Observation on natural enemies of the stem-borer complex on sugar-cane in southern Ghana indicated that Descampsina sesamiae Mensil (Diptera:Tachinidae) is the most important larval parasite of Sesamia species. The relative abundance of this tachinid parasite appeared to vary with the rainfall pattern throughout the year and with the phenology of the sugar-cane plant. The rate of parasitism was found to be higher in the outgrowers fields than in the sugar estate's fields. Differences in cultural practices used as well as the type of vegetation bordering the sugar-cane fields, were believed to be responsible for the difference in the rate of parasitism of D. sesamiae on Sesamia species.