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Section 7 - Neuromyelitis in Children

Published online by Cambridge University Press:  11 April 2011

Dorothée Chabas
Affiliation:
University of California, San Francisco
Emmanuelle L. Waubant
Affiliation:
University of California, San Francisco
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Summary

This chapter reviews the growing clinical and scientific literature regarding neuromyelitis optica (NMO) and Aquaporin (AQP)-4 autoimmunity, with the emphasis on recent studies in children. Most of the clinical, immunological, and pathological insights into NMO in recent years have emanated from the identification of the disease-specific NMO-IgG antibody and its antigenic target, AQP4. NMO was considered to require absence of clinical disease outside the optic nerve or spinal cord, although clinically silent brain lesions were recognized as common in NMO. Diagnostic criteria published in 1999 proposed negative brain MRI at onset as a supportive criterion to differentiate NMO from multiple sclerosis (MS). McKeon et al. described that the most common cerebrospinal fluid finding in NMO is a lymphocytic or neutrophil predominant leukocytosis and elevated protein. Treatment for NMO must include effective therapies for acute attacks as well as the use of chronic immunosuppressive treatments to prevent attacks and related disability.
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Publisher: Cambridge University Press
Print publication year: 2011

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  • Neuromyelitis in Children
  • Edited by Dorothée Chabas, University of California, San Francisco, Emmanuelle L. Waubant, University of California, San Francisco
  • Book: Demyelinating Disorders of the Central Nervous System in Childhood
  • Online publication: 11 April 2011
  • Chapter DOI: https://doi.org/10.1017/CBO9780511974373.024
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  • Neuromyelitis in Children
  • Edited by Dorothée Chabas, University of California, San Francisco, Emmanuelle L. Waubant, University of California, San Francisco
  • Book: Demyelinating Disorders of the Central Nervous System in Childhood
  • Online publication: 11 April 2011
  • Chapter DOI: https://doi.org/10.1017/CBO9780511974373.024
Available formats
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Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Neuromyelitis in Children
  • Edited by Dorothée Chabas, University of California, San Francisco, Emmanuelle L. Waubant, University of California, San Francisco
  • Book: Demyelinating Disorders of the Central Nervous System in Childhood
  • Online publication: 11 April 2011
  • Chapter DOI: https://doi.org/10.1017/CBO9780511974373.024
Available formats
×