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Chapter 13 - Blood Transfusion Components and Complications in Anesthesiology

Published online by Cambridge University Press:  24 May 2023

Alan David Kaye
Louisiana State University School of Medicine
Richard D. Urman
Brigham and Women’s Hospital, Boston
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Donation of one unit of whole blood or apheresis can be used to obtain red blood cell (RBC) units. For apheresis RBCs, a donor is connected to an apheresis machine and RBCs are separated from other constituents which are returned to the donor; this process may yield 2 units of RBCs or a single unit of RBCs, along with a unit of platelets and/or plasma. RBC units are stored in polyvinyl chloride bags with the plasticizer di-2-ethylhexylphthalate (DEHP) to maintain RBC membrane integrity during storage. Preservation includes an anticoagulant-preservative (A-P) solution, and the current additive solutions maintain pH and other parameters needed to allow RBC storage shelf life of 42 days [1]. ABO typing and matching are required to avoid reactions due to mismatch (see Table 13.1).

Publisher: Cambridge University Press
Print publication year: 2023

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