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Synthetic derivatives of progesterone are variously known as progestogens, progestagens or progestins and have a key role in hormonal contraception, either alone or in combination with oestrogen. Progestogen-only methods of contraception include pills, subdermal implants, injectables and the intrauterine system. There are several different types of subdermal implant licensed for contraceptive use across the world. The Nexplanon implant contains etonogestrel and is the most widely available subdermal contraceptive implant. Other progestogen-only contraceptive implants are licensed or being developed and include Jadelle, a two-rod implant containing levonorgestrel, and Capronor, a biodegradable single-rod implant also containing levonorgestrel. The two types of progestogen-only injectable contraception, both of which are long-acting reversible contraception (LARC) methods, are depot-medroxyprogesterone acetate (DMPA) and norethisterone oenanthate (NETEN). The most commonly used progestogen-releasing intrauterine system in most countries is the levonorgestrel-releasing intrauterine system (LNG-IUS) known as Mirena.
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