Examining the pandemic relations of violence emerged across interior portions of seventeenth-century North America, this chapter assesses the displacement of colonialism onto Indigenous peoples. Starting with the French and Dutch colonization of Northeastern American watersheds, concentric waves of devastation radiated into interior Iroquoian and Algonquian-speaking communities, disrupting existing social, military, and economic relations. This chapter revisits the clash of the Wendat (Huron) and Iroquois (Haudenosaunee) confederacies in the first half of the Seventeenth century and situates this violent history within the broader imperial contests remaking Native North America.