Book contents
- Hormones, Cognition and Dementia
- Hormones, Cognition and Dementia
- Copyright page
- Contents
- Contributors
- Preface
- Section 1 Estrogens and cognition: perspectives and opportunities in the wake of the Women's Health Initiative Memory Study
- Section 2 Varieties of estrogenic therapy
- Section 3 Potential modulators and modifiers of estrogenic effects
- Section 4 Possible genetic factors related to hormone treatment effects
- Section 5 Testosterone, estradiol and men, and sex hormone binding globulin
- Chapter 19 Androgens and cognitive functioning in women
- Chapter 20 The role of estradiol in testosterone treatment
- Chapter 21 Endogenous testosterone levels and cognitive aging in men
- Chapter 22 Clinical trials and neuroimaging studies of testosterone in men: insights into effects on verbal memory
- Chapter 23 Testosterone therapy and Alzheimer's disease: potential for treatment and prevention in women
- Chapter 24 Endogenous estradiol and dementia in elderly men: the roles of vascular risk, sex hormone binding globulin, and aromatase activity
- Chapter 25 Testosterone regulates Alzheimer's disease pathogenesis
- Section 6 Gonadotropin effects
- Index
- Plate Section
Chapter 25 - Testosterone regulates Alzheimer's disease pathogenesis
from Section 5 - Testosterone, estradiol and men, and sex hormone binding globulin
Published online by Cambridge University Press: 06 July 2010
- Hormones, Cognition and Dementia
- Hormones, Cognition and Dementia
- Copyright page
- Contents
- Contributors
- Preface
- Section 1 Estrogens and cognition: perspectives and opportunities in the wake of the Women's Health Initiative Memory Study
- Section 2 Varieties of estrogenic therapy
- Section 3 Potential modulators and modifiers of estrogenic effects
- Section 4 Possible genetic factors related to hormone treatment effects
- Section 5 Testosterone, estradiol and men, and sex hormone binding globulin
- Chapter 19 Androgens and cognitive functioning in women
- Chapter 20 The role of estradiol in testosterone treatment
- Chapter 21 Endogenous testosterone levels and cognitive aging in men
- Chapter 22 Clinical trials and neuroimaging studies of testosterone in men: insights into effects on verbal memory
- Chapter 23 Testosterone therapy and Alzheimer's disease: potential for treatment and prevention in women
- Chapter 24 Endogenous estradiol and dementia in elderly men: the roles of vascular risk, sex hormone binding globulin, and aromatase activity
- Chapter 25 Testosterone regulates Alzheimer's disease pathogenesis
- Section 6 Gonadotropin effects
- Index
- Plate Section
Summary
As aging is associated with decreased estradiol production in women, so is aging associated with decreased testosterone production in men. In this chapter, Pike and Rosario review novel and compelling data indicating testosterone regulation of β-amyloid production in the brain, as well as significant associations between low testosterone levels and risk for Alzheimer's-related dementia in men. Based on these data and on the various mechanisms by which testosterone can exert neuroprotective effects in brain, the authors conclude that low testosterone is a likely risk factor for Alzheimer's-related dementia in men. Their analysis points out the need for research focusing on the development of brain-selective androgen receptor modulators (SARMs) for use in the prevention of Alzheimer's disease (AD) in men.
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- Hormones, Cognition and DementiaState of the Art and Emergent Therapeutic Strategies, pp. 242 - 250Publisher: Cambridge University PressPrint publication year: 2009
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