Hostname: page-component-8448b6f56d-t5pn6 Total loading time: 0 Render date: 2024-04-20T02:38:18.463Z Has data issue: false hasContentIssue false
  • English
  • Français

Six-month course of mild cognitive impairment and affective symptoms in late-life depression

Published online by Cambridge University Press:  16 April 2020

Georg Adler ,
Katrin Chwalek  and
Ana Jajcevic
Georg Adler*
Affiliation:
Altentagesklinik, Zentralinstitut für Seelische Gesundheit, J5, 68159Mannheim, Germany
Katrin Chwalek
Affiliation:
Altentagesklinik, Zentralinstitut für Seelische Gesundheit, J5, 68159Mannheim, Germany
Ana Jajcevic
Affiliation:
Altentagesklinik, Zentralinstitut für Seelische Gesundheit, J5, 68159Mannheim, Germany
*
*Corresponding author. Email address: adler@zi-mannheim.de
Get access

Abstract

Mild cognitive impairment (MCI) is frequent in patients with late-life depression. Previous studies indicate that cognitive performance in these patients is not or only marginally improved when they recover from depression. However, recovery from cognitive impairments due to depression may have a longer time course than recovery from affective symptoms. In a group of 34 elderly depressed patients (mean age: 73.4 years) admitted to a gerontopsychiatric day-clinic, severity of depression and cognitive performance were assessed before the initiation of treatment and were reassessed 6 months later. At admission, 18 of 34 patients (53%) fulfilled the criteria for MCI, with a preponderance of impairments in short-term memory and visuospatial capabilities. At the 6-month follow-up, cognitive performance had not significantly improved for the entire group; 12 of 27 patients (44%) still were fulfilling the criteria for MCI. No relationships could be ascertained between cognitive impairment or functional level and severity or course of depression. Patients with diurnal variations of the depressive symptomatology were less likely to fully recover from depression.

Keywords

Late-life depressionMild cognitive impairmentShort-term memoryPrognosisDementia
Type
Short communication
Information
European Psychiatry , Volume 19 , Issue 8 , December 2004 , pp. 502 - 505
Copyright
Copyright © European Psychiatric Association 2004

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adler, GBramesfeld, AJajcevic, A.Mild cognitive impairment in old-age depression is associated with increased EEG slow-wave power. Neuropsychobiology 1999;40:218–22.CrossRefGoogle ScholarPubMed
Adler, GBramesfeld, AJajcevic, A.Leichte kognitive Beeinträchtigung bei älteren depressiven Patienten (Mild cognitive impairment in elderly depressed patients). Z Gerontopsychol psychiat 1999;12:97–105.Google Scholar
Alexopoulos, GSMeyers, BSYoung, RCCampbell, SSilberzweig, DCharlson, M.“Vascular depression” hypothesis. Arch Gen Psychiatry 1997;54:915–22.CrossRefGoogle ScholarPubMed
Bramesfeld, AAdler, GBrassen, SSchnitzler, M.Day-clinic treatment of late-life depression. Int J Geriatr Psychiatry 2001;16:82–7.3.0.CO;2-G>CrossRefGoogle ScholarPubMed
Butters, MABecker, JTNebes, RDZmuda, MDMulsant, BHPollock, BG, et al. Changes in cognitive functioning following treatment of late-life depression. Am J Psychiatry 2000;157:1949–54.CrossRefGoogle ScholarPubMed
Flicker, CFerris, SHReisberg, B.Mild cognitive impairment in the elderly: predictors of dementia. Neurology 1991;41:1006–9.CrossRefGoogle ScholarPubMed
Hamilton, M.Development of a rating scale for primary depressive illness. Br J Soc Cin Psychol 1967;6:278–96.CrossRefGoogle ScholarPubMed
Hughes, CPBerg, LDanziger, WLCoben, LAMartin, RL.A new clinical scale for the staging of dementia. Br J Psychiatry 1982;140: 566–72.CrossRefGoogle ScholarPubMed
Kivela, SLPahkala, K.The prognosis of depression in old age. Int Psychogeriatr 1989;1:119–33.CrossRefGoogle ScholarPubMed
La Rue, ASpar, JHill, CD.Cognitive impairment in late-life depression: clinical correlates and treatment implications. J Affect Disord 1986;11:179–84.CrossRefGoogle ScholarPubMed
Lawton, MPBrodie, EM. Assessment of older people, self maintaining and instrumental activities of daily living. Gerontologist 1969;9:179–86.CrossRefGoogle ScholarPubMed
Lockwood, KAAlexopoulos, GSKakuma, TVam Gorp, WG. Subtypes of cognitive impairment in depressed older adults. Am J Geriatr Psychiatry 2000;8:201–8.CrossRefGoogle ScholarPubMed
Mahoney, FIBarthel, DW.Functional evaluation: the Barthel Index. Md Med J 1965;14:61–5.Google ScholarPubMed
Maule, MMMilne, JSWilliamson, J.Mental illness and physical health in older people. Age Ageing 1984;13:349–56.CrossRefGoogle ScholarPubMed
Miller, IWBishop, SNorman, WHMaddever, H.The modified Hamilton rating scale for depression: reliability and validity. Psychiat Res 1985;14:131–42.CrossRefGoogle ScholarPubMed
Morris, JCStorandt, MMiller, JPMcKeel, DWPrice, JLRubin, EHBerg, L.Mild cognitive impairment represents early-stage Alzheimer disease. Arch Neurol 2001;58:397–405.CrossRefGoogle ScholarPubMed
O’Connor, DWPollitt, PAHyde, JBMiller, MDFellowes, JL.Clinical issues relating to the diagnoses of mild dementia in a British community survey. Arch Neurol 1991;48:530–4.CrossRefGoogle Scholar
Reisberg, BFerris, SHde Leon, MJCrook, T.The Global Deterioration Scale (GDS): an instrument for the assessment of primary degenerative dementia. Am J Psychiatry 1982;139:1135–9.Google Scholar
Reischies, FMNeu, P.Comorbidity of mild cognitive disorder and depression—a neuropsychological analysis. Eur Arch Psychiatry Clin Neurosci 2000;250:186–93.CrossRefGoogle ScholarPubMed
Van Reekum R, Simard, MClarke, DBinns, MAConn, D.Late-life depression as a possible predictor of dementia: cross-sectional and follow-up results. Am J Geriatr Psychiatry 1999;7:151–9.Google Scholar
Salloway, SMalloy, PKohn, RGillard, EDuffy, JRogg, J, et al. MRI and neuropsychological differences in early- and late-life-onset geriatric depression. Neurology 1996;46:1567–74.CrossRefGoogle ScholarPubMed
Zaudig, MHiller, W.Strukturiertes Interview für die Diagnose einer Demenz vom Alzheimer Typ, der Multiinfarkt- (oder vaskulären) Demenz und Demenzen anderer Ätiologie nach DSM-III-R, DSM-IV und ICD10. SIDAM. Bern-Göttingen-Toronto-Seattle: Verlag Hans Huber; 1996.Google Scholar
Zaudig, MMittelhammer, JHiller, WPauls, AThora, CMorinigo, A, et al. SIDAM—a structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct dementia and dementias of other aetiology according to ICD-10 and DSM-III-R. Psychol Med 1991;21:225–36.CrossRefGoogle Scholar
Submit a response

Comments

No Comments have been published for this article.