Skip to main content Accessibility help
×
Hostname: page-component-cc8bf7c57-n7qbj Total loading time: 0 Render date: 2024-12-11T06:03:41.807Z Has data issue: false hasContentIssue false

Chapter 1 - Introduction: historical perspective of pediatric multiple sclerosis and related disorders

Published online by Cambridge University Press:  11 April 2011

Dorothée Chabas
Affiliation:
University of California, San Francisco
Emmanuelle L. Waubant
Affiliation:
University of California, San Francisco
Get access

Summary

This chapter briefly summarizes the history of pediatric multiple sclerosis (MS) and related diseases, and current clinical and research directions. Pierre Marie observed that MS in children might be related to acute infectious diseases, syphilis or trauma, suggesting that there was some overlap with infectious or post-infectious central nervous system (CNS) diseases such as acute disseminated encephalomyelitis (ADEM). The reported cases of MS in children may have, in fact, been leukodystrophies. ADEM is classically described as monophasic illness, and one that predominantly occurs in childhood, as opposed to MS, a relapsing and remitting disease, which predominantly occurs in young adults. The study of pediatric MS provides a unique opportunity to examine factors contributing to MS pathogenesis in general, since in affected children there is a close temporal proximity between the interplay of biological, genetic and environmental factors leading to clinical expression of the disease.
Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×