Mechanical properties and micro-plastic deformation behavior of five bulk metallic glasses (BMGs) were studied by instrumented indentation. These materials included La60Al10Ni10Cu20, Mg65Cu25Gd10, Zr52.5Al10Ni10Cu15Be12.5, Cu60Zr20Hf10Ti10, and Ni60Nb37Sn3 alloys. Remarkable difference in deformation behavior was found in the load–displacement curves of nanoindentation and pileup morphologies around the indents. Serrated plastic deformation depended on the loading rate was found in Mg-, Zr-, and Cu-based BMGs. The subsurface plastic deformation zone of typical alloys was investigated through bonded interface technique using depth-sensing microindentation. Large and widely spaced shear bands were observed in Mg-based BMG. The effect of loading rate on the indentation deformation behaviors in different BMGs was elucidated by the change of shear band pattern.