Palmer amaranth is one of the most difficult to control weeds in row crop systems and has evolved resistance to several herbicide sites of action (SOAs). A late-season weed-escape survey was conducted earlier to determine the distribution of PPO-inhibitor resistance Palmer Amaranth in Arkansas. The objective of this study was to evaluate the susceptibility of Arkansas Palmer amaranth accessions to commonly used herbicide SOA. The SOA evaluated were group 2 + 9, 3, 4, 5, 10, 15, and 27 and the representative herbicide from each group was imazethapyr + glyphosate (79 + 860 g ha–1), trifluralin (1,120 g ha–1), dicamba (280 and 560 g ha–1), atrazine (560 g ha–1), glufosinate (594 g ha–1), S-metolachlor (1,064 g ha–1), and tembotrione (92 g ha–1), respectively. Palmer amaranth mortality varied among accessions across SOA. Averaged across accessions, the lowest to highest mortality rates were in the order of glyphosate + imazethapyr (16%), tembotrione (51%), dicamba at 280 g ha–1 (51%), fomesafen (76%), dicamba at 560 g ha–1 (82%), atrazine (85%), trifluralin (87%), S-metolachlor (96%), and glufosinate (99.5%). This study provides evidence that Palmer amaranth accessions with low susceptibility to glyphosate + imazethapyr, fomesafen, and tembotrione are widespread throughout Arkansas. Out of the remaining SOA, most Palmer amaranth accessions were sensitive; however, within each herbicide SOA, except glufosinate, control of some accessions was less than expected and resistance is suspected.