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The Dayao Paleolithic site, located in Inner Mongolia on the eastern margin of China's vast northwestern drylands, was a lithic quarry-workshop utilized by Pleistocene human migrants through the region. Determining the age of this activity has previously yielded controversial results. Our magnetostratigraphic and OSL dating results suggest the two artifact-bearing paleosols are correlated with MIS 5 and 7, respectively. Correlating paleoclimatic data with marine δ18O records leads us to conclude that two sandy gravel layers containing many artifacts in the lower part of the Dayao sequence were formed during MIS 9 and 11, if not earlier. Our results reveal that the earliest human occupation at the Dayao site occurred before ca. 400 ka during a relatively warm and moist interglacial period, similar to several subsequent occupations, documenting the earliest and northernmost archaeological assemblage yet reported in China's arid northwest. We conclude that the northward and southward displacements of the East Asian summer monsoon rain belt during past interglacial-glacial cycles were responsible for the discontinuous human occupation detected at the Dayao site. The penetration of this precipitation regime into dryland ecologies via the Huanghe (Yellow River) Valley effectively created a corridor for hominin migration into China's arid northwest.
Scholars have long debated when the Neolithic began in China. Neolithisation, however, is a process rather than an event. It is more realistic to investigate the timing and nature of the socio-economic trajectory from mobile, microblade-using foragers to sedentary communities during the Palaeolithic–Neolithic transition in northern China. Here, the authors use artefacts from Shuidonggou locality 12 to demonstrate the socio-economic organisation of the site's inhabitants. They identify long-term site occupation by a large group exhibiting high levels of individual mobility. Comparative analyses with contemporaneous data indicate that the early stages of complex social organisation—a fundamental element of Neolithisation—emerged among microblade-using groups.
A multidisciplinary fieldwork and research project was recently begun at the Yangshang site (220–140 ka), a late Early Paleolithic locale in the western Chinese Loess Plateau. 1696 lithic artifacts and 337 faunal remains were recovered during the excavation. Sedimentological and paleoenvironmental investigations indicate the site preserves a relatively long and minimally disturbed archaeological sequence associated with paleoenvironmental changes during MIS 7–6. A detailed techno-typological analysis of Yangshang's lithic assemblages was undertaken to examine the influence of glacial cycles on late Middle Pleistocene hominin technological strategies in the western Chinese Loess Plateau. The results show that while the Yangshang site is dominated by quartz-based core/flake assemblages typical of most Early Paleolithic sites in North China, the lithic assemblages provide evidence that different provisioning systems existed during the penultimate glaciation. We argue that these shifts reflect changes in land use and mobility that were tied to climate change. Our results suggest that theoretically informed statistical analyses of so-called unchanging and crude lithic technology can yield meaningful evidence for behavioral shifts.
The widespread occurrence of late Mesozoic volcanic rocks in SE China is associated with widespread mineralization. Most geologists have accepted the model of Pacific plate subduction beneath the eastern Asian continent, but there are still controversies, especially the initial timing of the tectonic transition. In order to understand the tectonic evolution of the palaeo-Pacific plate subduction, an integrated study of zircon U–Pb, Lu–Hf isotope compositions and whole-rock geochemistry was carried out for Mesozoic volcanic rocks in eastern Fujian Province. According to the field observations and zircon U–Pb ages, these volcanic rocks can be divided into three phases: an early stage of Late Jurassic volcanic rocks (Phase 1, 159–153 Ma), a late stage of Late Jurassic volcanic rocks (Phase 2, 152–146 Ma) and an early stage of Early Cretaceous volcanic rocks (Phase 3, 143–139 Ma). Overall, these volcanic rocks are composed of intermediate–acid pyroclastic rocks and lava, with high SiO2, Na2O, K2O and Al2O3 contents, belonging to the high-K calc-alkaline and peraluminous series, with enrichment in large ion lithophile and light rare earth elements but depletion in high-field-strength elements and heavy rare earth elements. However, the Phase 1 and 2 volcanic rocks contain different zircon Hf isotopic compositions and whole-rock geochemistry to the Phase 3 volcanic rocks, implying that they have a different petrogenesis. Our study combined with previous research shows that the decreasing zircon ϵHf(t) values of the Middle–Late Jurassic volcanic rocks indicate a decreasing mantle-derived material contribution. On the contrary, the majority of the Early Cretaceous volcanic rocks have variable ϵHf(t) values, requiring varied degrees of involvement of juvenile components in their origin. Thus, we consider that the Late Jurassic volcanic rocks were generated in a compressional tectonic environment during the early stage (> 146 Ma) of palaeo-Pacific subduction. In contrast, the Cretaceous volcanic rocks were formed in an extensional tectonic setting during a later stage (< 143 Ma) of subduction.
Toxoplasma gondii is an obligate intracellular protozoan parasite, which can infect almost all warm-blooded animals, including humans, leading to toxoplasmosis. Currently, the effective treatment for human toxoplasmosis is the combination of sulphadiazine and pyrimethamine. However, both drugs have serious side-effects and toxicity in the host. Therefore, there is an urgent need for the discovery of new anti-T. gondii drugs with high potency and less or no side-effects. Our findings suggest that lumefantrine exerts activity against T. gondii by inhibiting its proliferation in Vero cells in vitro without being toxic to Vero cells (P ≤ 0.01). Lumefantrine prolonged mice infected with T. gondii from death for 3 days at the concentration of 50 μg L−1 than negative control (phosphate-buffered saline treated only), and reduced the parasite burden in mouse tissues in vivo (P ≤ 0.01; P ≤ 0.05). In addition, a significant increase in interferon gamma (IFN-γ) production was observed in high-dose lumefantrine-treated mice (P ≤ 0.01), whereas interleukin 10 (IL-10) and IL-4 levels increased in low-dose lumefantrine-treated mice (P ≤ 0.01). The results demonstrated that lumefantrine may be a promising agent to treat toxoplasmosis, and more experiments on the protective mechanism of lumefantrine should be undertaken in further studies.
Solid solution 0.94Na0.5Bi0.5TiO3–6BaTiO3 (NBT–6BT) is considered to be one kind of lead-free piezoelectric materials with excellent electrical properties due to the existence of morphotropic phase boundary (MPB). However, its relatively lower depolarization temperature is a long-standing bottleneck for the application of NBT-based piezoelectric ceramics. In this work, the influence of thermal quenching on depolarization temperature and electrical properties of rare-earth Ho-doped NBT–6BT lead-free ceramics was investigated. It was shown that the relative high piezoelectric performance, as well as an improvement of depolarization temperature (Td), can be realized by thermal quenching. The results showed that the quenching process induced high concentration of oxygen vacancy, giving rise to the change of octahedra mode and enhanced lattice distortion, which is benefit to the temperature stability of piezoelectric and ferroelectric properties. Furthermore, up-conversion photoluminescence (PL) of Ho-doped NBT–6BT could be effectively tuned by the introduction of oxygen vacancy, suggesting a promising potential in optical–electrical multifunctional devices.
Renal fibrosis is common especially in the elderly population. Recently, we found that vitamin D deficiency caused prostatic hyperplasia. This study aimed to investigate whether vitamin D deficiency promotes renal fibrosis and functional impairment. All mice except controls were fed with vitamin D-deficient (VDD) diets, beginning from their early life. The absolute and relative kidney weights on postnatal week 20 were decreased in VDD diet-fed male pups but not in female pups. A mild pathological damage was observed in VDD diet-fed male pups but not in females. Further analysis showed that VDD-induced pathological damage was aggravated, accompanied by renal dysfunction in 40-week-old male pups. An obvious collagen deposition was observed in VDD diet-fed 40-week-old male pups. Moreover, renal α-smooth muscle actin (α-SMA), a marker of epithelial–mesenchymal transition (EMT), and Tgf-β mRNA were up-regulated. The in vitro experiment showed that 1,25-dihydroxyvitamin D3 alleviated transforming growth factor-β1 (TGF-β1)-mediated down-regulation of E-cadherin and inhibited TGF-β1-evoked up-regulation of N-cadherin, vimentin and α-SMA in renal epithelial HK-2 cells. Moreover, 1,25-dihydroxyvitamin D3 suppressed TGF-β1-evoked Smad2/3 phosphorylation in HK-2 cells. These results provide experimental evidence that long-term vitamin D deficiency promotes renal fibrosis and functional impairment, at least partially, through aggravating TGF-β/Smad2/3-mediated EMT in middle-aged male mice.
HIV-1 drug resistance can compromise the effectiveness of antiretroviral therapy (ART). A survey of pretreatment HIV-1 drug resistance (PDR) was conducted in Lincang Prefecture of Yunnan Province. From 372 people living with HIV/AIDS initiating ART for the first time during 2017–2018, 322 pol sequences were obtained, of which 11 HIV-1 strain types were detected. CRF08_BC (70.2%, 226/322) was the predominant strain, followed by URF strains (10.6%, 34/322). Drug resistance mutations (DRMs) were detected among 34.2% (110/322) of the participants. E138A/G/K/R (14.3%, 46/322) and V179E/D/T (13.7%, 47/322) were the predominant DRMs. Specifically, E138 mutations commonly occurred in CRF08_BC (19.9%, 45/226). Among the DRMs detected, some independently conferred resistance, such as K65R (1.6%, 5/322), Y188C/F/L (0.9%, 3/322), K103N (0.6%, 2/322) and G190A (0.3%, 1/322), which conferred high-level resistance. The prevalence of PDR was 7.5% (95% CI: 4.6–10.3%) and the prevalence of non-nucleotide reverse transcriptase inhibitor (NNRTI) resistance was 5.0% (95% CI: 2.6–7.4%), which is below the threshold (⩾10%) of initiating a public health response. In conclusion, HIV-1 genetic diversity and an overall moderate level of PDR prevalence were found in western Yunnan. PDR surveillance should be continually performed to decide whether a public health response to NNRTI resistance should be initiated.
In this study, the glass forming ability, thermal stability, and room-temperature mechanical behavior of a high Zr-containing Zr71Cu11Ni10.5Al7Ti0.5 bulk glassy alloy were investigated. The glassy alloy exhibits a high glass-forming ability with a critical casting diameter of 5 mm using copper mold injection casting, and its critical cooling rate is estimated to be smaller than 40 K/s. A small kinetic fragility index m of 32 indicates its good thermodynamic stability and glass-forming ability. Compressive tests indicate that the glassy alloy displays a significant average plastic strain of 12.3%, a high fracture strength of 1592 MPa, and Young's modulus of 74.5 GPa. The good ductility is attributed to the introduction of more free volume and local compositional inhomogeneity with increasing Zr addition. This finding may provide useful guidelines for the development of novel high Zr-containing glassy alloys.
The aim of this study was to analyze the profile of chest injuries, oxygen therapy for respiratory failure, and the outcomes of victims after the Jiangsu tornado, which occurred on June 23, 2016 in Yancheng City, Jiangsu Province, China.
The clinical records of 144 patients referred to Yancheng City No.1 People’s Hospital from June 23 through June 25 were retrospectively investigated. Of those patients, 68 (47.2%) sustained major chest injuries. The demographic details, trauma history, details of injuries and Abbreviated Injury Scores (AIS), therapy for respiratory failure, surgical procedures, length of intensive care unit (ICU) and hospital stay, and mortality were analyzed.
Of the 68 patients, 41 (60.3%) were female and 27 (39.7%) were male. The average age of the injured patients was 57.1 years. Forty-six patients (67.6%) suffered from polytrauma. The mean thoracic AIS of the victims was calculated as 2.85 (SD = 0.76). Rib fracture was the most common chest injury, noted in 56 patients (82.4%). Pulmonary contusion was the next most frequent injury, occurring in 12 patients (17.7%). Ten patients with severe chest trauma were admitted to ICU. The median ICU stay was 11.7 (SD = 8.5) days. Five patients required intubation and ventilation, one patient was treated with noninvasive positive pressure ventilation (NPPV), and four patients were treated with high-flow nasal cannula (HFNC). Three patients died during hospitalization. The hospital mortality was 4.41%.
Chest trauma was a common type of injury after tornado. The most frequent thoracic injuries were rib fractures and pulmonary contusion. Severe chest trauma is usually associated with a high incidence of respiratory support requirements and a long length of stay in the ICU. Early initiation of appropriate oxygen therapy was vital to restoring normal respiratory function and saving lives. Going forward, HFNC might be an effective and well-tolerated therapeutic addition to the management of acute respiratory failure in chest trauma.
The X-ray emissions in the interaction of 3–6 MeV Xe23+ ions into thick solid In target are measured. The projectile-to-target and target Lα/Lβ X-ray production intensity ratios are observed to strongly depend on the projectile energy. The dependence deviates from Coulomb ionization predictions, which implies the important roles of coupling between subshells and the activation of 4fσ rotational couplings for projectile energy larger than 5 MeV.
Most of original studies indicated maternal violence experiences is associated with adverse obstetric outcomes, to date, but it is not clear that the association of maternal violence experiences and the risk of postpartum depression (PPD). We aimed to assess the association between maternal violence experiences and risk of developing PPD by performing a meta-analysis of cohort studies.
PubMed, Google Scholar, Cochrane Libraries and Chinese databases were searched through December 2017 to identify studies that assessed the association between violence and PPD. Meta-analysis was conducted by the RevMan software and Stata software. Potential heterogeneity source was explored by subgroup analysis and potential publication bias was assessed by Begg's funnel plots and Egger’s linear regression test.
Overall, women experiencing any violence events compared with the reference group were at a higher risk of developing PPD (odds ratio [OR] = 2.04; 95% confidence interval [CI]: 1.72–2.41). Additionally, different types of violence events such as sexual (OR = 1.56; 95%CI: 1.35–1.81), emotional (OR = 1.75; 95%CI: 1.61–1.89), and physical violence (OR = 1.90; 95%CI: 1.36–2.67), as well as domestic (OR = 2.05; 95%CI: 1.50–2.80) or childhood violence (OR = 1.59; 95%CI: 1.34–1.88) also increased the risk of developing PPD. Relevant heterogeneity moderators have been identified by subgroup analysis. Sensitivity analysis yielded consistent results.
Maternal violence experiences are significantly associated with risk of developing PPD. These finding highlight the necessary to protect women from any types of violence and formulate preventive strategies to promote the maternal mental health.
p53, DNA damage regulated gene (PDRG) and apoptosis-stimulating p53 protein 2 (ASPP2) are p53-related genes which can promote apoptosis. The full-length cDNA sequence of the Px-pdrg and Px-aspp2 genes were characterized and their mRNA expression dynamics under heat stress were studied in diamondback moth (DBM) Plutella xylostella collected from Fuzhou, China. The full-length cDNA of Px-pdrg and Px-aspp2 spans 721 and 4201 bp, containing 395 and 3216 bp of the open reading frame, which encode a putative protein comprising 130 and 1072 amino acids with a calculated molecular weight of 14.58 and 118.91 kDa, respectively. As compared to 25°C, both Px-pdrg and Px-aspp2 were upregulated in chlorpyrifos-resistant (Rc) and -susceptible (Sm) strains of DBM adults and pupae under heat stress. In addition, Rc DBM showed a significantly higher expression level of Px-pdrg and Px-aspp2 in contrast to Sm DBM. The results indicate that high temperature can significantly promote apoptosis process, especially in Rc-DBM. Significant fitness cost in Rc-DBM might be associated with drastically higher transcript abundance of Px-pdrg and Px-aspp2 under the heat stress.
The aim of this study was to investigate the in vivo degradation mechanism and the mechanical properties of poly(lactide-co-glycolide)/beta-tricalcium phosphate (PLGA/β-TCP) composite anchors. Anchors composed of PLGA and β-TCP were implanted in the dorsal subcutaneous tissue of beagle dogs for 6, 12, 16, and 26 weeks. The degradation of the materials was evaluated by measuring the changes in thermal behavior, crystallinity, and mechanical properties. Scanning electron microscope (SEM) was used to observe the surface and longitudinal section of the material. The evaluation of mechanical strength retention and degradation properties suggest that the addition of β-TCP particles efficiently enhances their mechanical properties and thermal characteristics and delays their degradation rate. By analyzing the results of SEM, X-ray diffraction, and differential scanning calorimetry, we can infer that after 12 weeks, the connection between β-TCP and PLGA becomes less compact, which accelerates the decline of mechanical strength.
With the advancement of high-throughput sequencing technologies, the amount of available sequencing data is growing at a pace that has now begun to greatly challenge the data processing and storage capacities of modern computer systems. Removing redundancy from such data by clustering could be crucial for reducing memory, disk space and running time consumption. In addition, it also has good performance on reducing dataset noise in some analysis applications. In this study, we propose a high-performance short sequence classification algorithm (HSC) for next generation sequencing (NGS) data based on efficient hash function and text similarity. First, HSC converts all reads into k-mers, then it forms a unique k-mer set by merging the duplicated and reverse complementary elements. Second, all unique k-mers are stored in a hash table, where the k-mer string is stored in the key field, and the ID of the reads containing the k-mer are stored in the value field. Third, each hash unit is transformed into a short text consisting of reads. Fourth, texts that satisfy the similarity threshold are combined into a long text, the merge operation is executed iteratively until there is no text that satisfies the merge condition. Finally, the long text is transformed into a cluster consisting of reads. We tested HSC using five real datasets. The experimental results showed that HSC cluster 100 million short reads within 2 hours, and it has excellent performance in reducing memory consumption. Compared to existing methods, HSC is much faster than other tools, it can easily handle tens of millions of sequences. In addition, when HSC is used as a preprocessing tool to produce assembly data, the memory and time consumption of the assembler is greatly reduced. It can help the assembler to achieve better assemblies in terms of N50, NA50 and genome fraction.
(1 − x)Ba(Mg1/3Ta2/3)O3–xBa(Co1/3Nb2/3)O3 (BMT–BCN, x = 0.0, 0.20, 0.25, 0.30, 0.40) ceramics were prepared using the traditional solid-state reaction method. X-ray diffraction patterns have shown that the intensities of (001) and (100) super-lattices decrease with the increase in the BCN content. Seven main Raman vibrational modes are observed, assigned, and illustrated, in particular. Raman shifts of Eg(O) modes and the FWHM values of F2g(O)/A1g(O) modes have close relationship with the dielectric properties. The calculated values by the four-parameter semiquantum model based on IR reflectivity match well with the measured data (@3.8 GHz), which means that most of dielectric contribution to the system may be ascribed to the absorption of structural phononic oscillations at the infrared region, and the contribution from the scattering of the defective phonons is small. The contributions of each vibrational mode on the dielectric responses were investigated in detail, indicating that the low-frequency modes (A2u(1) and Eu(1)) have a decisive role to the dielectric properties.