The aim of this network meta-analysis is to compare bone mineral density (BMD) changes among different osteoporosis prevention interventions in postmenopausal women. We searched MEDLINE, EMBASE, and Cochrane Library from inception to 24 February 2019. Included studies were RCTs comparing the effects of different treatments on BMD in postmenopausal women, including single or combined treatment with calcium, vitamin D, vitamin K, estrogen, isoflavone, or exercise compared with each other, placebo, or no treatment. Studies were independently screened by six authors in three pairs. Data were extracted independently by two authors and synthesized using Bayesian random-effects network meta-analysis. Results were summarized as mean difference in BMD and surface under the cumulative ranking (SUCRA) of different interventions. A total of 90 RCTs (10,777 participants) were included. Calcium, vitamin D, vitamin K, estrogen, exercise, calcium + vitamin D, vitamin D + vitamin K, vitamin D + estrogen were associated with significantly beneficial effects relative to no treatment or placebo for lumbar spine (LS). For femoral neck (FN), calcium, exercise, and vitamin D + estrogen were associated with significant beneficial intervention effects relative to no treatment. Ranking probabilities indicated that estrogen + vitamin D is the best strategy in LS, with a SUCRA of 97.29% (mean difference: +0.072 g/cm2 compared with no treatment, 95%CrI 0.045 to 0.100 g/cm2), and calcium + exercise is the best strategy in FN with a SUCRA of 79.71% (mean difference: +0.029g/cm2 compared with placebo, 95%CrI -0.00093 to 0.060 g/cm2). In conclusion, in postmenopausal women, many interventions are valuable for improving BMD in LS and FN. Different intervention combinations can affect bone mineral density at different sites diversely.