Small burnet is a hardy, relatively long-lived evergreen forb with the potential to improve grazing lands, particularly to extend grazing into late fall and winter. Small burnet was evaluated for tolerance to spring and fall POST applications of aminopyralid, bromoxynil, clethodim, clopyralid, dicamba, dimethenamid-P, imazamox, metribuzin, pendimethalin, quinclorac, and 2,4-DB. Injury, seed yield, seed viability, and dry matter yield (DMY) were measured in the spring following application. Injury was observed in response to all spring and fall herbicide applications. Injury from aminopyralid was the highest for both spring and fall applications at 24 and 79%, respectively. Fall application of imazamox and dicamba resulted in 57 and 31% injury, respectively. Spring-applied aminopyralid and 2,4-DB both reduced DMY by 16%, whereas fall applications of imazamox, dicamba, and aminopyralid reduced DMY by 36, 12, and 67%, respectively. Fall applications of imazamox and aminopyralid reduced seed yield by 33 and 65%, respectively. Fall-applied aminopyralid reduced seed germination by 43%. None of the spring-applied herbicides affected seed yield or seed germination. Small burnet is severely injured by aminopyralid and to a lesser degree by imazamox and dicamba. Bromoxynil, clethodim, clopyralid, dimethenamid-P, metribuzin, pendimethalin, and quinclorac did not affect small burnet DMY, seed yield, or germination the year after application.