A wide margin of crop safety is a desirable trait of POST herbicides, and investigation of crop tolerance is a key step in evaluation of new herbicides. Six field experiments were conducted in Ontario, Canada, from 2017 to 2018 to examine the influence of corn (Zea mays L.) hybrid (DKC42-60RIB, DKC43-47RIB, P0094AM, and P9840AM), application rate (1X and 2X), and application timing (PRE, V1, V3, and V5) on the tolerance of field corn to tolpyralate, a new 4-hydroxyphenyl pyruvate dioxygenase inhibitor, co-applied with atrazine. Two corn hybrids (DKC42-60RIB and DKC43-47RIB) exhibited slightly greater visible injury from tolpyralate + atrazine, applied POST, than P0094AM and P9840AM at 1 to 2 wk after application (WAA); hybrids responded similarly with respect to height, grain moisture, and yield. Applications of tolpyralate + atrazine at a 2X rate (80 + 2,000 g ai ha−1) induced greater injury (≤31.6%) than the field rate (40 + 1,000 g ha−1) (≤11.6%); the 2X rate applied at V1 or V3 decreased corn height and slightly increased grain moisture at harvest. On average, field rates resulted in marginally higher grain yields than 2X rates. Based on mixed-model multiple stepwise regression analysis, the air temperature at application, time of day, temperature range in the 24 h before application, and precipitation following application were useful predictor variables in estimating crop injury with tolpyralate + atrazine; however, additional environmental variables also affected crop injury. These results demonstrate the margin of corn tolerance with tolpyralate + atrazine, which provides a basis for optimization of application timing, rate, and corn hybrid selection to mitigate the risk of crop injury with this herbicide tank mixture.

The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural–geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.

Effective POST herbicides and herbicide mixtures are key components of integrated weed management in corn; however, herbicides vary in their efficacy based on application timing. Six field experiments were conducted over 2 yr (2017–2018) in southwestern Ontario, Canada, to determine the effects of herbicide application timing and rate on the efficacy of tolpyralate, a new 4-hydroxyphenyl pyruvate dioxygenase inhibitor. Tolpyralate at 15, 30, or 40 g ai ha−1 in combination with atrazine at 500 or 1,000 g ai ha−1 was applied PRE, early POST, mid-POST, or late POST. Tolpyralate + atrazine at rates ≥30 + 1,000 g ha−1 provided equivalent control of common lambsquarters and Powell amaranth applied PRE or POST, whereas no rate applied PRE controlled common ragweed, velvetleaf, barnyardgrass, or green foxtail. Common ragweed, common lambsquarters, velvetleaf, and Powell amaranth were controlled equally regardless of POST timing. In contrast, control of barnyardgrass and green foxtail declined when herbicide application was delayed to the late-POST timing, irrespective of herbicide rate. Similarly, corn grain yield declined within each tolpyralate + atrazine rate when herbicide applications were delayed to late-POST timing. Overall, the results of this study indicate that several monocot and dicot weed species can be controlled with tolpyralate + atrazine with an early to mid-POST herbicide application timing, before weeds reach 30 cm in height, and Powell amaranth and common lambsquarters can also be controlled PRE. Additionally, this study provides further evidence highlighting the importance of effective, early-season weed control in corn.

This article analyses the evolution of nutritional inequality in Spain among cohorts born between 1840 and 1964. With male height data (N = 358,253), the secular trend of biological well-being and intergenerational anthropometric inequalities are studied based on the coefficient of variation, height percentiles and socioeconomic categories (students, literate non-students and illiterate). The results reveal that the nutritional inequalities were very large in the mid-19th century. Anthropometric inequalities diminished among those born between 1880 and 1919 and increased again, although only moderately, from the cohorts of the 1920s. From the 1930s there was a cycle of sustained increase in height. Despite nutritional improvement, the data suggest that nutritional inequalities increased during the Franco regime, affecting the low-income population segments particularly.

This paper explores the relationship between the physical stature of Colombians born during the 20th century and several socio-economic and demographic variables. Using a dataset of more than 225,000 individuals built with information from judicial background certificates, we found a sustained growth of the average height of women and men during the 20th century. The results show significant differences in stature according to gender, level of education, occupation, and place and date of birth. Similarly, health conditions and access to aqueducts significantly affect height. We found that departmental average height disparities decreased and the gap across regions closed throughout the century.

This article provides the first series of adult male height for 19th-century Chile. Our aim was not only to assess the trends indicated by height during this period, but also the relationship between stature and both GDP per capita and exports. Having analysed our data, our primary conclusion is that there was a reduction in height for cohorts born in the 1850s and 1860s with respect to cohorts born between 1820 and 1840. Height stagnated thereafter, with small to no improvement towards the end of the 19th century, in line with other Latin American countries for which there is comparable evidence. The increase in per capita GDP and exports during the second half of the century did not result in better biological welfare, as was the case in other Latin American countries during similar export booms.

This study aimed to assess the relationship between the Dietary Inflammatory Index (DII®), a validated tool for evaluating diet-associated inflammation, and anthropometric indices in children and adolescents. This multicentre survey was conducted on 5427 school students selected via multistage cluster sampling from thirty provinces of Iran. This survey was conducted under the framework of the weight disorders survey, which is part of a national surveillance programme entitled Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable Diseases-IV. For calculating the DII scores, twenty-five dietary factors were obtained from a validated 168-item FFQ. Height, weight, wrist circumference, neck circumference (NC), waist circumference (WC) and hip circumference (HC) were measured. BMI z-score, waist circumference:hip circumference ratio (WHR), waist circumference:height ratio (WHtR) and parental BMI were computed. Linear regression models were used to evaluate the association of DII and anthropometric indices. Significant trends were observed across quartiles of DII score for all anthropometric indices in all participants (P <0·05), except for WHR and WHtR. After adjustment for potential confounders, the multiple linear regression analysis for each anthropometric index revealed that participants in the highest DII quartile had higher BMI z-score, WC, HC and parental BMI compared with those in the first (or lowest) quartile. In summary, we found that a pro-inflammatory diet was associated with higher BMI z-score, wrist circumference, NC, WC, HC and parental BMI. The large sample size of the present study may influence the statistical significance of observed associations. Hence, the findings should be clinically interpreted with caution.

Dicamba may be an efficacious option for the control of glyphosate-resistant (GR) horseweed in glyphosate/dicamba-resistant soybean; research is needed to optimize the application rate based on horseweed height at the time of application. The purpose of this study was to determine the effect of glyphosate/dicamba rate and application timing for the control of GR horseweed. Glyphosate/dicamba was applied at three rates (900, 1,350, and 1,800 g ae ha−1) at three horseweed application timings (5, 15, and 25 cm) in a factorial design. There was no interaction between glyphosate/dicamba rate and timing for GR horseweed control or soybean yield; however, there was an interaction for GR horseweed density and biomass. At 2 and 4 wk after application (WAA), there was a decrease in GR horseweed control as the height at the time application increased. At 4 WAA, the application of glyphosate/dicamba to GR horseweed that was 5-, 15-, and 25-cm tall provided 87%, 76%, and 62% control, respectively. There was no impact of glyphosate/dicamba application timing on soybean yield. At 2, 4, and 8 WAA, there was an increase in GR horseweed control as the rate of glyphosate/dicamba was increased. At 8 WAA, glyphosate/dicamba applied at 900, 1,350, and 1,800 g ae ha−1 controlled GR horseweed 76%, 87%, and 92%, respectively. Earlier application timings and higher rates of glyphosate/dicamba caused the greatest reduction in GR horseweed density and biomass. Reduced GR horseweed competition resulted in a 100% to 144% increase in soybean yield, but there was no difference in soybean yield among glyphosate/dicamba rates tested.

Let $c$ be a curve of genus at least 2 embedded in ${{E}_{1}}\,\times \,.\,.\,.\,\times \,{{E}_{N}}$ , where the ${{\text{E}}_{i}}$ are elliptic curves for $i\,=\,1,\,.\,.\,.\,,\,N$ . In this article we give an explicit sharp bound for the Néron–Tate height of the points of $c$ contained in the union of all algebraic subgroups of dimension $<\,\max ({{r}_{C}}\,-{{t}_{C}},\,{{t}_{C}})$ , where ${{t}_{C}}(\text{resp}\text{.}{{r}_{C}})$ is the minimal dimension of a translate (resp. of a torsion variety) containing $c$ .

As a corollary, we give an explicit bound for the height of the rational points of special curves, proving new cases of the explicit Mordell Conjecture and in particular making explicit (and slightly more general in the CM case) the Manin–Dem’janenko method for curves in products of elliptic curves.

Fomesafen provides effective control of glyphosate-resistant Palmer amaranth in cotton. However, cotton seedlings can be injured when fomesafen is applied PRE. Therefore, greenhouse and field experiments were conducted at Athens, GA, and at six locations in Alabama and Georgia in 2013 and 2016 to evaluate cotton growth and yield response to fomesafen applied PRE at 70, 140, 280, 560, 1,120, or 2,240 g ai ha−1, and in combination with pendimethalin, diuron, acetochlor, and fluridone at 1×label rates. Greenhouse bioassays indicated that fomesafen reduced cotton height and dry weight with increasing rate in Cecil sandy loam and Tifton loamy sand but not in Greenville sandy clay loam––possibly as a result of this soil’s higher organic matter (OM) and clay content. Fomesafen applied at 2,240 g ai ha−1 reduced cotton stand by as much as 83% compared to the nontreated check (NTC) at all field locations except Alabama’s Macon and Baldwin counties, and 1,120 g ai ha−1 reduced cotton stand only at Pulaski County, GA, by 52%. Cotton height was reduced by the two highest rates of fomesafen at all locations except Clarke County, GA, and Baldwin County, AL. Injury data indicated more visual injury followed increasing fomesafen rates, and high-rate treatments produced more injury in sandier soils. Cotton yield was unaffected by herbicide treatments at any location, except for the 1,120 g ai ha−1 rate at Pulaski County (49% yield loss compared to NTC), 2,240 g ai ha−1 at Pulaski County (72% yield loss), and Tift County (29% yield loss). These data indicated cotton yield should not be negatively affected by fomesafen applied PRE alone within label rates or in combination with pendimethalin, diuron, acetochlor, and fluridone at 1×label rates, although some visual injury, or stand or height reduction may occur early in the growing season.

The objective of this study was to investigate the association of single nucleotide polymorphisms (SNPs) with birth weight, weight gain from birth to weaning and from weaning to yearling, yearling height and cow weight in Nelore cattle. Data from 5064 animals participating in the DeltaGen and PAINT breeding programs were used. The animals were genotyped with a panel of 777 962 SNPs (Illumina BovineHD BeadChip) and 412 993 SNPs remained after quality control analysis of the genomic data. A genome-wide association study was performed using a single-step methodology. The analyses were processed with the BLUPF90 family of programs. When applied to a genome-wide association studies, the single-step GBLUP methodology is an iterative process that estimates weights for the SNPs. The weights of SNPs were included in all analyses by iteratively applying the single-step GBLUP methodology and repeated twice so that the effect of the SNP and the effect of the animal were recalculated in order to increase the weight of SNPs with large effects and to reduce the weight of those with small effects. The genome-wide association results are reported based on the proportion of variance explained by windows of 50 adjacent SNPs. Considering the two iterations, only windows with an additive genetic variance >1.5% were presented in the results. Associations were observed with birth weight on BTA 14, with weight gain from birth to weaning on BTA 5 and 29, with weight gain from weaning to yearling on BTA 11, and with yearling height on BTA 8, showing the genes TMEM68 (transmembrane protein 8B) associated with birth weight and yearling height, XKR4 (XK, Kell blood group complex subunit-related family, member 4) associated with birth weight, NPR2 (natriuretic peptide receptor B) associated with yearling height, and REG3G (regenerating islet-derived 3-gamma) associated with weight gain from weaning to yearling. These genes play an important role in feed intake, weight gain and the regulation of skeletal growth.

We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant. First-born twins had greater BMI than the second-born twins over childhood and adolescence. After adjusting the results for birth weight, birth order was still associated with BMI until 12 years of age. No interaction effect between birth order and zygosity was found. Only limited evidence was found that birth order influenced variances of height or BMI. The results were similar among boys and girls and also in MZ and DZ twins. Overall, the differences in height and BMI between first- and second-born twins were modest even in early childhood, while adjustment for birth weight reduced the birth order differences but did not remove them for BMI.

In this paper, we give a general explicit form of Cassels’ $p$ -adic embedding theorem for number fields. We also give its refined form in the case of cyclotomic fields. As a byproduct, given an irreducible polynomial $f$ over $\mathbb{Z}$ , we give a general unconditional upper bound for the smallest prime number $p$ such that $f$ has a simple root modulo $p$ .

This study examined the genetic and environmental effects on variances in weight, height, and body mass index (BMI) under 18 years in a population-based sample from China. We selected 6,644 monozygotic and 5,969 dizygotic twin pairs from the Chinese National Twin Registry (CNTR) aged under 18 years (n = 12,613). Classic twin analyses with sex limitation were used to estimate the genetic and environmental components of weight, height, and BMI in six age groups. Sex-limitation of genetic and shared environmental effects was observed, especially when puberty begins. Heritability for weight, height, and BMI was low at 0–2 years old (less than 20% for both sexes) but increased over time, accounting for half or more of the variance in the 15–17 year age group for boys. For girls, heritabilities for weight, height and BMI was maintained at approximately 30% after puberty. Common environmental effects on all body measures were high for girls (59–87%) and presented a small peak during puberty. Genetics appear to play an increasingly important role in explaining the variation in weight, height, and BMI from early childhood to late adolescence, particularly in boys. Common environmental factors exert their strongest and most independent influence specifically in the pre-adolescent period and more significantly in girls. These findings emphasize the need to target family and social environmental interventions in early childhood years, especially for females. Further studies about puberty-related genes and social environment are needed to clarify the mechanism of sex differences.

A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.

For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.

In singletons, asthma may be associated with shorter height and delayed growth during adolescence. Yet, these studies do not account for heritability of asthma, puberty/menarche, and height. We aimed to study the association between asthma and puberty in boys and menarche in girls, and height, in a cohort of twins and subsequently in same-sex twin pairs discordant for asthma. From a Swedish twin cohort, parent- and self-reported data on asthma, puberty/menarche, and height were collected. Pubertal staging was established via the Petersen index. Logistic and linear regression was used to estimate associations between asthma and puberty/menarche and height, respectively. For within-pair analyses in twins discordant for asthma, conditional logistic and linear regression were used. Data on 2,658 (49.1% boys) twins were included. Among boys, asthma prevalence was 8.2% at 8–9 years and 10.2% at 13–14 years. Corresponding numbers for girls were 4.2% and 4.9%, respectively. In the entire cohort, no statistically significant associations were found between current asthma and puberty/menarche. Boys with asthma were shorter than boys without asthma at 8–9 years (on average, 1.86 [0.17–3.56] cm, p = .03) and at 13–14 years (on average, 2.94 [0.98–4.91] cm, p = .003) but not at 19–20 years. No such associations were found for girls. Within same-sex twin pairs discordant for asthma, no statistically significant associations were found for either sex. Twin boys, but not girls, with asthma were shorter than those without asthma. Non-statistically significant estimates from within-pair analyses suggest the association is partly confounded by genetic or familial environmental factors.

We prove a necessary and sufficient condition on the list of nonzero integers ${{u}_{1}},...,{{u}_{k}}$ , $k\,\ge \,2$ , under which a monic polynomial $f\,\in \,\mathbb{Z}\left| x \right|$ is expressible by a linear form ${{u}_{1}}\,{{f}_{1}}\,+\,\cdot \cdot \cdot \,+\,{{u}_{k}}\,{{f}_{k}}$ in monic polynomials ${{f}_{1}},...,\,{{f}_{k}}\,\in \,\mathbb{Z}\left| x \right|$ . This condition is independent of $f$ . We also show that if this condition holds, then the monic polynomials ${{f}_{1}},...,\,{{f}_{k}}$ can be chosen to be irreducible in $\mathbb{Z}\left[ x \right]$ .