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7 - Bioactive nanofibers

Published online by Cambridge University Press:  05 July 2014

Frank K. Ko
Affiliation:
University of British Columbia, Vancouver
Yuqin Wan
Affiliation:
University of British Columbia, Vancouver
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Summary

The development of biomaterials

A biomaterial has been defined by Hench and Erthridge as a synthetic material used to replace a part or a function of the body in a safe, reliable, economic and physiologically acceptable manner. The Celmson University Advisory Board for Biomaterials has formally defined a biomaterial to be “a systemically and pharmacologically inert substance designed for implantation within or in a medical device, intended to interact with biological systems.” Biomaterials have been widely used in many areas, including replacement of damaged parts (artificial hip), assisting in healing (sutures), improving biological functions (pacemaker, contact lens), correcting abnormalities (spinal rods), cosmetics (augmentation mammoplasty), aiding diagnoses (probes) and aiding treatment (catheters). A material is considered biocompatible if it causes no irritation, allergic or toxic responses when used in a biological system [1]. Table 7.1 provides some examples of biomaterials used in the body.

Biotechnology and nanotechnology are the two of twenty-first century's most promising technologies. Convergence of these two technologies is expected to create innovations and play a vital role in various biomedical applications. The symposium in 2000 entitled “Nanoscience and Technology: Shaping Biomedical Research” held by the National Institutes of Health Bioengineering Consortium (BECON) addressed eight areas of nanoscience and nanotechnology, which include synthesis and use of nanostructures, applications of nanotechnology to therapy, biomimetic and biologic nanostructures, electronic–biology interface, devices for early detection of disease, tools for the study of single molecules, nanotechnology and tissue engineering [2].

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Publisher: Cambridge University Press
Print publication year: 2014

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References

Park, J., and Bronzino, J., Biomaterials: Principles and Applications. Boca Raton, FL: CRC Press, 2003.Google Scholar
Ernest, H., and Shetty, R., “Impact of nanotechnology on biomedical sciences: review of current concepts on convergence of nanotechnology with biology,” Tissue Engineering, vol. 18, p. 19, 2005.Google Scholar
Hench, L. L., and Polak, J. M., “Third-generation biomedical materials,” Science, vol. 295(5557), pp. 1014–1017, 2002.CrossRefGoogle ScholarPubMed
Flemming, R., et al., “Effects of synthetic micro- and nano-structured surfaces on cell behavior,” Biomaterials, vol. 20(6), pp. 573–588, 1999.CrossRefGoogle ScholarPubMed
Desai, T., “Micro- and nanoscale structures for tissue engineering constructs,” Medical Engineering and Physics, vol. 22(9), pp. 595–606, 2000.CrossRefGoogle ScholarPubMed
Curtis, A., and Wilkinson, C., “Nanotechniques and approaches in biotechnology,” Materials Today, vol. 4(3), pp. 22–28, 2001.CrossRefGoogle Scholar
Zhang, Y., et al., “Recent development of polymer nanofibers for biomedical and biotechnological applications,” Journal of Materials Science: Materials in Medicine, vol. 16(10), pp. 933–946, 2005.Google ScholarPubMed
Gerardo-Nava, J., et al., “Human neural cell interactions with orientated electrospun nanofibers in vitro,” Nanomedicine, vol. 4(1), pp. 11–30, 2009.CrossRefGoogle ScholarPubMed
Zhang, Y., et al., “Recent development of polymer nanofibers for biomedical and biotechnological applications,” Journal of Materials Science: Materials in Medicine, vol. 16(10), pp. 933–946, 2005.Google ScholarPubMed
Skalak, R., Fox, C. F., and Fung, Y. C.. “Preface,” in Tissue Engineering, in NSF Workshop on Tissue Engineering. Lake Tahoe, California: Granlibakken, 1988.Google Scholar
Langer, R., and Vacanti, J. P., “Tissue engineering,” Science, vol. 260(5110), pp. 920–926, 1993.CrossRefGoogle ScholarPubMed
Dvir, T., et al., “Nanotechnological strategies for engineering complex tissues,” Nat Nano, vol. 6(1), pp. 13–22, 2011.CrossRefGoogle ScholarPubMed
Li, W. J., et al., “Electrospun nanofibrous structure: a novel scaffold for bioengineering,” Journal of Biomedical Materials Research, vol. 58, pp. 613–621, 2002.CrossRefGoogle Scholar
Ko, F. K., and Gandhi, M., Producing Nanofiber Structures by Electrospinning for Tissue Engineering, Brown, P. J. and Stevens, K., Ed. Woodhead Publishing, 2007.Google Scholar
Laurencin, C., et al., “Tissue engineering: orthopedic applications,” Annual Review of Biomedical Engineering, vol. 1(1), pp. 19–46, 1999.CrossRefGoogle ScholarPubMed
Zhang, R., and Ma, P., “Synthetic nano-fibrillar extracellular matrices with predesigned macroporous architectures,” Journal of Biomedical Materials Research, vol. 52(2), pp. 430–438, 2000.3.0.CO;2-L>CrossRefGoogle ScholarPubMed
Ma, P. X., “Biomimetic materials for tissue engineering,” Advanced Drug Delivery Reviews, vol. 60(2), pp. 184–198, 2008.CrossRefGoogle ScholarPubMed
Khil, M.-S., et al., “Novel fabricated matrix via electrospinning for tissue engineering,” Journal of Biomedical Materials Research, vol. 72B(1), pp. 117–124, 2005.CrossRefGoogle Scholar
Venugopal, J., Zhang, Y., and Ramakrishna, S., “In vitro culture of human dermal fibroblasts on electrospun polycaprolactone collagen nanofibrous membrane,” Artificial Organs, vol. 30(6), pp. 440–446, 2006.CrossRefGoogle ScholarPubMed
Leung, V., and Ko, F., “Biomedical applications of nanofibers,” Polymers for Advanced Technologies, vol. 22(3), pp. 350–365, 2011.CrossRefGoogle Scholar
Greiner, A., et al., “Biohybrid nanosystems with polymer nanofibers and nanotubes,” Applied Microbiology and Biotechnology, vol. 71(4), pp. 387–393, 2006.CrossRefGoogle ScholarPubMed
Li, M., et al., “Electrospun protein fibers as matrices for tissue engineering,” Biomaterials, vol. 26, pp. 5999–6008, 2005.CrossRefGoogle ScholarPubMed
Li, J., et al., “Preparation and biodegradation of electrospun PLLA/keratin nonwoven fibrous membrane,” Polymer Degradation and Stability, vol. 94(10), pp. 1800–1807, 2009.CrossRefGoogle Scholar
Yuan, J., Shen, J., and Kang, I., “Fabrication of protein-doped PLA composite nanofibrous scaffolds for tissue engineering,” Polymer International, vol. 57(10), pp. 1188–1193, 2008.CrossRefGoogle Scholar
Jose, M. V., et al., “Aligned PLGA/HA nanofibrous nanocomposite scaffolds for bone tissue engineering,” Acta Biomaterialia, vol. 5, pp. 305–315, 2009.CrossRefGoogle ScholarPubMed
Nie, H., et al., “BMP-2 plasmid loaded PLGA/HAp composite scaffolds for treatment of bone defects in nude mice,” Biomaterials, vol. 30(5), pp. 892–901, 2009.CrossRefGoogle ScholarPubMed
Price, R. L., et al., “Selective bone cell adhesion on formulations containing carbon nanofibers,” Biomaterials, vol. 24(11), pp. 1877–1887, 2003.CrossRefGoogle ScholarPubMed
Chung, T. W., et al., “Preparation of alginate/galactosylated chitosan scaffold for hepatocyte attachment,” Biomaterials, vol. 23(14), pp. 2827–2834, 2002.CrossRefGoogle ScholarPubMed
Chu, X. H., et al., Chitosan nanofiber scaffold enhances hepatocyte adhesion and function,” Biotechnology Letters, vol. 31, pp. 347–352, 2009.CrossRefGoogle ScholarPubMed
Chua, K. N., et al., “Stable immobilization of rat hepatocyte spheroids on glactosylated nanofiber scaffold,” Biomaterials, vol. 26, pp. 2537–2547, 2005.CrossRefGoogle Scholar
Xie, J., et al., “The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages,” Biomaterials, vol. 30, pp. 354–362, 2009.CrossRefGoogle ScholarPubMed
Yang, F., et al., “Electrospinning of nano/micro scale poly (l-lactic acid) aligned fibers and their potential in neural tissue engineering,” Biomaterials, vol. 26, pp. 2603–2610, 2005.CrossRefGoogle ScholarPubMed
Xu, C., et al., “Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering,” Biomaterials, vol. 25(5), pp. 877–886, 2004.CrossRefGoogle ScholarPubMed
Vaz, C., et al., “Design of scaffolds for blood vessel tissue engineering using a multi-layering electrospinning technique,” Acta Biomaterialia, vol. 1(5), pp. 575–582, 2005.CrossRefGoogle ScholarPubMed
Ko, F. K., “Fabrics,” in Encyclopedia of Biomaterials and Biomedical Engineering, Wnek, G. E. and Bowlin, G. L., Ed. Marcel Dekker, 2005.Google Scholar
Ko, F. K., “Preform architecture for ceramic matrix composites,” American Ceramic Society Bulletin, vol. 68(2), pp. 401–414, 1989.Google Scholar
Ko, F. K., “Medical applications for textile structures,” in Textile Asia, 1997.
Gonsalves, K. E., et al., Ed. Biomedical Nanostructures. John Wiley & Sons, 2008.Google Scholar
Xie, J., and Wang, C., “Electrospun micro- and nanofibers for sustained delivery of paclitaxel to treat C6 glioma in vitro,” Pharmaceutical Research, vol. 23(8), pp. 1817–1826, 2006.CrossRefGoogle ScholarPubMed
Huang, Z.-M., et al., “Encapsulating drugs in biodegradable ultrafine fibers through co-axial electrospinning,” Journal of Biomedical Materials Research Part A, vol. 77A(1), pp. 169–179, 2006.CrossRefGoogle Scholar
Ramakrishna, S., et al., “Electrospun nanofibers: solving global issues,” Materials Today, vol. 9(3), pp. 40–50, 2006.CrossRefGoogle Scholar
Tan, S., et al., “Biocompatible and biodegradable polymer nanofibers displaying superparamagnetic properties,” ChemPhysChem, vol. 6(8), pp. 1461–1465, 2005.CrossRefGoogle ScholarPubMed
Nakamura, H., and Karube, I., “Current research activity in biosensors,” Analytical and Bioanalytical Chemistry, vol. 377(3), pp. 446–468, 2003.CrossRefGoogle ScholarPubMed
Kossek, S., Padeste, C., and Tiefenauer, L., “Immobilization of streptavidin for immunosensors on nanostructured surfaces,” Journal of Molecular Recognition, vol. 9(5–6), pp. 485–487, 1996.3.0.CO;2-R>CrossRefGoogle ScholarPubMed
Méallet-Renault, R., Denjean, P., and Pansu, R., “Polymer beads as nano-sensors,” Sensors and Actuators B: Chemical, vol. 59(2–3), pp. 108–112, 1999.CrossRefGoogle Scholar
Lu, Y., Weng, L., and Cao, X., “Morphological, thermal and mechanical properties of ramie crystallites–reinforced plasticized starch biocomposites,” Carbohydrate Polymers, vol. 63(2), pp. 198–204, 2006.CrossRefGoogle Scholar
Ren, G., et al., “Electrospun poly (vinyl alcohol)/glucose oxidase biocomposite membranes for biosensor applications,” Reactive and Functional Polymers, vol. 66(12), pp. 1559–1564, 2006.CrossRefGoogle Scholar
Ding, B., et al., “Electrospun nanofibrous membranes coated quartz crystal microbalance as gas sensor for NH3 detection,” Sensors and Actuators B: Chemical, vol. 101(3), pp. 373–380, 2004.CrossRefGoogle Scholar
Kessick, R., and Tepper, G., “Electrospun polymer composite fiber arrays for the detection and identification of volatile organic compounds,” Sensors and Actuators B: Chemical, vol. 117(1), pp. 205–210, 2006.CrossRefGoogle Scholar
Wang, M., et al., “Electrospinning of silica nanochannels for single molecule detection,” Applied Physics Letters, vol. 88, p. 033106, 2006.CrossRefGoogle Scholar
Flueckiger, J., Ko, F. K., and Cheung, K. C., “Electrospun electroactive polymer and metal oxide nanofibers for chemical sensor applications,” in Proceedings of the ASME 2010 International Mechanical Engineering Congress & Exposition, 2010.
Wu, L., and Ding, J., “In vitro degradation of three-dimensional porous poly(-lactide-co-glycolide) scaffolds for tissue engineering,” Biomaterials, vol. 25(27), pp. 5821–5830, 2004.CrossRefGoogle ScholarPubMed
Kim, K., et al., “Control of degradation rate and hydrophilicity in electrospun non-woven poly (d, l-lactide) nanofiber scaffolds for biomedical applications,” Biomaterials, vol. 24(27), pp. 4977–4985, 2003.CrossRefGoogle ScholarPubMed
Ratner, B., et al., Biomaterials Science: an Introduction to Materials in Medicine. Elsevier Academic Press, 2004.Google Scholar

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  • Bioactive nanofibers
  • Frank K. Ko, University of British Columbia, Vancouver, Yuqin Wan, University of British Columbia, Vancouver
  • Book: Introduction to Nanofiber Materials
  • Online publication: 05 July 2014
  • Chapter DOI: https://doi.org/10.1017/CBO9781139021333.008
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  • Bioactive nanofibers
  • Frank K. Ko, University of British Columbia, Vancouver, Yuqin Wan, University of British Columbia, Vancouver
  • Book: Introduction to Nanofiber Materials
  • Online publication: 05 July 2014
  • Chapter DOI: https://doi.org/10.1017/CBO9781139021333.008
Available formats
×

Send book to Google Drive

To send content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Google Drive.

  • Bioactive nanofibers
  • Frank K. Ko, University of British Columbia, Vancouver, Yuqin Wan, University of British Columbia, Vancouver
  • Book: Introduction to Nanofiber Materials
  • Online publication: 05 July 2014
  • Chapter DOI: https://doi.org/10.1017/CBO9781139021333.008
Available formats
×