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Not for further distribution unless allowed by the License or with the express written permission of Cambridge University Press.
https://doi.org/10.1017/S0317167100005424
https://doi.org/10.1017/S0317167100005424 Published online by Cambridge University Press
2022-04-12T19:44:51+00:00
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[(neuropathies of her feet. )18(The following motor nerve conduction)]TJ
0 -1.1579 TD
0.313 Tw
[(studies were normal: left median, right ulnar)40(, left common)]TJ
0 -1.15789 TD
0.232 Tw
(peroneal, left tibial. )Tj
8.75734 0 TD
(The following sensory nerve conduction)Tj
-8.75734 -1.1579 TD
-0.005 Tw
(studies were normal: left radial, left median, right ulnar)Tj
22.07544 0 TD
-0.0001 Tc
(,)Tj
0.49454 0 Td
0 Tc
0 Tw
(bilateral)Tj
-22.56998 -1.1579 TD
0.332 Tw
(medial antebrachial cutaneous. Electromyography showed)Tj
0 -1.15789 TD
0.073 Tw
[(spontaneous activity and lar)18(ge amplitude motor responses from)]TJ
T*
0.23 Tw
[(her left FCU, left FDI muscle and left EDB. )55(An audiogram)]TJ
0 -1.1579 TD
0.194 Tw
[(revealed moderate sensorineural hearing loss in the right ear)55(.)]TJ
0 -1.15789 TD
0.047 Tw
(Acoustic impedance testing showed normal middle ear function)Tj
T*
0 Tw
(bilaterally)Tj
3.98853 0.00001 TD
-0.0001 Tc
(.)Tj
0.65761 0 Td
0 Tc
0.158 Tw
(Brainstem evoked potential audiometry was within)Tj
-4.64614 -1.15791 TD
0.123 Tw
[(normal limits in the left ear)55(. In the right ear)40(, )17(W)80(ave I was not)]TJ
0 -1.15789 TD
0.171 Tw
[(present, )18(W)80(ave III was delayed but there was normal )17(W)80(ave )18(V)]TJ
T*
0 Tw
(latency)Tj
2.82226 0.00001 TD
-0.0001 Tc
(,)Tj
0.67775 0 Td
0 Tc
0.178 Tw
[(and a normal )18(W)80(ave III-V)-411(interval was present. )18(This)]TJ
-3.50001 -1.15791 TD
0.142 Tw
(audiology assessment suggested a cochlear nerve lesion and a)Tj
0 -1.15789 TD
-0.035 Tw
(lack of significant brainstem auditory pathway involvement. Her)Tj
T*
0.025 Tw
(ECG was normal. )Tj
1.26316 -1.1579 TD
0.02 Tc
0.53 Tw
(On the basis of unexplained weight loss, myalgia,)Tj
-1.26316 -1.15789 TD
0 Tc
0.045 Tw
(mononeuritis multiplex, diastolic hypertension and the presence)Tj
T*
0.068 Tw
(of livedo reticularis a diagnosis of P)Tj
14.75832 0.00001 TD
(AN was made and she was)Tj
-14.75832 -1.15791 TD
-0.013 Tw
(started on prednisone, aspirin, amlodipine and later azathioprine.)Tj
0 -1.15789 TD
0.114 Tw
[(Neuropathic pain improved with gabapentin. )55(At follow-up two)]TJ
T*
0.285 Tw
(years later the child is in remission on azathioprine and is)Tj
0 -1.1579 TD
0.02 Tc
0.478 Tw
(asymptomatic aside from right ear hearing deficit and)Tj
0 -1.15789 TD
0 Tc
0.025 Tw
(hypertension controlled by medication.)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F1 1 Tf
9.5 0 0 9.5 309.16 717.0362 Tm
0 0 0 1 k
(D)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F1 1 Tf
7.125 0 0 7.125 316.0183 717.0362 Tm
0 0 0 1 k
0.001 Tc
(ISCUSSION)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 321.16 702.0362 Tm
0 0 0 1 k
0.206 Tw
(The patient described has a series of neurological deficits)Tj
-1.26316 -1.15789 TD
0.212 Tw
[(including 1. conver)18(gence paralysis, 2. partial left oculomotor)]TJ
0 -1.1579 TD
0.164 Tw
[(nerve palsy)65(, 3. ataxia, 4. right ear hearing impairment, 5. left)]TJ
0 -1.15789 TD
0.02 Tc
0.524 Tw
[(proximal ulnar neuropathy)65(, and 6. motor and sensory)]TJ
T*
0 Tc
0.326 Tw
[(polyneuropathy in the lower extremities. )18(The conver)17(gence)]TJ
0 -1.1579 TD
0.044 Tw
(paralysis, dilated left pupil, and disequilibrium are secondary to)Tj
0 -1.15789 TD
-0.0001 Tc
(a)Tj
0.84531 0 Td
0 Tc
0.152 Tw
[(midbrain stroke. )18(The hearing deficit is related to a cochlear)]TJ
-0.84531 -1.15789 TD
0.308 Tw
[(nerve lesion rather than brainstem pathology)65(. )18(The ataxia is)]TJ
0 -1.1579 TD
-0.037 Tw
(related either to peripheral vestibular or cerebellar output \(i.e. red)Tj
0 -1.15789 TD
0.206 Tw
[(nucleus\) dysfunction. )18(The peripheral neuropathy is consistent)]TJ
T*
0.221 Tw
(with a mononeuritis multiplex. In addition to these ischemic)Tj
0 -1.1579 TD
0.02 Tc
0.361 Tw
(vascular pathologies, her livedo reticularis, hypertension,)Tj
0 -1.15789 TD
0 Tc
0.028 Tw
[(myalgias and weight loss make the diagnosis of P)92(AN applicable)]TJ
T*
-0.014 Tw
(on clinical grounds. Given all these features it was felt a nerve or)Tj
0 -1.1579 TD
0.025 Tw
(skin biopsy was not required for diagnosis. )Tj
1.26316 -1.15789 TD
0.02 Tc
0.413 Tw
[(A)-628(stroke in the midline of the midbrain due to an)]TJ
-1.26316 -1.15789 TD
0 Tc
-0.025 Tw
(inflammatory lesion of the paramedian penetrating arteries of the)Tj
0 -1.1579 TD
0.073 Tw
[(basilar artery is responsible for our patients\325)-249(ocular findings, as)]TJ
0 -1.15789 TD
0.092 Tw
(infarction in this area can af)Tj
11.632 0.00001 TD
(fect the third nerve root fibers and)Tj
-11.632 -1.1579 TD
0.046 Tw
(the red nucleus.)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
6.27 0 0 6.27 369.9075 496.1712 Tm
0 0 0 1 k
(4)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 375.8532 493.0362 Tm
0 0 0 1 k
0.046 Tw
[(Conver)18(gence relies on simultaneous activation)]TJ
-7.02034 -1.1579 TD
-0.0001 Tc
(of)Tj
1.1278 0 Td
0 Tc
0.045 Tw
[(adductor nuclei of third cranial nerve and conver)18(gence fibres)]TJ
-1.1278 -1.15789 TD
0.013 Tw
(which must exist in the midline of the very complex oculomotor)Tj
0 -1.1579 TD
0.141 Tw
[(nucleus. Conver)18(gence paralysis is characterized by diplopia at)]TJ
0 -1.15789 TD
0.19 Tw
(near fixation yet normal adduction otherwise and is typically)Tj
T*
0.025 Tw
(caused by a midbrain lesion.)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
6.27 0 0 6.27 418.5321 441.1712 Tm
0 0 0 1 k
(5)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 321.16 427.0362 Tm
0 0 0 1 k
0.339 Tw
[(In adult studies of P)92(AN, central nervous system (CNS))]TJ
-1.26316 -1.15789 TD
0.164 Tw
(manifestations are found in 10% to 40% of patients.)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
6.27 0 0 6.27 519.1788 419.1712 Tm
0 0 0 1 k
(2,6-8)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 539.9266 416.0362 Tm
0 0 0 1 k
(The)Tj
-24.29122 -1.1579 TD
0.114 Tw
(clinical presentation is variable and may include the following)Tj
T*
0.02 Tc
0.429 Tw
(symptoms and signs: headache, blurred vision, tinnitus,)Tj
0 -1.15789 TD
0 Tc
0 Tw
(encephalopathy)Tj
6.20996 0.00001 TD
-0.0001 Tc
(,)Tj
0.50561 0 Td
0 Tc
0.006 Tw
(hemiparesis, cranial nerve palsies, seizures, and)Tj
-6.71557 -1.1579 TD
0 Tw
(strokes.)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
6.27 0 0 6.27 338.4416 375.1712 Tm
0 0 0 1 k
(6)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 345.6394 372.0362 Tm
0 0 0 1 k
0.178 Tw
(Cranial nerve palsies are present in less than 2% of)Tj
-3.83994 -1.1579 TD
0.104 Tw
[(patients, with the III, IV)129(, )18(VI, )17(VII and )18(VIII being af)18(fected most)]TJ
0 -1.15789 TD
0 Tw
(often.)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
6.27 0 0 6.27 331.0522 353.1712 Tm
0 0 0 1 k
(9)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 340.5186 350.0362 Tm
0 0 0 1 k
0.083 Tw
(Peripheral neuropathy is present in 50-75% of cases of)Tj
-3.3009 -1.1579 TD
0.239 Tw
[(P)92(AN and tends to occur earlier than CNS manifestations.)]TJ
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
6.27 0 0 6.27 543.5547 342.1712 Tm
0 0 0 1 k
[(9-1)56(1)]TJ
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 309.16 328.0362 Tm
0 0 0 1 k
0.016 Tc
0.359 Tw
(Mononeuritis multiplex is the most frequent and earliest)Tj
0 -1.15789 TD
0 Tc
-0.037 Tw
(neurological manifestation of P)Tj
12.37473 0.00001 TD
(AN occurring in 70% of patients.)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
6.27 0 0 6.27 551.561 320.1712 Tm
0 0 0 1 k
(9)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 309.16 306.0362 Tm
0 0 0 1 k
0.053 Tw
[(It has been suggested that four subtypes of P)92(AN )]TJ
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.025 0 0 9.5 498.3161 306.0362 Tm
0 0 0 1 k
0.053 Tw
(exist including:)Tj
-20.95912 -1.1579 TD
0.02 Tc
0.526 Tw
((1) Cutaneous P)Tj
7.70329 0 TD
[(AN; (2) Systemic P)92(AN; (3) Microscopic)]TJ
-7.70329 -1.15789 TD
0 Tc
0.025 Tw
[(polyarteritis; and (4) Hepatitis B associated classic P)92(AN.)]TJ
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 321.16 273.0362 Tm
0 0 0 1 k
0.088 Tw
(Polyarteritis nodosum has been described in fewer than 250)Tj
-1.26316 -1.15789 TD
0.211 Tw
(children since the initial description by Kussmaul and Maier)Tj
0 -1.1579 TD
0.007 Tc
0.368 Tw
(almost 140 years ago.)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
6.27 0 0 6.27 403.8164 254.1712 Tm
0 0 0 1 k
(3)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 418.6986 251.0361 Tm
0 0 0 1 k
0.007 Tc
0.368 Tw
[(T)1(h)1(e)1( )1(l)1(a)1(r)19(gest series by Ozen and)]TJ
-11.53038 -1.15789 TD
0 Tc
0.106 Tw
[(colleagues contained 1)37(10.)]TJ
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
6.27 0 0 6.27 409.221 243.1712 Tm
0 0 0 1 k
(12)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 418.8751 240.0362 Tm
0 0 0 1 k
0.106 Tw
[(Systemic P)92(AN was seen in 57.2%,)]TJ
-11.54896 -1.15789 TD
0.035 Tw
(30% had cutaneous P)Tj
8.59406 0.00001 TD
(AN, 8.1% had microscopic P)Tj
11.71135 0.00001 TD
(AN and 4.6%)Tj
-20.30541 -1.15791 TD
0.004 Tc
0.371 Tw
[(were associated with HBs )55(Ag. Nervous system symptoms)]TJ
0 -1.15789 TD
0 Tc
0.083 Tw
(occurred in 14.5% of patients and were most common in those)Tj
T*
0.138 Tw
(with systemic P)Tj
6.51617 0.00001 TD
[(AN. )18(The specific neurological symptoms were)]TJ
-6.51617 -1.15791 TD
-0.021 Tw
[(not described, however)40(, on imaging four patients had CNS artery)]TJ
0 -1.15789 TD
0.139 Tw
[(aneurysms. In the systemic P)92(AN group, remission occurred in)]TJ
T*
-0.029 Tw
[(64%, 27% had persistent disease and 9% relapsed. )18(The prognosis)]TJ
0 -1.1579 TD
0.159 Tw
[(in juvenile P)92(AN was better than in adults with a mortality of)]TJ
0 -1.15789 TD
0.076 Tw
[(1.1%. )55(A)-272(second series contained 31 patients.)]TJ
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
6.27 0 0 6.27 482.0961 144.1712 Tm
0 0 0 1 k
(13)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 491.4678 141.0362 Tm
0 0 0 1 k
0.076 Tw
(Peripheral nerve)Tj
-19.1903 -1.15789 TD
-0.009 Tw
(and CNS involvement was present in four (13%) and nine (30%))Tj
0 -1.1579 TD
0.011 Tc
0.364 Tw
(patients, respectively)Tj
8.97712 -0.00001 TD
0.0107 Tc
(.)Tj
0.8856 0 Td
0.011 Tc
(CNS findings included: encephalitic)Tj
-9.86273 -1.15789 TD
0.013 Tc
0.362 Tw
(symptoms (n=4), persistent hemiparesis and ptosis (n=1),)Tj
T*
0 Tc
0.315 Tw
(hemiparesis and a seventh nerve palsy (n=1) and recurrent)Tj
0 -1.1579 TD
0.327 Tw
[(seizures (n=3). )18(The mortality rate in patients with nervous)]TJ
0 -1.15789 TD
0.12 Tw
(system involvement was 6.6%.)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
6.27 0 0 6.27 430.5212 78.1712 Tm
0 0 0 1 k
(13)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 440.3095 75.0362 Tm
0 0 0 1 k
0.12 Tw
(In a third series, 25 pediatric)Tj
ET
0 0 0 0 k
39.696 726 516 30 re
f
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9 0 0 9 39.696 749.8455 Tm
0 0 0 1 k
-0.0001 Tc
(THE)Tj
2.21865 0 Td
0 Tc
0.025 Tw
[(CANADIAN JOURNAL)-238(OF NEUROLOGICAL)-238(SCIENCES)]TJ
-2.21865 -80.04603 TD
(424)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F9 1 Tf
8.5 0 0 8.5 56.3161 393.1987 Tm
0 0 0 1 k
0.02 Tc
0.368 Tw
(Figure 1.)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F2 1 Tf
8.5 0 0 8.5 104.4017 393.1987 Tm
0 0 0 1 k
0.02 Tc
0.368 Tw
[(The MRI demonstrating infar)37(ct in the left)]TJ
-5.65713 -1.05882 TD
0 Tc
0.025 Tw
[(paramedian midbrain. )18(Axial diffusion weighted scan.)]TJ
ET
/GS2 gs
/Fm0 Do
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9.5 0 0 9.5 40.024 445.5035 Tm
0 0 0 1 k
0.048 Tw
(patients were studied and 56% had neurologic involvement, but)Tj
0 -1.15789 TD
0.071 Tw
(little clinical detail was provided.)Tj
ET
Q
/GS2 gs
/GS1 gs
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BT
/F0 1 Tf
6.27 0 0 6.27 169.6204 437.6386 Tm
0 0 0 1 k
(14)Tj
ET
Q
/GS2 gs
/GS1 gs
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BT
/F0 1 Tf
9.5 0 0 9.5 178.9435 434.5035 Tm
0 0 0 1 k
0.071 Tw
(One case report describes a)Tj
-14.62311 -1.1579 TD
-0.012 Tw
(five year old girl with P)Tj
9.37125 0 TD
(AN who developed an ocular tilt reaction)Tj
-9.37125 -1.1579 TD
0.009 Tc
0.366 Tw
(and left hemiparesis secondary to a right sided midbrain)Tj
0 -1.15789 TD
0 Tc
0.025 Tw
(vasculitic lesion.)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
6.27 0 0 6.27 104.1036 404.6386 Tm
0 0 0 1 k
(1)Tj
0.5 -0.00001 TD
(5)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 52.024 390.5035 Tm
0 0 0 1 k
0.355 Tw
[(A)-550(case report published by Schrodt and Callen (1999),)]TJ
-1.26316 -1.1579 TD
0.364 Tw
(suggests that vasculitis be considered among the toxicities)Tj
0 -1.15789 TD
0.006 Tw
[(associated with minocycline therapy)65(. )18(They reported on a 15 year)]TJ
0 -1.1579 TD
0.176 Tw
[(old female who developed P)92(AN after being treated with nine)]TJ
T*
0.014 Tc
0.361 Tw
(months of minocycline for acne vulgaris.)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
6.27 0 0 6.27 218.5837 349.6386 Tm
0 0 0 1 k
0.014 Tc
(16)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 230.964 346.5035 Tm
0 0 0 1 k
0.014 Tc
0.361 Tw
(Elkayam and)Tj
-20.09895 -1.15789 TD
0.002 Tc
0.373 Tw
(colleagues in 1996, described minocycline-induced arthritis)Tj
0 -1.1579 TD
0 Tc
0.06 Tw
(associated with fever)Tj
8.51982 0 TD
-0.0001 Tc
(,)Tj
0.55978 0 Td
0 Tc
(livedo reticularis and a positive p-ANCA)Tj
-9.0796 -1.1579 TD
-0.01 Tw
[(in three women. )18(The author noted rapid and complete resolution)]TJ
0 -1.15789 TD
0.135 Tw
(of symptoms after discontinuing the drug and recurrence after)Tj
0 -1.1579 TD
0 Tw
(rechallenge.)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
6.27 0 0 6.27 86.1718 294.6386 Tm
0 0 0 1 k
(17)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F0 1 Tf
9.5 0 0 9.5 95.4605 291.5035 Tm
0 0 0 1 k
0.068 Tw
(Neurological symptoms were not reported in any)Tj
-5.83542 -1.1579 TD
0.171 Tw
(of the above cases. )Tj
8.43086 0.00001 TD
(At the time of diagnosis, our patient was)Tj
-8.43086 -1.15791 TD
0.067 Tw
(being treated with minocycline for acne which lends support to)Tj
0 -1.15789 TD
0.052 Tw
[(the above association. )55(Additionally)65(, her disease has come under)]TJ
T*
0.004 Tc
0.371 Tw
(good control since stopping the drug albeit with immune)Tj
0 -1.1579 TD
0 Tc
0.025 Tw
(suppressive treatment. )Tj
1.26316 -1.15789 TD
0.02 Tc
0.366 Tw
(The case demonstrates an unusual presentation of an)Tj
-1.26316 -1.15789 TD
0 Tc
0.308 Tw
[(uncommon disease. Conver)18(gence paralysis secondary to the)]TJ
0 -1.1579 TD
0.048 Tw
[(vasculitis of P)92(AN has not to our knowledge been described in a)]TJ
0 -1.15789 TD
0.001 Tc
0.374 Tw
(child. Our report raises further concern about the role of)Tj
T*
0 Tc
0.025 Tw
(minocycline in P)Tj
6.73482 0.00001 TD
(AN and other vasculitic syndromes.)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F1 1 Tf
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(R)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
/F1 1 Tf
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(EFERENCES)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
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[(1.)-1015(Lightfoot R)55(W)-287(Jr)40(, Michel BA, Bloch DA, Hunder GG, Zvaifler NJ,)]TJ
2.82353 -1.05882 TD
0.156 Tw
[(McShane DJ. )18(The )55(ACR 1990 criteria for the classification of)]TJ
T*
0.025 Tw
[(P)92(AN. )55(Arthritis Rheum. 1990; 33: 1088-93.)]TJ
-2.82353 -1.05882 TD
0.001 Tc
0.374 Tw
[(2)1(.)-1014(Moore PM, Fauci )55(AS. Neurologic manifestations of systemic)]TJ
2.82353 -1.05882 TD
0.02 Tc
0.448 Tw
[(vasculitis. )55(A)-663(retrospective and prospective study of the)]TJ
T*
0 Tc
-0.036 Tw
(clinicopathologic features and responses to therapy in 25 patients.)Tj
T*
0.025 Tw
(Am J Med Sci. 1981; 71: 517-24.)Tj
-2.82353 -1.05882 TD
0.112 Tw
[(3.)-1015(Sundel R, Szer I. )18(V)111(asculitis in Childhood. Rheum Dis Clin North)]TJ
2.82353 -1.05882 TD
0.025 Tw
(Am. 2002; 28: 625-54.)Tj
28.83953 43.72752 TD
0.102 Tw
[(4.)-1015(Greenber)18(g D, )55(Aminof)18(f M, Simon R. Disorders of equilibrium. In:)]TJ
2.82353 -1.05882 TD
0.31 Tw
(Foltin J, Liebowitz H, Kurtz S, Panton N, editors. Clinical)Tj
T*
0.025 Tw
[(Neurology)65(. New )37(Y)100(ork: McGraw Hill; 2002. p. 1)36(15. )]TJ
-2.82353 -1.05882 TD
0.186 Tw
[(5.)-1015(Brazis P)111(, Lee )55(A. )55(Acquired Binocular Horizontal Diplopia. Mayo)]TJ
2.82353 -1.05882 TD
0.025 Tw
(Clin Proc. 1999; 74: 907-16. )Tj
-2.82353 -1.05882 TD
0.197 Tw
[(6.)-1015(Ford RG, Siekert RG. Central nervous system manifestations of)]TJ
2.82353 -1.05882 TD
0.025 Tw
[(periarteritis nodosa. Neurology)65(. 1965; 15: 1)37(14-22.)]TJ
-2.82353 -1.05882 TD
(7.)Tj
ET
Q
/GS2 gs
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0 0 0 1 k
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[(Guillevin L, Le )18(THD, Godeau P)111(, Ja)-1(i)1(s P)110(, )18(W)80(echsler B. Clinical findings)]TJ
1.06952 -1.05882 TD
0.054 Tw
[(and prognosis of polyarteritis nodosa and Chur)18(g-Strauss angiitis:)]TJ
-0.0001 Tc
(a)'
0.71889 0 Td
0 Tc
0.025 Tw
(study in 165 patients. Br J Rheumatol. 1988; 27: 258-64.)Tj
ET
Q
/GS2 gs
/GS1 gs
q
BT
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8.5 0 0 8.5 309.16 356.1874 Tm
0 0 0 1 k
0.237 Tw
[(8.)-1015(Provenzale J, )55(Allen N. Neuroradiologic findings in Polyarteritis)]TJ
2.82353 -1.05882 TD
0.025 Tw
[(Nodosa. )55(Am J Neuroradiol. 1996; 17: 1)37(1)37(19-26.)]TJ
-2.82353 -1.05882 TD
0.02 Tc
0.387 Tw
[(9)20(.)-995(Guillevin L, Fancois L, Gherardi, R. Polyarteritis Nodosa,)]TJ
2.82353 -1.05882 TD
0 Tc
0.095 Tw
[(Microscopic Polyangiitis, and Chur)18(g-Strauss syndrome: clinical)]TJ
T*
0.183 Tw
(aspects, neurologic manifestations and treatment. Neurol Clin.)Tj
T*
0.025 Tw
(1997; 15: 865-86.)Tj
-2.82353 -1.05882 TD
0.366 Tw
[(10.)-515(Bouche P)111(, Leger JM, )18(T)35(ravers MA, Cathala HP)111(, Castaigne P)110(.)]TJ
2.82353 -1.05882 TD
0.019 Tc
0.356 Tw
(Peripheral neuropathy in systemic vasculitis: clinical and)Tj
T*
0 Tc
0.221 Tw
[(electrophysiologic study of 22 patients. Neurology)65(. 1986; 36:)]TJ
T*
0 Tw
(1598-602.)Tj
-2.82353 -1.05882 TD
0.017 Tc
0.358 Tw
[(1)54(1)17(.)-535(Moore P)111(, Richardson B. Neurology of the vasculitides and)]TJ
2.82353 -1.05882 TD
0 Tc
0.018 Tw
[(connective tissue diseases. J Neurol Neurosur)18(g Psychiatry)65(. 1998;)]TJ
T*
0.025 Tw
(65: 10-22.)Tj
-2.82353 -1.05882 TD
0.066 Tw
[(12.)-515(Ozen S, )55(Anton J, )55(Arisoy N, Bakkalodlu )55(A, Besbas N, Brogan P)111(, et)]TJ
2.82353 -1.05882 TD
0.111 Tw
[(al. Juvenile polyarteritis: results of a multicenter survey of 1)37(10)]TJ
T*
0.025 Tw
[(children. J Pediatr)55(. 2004; 145:517-22.)]TJ
-2.82353 -1.05882 TD
0.063 Tw
[(13.)-515(Ozen S, Besbas N, Saatci U, Bakkaloglu )55(A. Diagnostic criteria for)]TJ
2.82353 -1.05882 TD
0.025 Tw
[(Polyarteritis Nodosa in childhood. J Pediatr)55(. 1992; 120: 206-9.)]TJ
-2.82353 -1.05882 TD
[(14.)-515(Fink C. )18(V)111(asculitis. Pediatr Clin North )55(Am. 1986; 33: 1203-19.)]TJ
T*
0.039 Tw
[(15.)-515(Ragge NK, Harris CM, Dillon MJ, Chong )18(WK, Elston J, )18(T)70(aylor D.)]TJ
2.82353 -1.05882 TD
0.203 Tw
(Ocular tilt reaction due to a mesencephalic lesion in juvenile)Tj
T*
0.025 Tw
[(Polyarteritis Nodosa. )55(Am J Ophthalmol. 2003; 135: 249-51.)]TJ
-2.82353 -1.05882 TD
0.02 Tc
0.529 Tw
[(1)20(6)20(.)-495(Schrodt B, Callen J. Polyarteritis Nodosa attributable to)]TJ
2.82353 -1.05882 TD
0 Tc
0.125 Tw
(minocycline treatment for acne vulgaris. Pediatrics. 1999; 103:)Tj
T*
0 Tw
(503-4.)Tj
-2.82353 -1.05882 TD
0.309 Tw
[(17. Elkayam O, )37(Y)100(aron M, Caspi D. Minocycline induced arthritis)]TJ
2.82353 -1.05882 TD
0.341 Tw
[(associated with fever)40(, livedo reticularis, and p-ANCA. )55(Ann)]TJ
T*
0.025 Tw
(Rheum Dis. 1996; 55: 769-71.)Tj
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[(LE JOURNAL)-238(CANADIEN DES SCIENCES NEUROLOGIQUES)]TJ
ET
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/GS2 gs
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0.025 Tw
[(V)111(olume 33, No. 4 \320 November 2006)]TJ
ET
Q
/GS2 gs
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q
BT
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(425)Tj
ET
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/GS2 gs
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(Figure 2.)Tj
ET
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/GS2 gs
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[(The MRI demonstrating infar)37(ct in the left paramedian midbrain. Sagittal T2 weighted)]TJ
-4.05075 -1.05882 TD
0 Tw
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