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N-acetyltransferase-2 polymorphisms and schizophrenia

Published online by Cambridge University Press:  16 April 2020

Pilar Alejandra Saiz ,
Maria P Garcia-Portilla ,
Celso Arango ,
Blanca Morales ,
Victoria Alvarez ,
Eliecer Coto ,
Juan M Fernandez ,
Manuel Bousono  and
Julio Bobes
Pilar Alejandra Saiz*
Affiliation:
School of Medicine, University of Oviedo, Department of Psychiatry, Julian Claveria 6 - 3th, 33006, Oviedo, Asturias, Spain
Maria P Garcia-Portilla
Affiliation:
School of Medicine, University of Oviedo, Department of Psychiatry, Julian Claveria 6 - 3th, 33006, Oviedo, Asturias, Spain
Celso Arango
Affiliation:
School of Medicine, University of Oviedo, Department of Psychiatry, Julian Claveria 6 - 3th, 33006, Oviedo, Asturias, Spain
Blanca Morales
Affiliation:
School of Medicine, University of Oviedo, Department of Psychiatry, Julian Claveria 6 - 3th, 33006, Oviedo, Asturias, Spain
Victoria Alvarez
Affiliation:
School of Medicine, University of Oviedo, Department of Psychiatry, Julian Claveria 6 - 3th, 33006, Oviedo, Asturias, Spain
Eliecer Coto
Affiliation:
School of Medicine, University of Oviedo, Department of Psychiatry, Julian Claveria 6 - 3th, 33006, Oviedo, Asturias, Spain
Juan M Fernandez
Affiliation:
School of Medicine, University of Oviedo, Department of Psychiatry, Julian Claveria 6 - 3th, 33006, Oviedo, Asturias, Spain
Manuel Bousono
Affiliation:
School of Medicine, University of Oviedo, Department of Psychiatry, Julian Claveria 6 - 3th, 33006, Oviedo, Asturias, Spain
Julio Bobes
Affiliation:
School of Medicine, University of Oviedo, Department of Psychiatry, Julian Claveria 6 - 3th, 33006, Oviedo, Asturias, Spain
*
*Corresponding author. Tel: +34985103552, fax: +34985103552. E-mail address: frank@uniovi.es (P.A. Saiz).
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Abstract

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Keywords

SchizophreniaN-acetyltransferase-2Genetic associationGenetic polymorphisms
Type
Original articles
Information
European Psychiatry , Volume 21 , Issue 5 , July 2006 , pp. 333 - 337
Copyright
Copyright © Elsevier SAS 2006

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References

Ambrosone, C.B., Freudenheim, J.L., Graham, S., Marshall, J.R., Vena, J.E., Brasure, J.R.et al.Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk. JAMA 1996;276:1494–1501.CrossRefGoogle ScholarPubMed
Agundez, J.A., Jimenez-Jimenez, F.J., Luengo, A., Molina, J.A., Orti-Pareja, M., Vazquez, A.et al.Slow allotypic variants of the NAT2 gene and susceptibility to early-onset Parkinson’s disease. Neurology 1998;51:1587–1592.CrossRefGoogle ScholarPubMed
Agundez, J.A.G., Olivera, M., Martinez, C., Ladero, J.M., Benitez, J.Identification and prevalence study of 17 allelic variants of the human NAT2 gene in a white population. Pharmacogenetics 1996;6:423–428.CrossRefGoogle Scholar
Blouin, J.L., Dombroski, B.A., Nath, S.K., Lasseter, V.K., Wolyniec, P.S., Nestadt, G.et al.Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat. Genet 1998;20:70–73.CrossRefGoogle ScholarPubMed
Brzustowicz, L.M., Honer, W.G., Chow, E.W., Little, D., Hogan, J., Hodgkinson, K.et al.Linkage of familial schizophrenia to chromosome 13q32. Am. J. Hum. Genet 1999;65:1096–1103.CrossRefGoogle ScholarPubMed
Badner, J.A., Gershon, E.S.Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol. Psychiatr 2002;7:405–411.CrossRefGoogle Scholar
Blaveri, E., Kalsi, G., Lawrence, J., Quested, D., Moorey, H., Lamb, G.et al.Genetic association studies of schizophrenia using the 8p21-22 genes: prepronociceptin (PNOC), neuronal nicotinic cholinergic receptor alpha polypeptide 2 (CHRNA2) and arylamine N-acetyltransferase 1 (NAT1). Eur. J. Hum. Genet 2001;9:469–472.CrossRefGoogle Scholar
Bandmann, O., Vaughan, J., Holmans, P., Marsden, C.D., Wood, N.W.Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson’s disease. Lancet 1997;350:1136–1139.CrossRefGoogle ScholarPubMed
Butcher, N.J., Boukouvala, S., Sim, E., Minchin, R.F.Pharmacogenetics of the arylamine N-acetyltransferases. Pharmacogenomics J 2002;2:30–42.CrossRefGoogle ScholarPubMed
Blum, M., Demierre, A., Grant, D.M., Heim, M., Meyer, U.A.Molecular mechanism of slow acetylation of drugs and carcinogens in humans. Proc. Natl. Acad. Sci. USA 1991;88:5237–5241.CrossRefGoogle ScholarPubMed
Cascorbi, I., Drakoulis, N., Brockmoller, J., Maurer, A., Sperling, K., Roots, I.Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity. Am. J. Hum. Genet 1995;57:581–592.Google ScholarPubMed
Curtis, D., Knight, J. Genecounting Program. http://www.mds.qmul.ac.uk/statgen/dcurtis.html. 2003. Accessed, November 8, 2005.Google Scholar
Deutsch, S.I., Rosse, R.B., Schwartz, B.L., Mastropaolo, J.A revised excitotoxic hypothesis of schizophrenia: therapeutic implications. Clin. Neuropharmacol 2001;24:43–49.CrossRefGoogle ScholarPubMed
Dean, K., Murray, R.M.Environmental risk factors for psychosis. Dialogues Clin. Neurosci 2005;7:69–80.Google Scholar
Drozdz, M., Gierek, T., Jendryczko, A., Pilch, J., Piekarska, J.N-acetyltransferase phenotype of patients with cancer of the larynx. Neoplasma 1987;34:481–484.Google ScholarPubMed
De Leon, J., Diaz, F.J.A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviours. Schizophr. Res 2005;76:135–157.CrossRefGoogle Scholar
Gurling, H.M.D., Kalsi, G., Brynjolfson, J., Sigmundsson, T., Sherrington, R., Mankoo, B.S.et al.Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23. Am. J. Hum. Genet 2001;68:661–673.CrossRefGoogle ScholarPubMed
Garte, S., Gaspari, L., Alexandrie, A.K., Ambrosone, C., Autrup, H., Autrup, J.L.et al.Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol. Biomarkers Prev 2000;10:1239–1248.Google Scholar
González, M.V., Alvarez, V., Pello, M.F., Menéndez, M.J., Suárez, C., Coto, E.Genetic polimorphism of N-acetyltransferase-2, glutathione S-transferase-M1, and cytochromes P450IIE1 and P450IID6 in the susceptibility to head and neck cancer. J. Clin. Pathol 1998;51:294–298.CrossRefGoogle Scholar
Hovatta, I., Varilo, T., Suvisaari, J., Terwilliger, J.D., Ollikainen, V., Arajärvi, R.et al.A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. Am. J. Hum. Genet 1999;65:1114–1124.CrossRefGoogle Scholar
Hickman, D., Risch, A., Camilleri, P., Sim, E.Genotyping human polymorphic arylamine N-acetyltransferase: identification of new slow allotypic variants. Pharmacogenetics 1992;2:217–226.CrossRefGoogle ScholarPubMed
Hein, D.W., Doll, M.A., Fretland, A.J., Leff, M.A., Webb, S.J., Xiao, G.H.et al.Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms. Cancer Epidemiol. Biomarkers Prev 2000;9:29–42.Google ScholarPubMed
Hein, D.W., Ferguson, R.J., Doll, M.A., Rustan, T.D., Gray, K.Molecular genetics of human polymorphic N-acetyltransferase: enzymatic analysis of 15 recombinant wild-type, mutant, and chimeric NAT2 allozymes. Hum. Mol. Genet 1994;3:729–734.Google ScholarPubMed
Hirvonen, A.Genetic factors in individual responses to environmental exposures. J. Occup. Environ. Med 1995;37:37–43.CrossRefGoogle ScholarPubMed
Ilett, K.F., David, B.M., Detchon, P., Castleden, W.M., Kwa, R.Acetylation phenotype in colorectal carcinoma. Cancer Res 1987;47:1466–1469.Google ScholarPubMed
Kelly, C., McCreadie, R.G.Smoking habits, current symptoms, and premorbid characteristics of schizophrenic patients in Nithsdale, Scotland. Am. J. Psychiatry 1999;156:1751–1757.Google ScholarPubMed
Kaufmann, C.A., Suarez, B., Malaspina, D., Pepple, J., Svrakic, D., Markel, P.D.et al.NIMH Genetics Initiative Millenium Schizophrenia Consortium: linkage analysis of African-American pedigrees. Am. J. Med. Genet 1998;81:282–289.3.0.CO;2-W>CrossRefGoogle ScholarPubMed
Kendler, K.S., MacLean, C.J., O’Neill, F.A., Burke, J., Murphy, B., Duke, F.et al.Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families. Am. J. Psychiatry 1996;153:1534–1540.Google ScholarPubMed
Levinson, D.F., Wildenauer, D.B., Schwab, S.G., Albus, M., Hallmayer, J., Lerer, B.et al.Additional support for schizophrenia linkage on chromosomes 6 and 8: a multicenter study. Am. J. Med. Genet 1996;67:580–594.Google Scholar
Lewis, C.M., Levinson, D.F., Wise, L.H., DeLisi, L.E., Straub, R.E., Hovatta, I.et al.Genome scan metaanalysis of schizophrenia and bipolar disorder, part II: schizophrenia. Am. J. Hum. Genet 2003;73:34–48.CrossRefGoogle Scholar
Lin, H.J., Han, C.Y., Lin, B.K., Hardy, S.Slow acetylator mutations in the human polymorphic N-acetyltransferase gene in 786 Asians, Blacks, Hispanics, and Whites: application to metabolic epidemiology. Am. J. Hum. Genet 1993;52:827–834.Google ScholarPubMed
Lin, H.J., Han, C.Y., Lin, B.K., Hardy, S.Ethnic distribution of slow acetilator mutations in the polymorphic N-acetyltransferase (NAT2) gene. Pharmacogenetics 1994;4:125–134.CrossRefGoogle Scholar
Matas, N., Thygesen, P., Stacey, M., Rich, A., Sim, E.Mapping AAC1, AAC2 and AACP, the genes for arylamine N-acetyltransferases, carcinogen metabolising enzymes on human chromosome 8p22, a region frequently deleted in tumours. Cytogenet. Cell Genet 1997;77:290–295.CrossRefGoogle ScholarPubMed
O’Donovan, M.C., Owen, M.J.Candidate-gene association studies of schizophrenia. Am. J. Hum. Genet 1999;65:587–592.CrossRefGoogle ScholarPubMed
Pulver, A.E., Lasseter, V.K., Kasch, L., Wolyniec, P., Nestadt, G., Blouin, J.L.et al.Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am. J. Med. Genet 1995;60:252–260.CrossRefGoogle ScholarPubMed
Perneger, T.V.What’s wrong with Bonferroni adjustements. BMJ 1998 1236–1238.CrossRefGoogle Scholar
Rodrigo, L., Alvarez, V., Rodriguez, M., Perez, R., Alvarez, R., Coto, E.N-acetyltransferase-2, glutathione S-transferase M1, alcohol dehydrogenase, and cytochrome P450IIE1 genotypes in alcoholic liver cirrhosis: a case-control study. Scand. J. Gastroenterol 1999;34:303–307.Google ScholarPubMed
Risch, A., Wallace, D.M., Bathers, S., Sim, E.Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer. Hum. Mol. Genet 1995;4:231–236.CrossRefGoogle ScholarPubMed
Shaw, S.H., Kelly, M., Smith, A.B., Shields, G., Hopkins, P.J., Loftus, J.et al.A genome-wide search for schizophrenia susceptibility genes. Am. J. Med. Genet 1998;81:364–376.3.0.CO;2-T>CrossRefGoogle ScholarPubMed
Straub, R.E., MacLean, C.J., Ma, Y., Webb, B.T., Myakishev, M.V., Harris-Kerr, C.et al.Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes. Mol. Psychiatr 2002;7:542–559.CrossRefGoogle ScholarPubMed
Smythies, J.Endogenous neurotoxins relevant to schizophrenia. J. R. Soc. Med 1996;89:679–680.CrossRefGoogle Scholar
Vatsis, K.P., Martell, K.J., Weber, W.W.Diverse point mutations in the human gene for polymorphic N-acetyltransferase. Proc. Natl. Acad. Sci. USA 1991;88:6333–6337.CrossRefGoogle ScholarPubMed
Von Schmiedeberg, S., Fritsche, E., Ronnau, A.C., Specker, C., Golka, K., Richter-Hintz, D.et al.Polymorphisms of the xenobiotic metabolizing enzymes CYP1A1 and NAT-2 in systemic sclerosis and lupus erythematosus. Adv. Exp. Med. Biol 1999;455:147–152.CrossRefGoogle ScholarPubMed
Williams, N.M., Rees, M.I., Holmans, P., Norton, N., Cardno, A.G., Jones, L.A.et al.A two-stage genome scan for schizophrenia susceptibility genes in 196 affected sibling pairs. Hum. Mol. Genet 1999;8:1729–1739.CrossRefGoogle ScholarPubMed
World Medical Association. Declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects. Amened by the 41st World Medical Assembly, Hong Kong, September, 1989.Google Scholar
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