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Chapter 23 - Autotransplantation of Cryopreserved Ovarian Tissue

Techniques and Results

from Section 7 - Ovarian Cryopreservation and Transplantation

Published online by Cambridge University Press:  27 March 2021

By
Jacques Donnez ,
Diego D Manavella  and
Marie-Madeleine Dolmans
Edited by
Jacques Donnez  and
S. Samuel Kim
Jacques Donnez
Affiliation:
Catholic University of Louvain, Brussels
S. Samuel Kim
Affiliation:
University of Kansas School of Medicine
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Summary

Fertility preservation is now recognized as the most essential quality of life issue in young cancer survivors. Since the last decade several strategies to preserve fertility in women have been developed and applied clinically (although some are still experimental). Ovarian tissue cryobanking is currently perceived as a promising technology for fertility preservation which draws enormous attention not only from scientific communities but also from the general public. Ovarian tissue cryopreservation followed by transplantation has proven to be very successful not only in many animals but also in humans. Indeed, we have accumulated enough data since 2004 that ovarian transplantation can restore fertility in women. As of 2018, approximately 130 healthy babies have been born worldwide after transplantation of frozen-thawed ovarian tissue [1–9].

Type
Chapter
Information
Fertility Preservation
Principles and Practice
 , pp. 260 - 272
Publisher: Cambridge University Press
Print publication year: 2021

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References

Siegel, RL, Miller, KD, Jemal, A. Cancer statistics, 2018. CA: A Cancer J Clin, 2018;68:7–30.Google Scholar
Burns, KC, Hoefgen, H, Strine, A, Dasgupta, R. Fertility preservation options in pediatric and adolescent patients with cancer. Cancer, 2018;124:1867–1876.Google Scholar
Wallace, WH, Thomson, A, Kelsey, TW. The radiosensitivity of the human oocyte. Hum Reprod, 2003;18:117–121.Google Scholar
Wallace, WH, Anderson, RA, Irvine, DS. Fertility preservation for young patients with cancer: who is at risk and what can be offered? Lancet Oncol, 2005;6:209–18.Google Scholar
Meirow, D, Biederman, H, Anderson, RA, Wallace, WH. Toxicity of chemotherapy and radiation on female reproduction. Clin Obst Gynecol, 2010;53:727–739.Google Scholar
Meirow, D, Nugent, D. The effects of radiotherapy and chemotherapy on female reproduction. Hum Reprod Update, 2001;7:535–543.Google Scholar
Donnez, J, Dolmans, MM. Fertility preservation in women. Nat Rev Endocrinol, 2013;9:735–749.Google Scholar
Donnez, J, Dolmans, M-M. Fertility preservation in women. N Engl J Med, 2017;377:1657–1665.CrossRefGoogle ScholarPubMed
Jadoul, P, Anckaert, E, Dewandeleer, A et al. Clinical and biologic evaluation of ovarian function in women treated by bone marrow transplantation for various indications during childhood or adolescence. Fertil Steril, 2011;96:126–133.e3.Google Scholar
Dalle, JH, Lucchini, G, Balduzzi, A et al. State-of-the-art fertility preservation in children and adolescents undergoing haematopoietic stem cell transplantation: a report on the expert meeting of the Paediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) in Baden, Austria, 29–30 September 2015. Bone Marrow Transplant 2017;52:1029.Google Scholar
Oktem, O, Yagmur, H, Bengisu, H, Urman, B. Reproductive aspects of systemic lupus erythematosus. J Reprod Immunol, 2016;117:57–65.Google Scholar
Gellert, SE, Pors, SE, Kristensen, SG et al. Transplantation of frozen-thawed ovarian tissue: an update on worldwide activity published in peer-reviewed papers and on the Danish cohort. J Assist Reprod Geneti, 2018;35:561–570.Google Scholar
Donnez, J, Dolmans, MM, Demylle, D et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet, 2004;364:1405–1410.Google Scholar
Meirow, D, Levron, J, Eldar-Geva, T et al. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. New Engl Med, 2005;353:318–321.Google Scholar
Demeestere, I, Simon, P, Emiliani, S, Delbaere, A, Englert, Y. Fertility preservation: successful transplantation of cryopreserved ovarian tissue in a young patient previously treated for Hodgkin’s disease. The Oncologist, 2007;12:1437–1442.Google Scholar
Donnez, J, Silber, S, Andersen, CY et al. Children born after autotransplantation of cryopreserved ovarian tissue. a review of 13 live births. Ann Med, 2011;43:437–450.Google Scholar
Meirow, D, Ra’anani, H, Shapira, M et al. Transplantations of frozen-thawed ovarian tissue demonstrate high reproductive performance and the need to revise restrictive criteria. Fertil Steril, 2016;106:467–474.Google Scholar
Jensen, AK, Macklon, KT, Fedder, J et al. 86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children. J Assist Reprod Genet, 2016;34:325–336.Google Scholar
Donnez, J, Dolmans, M-M, Pellicer, A et al. Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation. Fertil Steril, 2013;99:1503–1513.Google Scholar
Donnez, J, Jadoul, P, Pirard, C et al. Live birth after transplantation of frozen-thawed ovarian tissue after bilateral oophorectomy for benign disease. Fertil Steril, 2012;98:720–725.Google Scholar
Van der Ven, H, Liebenthron, J, Beckmann, M et al. Ninety-five orthotopic transplantations in 74 women of ovarian tissue after cytotoxic treatment in a fertility preservation network: tissue activity, pregnancy and delivery rates. Hum Reprod, 2016;31:2031–2041.Google Scholar
Donnez, J, Squifflet, J, Jadoul, P et al. Pregnancy and live birth after autotransplantation of frozen-thawed ovarian tissue in a patient with metastatic disease undergoing chemotherapy and hematopoietic stem cell transplantation. Fertil Steril, 2011;95:1787 e1–4.Google Scholar
Rodriguez-Wallberg, KA, Tanbo, T, Tinkanen, H et al. Ovarian tissue cryopreservation and transplantation among alternatives for fertility preservation in the Nordic countries – compilation of 20 years of multicenter experience. Acta Obstet Gynecol Scand, 2016;95:1015–1026.Google Scholar
Oktay, K, Harvey, BE, Partridge, AH et al. Fertility preservation in patients with cancer: ASCO Clinical Practice Guideline Update. J Clin Oncol 2018:JCO.2018.78.1914.Google Scholar
Suzuki, N. Clinical practice guidelines for fertility preservation in pediatric, adolescent, and young adults with cancer. Int J Clin Oncol, 2018;24:20–27.CrossRefGoogle ScholarPubMed
Dolmans, M-M. Recent advances in fertility preservation and counseling for female cancer patients. Expert Rev Anticancer Ther, 2018;18:115–120.Google Scholar
Jadoul, P, Guilmain, A, Squifflet, J et al. Efficacy of ovarian tissue cryopreservation for fertility preservation: lessons learned from 545 cases. Hum Reprod, 2017;32:1046–1054.Google Scholar
Diaz-Garcia, C, Domingo, J, Garcia-Velasco, JA et al. Oocyte vitrification versus ovarian cortex transplantation in fertility preservation for adult women undergoing gonadotoxic treatments: a prospective cohort study. Fertil Steril, 2018;109:478–485.Google Scholar
Masciangelo, R, Bosisio, C, Donnez, J, Amorim, CA, Dolmans, M-M. Safety of ovarian tissue transplantation in patients with borderline ovarian tumors. Hum Reprod, 2018;33:212–219.Google Scholar
Donnez, J, Garcia-Solares, J, Dolmans, MM. Fertility preservation in women with endometriosis. Minerva Ginecol, 2018;70:408–414.Google Scholar
Donnez, J, Dolmans, M-M, Squifflet, J, Kerbrat, G, Jadoul, P. Live birth after allografting of ovarian cortex between monozygotic twins with Turner syndrome (45,XO/46,XX mosaicism) and discordant ovarian function. Fertil Steril, 2011;96:1407–1411.CrossRefGoogle Scholar
Borgström, B, Hreinsson, J, Rasmussen, C et al. Fertility preservation in girls with Turner syndrome: prognostic signs of the presence of ovarian follicles. JClin Endocrinol Metabol, 2009;94:74–80.Google Scholar
Wallace, WH, Smith, AG, Kelsey, TW, Edgar, AE, Anderson, RA. Fertility preservation for girls and young women with cancer: population-based validation of criteria for ovarian tissue cryopreservation. Lancet Oncol, 2014;15:1129–1136.Google Scholar
Donnez, J, Dolmans, MM. Fertility preservation in women. New Engl J Med, 2018;378:399–401.Google Scholar
Wallace, WH, Kelsey, TW, Anderson, RA. Fertility preservation in pre-pubertal girls with cancer: the role of ovarian tissue cryopreservation. Fertil Steril, 2016;105:6–12.Google Scholar
Donnez, J, Dolmans, MM. Ovarian cortex transplantation: 60 reported live births brings the success and worldwide expansion of the technique towards routine clinical practice. J Assist Reprod Gen, 2015;32:1167–1170.Google Scholar
Donnez, J, Martinez-Madrid, B, Jadoul, P et al. Ovarian tissue cryopreservation and transplantation: a review. Hum Reprod Update, 2006;12:519–535.CrossRefGoogle ScholarPubMed
Donnez, J, Jadoul, P, Squifflet, J et al. Ovarian tissue cryopreservation and transplantation in cancer patients. Best Pract Res Clin Obstet Gynaecol, 2010;24:87–100.Google Scholar
Greve, T, Schmidt, KT, Kristensen, SG, Ernst, E, Andersen, CY. Evaluation of the ovarian reserve in women transplanted with frozen and thawed ovarian cortical tissue. Fertil Steril, 2012;97:1394–8.e1.Google Scholar
Wilkosz, P, Greggains, GD, Tanbo, TG, Fedorcsak, P. Female reproductive decline is determined by remaining ovarian reserve and age. PloS One, 2014;9:e108343.Google Scholar
Bjelland, EK, Wilkosz, P, Tanbo, TG, Eskild, A. Is unilateral oophorectomy associated with age at menopause? A population study (the HUNT2 Survey). Hum Reprod, 2014;29:835–841.Google Scholar
Kristensen, SG, Rasmussen, A, Byskov, AG, Andersen, CY. Isolation of pre-antral follicles from human ovarian medulla tissue. Hum Reprod, 2011;26:157–166.Google Scholar
Donnez, J, Dolmans, M-M, Diaz, C, Pellicer, A. Ovarian cortex transplantation: time to move on from experimental studies to open clinical application. Fertil Steril, 2015;104:1097–1098.CrossRefGoogle ScholarPubMed
Suzuki, N. Ovarian tissue cryopreservation using vitrification and/or in vitro activated technology. Hum Reprod, 2015;30:2461–2462.Google Scholar
Amorim, CA, Curaba, M, Van Langendonckt, A, Dolmans, M-M, Donnez, J. Vitrification as an alternative means of cryopreserving ovarian tissue. Reprod Biomed Online, 2011;23:160–186.Google Scholar
Shapira, M, Raanani, H, Barshack, I et al. First delivery in a leukemia survivor after transplantation of cryopreserved ovarian tissue, evaluated for leukemia cells contamination. Fertil Steril, 2017;109:48–53.Google Scholar
Donnez, J, Dolmans, MM. Transplantation of ovarian tissue. Best Pract Res Clin Obstet Gynaecol, 2014;28:1188–1197.Google Scholar
Donnez, J, Dolmans, MM, Demylle, D et al. Restoration of ovarian function after orthotopic (intraovarian and periovarian) transplantation of cryopreserved ovarian tissue in a woman treated by bone marrow transplantation for sickle cell anaemia: case report. Hum Reprod, 2005;21:183–188.CrossRefGoogle Scholar
Silber, SJ, Lenahan, K, Levine, DJ et al. Ovarian transplantation between monozygotic twins discordant for premature ovarian failure. New Engl J Med, 2005;353:58–63.Google Scholar
Silber, SJ. Ovary cryopreservation and transplantation for fertility preservation. Mol Hum Reprod, 2012;18:59–67.Google Scholar
Silber, S. How ovarian transplantation works and how resting follicle recruitment occurs: a review of results reported from one center. Womens Health (Lond), 2016;12:217–227.Google Scholar
Andersen, CY, Rosendahl, M, Byskov, AG et al. Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue. Hum Reprod, 2008;23:2266–2272.Google Scholar
Kim, SS. Assessment of long term endocrine function after transplantation of frozen-thawed human ovarian tissue to the heterotopic site: 10 year longitudinal follow-up study. J Assist Reprod Genet, 2012;29:489–493.Google Scholar
Kim, S. Revisiting the role of heterotopic ovarian transplantation: futility or fertility. Reprod Biomed Online, 2014;28:141–145.Google Scholar
Poirot, C, Abirached, F, Prades, M et al. Induction of puberty by autograft of cryopreserved ovarian tissue. The Lancet, 2012;379:588.Google Scholar
Rosendahl, M, Loft, A, Byskov, AG et al. Biochemical pregnancy after fertilization of an oocyte aspirated from a heterotopic autotransplant of cryopreserved ovarian tissue: case report. Hum Reprod, 2006;21:2006–2009.Google Scholar
Stern, CJ, Gook, D, Hale, LG et al. First reported clinical pregnancy following heterotopic grafting of cryopreserved ovarian tissue in a woman after a bilateral oophorectomy. Hum Reprod, 2013;28:2996–2999.Google Scholar
Donnez, J, Manavella, DD, Dolmans, MM. Techniques for ovarian tissue transplantation and results. Minerva Ginecol, 2018;70:424–431.Google Scholar
Laschke, MW, Vollmar, B, Menger, MD. Inosculation: connecting the life-sustaining pipelines. Tissue Eng Part B: Rev, 2009;15:455–465.Google Scholar
Gavish, Z, Peer, G, Roness, H, Cohen, Y, Meirow, D. Follicle activation and ‘burn-out’ contribute to post-transplantation follicle loss in ovarian tissue grafts: the effect of graft thickness. Hum Reprod, 2015;30:1003.Google Scholar
Dath, C, Van Eyck, AS, Dolmans, MM et al. Xenotransplantation of human ovarian tissue to nude mice: comparison between four grafting sites. Hum Reprod, 2010;25:1734–1743.Google Scholar
Demeestere, I, Simon, P, Emiliani, S, Delbaere, A, Englert, Y. Orthotopic and heterotopic ovarian tissue transplantation. Hum Reprod Update, 2009;15:649–665.Google Scholar
Van Eyck, AS, Jordan, BF, Gallez, B et al. Electron paramagnetic resonance as a tool to evaluate human ovarian tissue reoxygenation after xenografting. Fertil Steril, 2009;92:374–381.Google Scholar
Van Eyck, AS, Bouzin, C, Feron, O et al. Both host and graft vessels contribute to revascularization of xenografted human ovarian tissue in a murine model. Fertil Steril, 2010;93:1676–1685.Google Scholar
Israely, T, Dafni, H, Nevo, N, Tsafriri, A, Neeman, M. Angiogenesis in ectopic ovarian xenotransplantation: multiparameter characterization of the neovasculature by dynamic contrast-enhanced MRI. Magn Reson Med, 2004;52:741–750.Google Scholar
Baird, DT, Webb, R, Campbell, BK, Harkness, LM, Gosden, RG. Long-term ovarian function in sheep after ovariectomy and transplantation of autografts stored at -196 C. Endocrinology, 1999;140:462–471.Google Scholar
Nisolle, M, Casanas-Roux, F, Qu, J, Motta, P, Donnez, J. Histologic and ultrastructural evaluation of fresh and frozen-thawed human ovarian xenografts in nude mice. Fertil Steril, 2000;74:122–129.Google Scholar
Dolmans, MM, Martinez-Madrid, B, Gadisseux, E et al. Short-term transplantation of isolated human ovarian follicles and cortical tissue into nude mice. Reproduction, 2007;134:253–262.Google Scholar
Gavish, Z, Spector, I, Peer, G et al. Follicle activation is a significant and immediate cause of follicle loss after ovarian tissue transplantation. J Assist Reprod and Genet, 2018;35:61–69.Google Scholar
Soleimani, R, Heytens, E, Oktay, K. Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants. PloS One, 2011;6:e19475.Google Scholar
Gao, J, Huang, Y, Li, M, et al. Effect of local basic fibroblast growth factor and vascular endothelial growth factor on subcutaneously allotransplanted ovarian tissue in ovariectomized mice. PloS One, 2015;10:e0134035.Google Scholar
Tavana, S, Valojerdi, MR, Azarnia, M, Shahverdi, A. Restoration of ovarian tissue function and estrous cycle in rat after autotransplantation using hyaluronic acid hydrogel scaffold containing VEGF and bFGF. Growth Factors, 2016;34:97–106.Google Scholar
Kang, B-J, Wang, Y, Zhang, L, Xiao, Z, Li, S-W. bFGF and VEGF improve the quality of vitrified-thawed human ovarian tissues after xenotransplantation to SCID mice. J Assist Reprod Genet, 2016;33:281–289.Google Scholar
Mahmoodi, M, Soleimani Mehranjani, M, Shariatzadeh, SM, Eimani, H, Shahverdi, A. Effects of erythropoietin on ischemia, follicular survival, and ovarian function in ovarian grafts. Reproduction, 2014;147:733–741.Google Scholar
Mahmoodi, M, Soleimani Mehranjani, M, Shariatzadeh, SM, Eimani, H, Shahverdi, A. N-acetylcysteine improves function and follicular survival in mice ovarian grafts through inhibition of oxidative stress. Reprod Biomed Online, 2015;30:101–110.Google Scholar
Kolusari, A, Okyay, AG, Koçkaya, EA. The effect of erythropoietin in preventing ischemia–reperfusion injury in ovarian tissue transplantation. Reprod Sci, 2017;25:406–413.Google Scholar
Manavella, DD, Cacciottola, L, Desmet, CM et al. Adipose tissue-derived stem cells in a fibrin implant enhance neovascularization in a peritoneal grafting site: a potential way to improve ovarian tissue transplantation. Hum Reprod, 2018;33:270–279.Google Scholar
Manavella, DD, Cacciottola, L, Pomme, S et al. Two-step transplantation with adipose tissue-derived stem cells increases follicle survival by enhancing vascularization in xenografted frozen-thawed human ovarian tissue. Hum Reprod, 2018; 33:1107–1116.Google Scholar
Manavella, DD, Cacciottola, L, Amorim, CA, Donnez, J, Dolmans, MM. Adipose tissue-derived stem cells boost vascularization in grafted ovarian tissue by growth factor secretion and differentiation into endothelial cell lineages. Hum Reprod, 2018;33(2):270–279.Google Scholar

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