We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure coreplatform@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
This chapter discusses the different ways textual criticism and reception history are interrelated. Textual criticism is not simply the prerequisite to the task of interpretation but can help to illuminate the compositional growth, transmission, and early interpretation of biblical texts.
Healthcare workers (HCWs) have increased exposure and subsequent risk of infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This case-control study was conducted to investigate the contemporaneous risks associated with confirmed SARS-CoV-2 infection amongst HCWs following in-work exposure to a confirmed coronavirus disease-2019 (COVID-19) case. We assessed the influence of demographic (age, sex, nationality, high risk co-morbidities and vaccination status) and work-related factors (job role, exposure location, contact type, personal protective equipment (PPE) use) on infection risk following nosocomial SARS-CoV-2 exposure. All contact tracing records within the hospital site during waves 1–3 of the COVID-19 pandemic in Ireland were screened to identify exposure events, cases and controls. In total, 285 cases and 1526 controls were enrolled, as a result of 1811 in-work exposure events with 745 index cases. We demonstrate that male sex, Eastern European nationality, exposure location, PPE use and vaccination status all impact the likelihood of SARS-CoV-2 infection following nosocomial SARS-CoV-2 exposure. The findings draw attention to the need for continuing emphasis on PPE use and its persisting benefit in the era of COVID-19 vaccinations. We suggest that non-work-related factors may influence infection risk seen in certain ethnic groups and that infection risk in high-risk HCW roles (e.g. nursing) may be the result of repeated exposures rather than risks inherent to a single event.
This chapter explores how writing affected the nature of custom itself. The writing of custom did not fix or petrify custom and end its malleability or creativity, as scholars have assumed. Drawing on the work of literary scholars on the nature of medieval vernacular text and manuscript culture, I argue instead that each manuscript provided one authoritative version of custom and constituted one voice in a conversation over custom that continued with written text. This conversation can be seen where differences between manuscripts show diverging opinions about proper custom. This, in turn, meant that custom remained creative and dynamic even in written form. The purpose of the coutumiers was not to copy practised custom and faithfully record it with perfect accuracy in text. Rather, the coutumiers were meant to change the patterns of thought of ‘those who would hear or read the text’ and show them how to think in a legal manner, like a lawyer, judge, or sophisticated litigant. Teaching modes of thought rather than rules permitted those who did not spend years in university to understand the framework and rhetoric of lay courts, and enabled them to navigate these through changing rules, time, and circumstance.
Written by an interdisciplinary team of scholars, this book offers novel perspectives on the history of medical writing and scientific thought-styles by examining patterns of change and reception in genres, discourse, and lexis in the period 1500-1820. Each chapter demonstrates in detail how changing textual forms were closely tied to major multi-faceted social developments: industrialisation, urbanisation, expanding trade, colonialization, and changes in communication, all of which posed new demands on medical care. It then shows how these developments were reflected in a range of medical discourses, such as bills of mortality, medical advertisements, medical recipes, and medical rhetoric, and provides an extensive body of case studies to highlight how varieties of medical discourse have been targeted at different audiences over time. It draws on a wide range of methodological frameworks and is accompanied by numerous relevant illustrations, making it essential reading for academic researchers and students across the human sciences.
Household transmission plays a key role in the spread of COVID-19 through populations. In this paper, we report on the transmission of COVID-19 within households in a metropolitan area in Australia, examine the impact of various factors and highlight priority areas for future public health responses. We collected and reviewed retrospective case report data and follow-up interview responses from households with a positive case of the Delta COVID-19 variant in Queensland in 2021. The overall secondary attack rate (SAR) among household contacts was 29.6% and the mean incubation period for secondary cases was 4.3 days. SAR was higher where the index case was male (57.9% vs. 14.3%) or aged ≤12 years (38.7% vs. 17.4%) but similar for adult contacts that were double vaccinated (35.7%) and unvaccinated (33.3%). Most interview participants emphasised the importance of clear, consistent and compassionate health advice as a key priority for managing outbreaks in the home. The overall rate of household transmission was slightly higher than that reported in previous studies on the wild COVID-19 variant and secondary infections developed more rapidly. While vaccination did not appear to affect the risk of transmission to adult subjects, uptake in the sample was ultimately high.
Coronavirus disease 2019 (COVID-19) asymptomatic cases are hard to identify, impeding transmissibility estimation. The value of COVID-19 transmissibility is worth further elucidation for key assumptions in further modelling studies. Through a population-based surveillance network, we collected data on 1342 confirmed cases with a 90-days follow-up for all asymptomatic cases. An age-stratified compartmental model containing contact information was built to estimate the transmissibility of symptomatic and asymptomatic COVID-19 cases. The difference in transmissibility of a symptomatic and asymptomatic case depended on age and was most distinct for the middle-age groups. The asymptomatic cases had a 66.7% lower transmissibility rate than symptomatic cases, and 74.1% (95% CI 65.9–80.7) of all asymptomatic cases were missed in detection. The average proportion of asymptomatic cases was 28.2% (95% CI 23.0–34.6). Simulation demonstrated that the burden of asymptomatic transmission increased as the epidemic continued and could potentially dominate total transmission. The transmissibility of asymptomatic COVID-19 cases is high and asymptomatic COVID-19 cases play a significant role in outbreaks.
Chapter 9 discusses the relationship between transmission, diffusion and orthography. While diffusion can be seen as a more dominant driver of orthographic change, changes induced by transmission are also possible in some historical scenarios, for example through formal instruction or via closely knit social networks. Drawing on a number of examples from previous studies, the chapter also engages with supralocalisation, intended as an antecedent to standardisation, as local and regional orthographic conventions in the pre-standardisation era give way to more supraregional writing traditions. Thus, instances of geographical diffusion across communities frequently provide essential groundwork for later standardisation initiatives. The chapter ends with a reference to the importance of including pluricentricity in our understanding of standardisation. It is by studying regional writing traditions that one can trace the formation of a standard not as an exclusive national form, but rather as a pluricentric scenario. In the development of many European pluricentric orthographies, not least German and French, some writing traditions eventually became part of the overall profile of the regional influence through diffusion, while still not becoming a uniform fixed set of shibboleths for the whole geographical area.
As an important application of the theory of elasticity in soil mechanics, the main principles of elastodynamics are introduced. On the basis of waves in 1D-continua the notions of transmission, reflexion and dynamic stiffness are explained, and the body waves are presented as compression and shear waves. Rayleigh waves are presented as an example of surface waves.
Lurking in the Historia Augusta's life of the short-lived Emperor Carus is what appears to be a reference to the genuine contemporary poet Nemesianus and an extant work by him, the Cynegetica. Given the HA's predilection for ‘bogus authors’, this is rather surprising, but because some of what the HA says about Nemesianus is true, the otherwise unique details of his life and works that it provides have been generally accepted. We show first that the reference to the Cynegetica is an incorporated gloss in the text of the HA, one that reveals that the text was being read and studied in northern Francia. We then demonstrate that the name ‘Olympius’, which the HA gives to Nemesianus, is not authentic, offering an analysis of the text's onomastic habits more generally. We show that ‘Olympius Nemesianus’ is one of several invented authors in the HA, lent a superficial plausibility by borrowing the name of a real ancient writer. Finally, we reflect on the way that these conclusions might undermine two developing tendencies in the study of the Historia Augusta.
Contemporary technologies for offshore electricity generation and transmission enable sea uses of types and at scales that could not have been envisaged when the text of UNCLOS was agreed. The chapter considers whether UNCLOS is able to accommodate the offshore renewables revolution. It focuses on offshore wind energy, which is likely to see massive growth during the next three decades as the world decarbonizes. The review finds that UNCLOS does not always make adequate legal provision for them. Support will be needed from national laws, interstate agreements, and resolutions and guidelines of international organizations such as the International Maritime Organization to fill gaps in the law, clarify uncertainties and to meet challenges posed by offshore wind’s growth. Further regulation by states of offshore wind will also be needed to address the environmental effects of relevant development in line with duties for marine environmental protection, and to answer difficult legal questions raised by the pursuit of development that may itself cause significant environmental harm to address the environmental threats posed by climate change.
In daycare centres, the close contact of children with other children and employees favours the transmission of infections. The majority of children <6 years attend daycare programmes in Germany, but the role of daycare centres in the SARS-CoV-2 pandemic is unclear. We investigated the transmission risk in daycare centres and the spread of SARS-CoV-2 to associated households. 30 daycare groups with at least one recent laboratory-confirmed SARS-CoV-2 case were enrolled in the study (10/2020–06/2021). Close contact persons within daycare and households were examined over a 12-day period (repeated SARS-CoV-2 PCR tests, genetic sequencing of viruses, symptom diary). Households were interviewed to gain comprehensive information on each outbreak. We determined primary cases for all daycare groups. The number of secondary cases varied considerably between daycare groups. The pooled secondary attack rate (SAR) across all 30 daycare centres was 9.6%. The SAR tended to be higher when the Alpha variant was detected (15.9% vs. 5.1% with evidence of wild type). The household SAR was 53.3%. Exposed daycare children were less likely to get infected with SARS-CoV-2 than employees (7.7% vs. 15.5%). Containment measures in daycare programmes are critical to reduce SARS-CoV-2 transmission, especially to avoid spread to associated households.
In addition to time and place, which are inseparable from sociolinguistic variation, language may vary according to age, social class, sex or (social) gender, ethnicity, medium, style, and register. Contact between speakers often leads to change, and different patterns result according to whether this contact involves first-language (L1) or second language (L2) acquisition. Thus, ‘family tree’ aspects of language change are largely accounted for by transmission (involving L1 acquisition), whilst ‘wave model’ changes can be explained in terms of diffusion (involving L2 acquisition). Languages with a high degree of L2 contact will tend to simplify, whilst stable bilingualism or isolation will often lead to complexification. Contact may be interlinguistic or intralinguistic, sometimes resulting in complex linguistic repertoires, with up to four different levels existing simultaneously (national standard, regional standard, interdialectal koiné, local dialect). Contact may also result in code-switching, the emergence of contact vernaculars, and ‘language death’. The receptiveness of a variety to contact influence depends on the extent to which its social networks are open or closed and on the social attitudes of its speakers. Standard languages emerge through a variety of conscious and unconscious processes, and attempts may be made to give non-standard speech varieties a distinct linguistic identity through codification and the creation of literature.
Moving into the wider world of the ancient Near East, Michael Fox and Suzanna R. Millar examine Egyptian wisdom literature. They begin with an overview of extant examples from the Old Kingdom to the Late Period, and then turn to some major themes and issues. They consider Ma’at (the regulating force of truth/justice), character development (particularly as expressed through polar character types), pedagogy (including the debate about who is capable of learning), and transmission (through the generations in oral and written forms). The second half of the chapter assesses some commonly proposed examples of Egyptian influence on biblical wisdom literature, namely the influence of Amenemope on Prov 22:17–23:11 and elsewhere in Proverbs, Egyptian parallels to Proverbs 8, Egyptian parallels to Prov 23:12–24:22, an alleged precursor to Job 38–39 in Egyptian onomastica, and connections between Ben Sira and the Demotic Instruction Phibis.
Lockdowns have been a core infection control measure in many countries during the coronavirus disease 2019 (COVID-19) pandemic. In England's first lockdown, children of single parent households (SPHs) were permitted to move between parental homes. By the second lockdown, SPH support bubbles between households were also permitted, enabling larger within-household networks. We investigated the combined impact of these approaches on household transmission dynamics, to inform policymaking for control and support mechanisms in a respiratory pandemic context. This network modelling study applied percolation theory to a base model of SPHs constructed using population survey estimates of SPH family size. To explore putative impact, varying estimates were applied regarding extent of bubbling and proportion of different-parentage within SPHs (DSPHs) (in which children do not share both the same parents). Results indicate that the formation of giant components (in which COVID-19 household transmission accelerates) are more contingent on DSPHs than on formation of bubbles between SPHs, and that bubbling with another SPH will accelerate giant component formation where one or both are DSPHs. Public health guidance should include supportive measures that mitigate the increased transmission risk afforded by support bubbling among DSPHs. Future network, mathematical and epidemiological studies should examine both independent and combined impact of policies.
Global warming is likely to lengthen the seasonal duration of larval release by parasites. We exposed freshwater mussel hosts, Anodonta anatina, from 2 high-latitude populations to high, intermediate and low temperatures throughout the annual cercarial shedding period of the sympatric trematodes Rhipidocotyle fennica and R. campanula, sharing the same transmission pathway. At the individual host level, under warmer conditions, the timing of the cercarial release in both parasite species shifted towards seasonally earlier period while its duration did not change. At the host population level, evidence for the lengthening of larvae shedding period with warming was found for R. fennica. R. campanula started the cercarial release seasonally clearly earlier, and at a lower temperature, than R. fennica. Furthermore, the proportion of mussels shedding cercariae increased, while day-degrees required to start the cercariae shedding decreased in high-temperature treatment in R. fennica. In R. campanula these effects were not found, suggesting that warming can benefit more R. fennica. These results do not completely support the view that climate warming would invariably increase the seasonal duration of larval shedding by parasites, but emphasizes species-specific differences in temperature-dependence and in seasonality of cercarial release.
We investigated risk factors associated with COVID-19 by conducting a retrospective, frequency-matched case-control study, with three sampling periods (August–October 2020). We compared cases completing routine contact tracing to asymptomatic population controls. Multivariable analyses estimated adjusted odds ratios (aORs) for non-household community settings. Meta-analyses using random effects provided pooled odds ratios (pORs). Working in healthcare (pOR 2.87; aORs 2.72, 2.81, 3.08, for study periods 1–3 respectively), social care (pOR 4.15; aORs 2.46, 5.06, 5.41, for study periods 1–3 respectively) or hospitality (pOR 2.36; aORs 2.01, 2.54, 2.63, for study periods 1–3 respectively) were associated with increased odds of being a COVID-19 case. Additionally, working in bars, pubs and restaurants, warehouse settings, construction, educational settings were significantly associated. While definitively determining where transmission occurs is impossible, we provide evidence that in certain sectors, the impact of mitigation measures may only be partial and reinforcement of measures should be considered in these settings.
Between 21 November and 22 December 2020, a SARS-CoV-2 community testing pilot took place in the South Wales Valleys. We conducted a case-control study in adults taking part in the pilot using an anonymous online questionnaire. Social, demographic and behavioural factors were compared in people with a positive lateral flow test (cases) and a sample of negatives (controls). A total of 199 cases and 2621 controls completed a questionnaire (response rates: 27.1 and 37.6% respectively). Following adjustment, cases were more likely to work in the hospitality sector (aOR 3.39, 95% CI 1.43–8.03), social care (aOR 2.63, 1.22–5.67) or healthcare (aOR 2.31, 1.29–4.13), live with someone self-isolating due to contact with a case (aOR 3.07, 2.03–4.62), visit a pub (aOR 2.87, 1.11–7.37) and smoke or vape (aOR 1.54, 1.02–2.32). In this community, and at this point in the epidemic, reducing transmission from a household contact who is self-isolating would have the biggest public health impact (population-attributable fraction: 0.2). As restrictions on social mixing are relaxed, hospitality venues will become of greater public health importance, and those working in this sector should be adequately protected. Smoking or vaping may be an important modifiable risk factor.
EURO2020 generated a growing media and population interest across the month period, that peaked with large spontaneous celebrations across the country upon winning the tournament.
Methods
We retrospectively analysed data from the national surveillance system (indicator-based) and from event-based surveillance to assess how the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) changed in June–July 2021 and to describe cases and clusters linked with EURO2020.
Results
Widespread increases in transmission and case numbers, mainly among younger males, were documented in Italy, none were linked with stadium attendance. Vaccination coverage against SARS-CoV-2 was longer among cases linked to EURO2020 than among the general population.
Conclusions
Transmission increased across the country, mainly due to gatherings outside the stadium, where, conversely, strict infection control measures were enforced. These informal ‘side’ gatherings were dispersed across the entire country and difficult to control. Targeted communication and control strategies to limit the impact of informal gatherings occurring outside official sites of mass gathering events should be further developed.
Healthcare facilities are a well-known high-risk environment for transmission of M. tuberculosis, the etiologic agent of tuberculosis (TB) disease. However, the link between M. tuberculosis transmission in healthcare facilities and its role in the general TB epidemic is unknown. We estimated the proportion of overall TB transmission in the general population attributable to healthcare facilities.
Methods:
We combined data from a prospective, population-based molecular epidemiologic study with a universal electronic medical record (EMR) covering all healthcare facilities in Botswana to identify biologically plausible transmission events occurring at the healthcare facility. Patients with M. tuberculosis isolates of the same genotype visiting the same facility concurrently were considered an overlapping event. We then used TB diagnosis and treatment data to categorize overlapping events into biologically plausible definitions. We calculated the proportion of overall TB cases in the cohort that could be attributable to healthcare facilities.
Results:
In total, 1,881 participants had TB genotypic and EMR data suitable for analysis, resulting in 46,853 clinical encounters at 338 healthcare facilities. We identified 326 unique overlapping events involving 370 individual patients; 91 (5%) had biologic plausibility for transmission occurring at a healthcare facility. A sensitivity analysis estimated that 3%–8% of transmission may be attributable to healthcare facilities.
Conclusions:
Although effective interventions are critical in reducing individual risk for healthcare workers and patients at healthcare facilities, our findings suggest that development of targeted interventions aimed at community transmission may have a larger impact in reducing TB.