frederick J. Suchy
Affiliation:
University of Colorado, Children’s Hospital Colorado, Aurora
Ronald J. Sokol
Affiliation:
University of Colorado, Children’s Hospital Colorado, Aurora
William F. Balistreri
Affiliation:
Cincinnati Children’s Hospital Medical Center, Cincinnati
Jorge A. Bezerra
Affiliation:
Cincinnati Children’s Hospital Medical Center, Cincinnati
Cara L. Mack
Affiliation:
University of Colorado, Children’s Hospital Colorado, Aurora
Benjamin L. Shneider
Affiliation:
Texas Children’s Hospital, Houston
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Publisher: Cambridge University Press
Print publication year: 2021

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References

References

Hamilton, JR, Sato, N. Jaundice associated with severe bacterial infection in young infants. Pediatrics 1963;63:121–32.Google ScholarPubMed
Shamir, R, Maayan-Metzger, A, Bujanover, Y, et al. Liver enzyme abnormalities in Gram-negative bacteremia of premature infants. Pediatr Infect Dis J 2000;19:495–8.CrossRefGoogle ScholarPubMed
Lanza, JS, Rosato, EL. Regulatory factors in the development of fatty infiltration of the liver during Gram-negative sepsis. Metabolism 1994;43:691–6.Google Scholar
Chusid, MJ. Pyogenic hepatic abscess in infancy and childhood. Pediatrics 1978;62:554–9.Google ScholarPubMed
Mishra, K, Basu, S, Roychoudhury, S, Kumar, P. Liver abscess in children: an overview. World J Pediatr 2010;6:210–16.CrossRefGoogle ScholarPubMed
Haider, SJ, Tarulli, M, McNulty, NJ, Hoffer, EK. Liver abscesses: factors that influence outcome of percutaneous drainage. AJR 2017;209;205–13.CrossRefGoogle ScholarPubMed
Pineiro, CV, Andres, JM. Morbidity and mortality in children with pyogenic liver abscess. Am J Dis Child 1989;143:1424–7.Google Scholar
Lederman, ER, Crum, NF. Pyogenic liver abscess with a focus on Klebsiella pneumoniae as a primary pathogen: an emerging disease with unique clinical characteristics. Am J Gastroenterol 2005;100:322–31.CrossRefGoogle ScholarPubMed
Pelton, SI, Kim, JY, Kradin, RL. Case records of the Massachusetts General Hospital. Case 27–2006. A 17-year-old boy with fever and lesions in the liver and spleen. N Engl J Med 2006;355:941–8.CrossRefGoogle ScholarPubMed
Rayes, AA, Teixeira, D, Serufo, JC, et al. Human toxocariasis and pyogenic liver abscess: a possible association. Am J Gastroenterol 2001;96:563–6.CrossRefGoogle ScholarPubMed
Muorah, M, Hinds, R, Verma, A, et al. Liver abscesses in children: a single center experience in the developed world. J Pediatr Gastroenterol Nutr 2006;42:201–6.CrossRefGoogle ScholarPubMed
Bari, S, Sheikh, KA, Malik, AA, Wani, RA, Naqash, SH. Percutaneous aspiration versus open drainage of liver abscess in children. Pediatr Surg Int 2007;23:6974.CrossRefGoogle ScholarPubMed
Ecoffey, C, Rothman, E, Bernard, O, et al. Bacterial cholangitis after surgery for biliary atresia. J Pediatr 1987;111(6 Pt 1): 824–9.CrossRefGoogle ScholarPubMed
Bornman, PC, van Beljon, JI, Krige, JE. Management of cholangitis. J Hepatobiliary Pancreat Surg 2003;10:406–14.CrossRefGoogle ScholarPubMed
Desmet, DM. (1979). Cholestasis: extrahepatic obstruction and secondary biliary cirrhosis. In Macsween, RNM, Anthony, PP, Scheuer, PJ, (Eds.), Pathology of the Liver (pp. 272305). Edinburgh: Churchill Livingstone.Google Scholar
Gerecht, WB, Henry, NK, Hoffman, WW, et al. Prospective randomized comparison of mezlocillin therapy alone with combined ampicillin and gentamicin therapy for patients with cholangitis. Arch Intern Med 1989;149:1279–84.CrossRefGoogle ScholarPubMed
Lee, JG. Diagnosis and management of acute cholangitis. Nat Rev Gastroent Hepatol 2009;6:533–41.CrossRefGoogle ScholarPubMed
Cheng, CL, Fogel, EL, Sherman, S, et al. Diagnostic and therapeutic endoscopic retrograde cholangiopancreatography in children: a large series report. J Pediatr Gastroenterol Nutr 2005;41:445–53.CrossRefGoogle ScholarPubMed
Fitz-Hugh, T. Acute gonococcic peritonitis of the right upper quadrant in women. JAMA 1934;102:2094–6.CrossRefGoogle Scholar
Curtis, AH. A cause of adhesions in the right upper quadrant. JAMA 1930;94:1221–2.CrossRefGoogle Scholar
Holmes, KK, Counts, GW, Beaty, HN. Disseminated gonococcal infection. Ann Intern Med 1971;74:979–93.CrossRefGoogle ScholarPubMed
Massei, F, Gori, L, Macchia, P, Maggiore, G. The expanded spectrum of bartonellosis in children. Infect Dis Clin North Am 2005;19:691711.CrossRefGoogle ScholarPubMed
Rocco, VK, Roman, RJ, Eigenbrodt, EH. Cat scratch disease. Report of a case with hepatic lesions and a brief review of the literature. Gastroenterology 1985;89:1400–6.Google Scholar
Byington CL for the AAP Committee on Infectious Diseases (2018). Red Book, 31st edn. Elk Grove Village, IL: American Academy of Pediatrics.Google Scholar
Ramachandran, S, Godfrey, JJ, Perera, MV. Typhoid hepatitis. JAMA 1974;230:236–40.CrossRefGoogle ScholarPubMed
Gonzalez-Quintela, A, Campos, J, Alende, R, et al. Abnormalities in liver enzyme levels during Salmonella enteritidis enterocolitis. Rev Esp Enferm Dig 2004;96:559–62.CrossRefGoogle ScholarPubMed
Mert, A, Tabak, F, Ozaras, R, et al. Typhoid fever as a rare cause of hepatic, splenic, and bone marrow granulomas. Intern Med 2004;43:436–9.CrossRefGoogle ScholarPubMed
Bolton, JP, Perihepatitis, Darougar S.. Br Med Bull 1983;39:159–62.CrossRefGoogle Scholar
Lulu, AR, Araj, GF, Khateeb, MI, et al. Human brucellosis in Kuwait: a prospective study of 400 cases. Q J Med 1988;66(249):3954.Google ScholarPubMed
Al Otaibi, FE. Acute acalculus cholecystitis and hepatitis caused by Brucella melitensis. J Infect Dev Ctries 2010;4:464–7.CrossRefGoogle ScholarPubMed
Cervantes, F, Bruguera, M, Carbonell, J, Force, L, Webb, S. Liver disease in brucellosis. A clinical and pathological study of 40 cases. Postgrad Med J 1982;58(680):346–50.CrossRefGoogle ScholarPubMed
Evans, ME, Gregory, DW, Schaffner, W, McGee, ZA. Tularemia: a 30-year experience with 88 cases. Medicine 1985;64:251–69.CrossRefGoogle ScholarPubMed
Crosbie, J, Varma, J, Mansfield, J. Yersinia enterocolitica infection in a patient with hemachromatosis masquerading as proximal colon cancer with liver metastases: report of a case. Dis Colon Rectum 2005;48:390–2.CrossRefGoogle Scholar
Ishak, KG, Rogers, WA. Cryptogenic acute cholangitis-association with toxic shock syndrome. Am J Clin Pathol 1981;76:619–26.CrossRefGoogle ScholarPubMed
Fishbein, WN. Jaundice as an early manifestation of scarlet fever. Report of three cases in adults and review of the literature. Ann Intern Med 1962;57:6072.CrossRefGoogle ScholarPubMed
Albrecht, H. (2003). Bacterial and miscellaneous infections of the liver. In Zakim, D, Boyer, TD, (Eds.), Hepatology (pp. 1109–24). Philadelphia, PA: Saunders.Google Scholar
Zimmerman, HJ, Thomas, LJ. The liver in pneumococcal pneumonia. Observations in 94 cases on liver function and jaundice in pneumonia. J Lab Clin Med 1950;35:556–67.Google ScholarPubMed
Korn, RJ, Kellow, WF, Heller, P, et al. Hepatic involvement in extrapulmonary tuberculosis. Am J Med 1959;27:6071.CrossRefGoogle ScholarPubMed
Sharma, S. (2003). Granulomatous diseases of the liver. In Zakim, D, Boyer, TD, (Eds.), Hepatology (pp. 131740). Philadelphia, PA: Saunders.Google Scholar
Alvarez, SZ, Carpio, R. Hepatobiliary tuberculosis. Dig Dis Sci 1983;28:193200.CrossRefGoogle ScholarPubMed
Vijayasekaran, D. Treatment of childhood tuberculosis. Indian J Pediatr 2011;78:443–8.CrossRefGoogle ScholarPubMed
Patel, S, DeSantis, ER. Treatment of congenital tuberculosis. Am J Health Syst Pharm 2008;65:2027–31.CrossRefGoogle ScholarPubMed
Wilkins, MJ, Lindley, R, Dourakis, SP, Goldin, RD. Surgical pathology of the liver in HIV infection. Histopathology 1991;18:459–64.CrossRefGoogle ScholarPubMed
Mofenson, LM, Brady, MT, Danner, SP, et al. Guidelines for the Prevention and Treatment of Opportunistic Infections among HIV-exposed and HIV-infected children: recommendations from CDC, the National Institutes of Health, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics. MMWR Recomm Rep 2009;58:1166.Google Scholar
Jonas, RB, Brasitus, TA, Chowdhury, L. Actinomycotic liver abscess. Case report and literature review. Dig Dis Sci 1987;32:1435–7.CrossRefGoogle ScholarPubMed
Thomas, LD, Hongo, I, Bloch, KC, Tang, YW, Dummer, S. Human ehrlichiosis in transplant recipients. Am J Transplant 2007;7:1641–7.CrossRefGoogle ScholarPubMed
Sehdev, AE, Dumler, JS. Hepatic pathology in human monocytic ehrlichiosis. Ehrlichia chaffeensis infection. Am J Clin Pathol 2003;119:859–65.Google ScholarPubMed
Listernick, R. Liver failure in a 2-day-old infant. Pediatr Ann 2004;33:1014.CrossRefGoogle Scholar
Wright, DJ, Berry, CL. Liver involvement in congenital syphilis. Br J Vener Dis 1974;50:241.Google ScholarPubMed
Nadelman, RB, Nowakowski, J, Forseter, G, et al. The clinical spectrum of early Lyme borreliosis in patients with culture-confirmed erythema migrans. Am J Med 1996;100:502–8.CrossRefGoogle ScholarPubMed
Schoen, RT. Relapsing or reinfectious lyme hepatitis. Hepatology 1989;9:335–6.CrossRefGoogle ScholarPubMed
Brown, V, Larouze, B, Desve, G, et al. Clinical presentation of louse-borne relapsing fever among Ethiopian refugees in northern Somalia. Ann Trop Med Parasitol 1988;82:499502.CrossRefGoogle ScholarPubMed
Wong, ML, Kaplan, S, Dunkle, LM, Stechenberg, BW, Feigin, RD. Leptospirosis: a childhood disease. J Pediatr 1977;90:532–7.CrossRefGoogle ScholarPubMed
Feigin, RD, Anderson, DC. (2004). Leptospirosis. In Feigin, RD, Cherry, JD, Demmler, GJ, Kaplan, S, (Eds.), Textbook of Pediatric Infectious Diseases (pp. 1708–22). Philadelphia, PA: Saunders.Google Scholar
Adams, JS, Walker, DH. The liver in Rocky Mountain spotted fever. Am J Clin Pathol 1981;75:156–61.CrossRefGoogle ScholarPubMed
Parker, NR, Barralet, JH, Bell, AM. Q fever. Lancet 2006;367:679–88.CrossRefGoogle ScholarPubMed
Domingo, P, Orobitg, J, Colomina, J, Alvarez, E, Cadafalch, J. Liver involvement in acute Q fever. Chest 1988;94:895–6.CrossRefGoogle ScholarPubMed
Geha, R, Peters, M, Gill, RM, Dhaliwal, G. Histology rings true. N Engl J Med 2017;376(9):869–74.CrossRefGoogle ScholarPubMed
Hotez, PJ, Strickland, AD. (2004). Amebiasis. In Feigin, RD, Cherry, JD, Demmler, GJ, Kaplan, S (Eds.), Textbook of Pediatric Infectious Diseases (pp. 2660–9). Philadelphia, PA: Saunders.Google Scholar
Rossignol, JF, Kabil, SM, El Gohary, Y, Younis, AM. Nitazoxanide in the treatment of amoebiasis. Trans R Soc Trop Med Hyg 2007;101:1025–31.CrossRefGoogle ScholarPubMed
Chavez-Tapia, NC, Hernandez-Calleros, J, Tellez-Avila, FI, Torre, A, Uribe, M. Image-guided percutaneous procedure plus metronidazole versus metronidazole alone for uncomplicated amoebic liver abscess. Cochrane Database Syst Rev 2009;1:CD004886. doi: 10.1002/14651858.CD004886.pub2Google Scholar
Agarwal, N, Kumar, S. Budd–Chiari syndrome owing to liver hydatid disease: case report and review of the literature. Ann Trop Paediatr 2009;29:301–4.CrossRefGoogle ScholarPubMed
Nunnari, G. Hepatic echinococcosis: clinical and therapeutic aspects. World J Gastroenterol 2012;18:1448–58.CrossRefGoogle ScholarPubMed
Kahriman, G, Ozcan, N, Dogan, S, Karaborklu, O. Percutaneous treatment of liver hydatid cysts in 190 patients: a retrospective study. Acta Radiologica 2017;58(6):676–84.CrossRefGoogle ScholarPubMed
Sciume, C, Geraci, G, Pisello, F, et al. Treatment of complications of hepatic hydatid disease by ERCP: our experience. Ann Ital Chir 2004;75:531–5.Google ScholarPubMed
Baraket, O, Feki, MN, Chaari, M, et al. Hydatid cyst open in biliary tract: therapeutic approaches. Report of 22 cases. J Visc Surg 2011;148:e211e216.CrossRefGoogle ScholarPubMed
Krige, J, Shaw, J. Cholangitis and pancreatitis caused by biliary ascariasis. Clin Gastroenterol Hepatol 2009;7:A30.CrossRefGoogle ScholarPubMed
Louw, JH. Abdominal complications of ascariasis. Surg Rounds 1981;4:5465.Google Scholar
Bektas, M, Dokmeci, A, Cinar, K, et al. Endoscopic management of biliary parasitic diseases. Dig Dis Sci 2010;55:1472–8.CrossRefGoogle ScholarPubMed
Edington, GM. (1979). Other viral and infectious diseases. In Macsween, RNM, Anthony, PP, Scheuer, PJ (Eds.), Pathology of the Liver (pp. 192220). Edinburgh: Churchill Livingstone.Google Scholar
Bica, I, Hamer, DH, Stadecker, MJ. Hepatic schistosomiasis. Infect Dis Clin North Am 2000;14:583604.CrossRefGoogle ScholarPubMed
Symmers, W. Note on a new form of liver cirrhosis due to the presence of ova of Bilharzia haematobium. J Pathol Bacteriol 1903;9:237–9.Google Scholar
Namwanje, H, Kabatereine, N, Olsen, A. A randomised controlled clinical trial on the safety of co-administration of albendazole, ivermectin and praziquantel in infected schoolchildren in Uganda. Trans R Soc Trop Med Hyg 2011;105:181–8.CrossRefGoogle ScholarPubMed
Qian, M, Utzinger, J, Keiser, J, Zjou, X. Clonorchiasis. Lancet 2016;387:800–10.CrossRefGoogle Scholar
Karahocagil, MK, Akdeniz, H, Sunnetcioglu, M, et al. A familial outbreak of fascioliasis in Eastern Anatolia: a report with review of literature. Acta Trop 2011;118:177–83.CrossRefGoogle ScholarPubMed
Moreno, A, Marazuela, M, Yebra, M, et al. Hepatic fibrin-ring granulomas in visceral leishmaniasis. Gastroenterology 1988;95:1123–6.CrossRefGoogle ScholarPubMed
Rajagopala, S, Dutta, U, Chandra, KS, et al. Visceral leishmaniasis associated hemophagocytic lymphohistiocytosis: case report and systematic review. J Infect 2008;56:381–8.CrossRefGoogle ScholarPubMed
Tangpukdee, N, Thanachartwet, V, Krudsood, S, et al. Minor liver profile dysfunctions in Plasmodium vivax, P. malaria and P. ovale patients and normalization after treatment. Korean J Parasitol 2006;44:295302.CrossRefGoogle ScholarPubMed
Kaely, N, Ahmad, S, Shirazi, N, Bhatia, R, Bhat, NK, Srivastava, S, Dhar, M, Kumar, M. Malarial hepatopathy: a 6-year retrospective observational study from Uttarakhand, North India. Tran R Soc Trop Med Hyg 2017;111(5):220–5.CrossRefGoogle Scholar
Raphemot, R, Posfai, D, Derbyshire, ER. Current therapies and future possibilities for drug development against liver-stage malaria. J Clin Invest 2016;126(6):2013–20.CrossRefGoogle ScholarPubMed
Epstein, JE, Tewari, K, Lyke, KE, et al. Live attenuated malaria vaccine designed to protect through hepatic CD8(+) T cell immunity. Science 2011;334(6055):475–80.CrossRefGoogle ScholarPubMed
Thaler, M, Pastakia, B, Shawker, TH, O’Leary, T, Pizzo, PA. Hepatic candidiasis in cancer patients: the evolving picture of the syndrome. Ann Intern Med 1988;108:88100.CrossRefGoogle ScholarPubMed
Aikawa, N, Kusachi, S, Oda, S, Takesue, Y, Tanaka, H. Clinical effects of micafungin, a novel echinocandin antifungal agent, on systemic fungal infections in surgery, emergency, and intensive-care medicine: evaluation using the AKOTT algorithm. J Infect Chemother 2009;15:219–27.CrossRefGoogle Scholar
Meyer, MH, Letscher-Bru, V, Waller, J, et al. Chronic disseminated Trichosporon asahii infection in a leukemic child. Clin Infect Dis 2002;35:e22e25.CrossRefGoogle Scholar
Kantipong, P, Panich, V, Pongsurachet, V, Watt, G. Hepatic penicilliosis in patients without skin lesions. Clin Infect Dis 1998;26:1215–17.CrossRefGoogle ScholarPubMed
Keckich, DW, Blair, JE, Vikram, HR. Coccidioides fungemia in six patients, with a review of the literature. Mycopathologia 2010;170:107–15.CrossRefGoogle ScholarPubMed
Smith, G, Hoover, S, Sobonya, R, Klotz, SA. Abdominal and pelvic coccidioidomycosis. Am J Med Sci 2011;341:308–11.CrossRefGoogle ScholarPubMed
Troillet, N, Llor, J, Kuchler, H, Deleze, G, Praz, G. Disseminated histoplasmosis in an adopted infant from El Salvador. Eur J Pediatr 1996;155:474–6.CrossRefGoogle Scholar
Hasan, RA, Abuhammour, W. Invasive aspergillosis in children with hematologic malignancies. Paediatr Drugs 2006;8:1524.CrossRefGoogle ScholarPubMed
Katragkou, A, Fisher, BT, Groll, AH, Roilides, E, Walsh, TJ. Diagnostic imaging and invasive fungal diseases in children. JPIDS 2017;6:S22S31.CrossRefGoogle ScholarPubMed
Boon, AP, O’Brien, D, Adams, DH. 10 year review of invasive aspergillosis detected at necropsy. J Clin Pathol 1991;44:452–4.CrossRefGoogle ScholarPubMed

References

Brienza, N, et al. Jaundice in critical illness: promoting factors of a concealed reality. Intensive Care Med 2006;32(2):267–74.CrossRefGoogle ScholarPubMed
Jakob, SM, et al. Effects of systemic arterial hypoperfusion on splanchnic hemodynamics and hepatic arterial buffer response in pigs. Am J Physiol Gastrointest Liver Physiol 2001;280(5):G819–27.CrossRefGoogle ScholarPubMed
Brienza, N, et al. Effects of PEEP on liver arterial and venous blood flows. Am J Respir Crit Care Med 1995;152(2):504–10.CrossRefGoogle ScholarPubMed
Parker, GA, Picut, CA. Immune functioning in nonlymphoid organs: the liver. Toxicol Pathol 2011. https://doi.org/10.1177/0192623311428475CrossRefGoogle Scholar
Sander, LE, et al. Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function. J Exp Med 2010;207(7):1453–64.CrossRefGoogle ScholarPubMed
Sakamori, R, et al. Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice. Hepatology 2007;46(5):1564–73.CrossRefGoogle ScholarPubMed
Geier, A, Fickert, P, Trauner, M. Mechanisms of disease: mechanisms and clinical implications of cholestasis in sepsis. Nat Clin Pract Gastroenterol Hepatol 2006;3(10):574–85.CrossRefGoogle ScholarPubMed
McDonald, B, Kubes, P. Neutrophils and intravascular immunity in the liver during infection and sterile inflammation. Toxicol Pathol 2011. https://doi.org/10.1177/0192623311427570CrossRefGoogle Scholar
Lin, CC, et al. Subacute nonsuppurative cholangitis (cholangitis lenta) in pediatric liver transplant patients. J Pediatr Gastroenterol Nutr 2007;45(2):228–33.CrossRefGoogle Scholar
Torous, VF, et al. Cholangitis lenta: a clinicopathologic study of 28 cases. Am J Surg Pathol 2017;41(12):1607–17.CrossRefGoogle ScholarPubMed
Lefkowitch, JH. Bile ductular cholestasis: an ominous histopathologic sign related to sepsis and “cholangitis lenta.” Hum Pathol 1982;13(1):1924.CrossRefGoogle Scholar
Lautt, WW. Regulatory processes interacting to maintain hepatic blood flow constancy: vascular compliance, hepatic arterial buffer response, hepatorenal reflex, liver regeneration, escape from vasoconstriction. Hepatol Res 2007;37(11):891903.CrossRefGoogle ScholarPubMed
Eipel, C, Abshagen, K, Vollmar, B. Regulation of hepatic blood flow: the hepatic arterial buffer response revisited. World J Gastroenterol 2010;16(48):6046–57.CrossRefGoogle ScholarPubMed
Vollmar, B, Menger, MD. The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair. Physiol Rev 2009;89(4):1269–339.CrossRefGoogle ScholarPubMed
Gracia-Sancho, J, Marrone, G, Fernandez-Iglesias, A. Hepatic microcirculation and mechanisms of portal hypertension. Nat Rev Gastroenterol Hepatol 2019;16(4):221–34.CrossRefGoogle ScholarPubMed
Wu, Y, et al. Laser speckle contrast imaging for measurement of hepatic microcirculation during the sepsis: a novel tool for early detection of microcirculation dysfunction. Microvasc Res 2015;97:137–46.CrossRefGoogle ScholarPubMed
Fan, J, et al. Hemodynamic changes in hepatic sinusoids of hepatic steatosis mice. World J Gastroenterol 2019;25(11):1355–65.CrossRefGoogle ScholarPubMed
Ebert, EC. Hypoxic liver injury. Mayo Clin Proc 2006;81(9):1232–6.CrossRefGoogle ScholarPubMed
Jäger, B, et al. Jaundice increases the rate of complications and one-year mortality in patients with hypoxic hepatitis. Hepatology 2012;56(6):2297–304.CrossRefGoogle ScholarPubMed
Peltenburg, HG, et al. Estimation of the fractional catabolic rate constants for the elimination of cytosolic liver enzymes from plasma. Hepatology 1989;10(5):833–9.CrossRefGoogle ScholarPubMed
Tapper, EB, Sengupta, N, Bonder, A. The incidence and outcomes of ischemic hepatitis: a systematic review with meta-analysis. Am J Med 2015;128(12):1314–21.CrossRefGoogle ScholarPubMed
Van den Broecke, A, et al. Epidemiology, causes, evolution and outcome in a single-center cohort of 1116 critically ill patients with hypoxic hepatitis. Ann Intensive Care 2018;8(1):15.CrossRefGoogle Scholar
Samavati, L, et al. Tumor necrosis factor alpha inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c oxidase. J Biol Chem 2008;283(30):21134–44.CrossRefGoogle ScholarPubMed
Horvatits, T, et al. Circulating bile acids predict outcome in critically ill patients. Ann Intensive Care 2017;7(1):48.CrossRefGoogle ScholarPubMed
Gudnason, HO, Björnsson, ES. Secondary sclerosing cholangitis in critically ill patients: current perspectives. Clin Exp Gastroenterol 2017;10:105–11.CrossRefGoogle ScholarPubMed
Leonhardt, S, et al. Secondary sclerosing cholangitis in critically ill patients: clinical presentation, cholangiographic features, natural history, and outcome: a series of 16 cases. Medicine 2015;94(49):e2188.CrossRefGoogle ScholarPubMed
Arcidi, JM Jr., Moore, GW, Hutchins, GM. Hepatic morphology in cardiac dysfunction: a clinicopathologic study of 1000 subjects at autopsy. Am J Pathol 1981;104(2):159–66.Google ScholarPubMed
Matsuda, H, et al. Acute liver dysfunction after modified Fontan operation for complex cardiac lesions. Analysis of the contributing factors and its relation to the early prognosis. J Thorac Cardiovasc Surg 1988;96(2):219–26.CrossRefGoogle ScholarPubMed
Camposilvan, S, et al. Liver and cardiac function in the long term after Fontan operation. Ann Thorac Surg 2008;86(1):177–82.CrossRefGoogle Scholar
Wu, FM, et al. Liver disease in the patient with Fontan circulation. Congenit Heart Dis 2011;6(3):190201.CrossRefGoogle ScholarPubMed
Goldberg, DJ, et al. Hepatic fibrosis is universal following Fontan operation, and severity is associated with time from surgery: a liver biopsy and hemodynamic study. J Am Heart Assoc 2017;6(5):pii:e004809. doi:10.1161/JAHA.116.004809CrossRefGoogle ScholarPubMed
Pike, NA, et al. Clinical profile of the adolescent/adult Fontan survivor. Congenit Heart Dis 2011;6(1):917.CrossRefGoogle ScholarPubMed
Yang, HK, et al. CT and MR imaging findings of the livers in adults with Fontan palliation: an observational study. Abdom Radiol 2020;45:188202.CrossRefGoogle Scholar
Rutledge, BP, et al. Transplant-amenable hepatocellular carcinoma in a Fontan patient. Case Rep Gastroenterol 2019;13(2):275–9.CrossRefGoogle Scholar
Alsaied, T, et al. Relation of magnetic resonance elastography to Fontan failure and portal hypertension. Am J Cardiol 2019;124(9):1454–9.CrossRefGoogle ScholarPubMed
Chen, H, et al. Budd–Chiari syndrome caused by multiple membranous obstruction of the inferior vena cava in a young man. Ann Vasc Surg 2011;25(8):1139 e57.CrossRefGoogle ScholarPubMed
Shetty, S, Ghosh, K. Thrombophilic dimension of Budd-Chiari syndrome and portal venous thrombosis–a concise review. Thromb Res 2011;127(6):505–12.CrossRefGoogle ScholarPubMed
Hernández-Gea, V, et al. Current knowledge in pathophysiology and management of Budd-Chiari syndrome and non-cirrhotic non-tumoral splanchnic vein thrombosis. J Hepatol 2019;71(1):175–99.CrossRefGoogle ScholarPubMed
Qi, X, et al. Review article: the aetiology of primary Budd-Chiari syndrome – differences between the West and China. Aliment Pharmacol Ther 2016;44(11–12):11521167.CrossRefGoogle ScholarPubMed
Hoekstra, J, et al. Impaired fibrinolysis as a risk factor for Budd-Chiari syndrome. Blood 2010;115(2):388–95.CrossRefGoogle ScholarPubMed
Zhang, P, et al. Association between JAK2 rs4495487 polymorphism and risk of Budd-Chiari syndrome in China. Gastroenterol Res Pract 2015;2015:807–65.CrossRefGoogle ScholarPubMed
Shukla, A, et al. Budd-Chiari syndrome has different presentations and disease severity during adolescence. Hepatol Int 2018;12(6):560–6.CrossRefGoogle ScholarPubMed
Coskun, ME, et al. Ruxolitinib treatment in an infant with JAK2+ polycythaemia vera-associated Budd-Chiari syndrome. BMJ Case Rep 2017;2017:pii:bcr-2017-220377. doi: 10.1136/bcr-2017-220377Google Scholar
Karakose, S, et al. Diagnostic value of the JAK2 V617F mutation for latent chronic myeloproliferative disorders in patients with Budd-Chiari syndrome and/or portal vein thrombosis. Turk J Gastroenterol 2015;26(1):42–8.CrossRefGoogle ScholarPubMed
Singh, V, et al. Budd-Chiari syndrome: our experience of 71 patients. J Gastroenterol Hepatol 2000;15(5):550–4.CrossRefGoogle ScholarPubMed
Nobre, S, et al. Primary Budd-Chiari syndrome in children: King’s College Hospital Experience. J Pediatr Gastroenterol Nutr 2017;65(1):93–6.CrossRefGoogle ScholarPubMed
Boozari, B, et al. Ultrasonography in patients with Budd-Chiari syndrome: diagnostic signs and prognostic implications. J Hepatol 2008;49(4):572–80.CrossRefGoogle ScholarPubMed
Faraoun, SA, et al. Budd-Chiari syndrome: an update on imaging features. Clin Imaging 2016;40(4):637–46.CrossRefGoogle ScholarPubMed
Wang, L, et al. Diagnosis of Budd-Chiari syndrome: three-dimensional dynamic contrast enhanced magnetic resonance angiography. Abdom Imaging 2011;36(4):399406.CrossRefGoogle ScholarPubMed
Nagral, A, et al. Budd-Chiari syndrome in children: experience with therapeutic radiological intervention. J Pediatr Gastroenterol Nutr 2010;50(1):74–8.CrossRefGoogle ScholarPubMed
Wang, Q, et al. Angioplasty with versus without routine stent placement for Budd-Chiari syndrome: a randomised controlled trial. Lancet Gastroenterol Hepatol 2019;4(9):686–97.CrossRefGoogle ScholarPubMed
Sharma, VK, et al. Long-term clinical outcome of Budd-Chiari syndrome in children after radiological intervention. Eur J Gastroenterol Hepatol 2016;28(5):567–75.CrossRefGoogle ScholarPubMed
Koskinas, J, et al. Liver involvement in acute vaso-occlusive crisis of sickle cell disease: prevalence and predisposing factors. Scand J Gastroenterol 2007;42(4):499507.CrossRefGoogle ScholarPubMed
Allali, S, et al. Hepatobiliary complications in children with sickle cell disease: a retrospective review of medical records from 616 patients. J Clin Med 2019;8(9):pii:E1481. doi: 10.3390/jcm8091481CrossRefGoogle ScholarPubMed
Ebert, EC, Nagar, M, Hagspiel, KD. Gastrointestinal and hepatic complications of sickle cell disease. Clin Gastroenterol Hepatol 2010;8(6):483–9; quiz e70.CrossRefGoogle ScholarPubMed
Herrera, JL. Liver in systemic diseases. Clin Liver Dis 2019;23(2):i.Google Scholar
Ahn, H, Li, CS, Wang, W. Sickle cell hepatopathy: clinical presentation, treatment, and outcome in pediatric and adult patients. Pediatr Blood Cancer 2005;45(2):184–90.CrossRefGoogle ScholarPubMed
Mekeel, KL, et al. Liver transplantation in children with sickle-cell disease. Liver Transpl 2007;13(4):505–8.CrossRefGoogle ScholarPubMed
Emre, S, et al. Liver transplantation in a patient with acute liver failure due to sickle cell intrahepatic cholestasis. Transplantation 2000;69(4):675–6.CrossRefGoogle Scholar
Blinder, MA, et al. Successful orthotopic liver transplantation in an adult patient with sickle cell disease and review of the literature. Hematol Rep 2013;5(1):14.CrossRefGoogle Scholar
Revel-Vilk, S, et al. The changing face of hepatitis in boys with haemophilia associated with increased prevalence of obesity. Haemophilia 2011;17(4):689–94.CrossRefGoogle ScholarPubMed
Alvarnas, JC, et al. Acute lymphoblastic leukemia. J Natl Compr Canc Netw 2015;13(10):1240–79.Google ScholarPubMed
Denton, CC, et al. Predictors of hepatotoxicity and pancreatitis in children and adolescents with acute lymphoblastic leukemia treated according to contemporary regimens. Pediatr Blood Cancer 2018;65(3). doi: 10.1002/pbc.26891CrossRefGoogle ScholarPubMed
Hashmi, SK, et al. Incidence and predictors of treatment-related conjugated hyperbilirubinemia during early treatment phases for children with acute lymphoblastic leukemia. Pediatr Blood Cancer 2019;2019:e28063.Google Scholar
Farrow, AC, et al. Serum aminotransferase elevation during and following treatment of childhood acute lymphoblastic leukemia. J Clin Oncol 1997;15(4):1560–6.CrossRefGoogle ScholarPubMed
Kamal, N, et al. Asparaginase-induced hepatotoxicity: rapid development of cholestasis and hepatic steatosis. Hepatol Int 2019;13(5):641–8.CrossRefGoogle ScholarPubMed
Aldoss, I, et al. Toxicity profile of repeated doses of PEG-asparaginase incorporated into a pediatric-type regimen for adult acute lymphoblastic leukemia. Eur J Haematol 2016;96(4):375–80.CrossRefGoogle ScholarPubMed
Schulte, RR, et al. Levocarnitine for asparaginase-induced hepatic injury: a multi-institutional case series and review of the literature. Leuk Lymphoma 2018;59(10):2360–8.CrossRefGoogle ScholarPubMed
Blackman, A, et al. Levocarnitine and vitamin B complex for the treatment of pegaspargase-induced hepatotoxicity: a case report and review of the literature. J Oncol Pharm Pract 2018;24(5):393–7.CrossRefGoogle ScholarPubMed
Athale, U, et al. Management of chronic myeloid leukemia in children and adolescents: recommendations from the Children’s Oncology Group CML Working Group. Pediatr Blood Cancer 2019;66(9):e27827.CrossRefGoogle ScholarPubMed
Pass, AK, et al. Vanishing bile duct syndrome and Hodgkin disease: a case series and review of the literature. J Pediatr Hematol Oncol 2008;30(12):976–80.CrossRefGoogle ScholarPubMed
Ballonoff, A, et al. Hodgkin lymphoma-related vanishing bile duct syndrome and idiopathic cholestasis: statistical analysis of all published cases and literature review. Acta Oncol 2008;47(5):962–70.CrossRefGoogle ScholarPubMed
Ghosh, I, Bakhshi, S. Jaundice as a presenting manifestation of pediatric non-Hodgkin lymphoma: etiology, management, and outcome. J Pediatr Hematol Oncol 2010;32(4):e131–5.CrossRefGoogle Scholar
McDonald, GB. Hepatobiliary complications of hematopoietic cell transplantation, 40 years on. Hepatology 2010;51(4):1450–60.CrossRefGoogle Scholar
Mahadeo, KM, et al. Diagnosis, grading, and treatment recommendations for children, adolescents, and young adults with sinusoidal obstructive syndrome: an international expert position statement. Lancet Haematol 2019. doi: https://doi.org/10.1016/S2352-3026(19)30201-7CrossRefGoogle Scholar
Corbacioglu, S, et al. Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation. Bone Marrow Transplant 2018;53(2):138–45.CrossRefGoogle ScholarPubMed
McCarville, MB, et al. Hepatic veno-occlusive disease in children undergoing bone-marrow transplantation: usefulness of sonographic findings. Pediatr Radiol 2001;31(2):102–5.CrossRefGoogle ScholarPubMed
Shulman, HM, et al. Utility of transvenous liver biopsies and wedged hepatic venous pressure measurements in sixty marrow transplant recipients. Transplantation 1995;59(7):1015–22.CrossRefGoogle ScholarPubMed
Cheuk, DK, et al. Interventions for prophylaxis of hepatic veno-occlusive disease in people undergoing haematopoietic stem cell transplantation. Cochrane Database Syst Rev 2015;5:CD009311.Google Scholar
Tay, J, et al. Systematic review of controlled clinical trials on the use of ursodeoxycholic acid for the prevention of hepatic veno-occlusive disease in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2007;13(2):206–17.CrossRefGoogle ScholarPubMed
Corbacioglu, S, et al. Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haemopoietic stem-cell transplantation: an open-label, phase 3, randomised controlled trial. Lancet 2012;379(9823):1301–9. doi: 10.1016/S0140-6736(11)61938-7CrossRefGoogle ScholarPubMed
Bajwa, RPS, et al. Consensus Report by Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplantation Consortium Joint Working Committees: Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents, Part 1: Focus on Investigations, Prophylaxis, and Specific Treatment. Biol Blood Marrow Transplant 2017;23(11):1817–25.CrossRefGoogle ScholarPubMed
Mahadeo, KM, et al. Consensus Report by the Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplant Consortium Joint Working Committees on Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents: Part 2-Focus on Ascites, Fluid and Electrolytes, Renal, and Transfusion Issues. Biol Blood Marrow Transplant 2017;23(12):2023–33.CrossRefGoogle ScholarPubMed
Coppell, JA, et al. Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant 2010;16(2):157–68.CrossRefGoogle ScholarPubMed
Pidala, J. Graft-vs-host disease following allogeneic hematopoietic cell transplantation. Cancer Control 2011;18(4):268–76.CrossRefGoogle ScholarPubMed
Matsukuma, KE, et al. Diagnosis and differential diagnosis of hepatic graft versus host disease (GVHD). J Gastrointest Oncol 2016;7(Suppl. 1):S2131.Google Scholar
Ruggiu, M, et al. Utility and safety of liver biopsy in patients with undetermined liver blood test anomalies after allogeneic hematopoietic stem cell transplantation: a monocentric retrospective cohort study. Biol Blood Marrow Transplant 2018;24(12):2523–31.CrossRefGoogle ScholarPubMed
Oshrine, B, Lehmann, LE, Duncan, CN. Safety and utility of liver biopsy after pediatric hematopoietic stem cell transplantation. J Pediatr Hematol Oncol 2011;33(3):e92–7.CrossRefGoogle ScholarPubMed
Salomao, M, et al. Histopathology of graft-vs-host disease of gastrointestinal tract and liver: an update. Am J Clin Pathol 2016;145(5):591603.CrossRefGoogle ScholarPubMed
Shulman, HM, et al. Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group Report. Biol Blood Marrow Transplant 2006;12(1):3147.CrossRefGoogle ScholarPubMed
Jamil, MO, Mineishi, S. State-of-the-art acute and chronic GVHD treatment. Int J Hematol 2015;101(5):452–66.CrossRefGoogle ScholarPubMed
Cutler, CS, Koreth, J, Ritz, J. Mechanistic approaches for the prevention and treatment of chronic GVHD. Blood 2017;129(1):22–9.CrossRefGoogle ScholarPubMed
Barshes, NR, et al. Liver transplantation for severe hepatic graft-versus-host disease. An analysis of aggregate survival data. Liver Transplantation 2005;11(5):525–31.CrossRefGoogle ScholarPubMed
Zeidan, AM, et al. Successful treatment of severe refractory hepatic graft-versus-host disease by cadaveric liver transplant. Leuk Lymphoma 2013;54(12):2756–9.CrossRefGoogle ScholarPubMed
Tomita, Y, et al. High incidence of fatty liver and insulin resistance in long-term adult survivors of childhood SCT. Bone Marrow Transplant 2011;46(3):416–25.CrossRefGoogle ScholarPubMed
Behrens, EM, et al. Evaluation of the presentation of systemic onset juvenile rheumatoid arthritis: data from the Pennsylvania Systemic Onset Juvenile Arthritis Registry (PASOJAR). J Rheumatol 2008;35(2):343–8.Google Scholar
Lee, JJY, Schneider, R. Systemic juvenile idiopathic arthritis. Pediatr Clin North Am 2018;65(4):691709.CrossRefGoogle ScholarPubMed
Takahashi, A, et al. Clinical features of liver dysfunction in collagen diseases. Hepatol Res 2010;40(11):1092–7.CrossRefGoogle ScholarPubMed
Hashkes, PJ, et al. The relationship of hepatotoxic risk factors and liver histology in methotrexate therapy for juvenile rheumatoid arthritis. J Peds 1999;134:4752.CrossRefGoogle ScholarPubMed
Wood, PR, Caplan, L. Drug-induced gastrointestinal and hepatic disease associated with biologic and nonbiologic disease-modifying antirheumatic drugs. Rheum Dis Clin North Am 2018;44(1):2943.CrossRefGoogle Scholar
Kaplowitz, N, DeLeve, LD. (2007). Drug-Induced Liver Disease, 2nd edn., (pp. xv, 8081). New York: Informa Healthcare.CrossRefGoogle Scholar
Shimizu, M, et al. Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis. Rheumatology 2010;49(9):1645–53.CrossRefGoogle ScholarPubMed
Minoia, F, et al. Clinical features, treatment, and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: a multinational, multicenter study of 362 patients. Arthritis Rheumatol 2014;66(11):3160–9.CrossRefGoogle ScholarPubMed
Ebert, EC, Hagspiel, KD. Gastrointestinal and hepatic manifestations of rheumatoid arthritis. Dig Dis Sci 2011;56(2):295302.CrossRefGoogle ScholarPubMed
Harry, O, Yasin, S, Brunner, H. Childhood-onset systemic lupus erythematosus: a review and update. J Pediatr 2018;196:22–30.e2.CrossRefGoogle ScholarPubMed
Gebreselassie, A, Aduli, F, Howell, CD. Rheumatologic diseases and the liver. Clin Liver Dis 2019;23(2):247–61.CrossRefGoogle ScholarPubMed
Ohira, H, et al. High frequency of anti-ribosomal P antibody in patients with systemic lupus erythematosus-associated hepatitis. Hepatol Res 2004;28(3):137–9.CrossRefGoogle ScholarPubMed
Vanoni, F, et al. Neonatal systemic lupus erythematosus syndrome: a comprehensive review. Clin Rev Allergy Immunol 2017;53(3):469–76.CrossRefGoogle ScholarPubMed
Lee, LA, Sokol, RJ, Buyon, JP. Hepatobiliary disease in neonatal lupus: prevalence and clinical characteristics in cases enrolled in a national registry. Pediatrics 2002;109(1):E11.CrossRefGoogle Scholar
Eladawy, M, et al. Abnormal liver panel in acute kawasaki disease. Pediatr Infect Dis J 2011;30(2):141–4.CrossRefGoogle ScholarPubMed
Wang, Y, et al. Unique molecular patterns uncovered in Kawasaki disease patients with elevated serum gamma glutamyl transferase levels: implications for intravenous immunoglobulin responsiveness. PLoS One 2016;11(12):e0167434.CrossRefGoogle ScholarPubMed
Kim, BY, et al. Non-responders to intravenous immunoglobulin and coronary artery dilatation in Kawasaki disease: predictive parameters in Korean children. Korean Circ J 2016;46(4):542–9.CrossRefGoogle ScholarPubMed
Grammatikopoulos, T, et al. Reduced hepatocellular expression of canalicular transport proteins in infants with neonatal cholestasis and congenital hypopituitarism. J Pediatr 2018;200:181–7.CrossRefGoogle ScholarPubMed
Malik, R, Hodgson, H. The relationship between the thyroid gland and the liver. QJM 2002;95(9):559–69.CrossRefGoogle ScholarPubMed
Eshraghian, A, Hamidian Jahromi, A. Non-alcoholic fatty liver disease and thyroid dysfunction: a systematic review. World J Gastroenterol 2014;20(25):8102–9.CrossRefGoogle ScholarPubMed
Elder, CJ, Natarajan, A. Mauriac syndrome–a modern reality. J Pediatr Endocrinol Metab 2010;23(3):311–13.CrossRefGoogle ScholarPubMed
Sumida, Y, Yoneda, M. Glycogen hepatopathy: an under-recognized hepatic complication of uncontrolled type 1 diabetes mellitus. Intern Med 2018;57(8):1063–4.CrossRefGoogle ScholarPubMed
Rubio-Tapia, A, Murray, JA. The liver and celiac disease. Clin Liver Dis 2019;23(2):167–76.CrossRefGoogle ScholarPubMed
Mounajjed, T, et al. The liver in celiac disease: clinical manifestations, histologic features, and response to gluten-free diet in 30 patients. Am J Clin Pathol 2011;136(1):128–37.CrossRefGoogle ScholarPubMed
Finn, PF, Dice, JF. Proteolytic and lipolytic responses to starvation. Nutrition 2006;22(7–8):830–44.CrossRefGoogle ScholarPubMed
Grover, Z, Ee, LC. Protein energy malnutrition. Pediatr Clin North Am 2009;56(5):1055–68.CrossRefGoogle ScholarPubMed
Fong, HF, et al. Prevalence and predictors of abnormal liver enzymes in young women with anorexia nervosa. J Pediatr 2008;153(2):247–53.CrossRefGoogle ScholarPubMed
Rautou, PE, et al. Acute liver cell damage in patients with anorexia nervosa: a possible role of starvation-induced hepatocyte autophagy. Gastroenterology 2008;135(3):840–8, 848.e1–3.CrossRefGoogle ScholarPubMed
Nadelson, AC, et al. Expanding the differential diagnosis for transaminitis in patients with anorexia nervosa. J Gen Intern Med 2017;32(4):486–9.CrossRefGoogle ScholarPubMed
De Caprio, C, et al. Severe acute liver damage in anorexia nervosa: two case reports. Nutrition 2006;22(5):572–5.CrossRefGoogle ScholarPubMed
Rosen, E, et al. Hepatic complications of anorexia nervosa. Dig Dis Sci 2017;62(11):2977–81.CrossRefGoogle ScholarPubMed
Navarro, VJ, et al. Liver injury from herbal and dietary supplements. Hepatology 2017;65(1):363–73.CrossRefGoogle ScholarPubMed
García-Cortés, M, et al. Hepatotoxicity by dietary supplements: a tabular listing and clinical characteristics.Int J Mol Sci 2016;17(4):537.CrossRefGoogle ScholarPubMed
Dulai, PS, Rothstein, RI. Disseminated sarcoidosis presenting as granulomatous gastritis: a clinical review of the gastrointestinal and hepatic manifestations of sarcoidosis. J Clin Gastroenterol 2012;46(5):367–74. doi: 10.1097/MCG.0b013e318247106bCrossRefGoogle ScholarPubMed
Kumar, M, Herrera, JL. Sarcoidosis and the liver. Clin Liver Dis 2019;23(2):331–43.CrossRefGoogle ScholarPubMed
Cremers, J, et al. Liver-test abnormalities in sarcoidosis. Eur J Gastroenterol Hepatol 2012;24(1):1724.CrossRefGoogle ScholarPubMed
Vuppalanchi, R, et al. Effects of liver biopsy sample length and number of readings on sampling variability in nonalcoholic Fatty liver disease. Clin Gastroenterol Hepatol 2009;7(4):481–6.CrossRefGoogle ScholarPubMed
Patnaik, MM, Kamath, PS, Simonetto, DA. Hepatic manifestations of telomere biology disorders. J Hepatol 2018;69(3):736–43.CrossRefGoogle ScholarPubMed
Mangaonkar, AA, Patnaik, MM. Short telomere syndromes in clinical practice: bridging bench and bedside. Mayo Clin Proc 2018;93(7):904–16.CrossRefGoogle ScholarPubMed

References

Bristowe, C. Cystic disease of the liver associated with a similar disease of the kidneys. Trans Pathol Soc Lond 1856;7:229–34.Google Scholar
Jorgensen, MJ. The ductal plate malformation. Acta Pathol Microbiol Scand Suppl 1977(257):187.Google Scholar
Desmet, VJ. Congenital diseases of intrahepatic bile ducts: variations on the theme “ductal plate malformation.” Hepatology 1992;16(4):1069–83.CrossRefGoogle Scholar
Rogers, TN, Woodley, H, Ramsden, W, Wyatt, JI, Stringer, MD. Solitary liver cysts in children: not always so simple. J Pediatr Surg 2007;42(2):333–9.CrossRefGoogle Scholar
Kerr, DN, Harrison, CV, Sherlock, S, Walker, RM. Congenital hepatic fibrosis. Q J Med 1961;30:91117.Google ScholarPubMed
Ward, CJ, Hogan, MC, Rossetti, S, Walker, D, Sneddon, T, Wang, X, et al. The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein. Nat Genet 2002;30(3):259–69.CrossRefGoogle ScholarPubMed
Bergmann, C, Senderek, J, Windelen, E, Kupper, F, Middeldorf, I, Schneider, F, et al. Clinical consequences of PKHD1 mutations in 164 patients with autosomal-recessive polycystic kidney disease (ARPKD). Kidney Int 2005;67(3):829–48.CrossRefGoogle Scholar
Rossetti, S, Torra, R, Coto, E, Consugar, M, Kubly, V, Malaga, S, et al. A complete mutation screen of PKHD1 in autosomal-recessive polycystic kidney disease (ARPKD) pedigrees. Kidney Int 2003;64(2):391403.CrossRefGoogle ScholarPubMed
O’Brien, K, Font-Montgomery, E, Lukose, L, Bryant, J, Piwnica-Worms, K, Edwards, H, et al. Congenital hepatic fibrosis and portal hypertension in autosomal dominant polycystic kidney disease. J Pediatr Gastroenterol Nutr 2012;54(1):83–9.CrossRefGoogle ScholarPubMed
Gunay-Aygun, M, Gahl, WA, Heller, T. (1993). Congenital hepatic fibrosis overview. In: Adam, MP, Ardinger, HH, Pagon, RA, Wallace, SE, Bean, LJH, Stephens, K, et al., (Eds.), GeneReviews((R)). Seattle, WA: University of Washington.Google Scholar
Srinath, A, Shneider, BL. Congenital hepatic fibrosis and autosomal recessive polycystic kidney disease. J Pediatr Gastroenterol Nutr 2012;54(5):580–7.CrossRefGoogle ScholarPubMed
Gunay-Aygun, M, Font-Montgomery, E, Lukose, L, Tuchman Gerstein, M, Piwnica-Worms, K, Choyke, P, et al. Characteristics of congenital hepatic fibrosis in a large cohort of patients with autosomal recessive polycystic kidney disease. Gastroenterology 2013;144(1):112–21 e2.CrossRefGoogle Scholar
Summerfield, JA, Nagafuchi, Y, Sherlock, S, Cadafalch, J, Scheuer, PJ. Hepatobiliary fibropolycystic diseases. A clinical and histological review of 51 patients. J Hepatol 1986;2(2):141–56.CrossRefGoogle Scholar
Guay-Woodford, LM, Bissler, JJ, Braun, MC, Bockenhauer, D, Cadnapaphornchai, MA, Dell, KM, et al. Consensus expert recommendations for the diagnosis and management of autosomal recessive polycystic kidney disease: report of an international conference. J Pediatr 2014;165(3):611–17.CrossRefGoogle ScholarPubMed
Akhan, O, Karaosmanoglu, AD, Ergen, B. Imaging findings in congenital hepatic fibrosis. Eur J Radiol 2007;61(1):1824.CrossRefGoogle ScholarPubMed
Kummer, S, Sagir, A, Pandey, S, Feldkotter, M, Habbig, S, Korber, F, et al. Liver fibrosis in recessive multicystic kidney diseases: transient elastography for early detection. Pediatr Nephrol 2011;26(5):725–31.CrossRefGoogle ScholarPubMed
Wicher, D, Jankowska, I, Lipinski, P, Szymanska-Rozek, P, Kmiotek, J, Janczyk, W, et al. Transient elastography for detection of liver fibrosis in children with autosomal recessive polycystic kidney disease. Front Pediatr 2018;6:422.CrossRefGoogle ScholarPubMed
Hartung, EA, Wen, J, Poznick, L, Furth, SL, Darge, K. Ultrasound elastography to quantify liver disease severity in autosomal recessive polycystic kidney disease. J Pediatr 2019;209:107–15.CrossRefGoogle ScholarPubMed
Munoz-Garrido, P, Marin, JJ, Perugorria, MJ, Urribarri, AD, Erice, O, Saez, E, et al. Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease. J Hepatol 2015;63(4):952–61.CrossRefGoogle ScholarPubMed
Shneider, BL, de Ville de Goyet, J, Leung, DH, Srivastava, A, Ling, SC, Duche, M, et al. Primary prophylaxis of variceal bleeding in children and the role of MesoRex bypass: summary of the Baveno VI Pediatric Satellite Symposium. Hepatology 2016;63(4):1368–80.CrossRefGoogle ScholarPubMed
Shneider, BL, Magid, MS. Liver disease in autosomal recessive polycystic kidney disease. Pediatric Transplantation 2005;9(5):634–9.CrossRefGoogle ScholarPubMed
Guay-Woodford, LM, Desmond, RA. Autosomal recessive polycystic kidney disease: the clinical experience in North America. Pediatrics 2003;111(5 Pt 1):1072–80.CrossRefGoogle ScholarPubMed
Garcia-Tsao, G, Sanyal, AJ, Grace, ND, Carey, W. Practice Guidelines Committee of the American Association for the Study of Liver Disease, Practice Parameters Committee of the American College of Gastroenterology. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology 2007;46(3):922–38.Google Scholar
Kinugasa, H, Nouso, K, Kobayashi, Y, Yasunaka, T, Onishi, H, Nakamura, S, et al. Hepatocellular carcinoma occurring in hepatobiliary fibropolycystic disease. Hepatol Res 2011;41(3):277–81.CrossRefGoogle ScholarPubMed
Onuchic, LF, Furu, L, Nagasawa, Y, Hou, X, Eggermann, T, Ren, Z, et al. PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats. Am J Hum Genet 2002;70(5):1305–17.CrossRefGoogle ScholarPubMed
Lu, H, Galeano, MCR, Ott, E, Kaeslin, G, Kausalya, PJ, Kramer, C, et al. Mutations in DZIP1 L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease. Nat Genet 2017;49(7):1025–34.CrossRefGoogle Scholar
Caroli, J, Couinaud, C, Soupault, R, Porcher, P, Eteve, J. A new disease, undoubtedly congenital, of the bile ducts: unilobar cystic dilation of the hepatic ducts. Sem Hop 1958;34(8/2):496502.Google ScholarPubMed
Jordon, D, Harpaz, N, Thung, SN. Caroli’s disease and adult polycystic kidney disease: a rarely recognized association. Liver 1989;9(1):30–5.Google ScholarPubMed
Rawat, D, Kelly, DA, Milford, DV, Sharif, K, Lloyd, C, McKiernan, PJ. Phenotypic variation and long-term outcome in children with congenital hepatic fibrosis. J Pediatr Gastroenterol Nutr 2013;57(2):161–6.CrossRefGoogle ScholarPubMed
Ramond, MJ, Huguet, C, Danan, G, Rueff, B, Benhamou, JP. Partial hepatectomy in the treatment of Caroli’s disease. Report of a case and review of the literature. Dig Dis Sci 1984;29(4):367–70.Google ScholarPubMed
Lendoire, JC, Raffin, G, Grondona, J, Bracco, R, Russi, R, Ardiles, V, et al. Caroli’s disease: report of surgical options and long-term outcome of patients treated in Argentina. Multicenter study. J Gastrointest Surg 2011;15(10):1814–19.Google ScholarPubMed
Kim, RD, Book, L, Haafiz, A, Schwartz, JJ, Sorensen, JB, Gonzalez-Peralta, RP. Liver transplantation in a 7-month-old girl with Caroli’s disease. J Pediatr Surg 2011;46(8):1638–41.CrossRefGoogle Scholar
Millwala, F, Segev, DL, Thuluvath, PJ. Caroli’s disease and outcomes after liver transplantation. Liver Transpl 2008;14(1):1117.CrossRefGoogle ScholarPubMed
Harris, PC, Torres, VE. Polycystic kidney disease. Annu Rev Med 2009;60:321–37.CrossRefGoogle ScholarPubMed
Cornec-Le Gall, E, Torres, VE, Harris, PC. Genetic complexity of autosomal dominant polycystic kidney and liver diseases. J Am Soc Nephrol 2018;29(1):1323.CrossRefGoogle ScholarPubMed
Porath, B, Gainullin, VG, Cornec-Le Gall, E, Dillinger, EK, Heyer, CM, Hopp, K, et al. Mutations in GANAB, encoding the glucosidase II alpha subunit, cause autosomal-dominant polycystic kidney and liver disease. Am J Hum Genet 2016;98(6):1193–207.CrossRefGoogle ScholarPubMed
Dell, KM. The spectrum of polycystic kidney disease in children. Adv Chronic Kidney Dis 2011;18(5):339–47.Google ScholarPubMed
Gascue, C, Katsanis, N, Badano, JL. Cystic diseases of the kidney: ciliary dysfunction and cystogenic mechanisms. Pediatr Nephrol 2011;26(8):1181–95.CrossRefGoogle ScholarPubMed
Wilson, PD. Polycystic kidney disease: new understanding in the pathogenesis. Int J Biochem Cell Biol 2004;36(10):1868–73.CrossRefGoogle ScholarPubMed
Lee-Law, PY, van de Laarschot, LFM, Banales, JM, Drenth, JPH. Genetics of polycystic liver diseases. Curr Opin Gastroenterol 2019;35(2):6572.CrossRefGoogle ScholarPubMed
Gimpel, C, Bergmann, C, Bockenhauer, D, Breysem, L, Cadnapaphornchai, MA, Cetiner, M, et al. International consensus statement on the diagnosis and management of autosomal dominant polycystic kidney disease in children and young people. Nat Rev Nephrol 2019;15(11):713–26.CrossRefGoogle ScholarPubMed
Bae, KT, Zhu, F, Chapman, AB, Torres, VE, Grantham, JJ, Guay-Woodford, LM, et al. Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort. Clin J Am Soc Nephrol 2006;1(1):64–9.CrossRefGoogle Scholar
Gunay-Aygun, M. Liver and kidney disease in ciliopathies. Am J Med Genet C Semin Med Genet 2009;151 C(4):296306.CrossRefGoogle Scholar
Torres, VE, Harris, PC, Pirson, Y. Autosomal dominant polycystic kidney disease. Lancet 2007;369(9569):1287–301.CrossRefGoogle ScholarPubMed
Janssens, P, Weydert, C, De Rechter, S, Wissing, KM, Liebau, MC, Mekahli, D. Expanding the role of vasopressin antagonism in polycystic kidney diseases: from adults to children? Pediatr Nephrol 2018;33(3):395408.CrossRefGoogle Scholar
Chebib, FT, Perrone, RD, Chapman, AB, Dahl, NK, Harris, PC, Mrug, M, et al. A practical guide for treatment of rapidly progressive ADPKD with tolvaptan. J Am Soc Nephrol 2018;29(10):2458–70.CrossRefGoogle ScholarPubMed
Desmet, VJ. Ludwig symposium on biliary disorders–part I. Pathogenesis of ductal plate abnormalities. Mayo Clin Proc 1998;73(1):80–9.Google Scholar
Burns, CD, Kuhns, JG, Wieman, TJ. Cholangiocarcinoma in association with multiple biliary microhamartomas. Arch Pathol Lab Med 1990;114(12):1287–9.Google ScholarPubMed
Xu, AM, Xian, ZH, Zhang, SH, Chen, XF. Intrahepatic cholangiocarcinoma arising in multiple bile duct hamartomas: report of two cases and review of the literature. Eur J Gastroenterol Hepatol 2009;21(5):580–4.CrossRefGoogle ScholarPubMed
Nagano, Y, Matsuo, K, Gorai, K, Sugimori, K, Kunisaki, C, Ike, H, et al. Bile duct hamartomas (von Mayenburg complexes) mimicking liver metastases from bile duct cancer: MRC findings. World J Gastroenterol 2006;12(8):1321–3.CrossRefGoogle Scholar
Temmerman, F, Missiaen, L, Bammens, B, Laleman, W, Cassiman, D, Verslype, C, et al. Systematic review: the pathophysiology and management of polycystic liver disease. Aliment Pharmacol Ther 2011;34(7):702–13.CrossRefGoogle ScholarPubMed
van Keimpema, L, Nevens, F, Vanslembrouck, R, van Oijen, MG, Hoffmann, AL, Dekker, HM, et al. Lanreotide reduces the volume of polycystic liver: a randomized, double-blind, placebo-controlled trial. Gastroenterology 2009;137(5):1661–8 e1–2.CrossRefGoogle ScholarPubMed
Gevers, TJ, Drenth, JP. Diagnosis and management of polycystic liver disease. Nat Rev Gastroenterol Hepatol 2013;10(2):101–8.CrossRefGoogle ScholarPubMed
Kabbej, M, Sauvanet, A, Chauveau, D, Farges, O, Belghiti, J. Laparoscopic fenestration in polycystic liver disease. Br J Surg 1996;83(12):1697–701.CrossRefGoogle ScholarPubMed
Hoevenaren, IA, Wester, R, Schrier, RW, McFann, K, Doctor, RB, Drenth, JP, et al. Polycystic liver: clinical characteristics of patients with isolated polycystic liver disease compared with patients with polycystic liver and autosomal dominant polycystic kidney disease. Liver Int 2008;28(2):264–70.Google ScholarPubMed
Drenth, JP, Chrispijn, M, Nagorney, DM, Kamath, PS, Torres, VE. Medical and surgical treatment options for polycystic liver disease. Hepatology 2010;52(6):2223–30.CrossRefGoogle ScholarPubMed
Doshi, SD, Bittermann, T, Schiano, TD, Goldberg, DS. Waitlisted candidates with polycystic liver disease are more likely to be transplanted than those with chronic liver failure. Transplantation 2017;101(8):1838–44.CrossRefGoogle ScholarPubMed
Waanders, E, te Morsche, RH, de Man, RA, Jansen, JB, Drenth, JP. Extensive mutational analysis of PRKCSH and SEC63 broadens the spectrum of polycystic liver disease. Hum Mutat 2006;27(8):830.CrossRefGoogle ScholarPubMed
Drenth, JP, Tahvanainen, E, te Morsche, RH, Tahvanainen, P, Kaariainen, H, Hockerstedt, K, et al. Abnormal hepatocystin caused by truncating PRKCSH mutations leads to autosomal dominant polycystic liver disease. Hepatology 2004;39(4):924–31.Google Scholar
Jaeken, J, Matthijs, G, Saudubray, JM, Dionisi-Vici, C, Bertini, E, de Lonlay, P, et al. Phosphomannose isomerase deficiency: a carbohydrate-deficient glycoprotein syndrome with hepatic-intestinal presentation. Am J Hum Genet 1998;62(6):1535–9.CrossRefGoogle ScholarPubMed
Janssen, MJ, Waanders, E, Te Morsche, RH, Xing, R, Dijkman, HB, Woudenberg, J, et al. Secondary, somatic mutations might promote cyst formation in patients with autosomal dominant polycystic liver disease. Gastroenterology 2011;141(6):2056–63 e2.CrossRefGoogle ScholarPubMed
Lu, W, Fan, X, Basora, N, Babakhanlou, H, Law, T, Rifai, N, et al. Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes. Nat Genet 1999;21(2):160–1.CrossRefGoogle ScholarPubMed
Wills, ES, Roepman, R, Drenth, JP. Polycystic liver disease: ductal plate malformation and the primary cilium. Trends Mol Med 2014;20(5):261–70.CrossRefGoogle ScholarPubMed
Carone, FA, Nakamura, S, Schumacher, BS, Punyarit, P, Bauer, KD. Cyst-derived cells do not exhibit accelerated growth or features of transformed cells in vitro. Kidney Int 1989;35(6):1351–7.CrossRefGoogle ScholarPubMed
Calvet, JP. Polycystic kidney disease: primary extracellular matrix abnormality or defective cellular differentiation? Kidney Int 1993;43(1):101–8.CrossRefGoogle ScholarPubMed
Nauta, J, Sweeney, WE, Rutledge, JC, Avner, ED. Biliary epithelial cells from mice with congenital polycystic kidney disease are hyperresponsive to epidermal growth factor. Pediatr Res 1995;37(6):755–63.CrossRefGoogle ScholarPubMed
Santos-Laso, A, Izquierdo-Sanchez, L, Lee-Law, PY, Perugorria, MJ, Marzioni, M, Marin, JJ, et al. New advances in polycystic liver diseases. Semin Liver Dis 2017;37(1):4555.CrossRefGoogle ScholarPubMed
Masyuk, AI, Masyuk, TV, Splinter, PL, Huang, BQ, Stroope, AJ, LaRusso, NF. Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling. Gastroenterology 2006;131(3):911–20.CrossRefGoogle ScholarPubMed
Nauli, SM, Alenghat, FJ, Luo, Y, Williams, E, Vassilev, P, Li, X, et al. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 2003;33(2):129–37.CrossRefGoogle ScholarPubMed
Chebib, FT, Sussman, CR, Wang, X, Harris, PC, Torres, VE. Vasopressin and disruption of calcium signalling in polycystic kidney disease. Nat Rev Nephrol 2015;11(8):451–64.CrossRefGoogle ScholarPubMed
Graf, A, Meng, F, Hargrove, L, Kennedy, L, Han, Y, Francis, T, et al. Knockout of histidine decarboxylase decreases bile duct ligation-induced biliary hyperplasia via downregulation of the histidine decarboxylase/VEGF axis through PKA-ERK1/2 signaling. Am J Physiol Gastrointest Liver Physiol 2014;307(8):G813–23.CrossRefGoogle ScholarPubMed
Banales, JM, Masyuk, TV, Gradilone, SA, Masyuk, AI, Medina, JF, LaRusso, NF. The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD). Hepatology 2009;49(1):160–74.CrossRefGoogle Scholar
Spirli, C, Okolicsanyi, S, Fiorotto, R, Fabris, L, Cadamuro, M, Lecchi, S, et al. ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice. Gastroenterology 2010;138(1):360–71 e7.CrossRefGoogle ScholarPubMed
Spirli, C, Okolicsanyi, S, Fiorotto, R, Fabris, L, Cadamuro, M, Lecchi, S, et al. Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice. Hepatology 2010;51(5):1778–88.CrossRefGoogle ScholarPubMed
Alvaro, D, Onori, P, Alpini, G, Franchitto, A, Jefferson, DM, Torrice, A, et al. Morphological and functional features of hepatic cyst epithelium in autosomal dominant polycystic kidney disease. Am J Pathol 2008;172(2):321–32.CrossRefGoogle ScholarPubMed
Masyuk, TV, Masyuk, AI, LaRusso, NF. Therapeutic targets in polycystic liver disease. Curr Drug Targets 2017;18(8):950–7.CrossRefGoogle ScholarPubMed
Sanzen, T, Harada, K, Yasoshima, M, Kawamura, Y, Ishibashi, M, Nakanuma, Y. Polycystic kidney rat is a novel animal model of Caroli’s disease associated with congenital hepatic fibrosis. Am J Pathol 2001;158(5):1605–12.CrossRefGoogle ScholarPubMed
Goto, M, Hoxha, N, Osman, R, Wen, J, Wells, RG, Dell, KM. Renin-angiotensin system activation in congenital hepatic fibrosis in the PCK rat model of autosomal recessive polycystic kidney disease. J Pediatr Gastroenterol Nutr 2010;50(6):639–44.CrossRefGoogle ScholarPubMed
Moyer, JH, Lee-Tischler, MJ, Kwon, HY, Schrick, JJ, Avner, ED, Sweeney, WE, et al. Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science 1994;264(5163):1329–33.CrossRefGoogle ScholarPubMed
Guay-Woodford, LM, Green, WJ, Lindsey, JR, Beier, DR. Germline and somatic loss of function of the mouse cpk gene causes biliary ductal pathology that is genetically modulated. Hum Mol Genet 2000;9(5):769–78.CrossRefGoogle Scholar
Raynaud, P, Tate, J, Callens, C, Cordi, S, Vandersmissen, P, Carpentier, R, et al. A classification of ductal plate malformations based on distinct pathogenic mechanisms of biliary dysmorphogenesis. Hepatology 2011;53(6):1959–66.CrossRefGoogle ScholarPubMed
Yoder, BK, Richards, WG, Sommardahl, C, Sweeney, WE, Michaud, EJ, Wilkinson, JE, et al. Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant. A new model to study the liver lesion. Am J Pathol 1997;150(6):2231–41.Google Scholar
Isfort, RJ, Cody, DB, Doersen, CJ, Richards, WG, Yoder, BK, Wilkinson, JE, et al. The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene. Oncogene 1997;15(15):1797–803.CrossRefGoogle ScholarPubMed
El-Youssef, M, Mu, Y, Huang, L, Stellmach, V, Crawford, SE. Increased expression of transforming growth factor-beta1 and thrombospondin-1 in congenital hepatic fibrosis: possible role of the hepatic stellate cell. J Pediatr Gastroenterol Nutr 1999;28(4):386–92.CrossRefGoogle ScholarPubMed
Locatelli, L, Cadamuro, M, Spirli, C, Fiorotto, R, Lecchi, S, Morell, CM, et al. Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis. Hepatology 2016;63(3):965–82.CrossRefGoogle ScholarPubMed
Lee, SO, Masyuk, T, Splinter, P, Banales, JM, Masyuk, A, Stroope, A, et al. MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease. J Clin Invest 2008;118(11):3714–24.CrossRefGoogle Scholar
Hand, NJ, Master, ZR, Eauclaire, SF, Weinblatt, DE, Matthews, RP, Friedman, JR. The microRNA-30 family is required for vertebrate hepatobiliary development. Gastroenterology 2009;136(3):1081–90.CrossRefGoogle ScholarPubMed

References

Lopez-Terrada, D, Finegold, M. (2014). Tumors of the liver. In: Suchy, F, Sokol, RJ, Balistreri, WF, (Eds.), Liver Disease in Children, 4th edn. (pp. 728–59). Cambridge: Cambridge University Press.Google Scholar
Czauderna, P, Haeberle, B, Hiyama, E, et al. The Children’s Hepatic tumors International Collaboration (CHIC): Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model. Eur J Cancer 2016;52:92101.CrossRefGoogle ScholarPubMed
National Institutes of Health. Surveillance, Epidemiology, and End Results Program (SEER). Available at: https://seer.cancer.gov/csr/1975_2016/ [last accessed June 30, 2020].Google Scholar
Darbari, A, Sabin, KM, Shapiro, CN, Schwarz, KB. Epidemiology of primary hepatic malignancies in US children. Hepatology 2003;38:560–6.CrossRefGoogle Scholar
Hubbard, AK, Spector, LG, Fortuna, G, Marcotte, EL, Poynter, JN. Trends in international incidence of pediatric cancers in children under 5 years of age: 1988–2012. JNCI Cancer Spectr 2019;3:pkz007.CrossRefGoogle ScholarPubMed
Katzenstein, HM, Krailo, MD, Malogolowkin, MH, et al. Fibrolamellar hepatocellular carcinoma in children and adolescents. Cancer 2003;97:2006–12.CrossRefGoogle ScholarPubMed
McLaughlin, CC, Baptiste, MS, Schymura, MJ, Nasca, PC, Zdeb, MS. Maternal and infant birth characteristics and hepatoblastoma. Am J Epidemiol 2006;163:818–28.CrossRefGoogle ScholarPubMed
Spector, LG, Puumala, SE, Carozza, SE, et al. Cancer risk among children with very low birth weights. Pediatrics 2009;124:96104.CrossRefGoogle ScholarPubMed
Janitz, AE, Ramachandran, G, Tomlinson, GE, et al. Maternal and paternal occupational exposures and hepatoblastoma: results from the HOPE study through the Children’s Oncology Group. J Expo Sci Environ Epidemiol 2017;27:359–64.CrossRefGoogle ScholarPubMed
Duffy, KA, Cohen, JL, Elci, OU, Kalish, JM. Development of the serum alpha-fetoprotein reference range in patients with Beckwith-Wiedemann spectrum. J Pediatr 2019. doi: 10.1016/j.jpeds.2019.1005.1051CrossRefGoogle Scholar
Li, M, Shuman, C, Fei, YL, et al. GPC3 mutation analysis in a spectrum of patients with overgrowth expands the phenotype of Simpson-Golabi-Behmel syndrome. Am J Med Genet 2001;102:161–8.3.0.CO;2-O>CrossRefGoogle Scholar
Aretz, S, Koch, A, Uhlhaas, S, et al. Should children at risk for familial adenomatous polyposis be screened for hepatoblastoma and children with apparently sporadic hepatoblastoma be screened for APC germline mutations? Pediatr Blood Cancer 2006;47:811–18.CrossRefGoogle ScholarPubMed
Roy, A, Finegold, MJ. Hepatic neoplasia and metabolic diseases in children. Clin Liver Dis 2010;14:731–46.CrossRefGoogle ScholarPubMed
Evason, K, Bove, KE, Finegold, MJ, et al. Morphologic findings in progressive familial intrahepatic cholestasis 2 (PFIC2): correlation with genetic and immunohistochemical studies. Am J Surg Pathol 2011;35:687–96.CrossRefGoogle ScholarPubMed
Scheimann, AO, Strautnieks, SS, Knisely, AS, et al. Mutations in bile salt export pump (ABCB11) in two children with progressive familial intrahepatic cholestasis and cholangiocarcinoma. J Pediatr 2007;150:556–9.CrossRefGoogle ScholarPubMed
Vilarinho, S, Erson-Omay, EZ, Harmanci, AS, et al. Paediatric hepatocellular carcinoma due to somatic CTNNB1 and NFE2L2 mutations in the setting of inherited bi-allelic ABCB11 mutations. J Hepatol 2014;61:1178–83.CrossRefGoogle ScholarPubMed
Zen, Y, Vara, R, Portmann, B, Hadzic, N. Childhood hepatocellular carcinoma: a clinicopathological study of 12 cases with special reference to EpCAM. Histopathology 2014;64:671–82.CrossRefGoogle ScholarPubMed
Newsome, JR, Venkatramani, R, Heczey, A, et al. Cholangiocarcinoma among children and adolescents: a review of the literature and surveillance, epidemiology, and end results program database analysis. J Pediatr Gastroenterol Nutr 2018;66:e12e18.CrossRefGoogle ScholarPubMed
Hadzic, N, Finegold, MJ. Liver neoplasia in children. Clin Liver Dis 2011;15:443–62,viix.CrossRefGoogle ScholarPubMed
Richter, A, Grabhorn, E, Schulz, A, et al. Hepatoblastoma in a child with progressive familial intrahepatic cholestasis. Pediatr Transplant 2005;9:805–8.CrossRefGoogle Scholar
Kadakia, N, Lobritto, SJ, Ovchinsky, N, et al. A challenging case of hepatoblastoma concomitant with autosomal recessive polycystic kidney disease and Caroli syndrome-review of the literature. Front Pediatr 2017;5:114.CrossRefGoogle ScholarPubMed
Johansen, L, Haller, W, Thyagarajan, M, Kelly, D, McKiernan, P. Hepatic lesions associated with McCune Albright syndrome. J Pediatr Gastroenterol Nutr 2019;68:e54e57.CrossRefGoogle ScholarPubMed
Osada, A, Araki, E, Yamashita, Y, Ishii, T. Combination therapy of propranolol, levothyroxine, and liothyronine was effective in a case of severe consumptive hypothyroidism associated with infantile hepatic hemangioma. Clin Pediatr Endocrinol 2019;28:914.CrossRefGoogle Scholar
Lemoine, C, Nilsen, A, Brandt, K, et al. Liver histopathology in patients with hepatic masses and the Abernethy malformation. J Pediatr Surg 2019;54:266–71.CrossRefGoogle ScholarPubMed
McCarville, MB, Kao, SC. Imaging recommendations for malignant liver neoplasms in children. Pediatr Blood Cancer 2006;46:27.CrossRefGoogle ScholarPubMed
Liu, AP, Wong, KN, See, QW, Chan, GC, Chiang, AK. 11 C-Acetate positron emission tomography for detection of occult metastatic recurrence in hepatoblastoma. J Pediatr Hematol Oncol 2016;38:317–20.CrossRefGoogle Scholar
Shi, Y, Commander, SJ, Masand, PM, et al. Vascular invasion is a prognostic indicator in hepatoblastoma. J Pediatr Surg 2017;52:956–61.CrossRefGoogle ScholarPubMed
Boman, F, Bossard, C, Fabre, M, et al. Mesenchymal hamartomas of the liver may be associated with increased serum alpha foetoprotein concentrations and mimic hepatoblastomas. Eur J Pediatr Surg 2004;14:63–6.Google ScholarPubMed
Meyers, RL, Maibach, R, Hiyama, E, et al. Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children’s Hepatic tumors International Collaboration. Lancet Oncol 2017;18:122–31.CrossRefGoogle ScholarPubMed
Rudzinski, E, Ranganathan, S, Hicks, MJ, Kim, GE. Protocol for the examination of resection specimens from patients with hepatoblastoma. Available at: https://www.cap.org/protocols-and-guidelines/cancer-reporting-tools/cancer-protocol-templates [last accessed June 30, 2020].Google Scholar
Aronson, DC, Schnater, JM, Staalman, CR, et al. Predictive value of the pretreatment extent of disease system in hepatoblastoma: results from the International Society of Pediatric Oncology Liver Tumor Study Group SIOPEL-1 study. J Clin Oncol 2005;23:1245–52.CrossRefGoogle Scholar
Meyers, R, Trobaugh-Lotrario, AD, Malogolowkin, MH, Katzenstein, HM, Lopez-Terrada, DH, Finegold, MJ. (2016). Pediatric liver tumors. In: PA Pizzo, (Ed.), Principles and Practice of Pediatric Oncology, 7th edn. (p. 726–52). Philadelphia: Wolters Kluwer.Google Scholar
Wang, LL, Filippi, RZ, Zurakowski, D, et al. Effects of neoadjuvant chemotherapy on hepatoblastoma: a morphologic and immunohistochemical study. Am J Surg Pathol 2010;34:287–99.CrossRefGoogle ScholarPubMed
Biegel, JA, Tan, L, Zhang, F, et al. Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumors. Clin Cancer Res 2002;8:3461–7.Google ScholarPubMed
Trobaugh-Lotrario, AD, Finegold, MJ, Feusner, JH. Rhabdoid tumors of the liver: rare, aggressive, and poorly responsive to standard cytotoxic chemotherapy. Pediatr Blood Cancer 2011;57:423–8.CrossRefGoogle ScholarPubMed
Trobaugh-Lotrario, AD, Tomlinson, GE, Finegold, MJ, Gore, L, Feusner, JH. Small cell undifferentiated variant of hepatoblastoma: adverse clinical and molecular features similar to rhabdoid tumors. Pediatr Blood Cancer 2009;52:328–34.CrossRefGoogle ScholarPubMed
Kiss, A, Szepesi, A, Lotz, G, et al. Expression of transforming growth factor-alpha in hepatoblastoma. Cancer 1998;83:690–7.3.0.CO;2-O>CrossRefGoogle Scholar
Lopez-Terrada, D, Alaggio, R, de Davila, MT, et al. Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium. Mod Pathol 2014;27:472–91.CrossRefGoogle ScholarPubMed
Zhou, S, Gomulia, E, Mascarenhas, L, Wang, L. Is INI1-retained small cell undifferentiated histology in hepatoblastoma unfavorable? Hum Pathol 2015;46:620–4.CrossRefGoogle ScholarPubMed
Prokurat, A, Kluge, P, Kosciesza, A, et al. Transitional liver cell tumors (TLCT) in older children and adolescents: a novel group of aggressive hepatic tumors expressing beta-catenin. Med Pediatr Oncol 2002;39:510–18.CrossRefGoogle ScholarPubMed
Benedict, M, Zhang, X. Calcifying nested stromal-epithelial tumor of the liver: an update and literature review. Arch Pathol Lab Med 2019;143:264–8.CrossRefGoogle ScholarPubMed
Assmann, G, Kappler, R, Zeindl-Eberhart, E, et al. beta-Catenin mutations in 2 nested stromal epithelial tumors of the liver–a neoplasia with defective mesenchymal-epithelial transition. Hum Pathol 2012;43:1815–27.CrossRefGoogle ScholarPubMed
Mo, JQ, Dimashkieh, HH, Bove, KE. GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular malformation with associated capillary proliferation. Hum Pathol 2004;35:200–9.CrossRefGoogle ScholarPubMed
Iacobas, I, Phung, TL, Adams, DM, et al. Guidance document for hepatic hemangioma (infantile and congenital) evaluation and monitoring. J Pediatr 2018;203:294300, e292.CrossRefGoogle ScholarPubMed
Adler, B, Naheedy, J, Yeager, N, Nicol, K, Klamar, J. Multifocal epithelioid hemangioendothelioma in a 16-year-old boy. Pediatr Radiol 2005;35:1014–18.CrossRefGoogle ScholarPubMed
Antonescu, CR, Le Loarer, F, Mosquera, JM, et al. Novel YAP1-TFE3 fusion defines a distinct subset of epithelioid hemangioendothelioma. Genes Chromosomes Cancer 2013;52:775–84.CrossRefGoogle ScholarPubMed
Doyle, LA, Fletcher, CD, Hornick, JL. Nuclear expression of CAMTA1 distinguishes epithelioid hemangioendothelioma from histologic mimics. Am J Surg Pathol 2016;40:94102.CrossRefGoogle ScholarPubMed
Grassia, KL, Peterman, CM, Iacobas, I, et al. Clinical case series of pediatric hepatic angiosarcoma. Pediatr Blood Cancer 2017;64:e26627.CrossRefGoogle ScholarPubMed
Shehata, BM, Gupta, NA, Katzenstein, HM, et al. Undifferentiated embryonal sarcoma of the liver is associated with mesenchymal hamartoma and multiple chromosomal abnormalities: a review of eleven cases. Pediatr Dev Pathol 2011;14:111–16.CrossRefGoogle ScholarPubMed
Keller, RB, Demellawy, DE, Quaglia, A, Finegold, M, Kapur, RP. Methylation status of the chromosome arm 19q MicroRNA cluster in sporadic and androgenetic-biparental mosaicism-associated hepatic mesenchymal hamartoma. Pediatr Dev Pathol 2015;18:218–27.CrossRefGoogle ScholarPubMed
Yan, Z, Grenert, JP, Joseph, NM, et al. Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis. Histopathology 2018;73:101–8.CrossRefGoogle ScholarPubMed
Malogolowkin, MH, Stanley, P, Steele, DA, Ortega, JA. Feasibility and toxicity of chemoembolization for children with liver tumors. J Clin Oncol 2000;18:1279–84.CrossRefGoogle Scholar
Nault, JC, Couchy, G, Balabaud, C, et al. Molecular classification of hepatocellular adenoma associates with risk factors, bleeding, and malignant transformation. Gastroenterology 2017;152:880–94, e886.CrossRefGoogle ScholarPubMed
Sumazin, P, Chen, Y, Trevino, LR, et al. Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups. Hepatology 2017;65:104–21.CrossRefGoogle ScholarPubMed
Sweet-Cordero, EA, Biegel, JA. The genomic landscape of pediatric cancers: implications for diagnosis and treatment. Science 2019;363:1170–5.CrossRefGoogle ScholarPubMed
Cairo, S, Armengol, C, De Reynies, A, et al. Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer. Cancer Cell 2008;14:471–84.CrossRefGoogle ScholarPubMed
Cairo, S, Wang, Y, de Reynies, A, et al. Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer. Proc Natl Acad Sci U S A 2010;107:20471–6.CrossRefGoogle ScholarPubMed
Hooks, KB, Audoux, J, Fazli, H, et al. New insights into diagnosis and therapeutic options for proliferative hepatoblastoma. Hepatology 2018;68:89102.CrossRefGoogle ScholarPubMed
Nagata, T, Takahashi, Y, Ishii, Y, et al. Transcriptional profiling in hepatoblastomas using high-density oligonucleotide DNA array. Cancer Genet Cytogenet 2003;145:152–60.CrossRefGoogle ScholarPubMed
Luo, JH, Ren, B, Keryanov, S, et al. Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas. Hepatology 2006;44:1012–24.CrossRefGoogle ScholarPubMed
Litten, JB, Chen, TT, Schultz, R, et al. Activated NOTCH2 is overexpressed in hepatoblastomas: an immunohistochemical study. Pediatr Dev Pathol 2011;14:378–83.CrossRefGoogle Scholar
Gray, SG, Eriksson, T, Ekstrom, C, et al. Altered expression of members of the IGF-axis in hepatoblastomas. Br J Cancer 2000;82:1561–7.CrossRefGoogle ScholarPubMed
Prawitt, D, Enklaar, T, Gartner-Rupprecht, B, et al. Microdeletion and IGF2 loss of imprinting in a cascade causing Beckwith-Wiedemann syndrome with Wilms’ tumor. Nat Genet 2005;37:785–6; author reply 786–7.CrossRefGoogle Scholar
Adesina, AM, Lopez-Terrada, D, Wong, KK, et al. Gene expression profiling reveals signatures characterizing histologic subtypes of hepatoblastoma and global deregulation in cell growth and survival pathways. Hum Pathol 2009;40:843–53.CrossRefGoogle ScholarPubMed
Hartmann, W, Kuchler, J, Koch, A, et al. Activation of phosphatidylinositol-3′-kinase/AKT signaling is essential in hepatoblastoma survival. Clin Cancer Res 2009;15:4538–45.CrossRefGoogle ScholarPubMed
Grotegut, S, Kappler, R, Tarimoradi, S, et al. Hepatocyte growth factor protects hepatoblastoma cells from chemotherapy-induced apoptosis by AKT activation. Int J Oncol 2010;36:1261–7.Google ScholarPubMed
Lee, SH, Shin, MS, Lee, JY, et al. In vivo expression of soluble Fas and FAP-1: possible mechanisms of Fas resistance in human hepatoblastomas. J Pathol 1999;188:207–12.3.0.CO;2-8>CrossRefGoogle ScholarPubMed
Eichenmuller, M, Trippel, F, Kreuder, M, et al. The genomic landscape of hepatoblastoma and their progenies with HCC-like features. J Hepatol 2014;61:1312–20.CrossRefGoogle ScholarPubMed
Zhou, S, Venkatramani, R, Gupta, S, et al. Hepatocellular malignant neoplasm, NOS: a clinicopathological study of 11 cases from a single institution. Histopathology 2017;71:813–22.CrossRefGoogle ScholarPubMed
Hiyama, E, Yamaoka, H, Matsunaga, T, et al. High expression of telomerase is an independent prognostic indicator of poor outcome in hepatoblastoma. Br J Cancer 2004;91:972–9.CrossRefGoogle ScholarPubMed
Cancer Genome Atlas Research Network. Comprehensive and integrative genomic characterization of hepatocellular carcinoma. Cell 2017;169:1327–41, e1323.Google Scholar
Haines, K, Sarabia, SF, Alvarez, KR, et al. Characterization of pediatric hepatocellular carcinoma reveals genomic heterogeneity and diverse signaling pathway activation. Pediatr Blood Cancer 2019;66:e27745.CrossRefGoogle ScholarPubMed
Graham, RP, Jin, L, Knutson, DL, et al. DNAJB1-PRKACA is specific for fibrolamellar carcinoma. Mod Pathol 2015;28:822–9.CrossRefGoogle ScholarPubMed
Graham, RP, Lackner, C, Terracciano, L, et al. Fibrolamellar carcinoma in the Carney complex: PRKAR1A loss instead of the classic DNAJB1-PRKACA fusion. Hepatology 2018;68:1441–7.CrossRefGoogle ScholarPubMed
Patel, NR, Salim, AA, Sayeed, H, et al. Molecular characterization of epithelioid haemangioendotheliomas identifies novel WWTR1-CAMTA1 fusion variants. Histopathology 2015;67:699708.CrossRefGoogle ScholarPubMed
Nguyen, R, McCarville, MB, Sykes, A, et al. Rapid decrease of serum alpha-fetoprotein and tumor volume predicts outcome in children with hepatoblastoma treated with neoadjuvant chemotherapy. Int J Clin Oncol 2018;23:900–7.CrossRefGoogle ScholarPubMed
Malogolowkin, MH, Katzenstein, HM, Meyers, RL, et al. Complete surgical resection is curative for children with hepatoblastoma with pure fetal histology: a report from the Children’s Oncology Group. J Clin Oncol 2011;29:3301–6.CrossRefGoogle ScholarPubMed
Aronson, DC, Weeda, VB, Maibach, R, et al. Microscopically positive resection margin after hepatoblastoma resection: what is the impact on prognosis? A Childhood Liver Tumours Strategy Group (SIOPEL) report. Eur J Cancer 2019;106:126–32.CrossRefGoogle ScholarPubMed
Lopez-Terrada, D, Gunaratne, PH, Adesina, AM, et al. Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and Notch pathway activation in DLK+ precursors. Hum Pathol 2009;40:783–94.CrossRefGoogle ScholarPubMed
Li, YC, Deng, YH, Guo, ZH, et al. Prognostic value of hedgehog signal component expressions in hepatoblastoma patients. Eur J Med Res 2010;15:468–74.CrossRefGoogle ScholarPubMed
Cristobal, I, Sanz-Alvarez, M, Luque, M, et al. The role of microRNAs in hepatoblastoma tumors. Cancers 2019;11(3):409.CrossRefGoogle ScholarPubMed
Katzenstein, HM, Langham, MR, Malogolowkin, MH, et al. Minimal adjuvant chemotherapy for children with hepatoblastoma resected at diagnosis (AHEP0731): a Children’s Oncology Group, multicentre, phase 3 trial. Lancet Oncol 2019;20:719–27.CrossRefGoogle ScholarPubMed
Shi, Y, Rojas, Y, Zhang, W, et al. Characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver: a report from the National Cancer Database. Pediatr Blood Cancer 2017;64, e26272.CrossRefGoogle ScholarPubMed
Katzenstein, HM, Furman, WL, Malogolowkin, MH, et al. Upfront window vincristine/irinotecan treatment of high-risk hepatoblastoma: a report from the Children’s Oncology Group AHEP0731 study committee. Cancer 2017;123:2360–7.CrossRefGoogle ScholarPubMed
Liu, Y, Yue, H, Xu, S, et al. First-line gemcitabine and oxaliplatin (GEMOX) plus sorafenib, followed by sorafenib as maintenance therapy, for patients with advanced hepatocellular carcinoma: a preliminary study. Int J Clin Oncol 2015;20:952–9.CrossRefGoogle ScholarPubMed
O’Neill, AF, Towbin, AJ, Krailo, MD, et al. Characterization of pulmonary metastases in Children with hepatoblastoma treated on Children’s Oncology Group Protocol AHEP0731 (The Treatment of Children with All Stages of Hepatoblastoma): a report from the Children’s Oncology Group. J Clin Oncol 2017;35:3465–73.CrossRefGoogle ScholarPubMed
Cruz, RJ Jr., Ranganathan, S, Mazariegos, G, et al. Analysis of national and single-center incidence and survival after liver transplantation for hepatoblastoma: new trends and future opportunities. Surgery 2013;153:150–9.CrossRefGoogle ScholarPubMed
Ramos-Gonzalez, G, LaQuaglia, M, O’Neill, AF, et al. Long-term outcomes of liver transplantation for hepatoblastoma: a single-center 14-year experience. Pediatr Transplant 2018:e13250. doi: 10.1111/petr.13250CrossRefGoogle Scholar
Tan, X, Zhang, J, Wen, Z, et al. Preoperative transcatheter arterial chemoembolization of hepatoblastoma in infants. J Vasc Interv Radiol 2014;25:1029–35.CrossRefGoogle ScholarPubMed
Jiang, Y, Zhou, S, Shen, G, Jiang, H, Zhang, J. Microwave ablation combined with transcatheter arterial chemoembolization is effective for treating unresectable hepatoblastoma in infants and children. Medicine 2018;97:e12607.CrossRefGoogle ScholarPubMed
Trobaugh-Lotrario, AD, Lopez-Terrada, D, Li, P, Feusner, JH. Hepatoblastoma in patients with molecularly proven familial adenomatous polyposis: clinical characteristics and rationale for surveillance screening. Pediatr Blood Cancer 2018;65:e27103.CrossRefGoogle ScholarPubMed
Cho, JH, Lee, YM, Starost, MF, Mansfield, BC, Chou, JY. Gene therapy prevents hepatic tumor initiation in murine glycogen storage disease type Ia at the tumor-developing stage. J Inherit Metab Dis 2019;42:459–69.CrossRefGoogle ScholarPubMed
Xue, F, Shi, S, Zhang, Z, et al. Application of a novel liquid biopsy in patients with hepatocellular carcinoma undergoing liver transplantation. Oncol Lett 2018;15:5481–8.Google ScholarPubMed
Campo, DS, Nayak, V, Srinivasamoorthy, G, Khudyakov, Y. Entropy of mitochondrial DNA circulating in blood is associated with hepatocellular carcinoma. BMC Med Genomics 2019;12:74.CrossRefGoogle ScholarPubMed
D’Avola, D, Villacorta-Martin, C, Martins-Filho, SN, et al. High-density single cell mRNA sequencing to characterize circulating tumor cells in hepatocellular carcinoma. Sci Rep 2018;8:11570.CrossRefGoogle ScholarPubMed
Zhu, J, Warner, E, Parikh, ND, Lubman, DM. Glycoproteomic markers of hepatocellular carcinoma-mass spectrometry based approaches. Mass Spectrom Rev 2019;38:265–90.CrossRefGoogle ScholarPubMed
Molina, L, Bell, D, Tao, J, et al. Hepatocyte-derived lipocalin 2 is a potential serum biomarker reflecting tumor burden in hepatoblastoma. Am J Pathol 2018;188:1895–909.CrossRefGoogle ScholarPubMed
Bei, R, Mizejewski, GJ. Alpha fetoprotein is more than a hepatocellular cancer biomarker: from spontaneous immune response in cancer patients to the development of an AFP-based cancer vaccine. Curr Mol Med 2011;11:564–81.CrossRefGoogle ScholarPubMed
Ortiz, MV, Roberts, SS, Glade Bender, J, Shukla, N, Wexler, LH. Immunotherapeutic targeting of GPC3 in pediatric solid embryoneal tumors. Front Oncol 2019;9:108.CrossRefGoogle ScholarPubMed
Dong, B, Lee, JS, Park, YY, et al. Activating CAR and beta-catenin induces uncontrolled liver growth and tumorigenesis. Nat Commun 2015;6:5944.CrossRefGoogle ScholarPubMed
National Institutes of Health. ClinicalTrials.gov. Available at: https://clinicaltrials.gov/ [last accessed June 30, 2020].Google Scholar
Vij, M, Shanmugam, NP, Reddy, MS, Sankaranarayanan, S, Rela, M. Paediatric hepatocellular carcinoma in tight junction protein 2 (TJP2) deficiency. Virchows Arch 2017;471:679–83.CrossRefGoogle ScholarPubMed
Zhou, S, Hertel, PM, Finegold, MJ, et al. Hepatocellular carcinoma associated with tight-junction protein 2 deficiency. Hepatology 2015;62:1914–16.CrossRefGoogle ScholarPubMed
Erez, A, Shchelochkov, OA, Plon, SE, Scaglia, F, Lee, B. Insights into the pathogenesis and treatment of cancer from inborn errors of metabolism. Am J Hum Genet 2011;88:402–21.CrossRefGoogle ScholarPubMed
Wirojanan, J, Kraff, J, Hawkins, DS, et al. Two boys with fragile x syndrome and hepatic tumors. J Pediatr Hematol Oncol 2008;30:239–41.CrossRefGoogle ScholarPubMed
Castro Narro, GE, Gamboa Dominguez, A, Consuelo Sanchez, A, et al. Combined hepatocellular-cholangiocarcinoma in a patient with cirrhosis due to cholesteryl ester storage disease. Hepatology 2019;69:1838–41.CrossRefGoogle Scholar
Trobaugh-Lotrario, A, Martin, J, Lopez-Terrada, D. Hepatoblastoma in a male with MECP2 duplication syndrome. Am J Med Genet A 2016;170:790–1.CrossRefGoogle Scholar
Wu, JT, Book, L, Sudar, K. Serum alpha fetoprotein (AFP) levels in normal infants. Pediatr Res 1981;15:50–2.CrossRefGoogle ScholarPubMed
Towbin, AJ, Meyers, RL, Woodley, H, et al. 2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT). Pediatr Radiol 2018;48:536–54.Google Scholar

References

Squires, RH, Ng, V, Romero, R, et al. Evaluation of the pediatric patient for liver transplantation: 2014 practice guideline by the American Association for the Study of Liver Diseases, American Society of Transplantation and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Hepatology 2014;60(1):362–98CrossRefGoogle Scholar
Kim, WR, Lake, JR, Smith, JM, et al. OPTN/SRTR 2016 Annual Data Report: Liver. Am J Transplant 2018;18(Suppl. 1):172253CrossRefGoogle ScholarPubMed
Kasai, M, Mochizuki, I, Ohkohchi, N, et al. Surgical limitation for biliary atresia: indication for liver transplantation. J Pediatr Surg 1989;24:851–4.CrossRefGoogle ScholarPubMed
Altman, RP, Lilly, JR, Greenfeld, J, et al. A multivariable risk factor analysis of the portoenterostomy (Kasai) procedure for biliary atresia: twenty-five years of experience from two centers. Ann Surg 1997;226:348–53; discussion 353–5.CrossRefGoogle ScholarPubMed
Otte, JB, de Ville de Goyet, J, Reding, R, et al. Sequential treatment of biliary atresia with Kasai portoenterostomy and liver transplantation: a review. Hepatology 1994;20:41S–8S.Google ScholarPubMed
Kamath, BM, Schwarz, KB, Hadzić, N. Alagille syndrome and liver transplantation. J Pediatr Gastroenterol Nutr 2010;50(1):1115.CrossRefGoogle ScholarPubMed
Perito, ER, Rhee, S, Roberts, JP, Rosenthal, P. Pediatric liver transplantation for urea cycle disorders and organic acidemias: United Network for Organ Sharing data for 2002–2012. Liver Transpl 2014;20(1):8999.CrossRefGoogle ScholarPubMed
Morioka, D, Kasahara, M, Takada, Y, et al. Current role of liver transplantation for the treatment of urea cycle disorders: a review of the worldwide English literature and 13 cases at Kyoto University. Liver Transpl 2005;11:1332–42.CrossRefGoogle Scholar
Sheflin-Findling, S, Annunziato, RA, Chu, J, et al. Liver transplantation for neonatal hemochromatosis: analysis of the UNOS database. Pediatr Transplant 2015;19(2):164–9.CrossRefGoogle ScholarPubMed
Taylor, SA, Whitington, PF. Neonatal acute liver failure. Liver Transpl 2016;22(5):677–85.CrossRefGoogle ScholarPubMed
Rand, EB, Karpen, SJ, Kelly, S, et al. Treatment of neonatal hemochromatosis with exchange transfusion and intravenous immunoglobulin. J Pediatr 2009;155(4):566–71.CrossRefGoogle ScholarPubMed
Narkewicz, MR, Horslen, S, Hardison, RM, et al. A learning collaborative approach increases specificity of diagnosis of acute liver failure in pediatric patients. Clin Gastroenterol Hepatol 2018;16(11):1801–10.CrossRefGoogle ScholarPubMed
Lee, WS, Sokol, RJ. Mitochondrial hepatopathies: advances in genetics, therapeutic approaches, and outcomes. J Pediatr 2013;163(4):942–8.CrossRefGoogle ScholarPubMed
Dimmock, DP, Dunn, JK, Feigenbaum, A, et al. Abnormal neurological features predict poor survival and should preclude liver transplantation in patients with deoxyguanosine kinase deficiency. Liver Transpl 2008;14(10):1480–5.CrossRefGoogle ScholarPubMed
Mindikoglu, AL, King, D, Magder, LS, et al. Valproic acid-associated acute liver failure in children: case report and analysis of liver transplantation outcomes in the United States. J Pediatr 2011;158(5):802–7.CrossRefGoogle ScholarPubMed
Amir, AZ, Ling, SC, Naqvi, A, et al. Liver transplantation for children with acute liver failure associated with secondary hemophagocytic lymphohistiocytosis. Liver Transpl 2016;22(9):1245–53.CrossRefGoogle ScholarPubMed
Dhawan, A, Cheeseman, P, Mieli-Vergani, G. Approaches to acute liver failure in children. Pediatr Transplant 2004;8:584–8.CrossRefGoogle ScholarPubMed
Lee, WS, McKiernan, P, Kelly, DA. Etiology, outcome and prognostic indicators of childhood fulminant hepatic failure in the United Kingdom. J Pediatr Gastroenterol Nutr 2005;40:575–81.CrossRefGoogle ScholarPubMed
Baliga, P, Alvarez, S, Lindblad, A, Zeng, L. Posttransplant survival in pediatric fulminant hepatic failure: the SPLIT experience. Liver Transpl 2004;10:1364–71CrossRefGoogle ScholarPubMed
Ng, VL, Li, R, Loomes, KM, Leonis, MA, et al. Outcomes of children with and without hepatic encephalopathy from the Pediatric Acute Liver Failure Study Group. J Pediatr Gastroenterol Nutr 2016;63(3):357–64.CrossRefGoogle ScholarPubMed
Rivera-Penera, T, Moreno, J, Skaff, C, et al. Delayed encephalopathy in fulminant hepatic failure in the pediatric population and the role of liver transplantation. J Pediatr Gastroenterol Nutr 1997;24:128–34.CrossRefGoogle ScholarPubMed
Trobaugh-Lotrario, AD, Meyers, RL, Tiao, GM, Feusner, JH. Pediatric liver transplantation for hepatoblastoma. Transl Gastroenterol Hepatol 2016;20(1):44.CrossRefGoogle Scholar
Palaniappan, K, Borkar, VV, Safwan, M, Vij, M, et al. Pediatric hepatocellular carcinoma in a developing country: is the etiology changing? Pediatr Transplant 2016;20(7):898903.CrossRefGoogle Scholar
Baiges, A, Turon, F, Simón-Talero, M, et al. Congenital extrahepatic portosystemic shunts (Abernethy malformation): an international observational study. Hepatology 2019. doi: 10.1002/hep.30817 [Epub ahead of print].CrossRefGoogle Scholar
Khanna, R, Kumar Verma, S. Pediatric hepatocellular carcinoma. World J Gastroenterol 2018;24(35):3980–99.CrossRefGoogle ScholarPubMed
Mazzaferro, V, Coppa, Sposito C J, et. al. The long-term benefit of liver transplantation for hepatic metastases from neuroendocrine tumors. Am J Transplant 2016;16(10):2892–902.Google Scholar
Organ Procurement and Transplantation Network. OPTN Policies. Available at: https://optn.transplant.hrsa.gov/media/1200/optn_policies.pdf#nameddest=Policy_09 [last accessed June 30, 2020].Google Scholar
Organ Procurement and Transplantation Network. Guidance for Pediatric MELD. Available at: https://optn.transplant.hrsa.gov/media/2848/liver_guidance_pediatric_meld_201706.pdf [last accessed June 30, 2020].Google Scholar
Freeman, AJ, Sellers, ZM, Mazariegos, G, et al. A multidisciplinary approach to pretransplant and posttransplant management of cystic fibrosis-associated liver disease. Liver Transpl 2019;25(4):640–57.CrossRefGoogle ScholarPubMed
Dowman, JK, Watson, D, Loganathan, S, et al. Long-term impact of liver transplantation on respiratory function and nutritional status in children and adults with cystic fibrosis. Am J Transplant 2012;12:954–64.CrossRefGoogle ScholarPubMed
Organ Procurement and Transplantation Network. OPTN policies national liver review board. Available at: https://optn.transplant.hrsa.gov/media/2197/policy-notice-july-2017-national-liver-review-board.pdf [last accessed June 30, 2020].Google Scholar
Heffron, TG, Pillen, T, Smallwood, G, et al. Liver retransplantation in children: the Atlanta experience. Pediatr Transplant 2010;14(3):417–25.CrossRefGoogle ScholarPubMed
Freeman, RB Jr., Edwards, EB. Liver transplant waiting time does not correlate with waiting list mortality: implications for liver allocation policy. Liver Transpl 2000;6:543–52.CrossRefGoogle Scholar
Organ Procurement and Transplantation NetworkHRSA. Final rule with comment period. Fed Regist 1998;63:16296–338.Google Scholar
Freeman, RB Jr., Wiesner, RH, Roberts, JP, et al. Improving liver allocation: MELD and PELD. Am J Transplant 2004;4(Suppl. 9):114–31.CrossRefGoogle ScholarPubMed
Biggins, SW, Rodriguez, HJ, Bacchetti, P, et al. Serum sodium predicts mortality in patients listed for liver transplantation. Hepatology 2005;41(1):32–9.CrossRefGoogle ScholarPubMed
Carey, RG, Bucuvalas, JC, Balistreri, WF, et al. Hyponatremia increases mortality in pediatric patients listed for liver transplantation. Pediatr Transplant 2010;14(1):115–20.CrossRefGoogle ScholarPubMed
Organ Procurement and Transplantation Network. MELD serum sodium policy changes-OPTN. Available at: https://optn.transplant.hrsa.gov/news/meld-serum-sodium-policy-changes/ [last accessed June 30, 2020].Google Scholar
Hsu, EK, Shaffer, ML, Gao, L, et al. Analysis of liver offers to pediatric candidates on the transplant list. Gastroenterology 2017;153(4):988–95.CrossRefGoogle Scholar
Alexopoulos, SP, Nekrasov, V, Cao, S, et al. Effects of recipient size and allograft type on pediatric liver transplantation for biliary atresia. Liver Transpl 2017;23(2):221–33.CrossRefGoogle ScholarPubMed
Strong, RW, Lynch, SV, Ong, TH, et al. Successful liver transplantation from a living donor to her son. N Engl J Med 1990;322:1505–7.CrossRefGoogle ScholarPubMed
Adam, R, Karam, V, Cailliez, V, et al. 2018 Annual Report of the European Liver Transplant Registry (ELTR) – 50-year evolution of liver transplantation. Transpl Int 2018;31(12):1293–317.CrossRefGoogle ScholarPubMed
Kasahara, M, Umeshita, K, Sakamoto, S, et al. Living donor liver transplantation for biliary atresia: an analysis of 2085 cases in the registry of the Japanese Liver Transplantation Society. Am J Transplant 2018;18(3):659–68.CrossRefGoogle ScholarPubMed
Yoo, PS, Olthoff, KM, Abt, PL. Donation after cardiac death in pediatric organ transplantation. Curr Opin Organ Transplant 2011;16(5):483–8.CrossRefGoogle ScholarPubMed
van Rijn, R, Hoogland, PER, Lehner, F, et al. Long-term results after transplantation of pediatric liver grafts from donation after circulatory death donors. PLoS One 2017;12(4):e0175097.CrossRefGoogle ScholarPubMed
Urata, K, Kawasaki, S, Matsunami, H, et al. Calculation of child and adult standard liver volume for liver transplantation. Hepatology 1995;21:1317–21.CrossRefGoogle ScholarPubMed
Dahm, F, Georgiev, P, Clavien, PA. Small-for-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications. Am J Transplant 2005;5:2605–10.CrossRefGoogle ScholarPubMed
Kiuchi, T, Kasahara, M, Uryuhara, K, Inomata, Y, Uemoto, S, Asonuma, K, et al. Impact of graft size mismatching on graft prognosis in liver transplantation from living donors. Transplantation 1999;67:321–7.CrossRefGoogle ScholarPubMed
Morimoto, T, Ichimiya, M, Tanaka, A, et al. Guidelines for donor selection and an overview of the donor operation in living related liver transplantation. Transpl Int 1996;9:208–13.CrossRefGoogle Scholar
Cuende, N, Miranda, B, Cañón, JF, et al. Donor characteristics associated with liver graft survival. Transplantation 2005;79(10):1445–52.CrossRefGoogle ScholarPubMed
Spitzer, AL, Lao, OB, Dick, AA, et al. The biopsied donor liver: incorporating macrosteatosis into high-risk donor assessment. Liver Transpl 2010;16(7):874–84.CrossRefGoogle ScholarPubMed
Organ Procurement and Transplantation Network. Guidance for the Informed Consent of Living Donors. Available at: https://optn.transplant.hrsa.gov/resources/guidance/guidance-for-the-informed-consent-of-living-donors/ [last accessed June 30, 2020].Google Scholar
Goldaracena, N, Jung, J, Aravinthan, AD, et al. Donor Outcomes in Anonymous Live Liver Donation. J Hepatol 2019;71(5):951–9.CrossRefGoogle ScholarPubMed
Przybyszewski, EM, Verna, EC, Lobritto, SJ, Martinez, M, Vittorio, JM, Fox, AN, Samstein, B, Kato, T, Griesemer, AD, Emond, JC. Durable clinical and immunologic advantage of living donor liver transplantation in children. Transplantation 2018;102(6):953–60.Google ScholarPubMed
Knaak, M, Goldaracena, N, Doyle, A, et al. Donor BMI >30 is not a contraindication for live liver donation. Am J Transplant 2017;17(3):754–60.CrossRefGoogle Scholar
Miller, CM, Durand, F, Heimbach, JK, et al. The International Liver Transplant Society Guideline on Living Liver Donation. Transplantation 2016;100(6):1238–43.CrossRefGoogle ScholarPubMed
Ryckman, FC, Flake, AW, Fisher, RA, et al. Segmental orthotopic hepatic transplantation as a means to improve patient survival and diminish waiting-list mortality. J Pediatr Surg 1991;26:422–7; discussion 427–8.CrossRefGoogle ScholarPubMed
Rodriguez-Davalos, MI, Arvelakis, A, Umman, V, et al. Segmental grafts in adult and pediatric liver transplantation: improving outcomes by minimizing vascular complications. JAMA Surg 2014;149(1):6370.CrossRefGoogle ScholarPubMed
Organ Procurement and Transplantation Network. Ethics - split versus whole liver transplantation. Available at: https://optn.transplant.hrsa.gov/resources/ethics/split-versus-whole-liver-transplantation/ [last accessed June 30, 2020].Google Scholar
Vulchev, A, Roberts, JP, Stock, PG. Ethical issues in split versus whole liver transplantation. Am J Transplant 2004;4:1737–40.CrossRefGoogle ScholarPubMed
Mogul, DB, Luo, X, Bowring, MG, Chow, EK, Massie, AB, Schwarz, KB, Cameron, AM, Bridges, JFP, Segev, DL. Fifteen-year trends in pediatric liver transplants: split, whole deceased, and living donor grafts. J Pediatr 2018;196:148–53.Google ScholarPubMed
Govil, S, Shanmugam, NP, Reddy, MS, et al. A metabolic chimera: two defective genotypes make a normal phenotype. Liver Transpl 2015;21(11):1453–4.CrossRefGoogle ScholarPubMed
Rela, M, Kaliamoorthy, I, Reddy, MS. Current status of auxiliary partial orthotopic liver transplantation for acute liver failure. Liver Transpl 2016;22(9):1265–74.CrossRefGoogle ScholarPubMed
Squires, JE, Soltys, KA, McKiernan, P, et al. Clinical hepatocyte transplantation: what is next? Curr Transplant Rep 2017;4(4):280–9.Google ScholarPubMed
Ryckman, FC, Fisher, RA, Pedersen, SH, Balistreri, WF. Liver transplantation in children. Semin Pediatr Surg 1992;1:162–72.Google ScholarPubMed
Otte, JB, de Ville de Goyet, J, Sokal, E, et al. Size reduction of the donor liver is a safe way to alleviate the shortage of size-matched organs in pediatric liver transplantation. Ann Surg 1990;211:146–57.CrossRefGoogle ScholarPubMed
Emre, S, Umman, V, Cimsit, B, Rosencrantz, R. Current concepts in pediatric liver transplantation. Mt Sinai J Med 2012;79(2):199213.Google ScholarPubMed
Tannuri, U, Mello, ES, Carnevale, FC, et al. Hepatic venous reconstruction in pediatric living-related donor liver transplantation – experience of a single center. Pediatr Transplant 2005;9:293–8.CrossRefGoogle ScholarPubMed
Heffron, TG, Pillen, T, Smallwood, G, et al. Incidence, impact, and treatment of portal and hepatic venous complications following pediatric liver transplantation: a single-center 12 year experience. Pediatr Transplant 2010;14(6):722–9.CrossRefGoogle ScholarPubMed
Marwan, IK, Fawzy, AT, Egawa, H, et al. Innovative techniques for and results of portal vein reconstruction in living-related liver transplantation. Surgery 1999;125(3):265–70.CrossRefGoogle ScholarPubMed
Inomoto, T, Nishizawa, F, Sasaki, H, et al. Experiences of 120 microsurgical reconstructions of hepatic artery in living related liver transplantation. Surgery 1996;119:20–6.CrossRefGoogle ScholarPubMed
Guarrera, JV, Sinha, P, Lobritto, SJ, et al. Microvascular hepatic artery anastomosis in pediatric segmental liver transplantation: microscope vs loupe. Transpl Int 2004;17:585–8.CrossRefGoogle ScholarPubMed
Gondolesi, GE. Role for biological meshes for delayed abdominal wall closure after pediatric liver transplantation? Pediatr Transplant 2014;18(6):554–5.CrossRefGoogle ScholarPubMed

References

Iinuma, Y, Senda, K, Fujihara, N, Saito, T, Takakura, S, Kudo, T, et al. Surgical site infection in living-donor liver transplant recipients: a prospective study. Transplantation 2004;78(5):704–9.CrossRefGoogle ScholarPubMed
Kawecki, D, Chmura, A, Pacholczyk, M, Lagiewska, B, Adadynski, L, Wasiak, D, et al. Bacterial infections in the early period after liver transplantation: etiological agents and their susceptibility. Med Sci Monit 2009;15(12):CR62837.Google ScholarPubMed
Shepherd, RW, Turmelle, Y, Nadler, M, Lowell, JA, Narkewicz, MR, McDiarmid, SV, et al. Risk factors for rejection and infection in pediatric liver transplantation. Am J Transplant 2008;8(2):396403.CrossRefGoogle ScholarPubMed
Danziger-Isakov, L, Bucavalas, J. Current Prevention Strategies Against Cytomegalovirus in the Studies in Pediatric Liver Transplantation (SPLIT) Centers. AJT 2014;14(8):1908–11.Google ScholarPubMed
Urschel, S, Altamirano-Diaz, LA, West, LJ. Immunosuppression armamentarium in 2010: mechanistic and clinical considerations. Pediatr Clin North Am 2010;57(2):433–57.CrossRefGoogle ScholarPubMed
Wiesner, RH, Demetris, AJ, Belle, SH, Seaberg, EC, Lake, JR, Zetterman, RK, et al. Acute hepatic allograft rejection: incidence, risk factors, and impact on outcome. Hepatology 1998;28(3):638–45.CrossRefGoogle Scholar
Feng, S. Long-term management of immunosuppression after pediatric liver transplantation: is minimization or withdrawal desirable or possible or both? Curr Opin Organ Transplant 2008;13(5):506–12.CrossRefGoogle ScholarPubMed
Miloh, T, Barton, A, Wheeler, J, Pham, Y, Hewitt, W, Keegan, T, et al. Immunosuppression in pediatric liver transplant recipients: unique aspects. Liver Transpl 2017;23(2):244–56.CrossRefGoogle ScholarPubMed
Alonso, EM, Piper, JB, Echols, G, Thistlethwaite, JR, Whitington, PF. Allograft rejection in pediatric recipients of living related liver transplants. Hepatology 1996;23(1):40–3.CrossRefGoogle ScholarPubMed
Ng, VL, Alonso, EM, Bucuvalas, JC, Cohen, G, Limbers, CA, Varni, JW, et al. Health status of children alive 10 years after pediatric liver transplantation performed in the US and Canada: report of the studies of pediatric liver transplantation experience. J Pediatr 2012;160(5):820–6, e3.CrossRefGoogle ScholarPubMed
Ng, VL, Fecteau, A, Shepherd, R, Magee, J, Bucuvalas, J, Alonso, E, et al. Outcomes of 5-year survivors of pediatric liver transplantation: report on 461 children from a North American multicenter registry. Pediatrics 2008;122(6):e1128–35.CrossRefGoogle ScholarPubMed
Ekong, UD, Bhagat, H, Alonso, EM. Once daily calcineurin inhibitor monotherapy in pediatric liver transplantation. Am J Transplant 2010;10(4):883–8.CrossRefGoogle ScholarPubMed
Lin, HC, Melin-Aldana, H, Mohammad, S, Ekong, UD, Alonso, EM. Extended follow-up of pediatric liver transplantation patients receiving once daily calcineurin inhibitor. Pediatr Transplant 2015;19(7):709–15.CrossRefGoogle ScholarPubMed
Feng, S, Bucuvalas, J. Tolerance after liver transplantation: Where are we? Liver Transpl 2017;23(12):1601–14.CrossRefGoogle Scholar
Gladdy, RA, Richardson, SE, Davies, HD, Superina, RA. Candida infection in pediatric liver transplant recipients. Liver Transplant Surg 1999;5(1):1624.CrossRefGoogle ScholarPubMed
Nafady-Hego, H, Elgendy, H, Moghazy, WE, Fukuda, K, Uemoto, S. Pattern of bacterial and fungal infections in the first 3 months after pediatric living donor liver transplantation: an 11-year single-center experience. Liver Transpl 2011;17(8):976–84.CrossRefGoogle Scholar
McDiarmid, SV, Anand, R, Martz, K, Millis, MJ, Mazariegos, G. A multivariate analysis of pre-, peri-, and post-transplant factors affecting outcome after pediatric liver transplantation. Ann Surg. 2011, 254(1):145–54.CrossRefGoogle Scholar
Narkewicz, MR, Green, M, Dunn, S, Millis, M, McDiarmid, S, Mazariegos, G, et al. Decreasing incidence of symptomatic Epstein-Barr virus disease and posttransplant lymphoproliferative