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A total of 65 cases of Creutzfeldt–Jakob disease with a history of cadaveric dura
transplantation in Japan were analysed to clarify the epidemiologic features of such patients
and to explore whether other such patients will appear in the future. The age at
transplantation averaged 44·4 years with a standard deviation of 14·4 years. The age at onset
had an average of 53·0 years with a standard deviation of 14·1 years. The shortest latent period
was 14 months, and the longest was 218 months with an average of 103·1 months and a
standard deviation of 49·9 months. From the relationship between the calendar year at
transplantation and the latent period, other such patients will appear in the near future. The
current data suggested that several patients with Creutzfeldt–Jakob disease will occur from
those receiving cadaveric dura mater grafts in the near future.