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Arterial pulse waveform analysis has been proposed for cardiac output (CO)
determination and monitoring without calibration or thermodilution
(FloTrac™/Vigileo™; Edwards Lifesciences, Irvine, CA,
USA). The accuracy and clinical applicability of this technology has not
been fully evaluated. We designed this prospective study to compare the
accuracy of the FloTrac™ system (COFT) vs. pulmonary
artery catheter standard bolus thermodilution (COPAC) in patients
undergoing coronary artery bypass grafting.
We studied 11 patients referred for coronary artery bypass grafting.
COFT and COPAC were determined at six time points
in the operating room including before and 5 min after volume expansion (500
mL 6% hetastarch). Measurements were performed on arrival in the intensive
care unit and every 4 h afterwards. Bland–Altman analysis was
used to assess the agreement between COFT and
COPAC ranged from 2.0 to 7.6 L min−1 and
COFT ranged from 1.9 to 8.2 L min−1.
There was a significant relationship between COPAC and
COFT (r = 0.662; P < 0.001). Agreement between
COPAC and COFT was −0.26 ±
0.87 L min−1. Volume expansion induced a significant
increase in both COPAC and COFT (from 3.4 ±
0.8 to 4.4 ± 1.0 L min−1; P < 0.001 and from 3.9 ±
1.2 to 5.0 ± 1.1 L min−1; P < 0.001, respectively) and there
was a significant relationship between percent change in COPAC
and COFT following volume expansion (r = 0.722; P = 0.01).
We found clinically acceptable agreement between COFT and
COPAC in this setting. This new device has potential clinical
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