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Deep brain stimulation (DBS) for Parkinson's disease (PD) has now become a routine therapeutic option. The success of surgery depends on proper patient selection, proper placement of electrodes, and postoperative programming. This chapter presents a case study of a 62-year-old female with a 15-year history of PD who was scheduled to have bilateral subthalamic nucleus (STN) DBS implantation. In this case the chapter highlights the importance of restarting PD medications soon after surgery, interactions between the STN DBS and levodopa, effect of postoperative neurologic changes and medication, and interactions of other medication and Parkinsonism. The best antinausea medication for PD patients in the postoperative period is ondansetron, lorazepam in small doses works very well for confusion. STN DBS has been demonstrated to be effective in alleviating the symptoms of medically refractory PD across multiple reports in the literature. These results were confirmed by prospective series with double-blinded assessments.