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Psychiatric disorders as well as subcortical brain volumes are highly heritable. Large-scale genome-wide association studies (GWASs) for these traits have been performed. We investigated the genetic correlations between five psychiatric disorders and the seven subcortical brain volumes and the intracranial volume from large-scale GWASs by linkage disequilibrium score regression. We revealed weak overlaps between the genetic variants associated with psychiatric disorders and subcortical brain and intracranial volumes, such as in schizophrenia and the hippocampus and bipolar disorder and the accumbens. We confirmed shared aetiology and polygenic architecture across the psychiatric disorders and the specific subcortical brain and intracranial volume.
Morphological abnormalities of the superior temporal gyrus have been
consistently reported in schizophrenia, but the timing of their
occurrence remains unclear.
To determine whether individuals exhibit superior temporal gyral changes
before the onset of psychosis.
We used magnetic resonance imaging to examine grey matter volumes of the
superior temporal gyrus and its subregions (planum polare, Heschl's
gyrus, planum temporale, and rostral and caudal regions) in 97
antipsychotic-naive individuals at ultra-high risk of psychosis, of whom
31 subsequently developed psychosis and 66 did not, and 42 controls.
Those at risk of psychosis had significantly smaller superior temporal
gyri at baseline compared with controls bilaterally, without any
prominent subregional effect; however, there was no difference between
those who did and did not subsequently develop psychosis.
Our findings indicate that grey matter reductions of the superior
temporal gyrus are present before psychosis onset, and are not due to
medication, but these baseline changes are not predictive of transition
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