It is known that every frame is isomorphic to the generalized Gleason algebra of an essentially unique bi-Stonian space (X, σ, τ) in which σ is T0. Let (X, σ, τ) be as above. The specialization order ≤σ, of (X, σ) is τ × τ-closed. By Nachbin's Theorem there is exactly one quasi-uniformity U on X such that ∩U = ≤σ and J(U*) = τ. This quasi-uniformity is compatible with σ and is coarser than the Pervin quasi-uniformity U of (X, σ). Consequently, τ is coarser than the Skula topology of σ and coincides with the Skula topology if and only if U = P.