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Prognostic power of anaerobic threshold parameters in patients with transposition of the great arteries and systemic right ventricle

Published online by Cambridge University Press:  18 October 2019

António V. Gonçalves Open the ORCID record for António V. Gonçalves [Opens in a new window] ,
Tânia Mano ,
Ana Agapito ,
Sílvia A. Rosa ,
Lídia de Sousa ,
Pedro Rio ,
José Alberto ,
André Monteiro ,
Tiago P. da Silva  and
Rita I. Moreira Open the ORCID record for Rita I. Moreira [Opens in a new window]
...Show all authors
António V. Gonçalves*
Affiliation:
Department of Cardiology, Hospital de Santa Marta, Centro Universitário Hospitalar de Lisboa Central, Lisbon, Portugal
Tânia Mano
Affiliation:
Department of Cardiology, Hospital de Santa Marta, Centro Universitário Hospitalar de Lisboa Central, Lisbon, Portugal
Ana Agapito
Affiliation:
Department of Cardiology, Hospital de Santa Marta, Centro Universitário Hospitalar de Lisboa Central, Lisbon, Portugal
Sílvia A. Rosa
Affiliation:
Department of Cardiology, Hospital de Santa Marta, Centro Universitário Hospitalar de Lisboa Central, Lisbon, Portugal
Lídia de Sousa
Affiliation:
Department of Cardiology, Hospital de Santa Marta, Centro Universitário Hospitalar de Lisboa Central, Lisbon, Portugal
Pedro Rio
Affiliation:
Department of Cardiology, Hospital de Santa Marta, Centro Universitário Hospitalar de Lisboa Central, Lisbon, Portugal
José Alberto
Affiliation:
Department of Cardiology, Hospital de Santa Marta, Centro Universitário Hospitalar de Lisboa Central, Lisbon, Portugal
André Monteiro
Affiliation:
Department of Cardiology, Hospital de Santa Marta, Centro Universitário Hospitalar de Lisboa Central, Lisbon, Portugal
Tiago P. da Silva
Affiliation:
Department of Cardiology, Hospital de Santa Marta, Centro Universitário Hospitalar de Lisboa Central, Lisbon, Portugal
Rita I. Moreira
Affiliation:
Department of Cardiology, Hospital de Santa Marta, Centro Universitário Hospitalar de Lisboa Central, Lisbon, Portugal
Rui Soares
Affiliation:
Department of Cardiology, Hospital de Santa Marta, Centro Universitário Hospitalar de Lisboa Central, Lisbon, Portugal
Fátima Pinto
Affiliation:
Reference Center for Congenital Heart Defects, Hospital de Santa Marta, Centro Universitário Hospitalar de Lisboa Central, Lisbon, Portugal
Rui C. Ferreira
Affiliation:
Department of Cardiology, Hospital de Santa Marta, Centro Universitário Hospitalar de Lisboa Central, Lisbon, Portugal
*
Author for correspondence: A. V. Gonçalves, Department of Cardiology, Hospital de Santa Marta, Rua de Santa Marta, nº 50, 1169-024 Lisbon, Portugal. Tel: +351 961156697; E-mail: antonio.a.goncalves.14@gmail.com
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Abstract

Introduction:

Both transposition of the great arteries (TGA) previously submitted to a Senning/Mustard procedure and congenitally corrected TGA (cc-TGA) have the systemic circulation supported by the morphological right ventricle, thereby rendering these patients to heart failure events risk. The aim of this study was to evaluate cardiopulmonary exercise test parameters for stratifying the risk of heart failure events in TGA patients.

Methods:

Retrospective evaluation of adult TGA patients with systemic circulation supported by the morphological right ventricle submitted to cardiopulmonary exercise test in a tertiary centre. Patients were followed up for at least 1 year for the primary endpoint of cardiac death or heart failure hospitalisation. Several cardiopulmonary exercise test parameters were analysed as potential predictors of the combined endpoint and their predictive power were compared (area under the curve).

Results:

Cardiopulmonary exercise test was performed in 44 TGA patients (8 cc-TGA), with a mean age of 35.1 ± 8.4 years. The primary endpoint was reached by 10 (22.7%) patients, with a mean follow-up of 36.7 ± 26.8 months. Heart rate at anaerobic threshold had the highest area under the curve value (0.864), followed by peak oxygen consumption (pVO2) (0.838). Heart rate at anaerobic threshold ≤95 bpm and pVO2 ≤20 ml/kg/min had a sensitivity of 87.5 and 80.0% and a specificity of 82.4 and 76.5%, respectively, for the primary outcome.

Conclusion:

Heart rate at anaerobic threshold ≤95 bpm had the highest predictive power of all cardiopulmonary exercise test parameters analysed for heart failure events in TGA patients with systemic circulation supported by the morphological right ventricle.

Keywords

Transposition of the great arteriessystemic right ventricleheart failureprognosticSenning/Mustard
Type
Original Article
Information
Cardiology in the Young , Volume 29 , Issue 12 , December 2019 , pp. 1445 - 1451
Copyright
© Cambridge University Press 2019 

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