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Apical hypertrophic cardiomyopathy is an uncommon morphologic variant of hypertrophic cardiomyopathy, which is rarely diagnosed in childhood. To date, very few cases of asymptomatic children younger than 18 years have been reported in the literature. To the best of our knowledge, this is the first case of paediatric apical hypertrophic cardiomyopathy presenting with exertional chest pain, with characteristic electrocardiographic, echocardiographic, MRI, and cardiac angiography findings.
Lipid biomarker analysis is a useful tool for characterizing microbial communities in geomicrobiology. Phospholipid fatty acids (PLFA) are major components of microbial membranes, and analysis of these markers provides insight into microbial biomass, community structure, and metabolic processes. This article reviews the methods for extraction, fractionation, derivatization, and quantification of PLFA, as well as the interpretation of PLFA patterns for microbial community analysis in natural environmental systems. The discussion centers on the development, the subsequent modifications, and the advantages and limitations of the methods. Two case studies are given to illustrate the applications of intact phospholipid profiling (IPP) and PLFA in geomicrobiology. The recent developments and future directions of microbial signature lipid analysis are also discussed.
We identified and characterized a new cosmocercid nematode species, Cosmocercoides wuyiensis n. sp., through microscopic examination and sequencing of the partial small ribosomal RNA gene (18S rDNA), internal transcribed spacer (ITS) and mitochondrial cytochrome c oxidase subunit 1 (COI) genes. The new species was isolated from the intestine of the Asiatic frog Amolops wuyiensis Liu and Hu, 1975 captured from four localities of the Anhui province in south-east China. Among the 25 recorded species of the Cosmocercoides genus, the morphology of C. wuyiensis n. sp. is closest to that of C. kiliwai and C. malayensis, which were isolated from various Mexican frog and Malaysian lizard species, respectively. However, C. wuyiensis n. sp. displayed several distinguishing features, such as small size of the male body, two spicules of unequal lengths in the male, small gubernaculum, pre-, ad- and post-cloacal caudal rosette papillae in the ratio of 18–24:2:6 and simple papillae in the ratio of 14:multiple:4, circle and number of punctation in each rosette at 1:11–16, sharply conical tail-end and the presence of lateral alae and somatic papillae in both sexes. BLAST and the phylogenetic analyses of the 18S rDNA and ITS sequences indicated that C. wuyiensis n. sp. belonged to the genus Cosmocercoides, while that of the COI gene sequence of C. wuyiensis n. sp. showed 16.36% nucleotide divergence with C. pulcher and 47.99% nucleotide divergence with C. qingtianensis. The morphological and molecular characterization of C. wuyiensis n. sp. provides new taxonomic data for this genus.
Existing data on folate status and hepatocellular carcinoma (HCC) prognosis are scarce. We prospectively examined whether serum folate concentrations at diagnosis were associated with liver cancer-specific survival (LCSS) and overall survival (OS) among 982 patients with newly diagnosed, previously untreated HCC, who were enrolled in the Guangdong Liver Cancer Cohort (GLCC) study between September 2013 and February 2017. Serum folate concentrations were measured using chemiluminescent microparticle immunoassay. Cox proportional hazards models were performed to estimate hazard ratios (HR) and 95 % CI by sex-specific quartile of serum folate. Compared with patients in the third quartile of serum folate, patients in the lowest quartile had significantly inferior LCSS (HR = 1·48; 95 % CI 1·05, 2·09) and OS (HR = 1·43; 95 % CI 1·03, 1·99) after adjustment for non-clinical and clinical prognostic factors. The associations were not significantly modified by sex, age at diagnosis, alcohol drinking status and Barcelona Clinic Liver Cancer (BCLC) stage. However, there were statistically significant interactions on both multiplicative and additive scale between serum folate and C-reactive protein (CRP) levels or smoking status and the associations of lower serum folate with worse LCSS and OS were only evident among patients with CRP > 3·0 mg/l or current smokers. An inverse association with LCSS were also observed among patients with liver damage score ≥3. These results suggest that lower serum folate concentrations at diagnosis are independently associated with worse HCC survival, most prominently among patients with systemic inflammation and current smokers. A future trial of folate supplementation seems to be promising in HCC patients with lower folate status.
In this paper we treat a two-stage grouping procedure of building a k-out-of-n system from several clusters of components. We use a static framework in which the component reliabilities are fixed. Under such a framework, we address the impact of the selecting strategies, the sampling probabilities, and the component reliabilities on the constructed system’s reliability. An interesting finding is that the level of component reliabilities could be identified as a decisive factor in determining how the selecting strategies and the component reliabilities affect the system reliability. The new results generalize and extend those established earlier in the literature such as Di Crescenzo and Pellerey (2011), Hazra and Nanda (2014), Navarro, Pellerey, and Di Crescenzo (2015), and Hazra, Finkelstein, and Cha (2017). Several Monte Carlo simulation experiments are provided to illustrate the theoretical results.
A bottom-feed omni-directional CP (circularly polarized) antenna array is proposed in this letter. The antenna array is composed of four elements (two printed ZPS (zero-phase-shift) line loops and two half-wavelength dipoles). The four elements are fed with the same phase and amplitude. The ZPS line loops provide the horizontal polarization while the dipoles provide the vertical polarization. Therefore, omni-directional circular polarization is formed in the far field. The feeding network consists of a 1–4 T-shaped power divider formed by parallel strip lines. In order to balance the amplitude of the feeding coaxial cable, the structure is used in the bottom to transfer parallel strip line to micro-strip line. Besides, the loops and the dipoles are placed on the different side of the network to guarantee the omni-directional radiation property. The measured impedance bandwidth of the fabricated antenna is 0.13 GHz (2.40–2.53 GHz) and the measured maximum CP gain at 2.45 GHz is 4.8 dBic.
Challenges remain in the judgement of pathological murmurs in newborns at maternity hospitals, and there are still many simple major CHD patients in developing countries who are not diagnosed in a timely fashion. This study aimed to evaluate the accuracy of cardiac auscultation on neonatal CHD by general paediatricians.
We conducted a prospective study at three hospitals. All asymptomatic newborns underwent auscultation, pulse oximetry monitoring, and echocardiography. Major CHD was classified and confirmed through follow-up. We evaluated the accuracy of various degrees of murmurs for detecting major CHD to determine the most appropriate standards and time of auscultation.
A total of 6750 newborns were included. The median age of auscultation was 43 hours. Cardiac murmurs were identified in 6.6% of newborns. For all CHD, 44.4% had varying degrees of murmurs. A murmur of grade ≥2 used as a reference standard for major CHD had a sensitivity of 89.58%. The false positive rate of murmurs of grade ≥2 for detecting major CHD was significantly negatively related to auscultation time, with 84.4% of false positives requiring follow-up for non-major CHD cardiac issues. Auscultation after 27 hours of life could reduce the false positive rate of major CHD from 2.7 to 0.9%.
With appropriate training, maternity hospital’s paediatricians can detect major CHD with high detection rates with an acceptable false positive rate.
Cesium lead iodide perovskite (CsPbI3) with excellent optical and electrical properties have attracted numerous academic attentions. Specifically, the black cubic phase CsPbI3 with a direct band gap of 1.74 eV has been most appropriate materials for various optoelectronic applications, especially for photovoltaic (PV), Light-Emitting Diodes (LED) and photodetector applications1. However, the preferred cubic phase of bulk CsPbI3 (α-CsPbI3) is usually only stable at high temperatures and it will undergo an immediate phase transformation to orthorhombic phase (δ-CsPbI3) after fabrication at room temperature. In this work, we have discovered a convenient CVD method to investigate the growth behavior of the cubic α-CsPbI3 film on the porous alumina substrate. The lead iodide and cesium iodide were used as the precursors for the deposition of CsPbI3. The porous alumina with high surface area and large pore volume was used as growth substrate. It was shown that the porous alumina promoted the growth of CsPbI3 film by absorbing the precursor and increasing the nucleation density. The prepared CsPbI3 film emitted strong and stable red light under ultraviolet light excitation at room temperature and ambient atmosphere. The lead iodide was absorbed on the surface of the porous alumina firstly then reacted with cesiumiodide to form the CsPbI3. The successful preparation of the CsPbI3 by the direct CVD method paves the way for its large scale growth and application in optoelectronic devices.
Current available methods to detect cow milk adulteration or accidental contamination of goat milk are both laborious and time consuming. The aim of this technical research communication was to develop a simple, rapid, specific and sensitive method for quantitative detection of cow milk in goat milk. A competitive lateral flow immunoassay (LFIA) strip was developed using a specific monoclonal antibody (mAb) labeled with colloidal gold nanoparticles (GNPs) for specifically binding to cow milk casein. The detection limit of this rapid detection was 0.07% of cow milk in goat milk, providing equal specificity and higher sensitivity when compared with a commercial enzyme-linked immunosorbent assay (ELISA). These result suggest that the established rapid GNPs-LFIA strip could be used for monitoring cow milk adulteration/contamination of goat milk.
In this work, we demonstrate a size-controlled synthesis of CuNi octahedral nanocrystals (NCs) using a hot colloidal solution approach. Two different sizes of CuNi nano-octahedra are chosen and investigated. It is determined that the reagent concentration remarkably plays a key role in the formation of the size-defined CuNi octahedral NCs. In terms of the reduction of 4-nitrophenol (4-NP), it uncovers that the obtained CuNi octahedral NCs (in both sizes) exhibit higher catalytic activity than those of CuNi spherical NCs reported previously. It further indicates that the catalytic performance is strongly size-dependent due to their devise specific surface areas of the exposed crystallographic planes.
In the synthesis of metallic nanocrystals (NCs) using a high-temperature colloidal approach, the competition between deposition and diffusion of “free atom (or clusters)” plays an important role as it can direct the morphology of NCs during their evolution. This competition is closely associated with some dynamic conditions such as heat and mass transfer. Stirring speed and ramp rate of heating are two factors that greatly impact the heat and mass transfer processes and consequently determine the morphology of the products but rarely discussed in most synthetic protocols. Herein, we study the syntheses of Pt-M (M = Ni, Fe) NCs as model reactions, showing that a low stirring speed and high ramp rate of heating result in ununiform pod-like NCs, whereas the inverse conditions promote NCs in a uniform shape. This observation can be plausibly explained using a competition mechanism between the deposition and diffusion of the newly reduced atoms during a stage of the NC’s growth.
To revise an abbreviated version of the Silhouettes subtest of the Visual Object and Space Perception (VOSP) battery in order to recognize mild cognitive impairment (MCI) and determine the optimal cutoffs to differentiate among cognitively normal controls (NC), MCI, and Alzheimer’s Disease (AD) in the Chinese elderly.
A cross-sectional validation study.
Huashan Hospital, Shanghai, China.
A total of 591 participants: Individuals with MCI (n = 211), AD (n = 139) and NC (n = 241) were recruited from the Memory Clinic, Huashan Hospital, Shanghai, China.
Baseline neuropsychological battery (including VOSP) scores were collected from firsthand data. An abbreviated version of silhouettes test (Silhouettes-A) was revised from the original English version more suitable for the elderly, including eight silhouettes of animals and seven silhouettes of inanimate objects, with a score ranging from 0 to 15.
Silhouettes-A was an effective test to screen MCI in the Chinese elderly with good sensitivity and specificity, similar to the Montreal cognitive assessment and superior to other single tests reflecting language, spatial, or executive function. However, it had no advantage in distinguishing MCI from AD. The corresponding optimal cutoff scores of Silhouettes-A were 10 for screening MCI and 8 for AD.
Silhouettes-A is a quick, simple, sensitive, and dependable cognitive test to distinguish among NC, MCI, and AD patients.
Carbon nanotubes (CNTs) were added to carbon nanofibers (CNFs) as additives to improve their electrochemical properties. In the present work, CNFs were prepared by using pressurized gyration with polyacrylonitrile as the precursor. The microstructure and electrochemical properties of samples were investigated by scanning electron microscopy and electrochemical workstation, respectively. The results showed that the network structure formed in the fiber, and the fiber diameter decreased with the increase of working pressure. The integral area of cyclic voltammetry curve reached the maximum and the charge/discharge time of constant current charge/discharge curve reached the longest in the case of the CNT concentration is 0.50 wt% and working pressure is 0.2 MPa. At the same time, it exhibited the best electrochemical performance with a specific capacitance of 79 F/g at a current density of 100 mA/g. Compared with the specific capacitance of pure CNFs, the specific capacitance of CNFs with the concentration of CNTs 0.50 wt% increased by about 40%.
In this paper, the design of a graded honeycomb radar absorbing structure (RAS) is presented to realize both a wide bandwidth and absorption over a wide range of angles. For both transverse-electric and transverse-magnetic polarization, a fractional bandwidth of more than 118.6% is achieved for at least a 10 dB reflectivity reduction when the incident angle is <45°, an 8 dB reduction when the incident angle is <55° and a 5 dB reduction when the incident angle is <70°. Meanwhile the 10 dB reduction upper angle limit is approximately 30° for the uniform coating honeycomb RAS in the literature, which loses its absorbing ability when the incident angle is larger than 55°. Furthermore, the total thickness of our design is 10.7 mm, which is only approximately 1.29 times that of the theoretical limitation. The good agreement between the calculated, simulated, and measured results demonstrates the validity of this optimization.
Soil moisture is a key issue for eco-hydrological research in arid and semi-arid regions, and is primarily concerned with water availability for vegetation. Shallow and deep soil moisture occurs according to the maximum infiltration depth. Soil moisture has three-dimensional characteristics: inter-layer variability, horizontal heterogeneity and temporal variability. Soil moisture is affected by various factors including terrain, soil characteristics, climate and vegetation, and the effects of these change with time (e.g., rainfall patterns) and space (e.g., soil depth). In arid and semi-arid regions, deep soil moisture is of particular importance to vegetation restoration and the evaluation of vegetation sustainability; however, accurate prediction of the spatial distribution of deep soil moisture in the Loess Plateau of China still faces numerous challenges. Therefore, future research should focus on the mechanisms, models and scale effects of soil moisture, particularly for deep soil moisture.
Graphitic carbon nitride (g-C3N4) microspheres (CNMS) were fabricated via a solvothermal method by using dicyandiamide and cyanuric chloride as precursors. The morphology, band structure, and defects can be simultaneously regulated by merely adjusting the concentration of precursors. Structural characterization results indicate that all the prepared samples possess spherical morphology, while the band gap decreased as the precursor concentration increased from 8 mmol (CNMS-1) to 24 mmol (CNMS-3). Besides, ultraviolet photoelectron spectroscopy results suggested that the valence band of CNMS-2 (16 mmol) was much higher than that of CNMS-1 and CNMS-3. Additionally, organic elemental analysis, X-ray photoelectron spectroscopy, and electron paramagnetic resonance results unveil the formation of nitrogen defects on the surface of prepared samples. Besides, CNMS-2 exhibits an enhanced apparent reaction rate constant of RhB degradation than that of CNMS-1 and CNMS-3. The improved apparent reaction rate constant may be due to the lowered valence band as well as the formation of nitrogen defects. This work might guide the regulation of the morphology and band structure of g-C3N4-based materials prepared via the one-pot hydrothermal method.
Astrophysical collisionless shocks are amazing phenomena in space and astrophysical plasmas, where supersonic flows generate electromagnetic fields through instabilities and particles can be accelerated to high energy cosmic rays. Until now, understanding these micro-processes is still a challenge despite rich astrophysical observation data have been obtained. Laboratory astrophysics, a new route to study the astrophysics, allows us to investigate them at similar extreme physical conditions in laboratory. Here we will review the recent progress of the collisionless shock experiments performed at SG-II laser facility in China. The evolution of the electrostatic shocks and Weibel-type/filamentation instabilities are observed. Inspired by the configurations of the counter-streaming plasma flows, we also carry out a novel plasma collider to generate energetic neutrons relevant to the astrophysical nuclear reactions.
(1 − x)Ba(Mg1/3Ta2/3)O3–xBa(Co1/3Nb2/3)O3 (BMT–BCN, x = 0.0, 0.20, 0.25, 0.30, 0.40) ceramics were prepared using the traditional solid-state reaction method. X-ray diffraction patterns have shown that the intensities of (001) and (100) super-lattices decrease with the increase in the BCN content. Seven main Raman vibrational modes are observed, assigned, and illustrated, in particular. Raman shifts of Eg(O) modes and the FWHM values of F2g(O)/A1g(O) modes have close relationship with the dielectric properties. The calculated values by the four-parameter semiquantum model based on IR reflectivity match well with the measured data (@3.8 GHz), which means that most of dielectric contribution to the system may be ascribed to the absorption of structural phononic oscillations at the infrared region, and the contribution from the scattering of the defective phonons is small. The contributions of each vibrational mode on the dielectric responses were investigated in detail, indicating that the low-frequency modes (A2u(1) and Eu(1)) have a decisive role to the dielectric properties.
As a promising new way to generate a controllable strong magnetic field, laser-driven magnetic coils have attracted interest in many research fields. In 2013, a kilotesla level magnetic field was achieved at the Gekko XII laser facility with a capacitor–coil target. A similar approach has been adopted in a number of laboratories, with a variety of targets of different shapes. The peak strength of the magnetic field varies from a few tesla to kilotesla, with different spatio-temporal ranges. The differences are determined by the target geometry and the parameters of the incident laser. Here we present a review of the results of recent experimental studies of laser-driven magnetic field generation, as well as a discussion of the diagnostic techniques required for such rapidly changing magnetic fields. As an extension of the magnetic field generation, some applications are discussed.