Let φ be a continuous nonzero homomorphism of the convolution algebra L1loc(R+) and also the unique extension of this homomorphism to Mloc(R+). We show that the map φis continuous in the weak* and strong opertor topologies on Mloc, considered as the dual space of Cc(R+) and as the multiplier algebra of L1loc. Analogous results are proved for homomorphism from L1 [0, a) to L1 [0, b). For each convolution algebra L1 (ω1), φ restricts to a continuous homomorphism from some L1 (ω1) to some L1 (ω2), and, for each sufficiently large L1 (ω2), φ restricts to a continuous homomorphism from some L1 (ω1) to L1 (ω2). We also determine which continuous homomorphisms between weighted convolution algebras extend to homomorphisms of L1loc. We also prove results on convergent nets, continuous semigroups, and bounded sets in Mloc that we need in our study of homomorphisms.