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Measuring Cognition in Bipolar Disorder with Psychosis Using the MATRICS Consensus Cognitive Battery

Published online by Cambridge University Press:  06 July 2015

Sarah H. Sperry ,
Lauren K. O’Connor ,
Dost Öngür ,
Bruce M. Cohen ,
Matcheri S. Keshavan  and
Kathryn E. Lewandowski
Sarah H. Sperry*
Affiliation:
Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, Massachusetts University of North Carolina at Greensboro, Greensboro, North Carolina
Lauren K. O’Connor
Affiliation:
Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, Massachusetts
Dost Öngür
Affiliation:
Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, Massachusetts Harvard Medical School, Boston, Massachusetts
Bruce M. Cohen
Affiliation:
Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, Massachusetts Harvard Medical School, Boston, Massachusetts
Matcheri S. Keshavan
Affiliation:
Harvard Medical School, Boston, Massachusetts Beth Israel Deaconess Hospital, Boston, Massachusetts
Kathryn E. Lewandowski
Affiliation:
Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, Massachusetts Harvard Medical School, Boston, Massachusetts
*
Correspondence and reprint requests to: Sarah H. Sperry, Department of Psychology, UNC-Greensboro, P.O. Box 26170, Greensboro, NC 27402-6170. E-mail: shsperry@uncg.edu
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Abstract

Given the substantial overlap in cognitive dysfunction between bipolar disorder (BD) and schizophrenia (SZ), we examined the utility of the MATRICS Consensus Cognitive Battery (MCCB)—developed for use in SZ—for the measurement of cognition in patients with BD with psychosis (BDP) and its association with community functioning. The MCCB, Multnomah Community Ability Scale, and measures of clinical symptoms were administered to participants with BDP (n=56), SZ (n=37), and healthy controls (HC) (n=57). Groups were compared on clinical and cognitive measures; linear regressions examined associations between MCCB and community functioning. BDP and SZ groups performed significantly worse than HC on most neurocognitive domains; BDP and HC did not differ on Social Cognition. Patients with BDP performed better than patients with SZ on most cognitive measures, although groups only differed on social cognition, working memory, verbal memory, and the composite after controlling for clinical variables. MCCB was not associated with community functioning. The MCCB is an appropriate measure of neurocognition in BDP but does not appear to capture social cognitive deficits in this population. The addition of appropriate social cognitive measures is recommended. (JINS, 2015, 21, 468–472)

Keywords

Bipolar disorderCognitionNeuropsychologySchizophreniaPsychometricsPsychosocial functioning
Type
Brief Communication
Information
Journal of the International Neuropsychological Society , Volume 21 , Issue 6 , July 2015 , pp. 468 - 472
Copyright
Copyright © The International Neuropsychological Society 2015 

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