No CrossRef data available.
Article contents
Organ meat consumption and risk of non-alcoholic fatty liver disease: the Tianjin Chronic Low-grade Systemic Inflammation and Health cohort study
Published online by Cambridge University Press: 28 February 2022
Abstract
Prospective cohort studies linking organ meat consumption and non-alcoholic fatty liver disease (NAFLD) are limited, especially in Asian populations. This study aimed to prospectively investigate the association between organ meat consumption and risk of NAFLD in a general Chinese adult population. This prospective cohort study included a total of 15 568 adults who were free of liver disease, CVD and cancer at baseline. Dietary information was collected at baseline using a validated FFQ. NAFLD was diagnosed by abdominal ultrasound after excluding other causes related to chronic liver disease. Cox proportional regression models were used to assess the association between organ meat consumption and risk of NAFLD. During a median of 4·2 years of follow-up, we identified 3604 incident NAFLD cases. After adjusting for demographic characteristics, lifestyle factors, vegetable, fruit, soft drink, seafood and red meat consumption, the multivariable hazard ratios (95 % CI) for incident NAFLD across consumption of organ meat were 1·00 (reference) for almost never, 1·04 (0·94, 1·15) for tertile 1, 1·08 (0·99, 1·19) for tertile 2 and 1·11 (1·01, 1·22) for tertile 3, respectively (P for trend < 0·05). Such association did not differ substantially in the sensitivity analysis. Our study indicates that organ meat consumption was related to a modestly higher risk of NAFLD among Chinese adults. Further investigations are needed to confirm this finding.
- Type
- Research Article
- Information
- Copyright
- © The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society
References
Kwok, R, Choi, KC, Wong, GL, et al. (2016) Screening diabetic patients for non-alcoholic fatty liver disease with controlled attenuation parameter and liver stiffness measurements: a prospective cohort study. Gut 65, 1359–1368.CrossRefGoogle ScholarPubMed
Chalasani, N, Younossi, Z, Lavine, JE, et al. (2012) The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 142, 1592–1609.CrossRefGoogle Scholar
Vernon, G, Baranova, A & Younossi, ZM (2011) Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 34, 274–285.CrossRefGoogle ScholarPubMed
Musso, G, Gambino, R, Cassader, M, et al. (2011) Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity. Ann Med 43, 617–649.CrossRefGoogle ScholarPubMed
Targher, G, Day, CP & Bonora, E (2010) Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 363, 1341–1350.CrossRefGoogle ScholarPubMed
Williamson, RM, Price, JF, Glancy, S, et al. (2011) Prevalence of and risk factors for hepatic steatosis and nonalcoholic Fatty liver disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes Care 34, 1139–1144.CrossRefGoogle ScholarPubMed
Simon, TG, Roelstraete, B, Khalili, H, et al. (2021) Mortality in biopsy-confirmed nonalcoholic fatty liver disease: results from a nationwide cohort. Gut 70, 1375–1382.CrossRefGoogle ScholarPubMed
Chalasani, N, Younossi, Z, Lavine, JE, et al. (2018) The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatol 67, 328–357.CrossRefGoogle ScholarPubMed
Berna, G & Romero-Gomez, M (2020) The role of nutrition in non-alcoholic fatty liver disease: pathophysiology and management. Liver Int 40, 102–108.CrossRefGoogle ScholarPubMed
Deng, YY, Zhong, QW, Zhong, HL, et al. (2021) Higher Healthy Lifestyle Score is associated with lower presence of non-alcoholic fatty liver disease in middle-aged and older Chinese adults: a community-based cross-sectional study. Public Health Nutr 1–9, 5081–5089.Google ScholarPubMed
Karimi, Z, Jessri, M, Houshiar-Rad, A, et al. (2014) Dietary patterns and breast cancer risk among women. Public Health Nutr 17, 1098–1106.CrossRefGoogle ScholarPubMed
Cheung, LTF, Chan, RSM, Ko, GTC, et al. (2018) Diet quality is inversely associated with obesity in Chinese adults with type 2 diabetes. Nutr J 17, 63.CrossRefGoogle ScholarPubMed
Hassannejad, R, Moosavian, SP, Mohammadifard, N, et al. (2021) Long-term association of red meat consumption and lipid profile: a 13-year prospective population-based cohort study. Nutr 86, 111144.CrossRefGoogle ScholarPubMed
Yang, YX, Wang, GY & Pan, XC (2009) China Food Composition, 2nd ed. Beijing: Peking University Medical Press.Google Scholar
Zeng, FF, Fan, F, Xue, WQ, et al. (2013) The association of red meat, poultry, and egg consumption with risk of hip fractures in elderly Chinese: a case-control study. Bone 56, 242–248.CrossRefGoogle ScholarPubMed
McGettigan, B, McMahan, R, Orlicky, D, et al. (2019) Dietary lipids differentially shape nonalcoholic steatohepatitis progression and the transcriptome of Kupffer cells and infiltrating macrophages. Hepatology 70, 67–83.CrossRefGoogle ScholarPubMed
Ji, S, Wang, F, Chen, Y, et al. (2017) Developmental changes in the level of free and conjugated sialic acids, Neu5Ac, Neu5Gc and KDN in different organs of pig: a LC-MS/MS quantitative analyses. Glycoconj J 34, 21–30.CrossRefGoogle ScholarPubMed
Luo, Y & Lin, H (2021) Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease. Immun Inflamm Dis 9, 59–73.CrossRefGoogle ScholarPubMed
Romeu, M, Aranda, N, Giralt, M, et al. (2013) Diet, iron biomarkers and oxidative stress in a representative sample of Mediterranean population. Nutr J 12, 102.CrossRefGoogle Scholar
Gueraud, F, Tache, S, Steghens, JP, et al. (2015) Dietary polyunsaturated fatty acids and heme iron induce oxidative stress biomarkers and a cancer promoting environment in the colon of rats. Free Radic Biol Med 83, 192–200.CrossRefGoogle Scholar
Zelber-Sagi, S, Ivancovsky-Wajcman, D, Fliss Isakov, N, et al. (2018) High red and processed meat consumption is associated with non-alcoholic fatty liver disease and insulin resistance. J Hepatol 68, 1239–1246.CrossRefGoogle ScholarPubMed
Hashemian, M, Merat, S, Poustchi, H, et al. (2021) Red meat consumption and risk of nonalcoholic fatty liver disease in a population with low meat consumption: the Golestan Cohort Study. Am J Gastroenterol 116, 1667–1675.CrossRefGoogle Scholar
Shi, L, Liu, ZW, Li, Y, et al. (2012) The prevalence of nonalcoholic fatty liver disease and its association with lifestyle/dietary habits among university faculty and staff in Chengdu. Biomed Environ Sci 25, 383–391.Google ScholarPubMed
Zhang, S, Gu, Y, Bian, S, et al. (2021) Soft drink consumption and risk of nonalcoholic fatty liver disease: results from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) cohort study. Am J Clin Nutr 113, 1265–1274.CrossRefGoogle ScholarPubMed
Zhang, S, Gan, S, Zhang, Q, et al. (2021) Ultra-processed food consumption and the risk of non-alcoholic fatty liver disease in the Tianjin Chronic Low-grade Systemic Inflammation and Health Cohort Study. Int J Epidemiol 51, 237–249.CrossRefGoogle Scholar
Farrell, GC, Chitturi, S, Lau, GK, et al. (2007) Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary. J Gastroenterol Hepatol 22, 775–777.CrossRefGoogle ScholarPubMed
Zhang, S, Fu, J, Zhang, Q, et al. (2019) Association between nut consumption and non-alcoholic fatty liver disease in adults. Liver Int 39, 1732–1741.CrossRefGoogle ScholarPubMed
Zhang, S, Wu, X, Bian, S, et al. (2021) Association between consumption frequency of honey and non-alcoholic fatty liver disease: results from a cross-sectional analysis based on the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) Cohort Study. Br J Nutr 125, 712–720.CrossRefGoogle ScholarPubMed
Xia, Y, Wang, N, Yu, B, et al. (2017) Dietary patterns are associated with depressive symptoms among Chinese adults: a case-control study with propensity score matching. Eur J Nutr 56, 2577–2587.CrossRefGoogle ScholarPubMed
Freedman, LS, Schatzkin, A, Midthune, D, et al. (2011) Dealing with dietary measurement error in nutritional cohort studies. J Natl Cancer Inst 103, 1086–1092.CrossRefGoogle ScholarPubMed
Craig, CL, Marshall, AL, Sjostrom, M, et al. (2003) International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 35, 1381–1395.CrossRefGoogle ScholarPubMed
Expert Panel on Detection E, Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285, 2486–2497.CrossRefGoogle Scholar
Chobanian, AV, Bakris, GL, Black, HR, et al. (2003) The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 289, 2560–2572.CrossRefGoogle ScholarPubMed
Hernandez, EA, Kahl, S, Seelig, A, et al. (2017) Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance. J Clin Invest 127, 695–708.CrossRefGoogle ScholarPubMed
Ioannou, GN (2016) The role of cholesterol in the pathogenesis of NASH. Trend Endocrinol Metab 27, 84–95.CrossRefGoogle ScholarPubMed
Zhang, X, Coker, OO, Chu, ES, et al. (2021) Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites. Gut 70, 761–774.CrossRefGoogle ScholarPubMed
Comhair, TM, Garcia Caraballo, SC, Dejong, CH, et al. (2011) Dietary cholesterol, female gender and n-3 fatty acid deficiency are more important factors in the development of non-alcoholic fatty liver disease than the saturation index of the fat. Nutr Metab 8, 4.CrossRefGoogle Scholar
Huang, J, Jones, D, Luo, B, et al. (2011) Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. Diabetes 60, 80–87.CrossRefGoogle Scholar
Rinella, ME (2015) Nonalcoholic fatty liver disease: a systematic review. JAMA 313, 2263–2273.CrossRefGoogle ScholarPubMed
Rajpathak, SN, Crandall, JP, Wylie-Rosett, J, et al. (2009) The role of iron in type 2 diabetes in humans. Biochim Biophys Acta 1790, 671–681.CrossRefGoogle ScholarPubMed
Freedman, ND, Cross, AJ, McGlynn, KA, et al. (2010) Association of meat and fat intake with liver disease and hepatocellular carcinoma in the NIH-AARP cohort. J Natl Cancer Inst 102, 1354–1365.CrossRefGoogle ScholarPubMed
Samraj, AN, Pearce, OM, Laubli, H, et al. (2015) A red meat-derived glycan promotes inflammation and cancer progression. Proc Natl Acad Sci USA 112, 542–547.CrossRefGoogle ScholarPubMed
Tangvoranuntakul, P, Gagneux, P, Diaz, S, et al. (2003) Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid. Proc Natl Acad Sci USA 100, 12045–12050.CrossRefGoogle ScholarPubMed
Hernaez, R, Lazo, M, Bonekamp, S, et al. (2011) Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis. Hepatology 54, 1082–1090.CrossRefGoogle ScholarPubMed
Li et al. supplementary material
Tables S1-S2
File
19.2 KB