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1 results

  • Regional differences in dendritic spine density confer resilience to chronic social defeat stress

  • Youge Qu, Chun Yang, Qian Ren, Min Ma, Chao Dong, Kenji Hashimoto
  • Journal:
    Acta Neuropsychiatrica / Volume 30 / Issue 2 / April 2018
    Published online by Cambridge University Press:
    01 June 2017, pp. 117-122
  • Objective

    Although alterations in the dendritic spine density in the brain regions may play a role in the stress-induced depression-like phenotype, the precise mechanisms are unknown. The aim was to investigate the role of spine density in the brain regions after chronic social defeat stress (CSDS).

    Methods

    We examined dendritic spine density in the medial prefrontal cortex (mPFC), CA1, CA3, dentate gyrus (DG) of hippocampus, nucleus accumbens (NAc), and ventral tegmental area (VTA) of susceptible and resilient mice after CSDS.

    Results

    Spine density in the prelimbic area of mPFC, CA3, and DG in the susceptible group, but not resilient group, was significantly lower than control group. In contrast, spine density in the NAc and VTA in the susceptible group, but not resilient group, was significantly higher than control group.

    Conclusions

    The results suggest that regional differences in spine density may contribute to resilience versus susceptibility in mice subjected to CSDS.