To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Experiments are presented on the deformation of free surface induced by water exit of axisymmetric bodies, particular at the moment before body detaching from water. A set of experimental apparatus is designed to provide driving force for the bodies. A high-speed camera is adopted to capture the motion and deformation of the free surface. Bodies of various shapes, including a stretched spheroid, a sphere, a circular cone and a combination of cylinder and circular cone, are lifted out of water with different velocities, by using a straight rod attached on the top of models. It is found that free-surface deformation is affected by the moving velocity a lot. Three wake flow or free-surface spike patterns are generated corresponding to different velocities. When the velocity is larger than a critical velocity, cavitation incepts and bubble is entrapped inside the water spike, which changes the flow pattern and shape of the spike. It is aimed to explore the spike phenomenon of free surface and explain the reasons behind it.
In the present work, Mo was added to an Al–Si–Mg foundry alloy to study its influence on the evolution of dispersoids during various heat treatments. The microhardness and the elevated-temperature tensile properties and creep resistance were measured to evaluate the contribution of dispersoids. Results showed that the addition of Mo greatly promoted the formation of α-dispersoids. During solution treatment, the formation of α-dispersoids started after 8 h at 500 °C. At high temperature (540 °C), the coarsening of dispersoids with increasing time became predominant. The optimum condition of dispersoids can be reached by 520 °C/12 h or 500 °C/4 h + 540 °C/2 h, leading to the highest differences in microhardness between the Mo-containing alloy and base alloy. The tensile strengths were improved at both room temperature and elevated temperatures, while the elongation at elevated temperature was greatly increased. The creep resistance at elevated temperature is further enhanced due to the Mo addition.
To compare the epidemiologic features (e.g. settings and transmission mode) and patient clinical characteristics associated with outbreaks of different norovirus (Nov) strains, we retrospectively analysed data of Nov outbreaks occurring in Guangzhou, China from 2012 to 2018. The results suggested that outbreaks of Nov GII.2, GII.17 and GII.4 Sydney exhibited different outbreak settings, transmission modes and symptoms. GII.2 outbreaks mainly occurred in kindergartens, elementary and high schools and were transmitted mainly through person-to-person contact. By contrast, GII.4 Sydney outbreaks frequently occurred in colleges and were primarily associated with foodborne transmission. Cases from GII.2 and GII.17 outbreaks reported vomiting more frequently than those from outbreaks associated with GII.4 Sydney.
A viscous damping model is proposed based on a simplified equation of fluid motion in a moonpool or the narrow gap formed by two fixed boxes. The model takes into account the damping induced by both flow separation and wall friction through two damping coefficients, namely, the local and friction loss coefficients. The local loss coefficient is determined through specifically designed physical model tests in this work, and the friction loss coefficient is estimated through an empirical formula found in the literature. The viscous damping model is implemented in the dynamic free-surface boundary condition in the gap of a modified potential flow model. The modified potential flow model is then applied to simulate the wave-induced fluid responses in a narrow gap formed by two fixed boxes and in a moonpool for which experimental data are available. The modified potential flow model with the proposed viscous damping model works well in capturing both the resonant amplitude and frequency under a wide range of damping conditions.
Optimizing the dietary calcium (Ca) level is essential to maximize the eggshell quality, egg production and bone formation in poultry. This study aimed to establish the Ca requirements of egg-type duck breeders from 23 to 57 weeks of age on egg production, eggshell, incubation, tibial, plasma and ovary-related indices, as well as the expression of matrix protein-related genes. Totally, 450 Longyan duck breeders aged 21 weeks of age were allotted randomly into five treatments, each with six replicates of 15 individually caged birds. The data collection started from 23 weeks of age and continued over the following 35 weeks. The five groups corresponded to five dietary treatments containing either 2.8%, 3.2%, 3.6%, 4.0% or 4.4% Ca. The tested dietary Ca levels increased (linear, P <0.01) egg production and egg mass, and linearly improved (P <0.01) the feed conversion ratio (FCR). Increasing the dietary Ca levels from 2.8% to 4.4% increased (P <0.01) the eggshell thickness and eggshell content. The tested Ca levels showed a quadratic effect on eggshell thickness and ovarian weight (P <0.01); the highest values were obtained with the Ca levels 4.0% and 3.6%, respectively. Dietary Ca levels affected the small yellow follicles (SYF) number and SYF weight/ovarian weight, and the linear response (P <0.01) was significant vis-à-vis SYF number. In addition, dietary Ca levels increased (P <0.05) the tibial dry weight, breaking strength, mineral density and ash content. Plasma and tibial phosphorus concentration exhibited a quadratic (P <0.01) response to dietary Ca levels. Plasma calcitonin concentration linearly (P <0.01) increased as dietary Ca levels increased. The relative expression of carbonic anhydrase 2 in the uterus rose (P <0.01) with the increment of dietary Ca levels, and the highest value was obtained with 3.2% Ca. In conclusion, Longyan duck breeders fed a diet with 4.0% Ca had superior eggshell and tibial quality, while those fed a diet with 3.6% Ca had the heaviest ovarian weights. The regression model indicated that the dietary Ca levels 3.86%, 3.48% and 4.00% are optimal levels to obtain maximum eggshell thickness, ovarian weight and tibial mineral density, respectively.
Gender inequality has severe consequences on public health in terms of delay in diagnosis of pulmonary tuberculosis (PTB). In order to explore gender-related differences in diagnosis delay, a cross-sectional study of 10 686 patients diagnosed with PTB in Yulin from 1 January 2009 to 31 December 2014 was conducted. Diagnosis delay was categorised into ‘short delay’ and ‘long delay’ by four commonly used cut-off points of 14, 30, 60 and 90 days. Logistic regression analysis was used to analyse gender differences in diagnostic delay. Stratified analyses by smear results, age, urban/rural were performed to examine whether the effect persisted across the strata. The median delay was 31 days (interquartile range 13–65). Diagnostic delay in females at cut-off points of 14, 30, 60 and 90 days had odds ratios (OR) of 0.99 (95% CI 0.91–1.09), 1.09 (95% CI 1.01–1.18), 1.15 (95% CI 1.05–1.26) and 1.18 (95% CI 1.06–1.31), respectively, compared with males. Stratified analysis showed that females were associated with increased risk of longer delay among those aged 30–60 years, smear positive and living in the rural areas (P < 0.05). The female-to-male OR increased along with increased delay time. Further inquiry into the underlying reasons for gender differences should be urgently addressed to improve the current situation.
This study investigates the stability and transition of Görtler vortices in a hypersonic boundary layer using linear stability theory and direct numerical simulations. In the simulations, Görtler vortices are separately excited by wall blowing and suction with spanwise wavelengths of 3, 6 and 9 mm. In addition to primary streaks with the same wavelength as the blowing and suction, secondary streaks with half the wavelength also emerge in the 6 and 9 mm cases. The streaks develop into mushroom structures before breaking down. The breakdown processes of the three cases are dominated by a sinuous-mode instability, a varicose-mode instability and a combination of the two, respectively. Both fundamental and subharmonic instabilities are relevant in all cases. Multiple modes are identified in the secondary-instability stage, some of which originate from the primary instabilities (first and second Mack modes). We demonstrate that the first Mack mode can be destabilized to either a varicose-mode or sinuous-mode streak instability depending on its frequency and wavelength, whereas the second Mack mode undergoes a stabilizing stage before turning into a varicose mode in the 6 and 9 mm cases. An energy analysis reveals the stabilizing and destabilizing mechanisms of the primary instabilities under the influence of Görtler vortices, highlighting the role played by the spanwise production based on the spanwise gradient of the streamwise velocity in both varicose and sinuous modes. The effects introduced by the secondary streaks are examined by filtering the secondary streaks in two new simulations with nominally identical conditions to those of the 6 and 9 mm cases. Remarkably, the secondary streaks can destabilize the Görtler vortices, therefore advancing the transition. The stability theory results are in good agreement with those from direct numerical simulations.
Hepatitis E is an important zoonosis that is prevalent in China. Hepatitis E virus (HEV) is a pathogen that affects humans and animals and endangers public health in China. In this study, the detection of HEV epidemics in swine in Sichuan Province, China, was carried out by nested real-time PCR. A total of 174 stool samples and 160 bile samples from swine in Sichuan Province were examined. In addition, software was used to analyse the biological evolution of HEV. The results showed that within 2 years of swine HEV (SHEV) infection in China, SHEV was first detected in Sichuan Province. HEV was endemic in Sichuan; the positive rate for pig farms was 11.1%, and the total positive sample rate was 10.5%. The age of swine with the highest positive rate (17.9%) was 5–9 weeks. The examined swine species in order of highest to lowest HEV infection rates were Chenghua pig, Large White, Duroc, Pietrain, Landrace and Hampshire. Nucleotide and amino acid sequence analysis showed that the HEV epidemic in swine in Sichuan Province was related to genotype IV, which had the highest homology to HEV in Beijing. Sichuan strains have greater variation than Chinese representative strains, which may indicate the presence of new HEV strains.
Nasal irrigation is commonly performed in patients with chronic rhinosinusitis after functional endoscopic sinus surgery. This study systematically assessed the clinical efficacy of nasal irrigation from the medical literature.
The PubMed, Embase and Cochrane Central Register of Controlled Trials databases were searched using a comprehensive strategy, limited to English-language articles, published from October 1971 to March 2017, and comprising human subjects.
A total of 824 trials were identified, 5 of which, involving 331 participants, were included in this systematic review. After selection, only three trials were eligible for inclusion in a meta-analysis. Nasal irrigation using normal saline and various solutions was found to be effective in reducing symptom scores and endoscopic scores for chronic rhinosinusitis patients after functional endoscopic sinus surgery. Comparison of outcome measures, such as eosinophil count reduction, revealed that various solutions are more effective than normal saline alone; however, no statistical significance was found in terms of reduced symptom or endoscopic scores.
Based on the current limited evidence, nasal irrigation is an effective therapy for chronic rhinosinusitis patients after functional endoscopic sinus surgery. However, when comparing various solutions with normal saline, no significant difference was found in symptom scores or endoscopic scores.
To investigate the control effect of the synthetic jet on the aerodynamic characteristic of rotors, a numerical simulation procedure for the rotor flowfield is established. First, a moving-embedded grid method and an unsteady Reynolds Averaged Navier–Stokes (URANS) solver are established for predicting the complex flowfield of rotors. A velocity jet boundary condition over the jet actuator orifice is constructed, and a numerical method for simulating the active flow control on rotors is developed. Then, the effectiveness of the simulation method is validated by comparing the numerical results of jet control on NACA 0015 aerofoil with the experimental data. At last, the aerodynamic characteristic of rotors with synthetic jet actuators located on the suction surface of the blade in forward flight is calculated. The results indicate that the synthetic jet has the capability of improving the aerodynamic characteristic of rotors, especially in inhibiting the flow separation over the surface. In addition, the increase of the jet momentum coefficient and the jet angle can both enhance the lift coefficient in the retreating side. Compared with a single jet, jet arrays have better control effects on improving the aerodynamic characteristic of rotors in forward flight.
The oxidative study has always been particularly topical in poultry science. However, little information about the occurrence of cellular apoptosis and autophagy through the reactive oxygen species (ROS) generation in nuclear factor-κB (NF-κB) signal pathway was reported in the liver of broilers exposed to hydrogen peroxide (H2O2). So we investigated the change of growth performance of broilers exposed to H2O2 and further explored the occurrence of apoptosis and autophagy, as well as the expression of NF-κB in these signaling pathways in the liver. A total of 320 1-day-old Arbor Acres male broiler chickens were raised on a basal diet and randomly divided into five treatments which were arranged as non-injected treatment (Control), physiological saline (0.75%) injected treatment (Saline) and H2O2 treatments (H2O2(0.74), H2O2(1.48) and H2O2(2.96)) received an intraperitoneal injection of H2O2 with 0.74, 1.48 and 2.96 mM/kg BW. The results showed that compared to those in the control and saline treatments, 2.96 mM/kg BW H2O2-treated broilers exhibited significantly higher feed/gain ratio at 22 to 42 days and 1 to 42 days, ROS formation, the contents of oxidation products, the mRNA expressions of caspases (3, 6, 8), microtubule-associated protein 1 light chain 3 (LC3)-II/LC3-I, autophagy-related gene 6, Bcl-2 associated X and protein expressions of total caspase-3 and total LC3-II, and significantly lower BW gain at 22 to 42 days and 1 to 42 days, the activities of total superoxide dismutase and glutathione peroxidase, the expression of NF-κB in the liver. Meanwhile, significantly higher feed/gain ratio at 1 to 42 days, ROS formation, the contents of protein carbonyl and malondialdehyde, the mRNA expression of caspase-3 and the protein expressions of total caspase-3 and total LC3-II, as well as significantly lower BW gain at 22 to 42 days and 1 to 42 days were observed in broilers received 1.48 mM/kg BW H2O2 treatment than those in control and saline treatments. These results indicated that oxidative stress induced by H2O2 had a negative effect on histomorphology and redox status in the liver of broilers, which was associated with a decline in growth performance of broilers. This may attribute to apoptosis and autophagy processes triggered by excessive ROS that suppress the NF-κB signaling pathway.
The present study aim to explore temporal–spatial patterns of water use (WU) efficiency and its influencing factors of maize production in China during 1998–2010. WU and productivity (WP) were quantified by taking irrigation loss into account and the links between WP and nine selected indicators were revealed by the partial least squares regression (PLSR) model. Results showed that national WU and WP in maize production were 138.56 cubic gigametres (Gm3; 0.755 green and 0.245 blue) and 1.079 kg/m3, respectively. WP was enhanced in the present study due to an increase in irrigated crop yield. Provinces located in the middle–lower part of the Yellow River had high proportions of green water and WP, while high proportions of irrigation water and low WP were found in Northwest China. The dosage of pesticides per unit area, relative humidity, average temperature and precipitation were the dominant factors that affected WP. However, the relationships between WP and solar radiation, fertilizer, agricultural machinery power, irrigation proportion and irrigated efficiency were not significant. Findings of the present research may also provide a reference for regional agricultural water management.
Curcumin has been attributed with antioxidant, anti-inflammatory, antibacterial activities, and has shown highly protective effects against enteropathogenic bacteria and mycotoxins. Ochratoxin A (OTA) is one of the major intestinal pathogenic mycotoxins. The possible effect of curcumin on the alleviation of enterotoxicity induced by OTA is unknown. The effects of dietary curcumin supplementation on OTA-induced oxidative stress, intestinal barrier and mitochondrial dysfunctions were examined in young ducks. A total of 540 mixed-sex 1-day-old White Pekin ducklings with initial BW (43.4±0.1 g) were randomly assigned into controls (fed only the basal diet), a group fed an OTA-contaminated diet (2 mg/kg feed), and a group fed the same OTA-contaminated feed plus 400 mg/kg of curcumin. Each treatment consisted of six replicates, each containing 30 ducklings and treatment lasted for 21 days. There was a significant decrease in average daily gain (ADG) and increased feed : gain caused by OTA (P<0.05); curcumin co-treatment prevented the decrease in BW and ADG compared with the OTA group (P<0.05). Histopathological and ultrastructural examination showed clear signs of enterotoxicity caused by OTA, but these changes were largely prevented by curcumin supplementation. Curcumin decreased the concentrations of interleukin-1β, tumor necrosis factor-α and malondialdehyde, and increased the activity of glutathione peroxidase induced by OTA in the jejunal mucosa of ducks (P<0.05). Additionally, curcumin increased jejunal mucosa occludin and tight junction protein 1 mRNA and protein levels, and decreased those of ρ-associated protein kinase 1 (P<0.05). Notably, curcumin inhibited the increased expression of apoptosis-related genes, and downregulated mitochondrial transcription factors A, B1 and B2 caused by OTA without any effects on RNA polymerase mitochondrial (P<0.05). These results indicated that curcumin could protect ducks from OTA-induced impairment of intestinal barrier function and mitochondrial integrity.
This paper reports the measurement of the energy loss of protons at the energy of 100 keV penetrating a partially ionized hydrogen plasma. The plasma of ne ≈ 1015–16 cm−3; Te ≈ 1–2 eV and lifetime of about 8 µs is created by the hydrogen gas discharge. The experimental results show an increase of a factor of 2.8 in the energy loss, which are in good agreement with the Bethe, Standard Stopping Model, Li–Petrasso and Vlasov models’ predictions within the error limit. The Bethe–Bloch Coulomb logarithm term is found to increase by a factor of 4.0 for free electrons as compared with the situation where bound electrons prevail. The potential application of protons energy loss for diagnosing the electron density in plasma is proposed too.
The study investigated whether different dietary energy and protein sources affect laying performance, antioxidant status, fresh yolk fatty acid profile and quality of salted yolks in laying ducks. In all, 360 19-week-old Longyan ducks were randomly assigned to four diets in a factorial arrangement (2×2). The four diets consisted of two energy sources, corn (CO) or sorghum (SO) and two protein sources, soybean meal (SM) and rapeseed meal with corn distillers dried grains with solubles (RMD), and each treatment contained six replicates of 15 birds each. The experimental diets were isocaloric (metabolizable energy, 10.84 MJ/kg) and isonitrogenous (CP, 17%). The results showed that egg production, average egg weight, egg mass and feed conversion ratio were not affected by diets (P>0.05). Plasma contents of reduced glutathione (GSH), GSH/oxidized glutathione and total antioxidant capacity were lower (P<0.05) in ducks fed the RMD diets compared with those fed SM diets with a substantial increase (P=0.006) in plasma content of malondialdehyde (MDA). Egg yolks from ducks fed SO diets had higher proportions of polyunsaturated fatty acids (PUFA) and lower saturated and monounsaturated fatty acids compared with CO diets (P<0.001). Similarly, ducks fed RMD diets had a higher content of PUFA and n-6/n-3 ratio in fresh yolks (P<0.001), and increased salted yolk MDA, carbonylated proteins content and incidence of hard salted yolks (P<0.05) compared with SM diets. Scanning electron microscopy showed that salted yolks contained rougher polyhedral granules and fewer fat droplets, and were surrounded with a layer of bunchy fibers in ducks fed SO+RMD than those fed CO+SM diet. In conclusion, the current study showed that feeding laying ducks with diets containing SO or RMD reduced antioxidant capacity and increased egg yolk concentrations of PUFA. It appeared that egg yolks from ducks fed these diets were more sensitive to lipid peroxidation and protein oxidation during salting, and reduced the quality of salted yolks.
Previous studies in sheep and cattle have demonstrated that the urinary excretion of purine derivatives (PD) provides an index of the intestinal flow of microbial protein (Chen et al. 1990). Yak is the most important ruminant species in Tibetan Plateau. It was of interest to establish whether the approach of PD excretion to estimate microbial protein supply is applicable in yaks. The objective of this work is to measure the effect of fasting and different levels of feeding on PD excretion in yaks.
The feeding experiments were carried out in Xi-ning, China at an altitude of 3100m and a latitude of 36.8° N. Six 5-year old female yaks were used and 3 experiments were completed.
Honeybee foraging can transfer exogenous genes from genetically modified (GM) oilseed rape (Brassica napus L.) to closely related plants, which not only induces potential ecological risks but also contaminates non-GM seeds or honey products with GM ingredients. These events may lead to international trade disputes. Chinese honeybees (Apis cerana cerana Fabricius) and a herbicide (glufosinate)-resistant GM strain of B. napus (Z7B10) were studied to examine the effects of honeybee short-range foraging on oilseed rape gene flow and honey ingredients. Results showed variable frequencies of gene flow between GM and non-GM oilseed rape cultivars, with the highest frequency under nylon net isolation with artificially stocked honeybees, the lowest frequency under nylon net isolation alone, and an intermediate frequency under natural pollination, suggesting the important role of honeybee foraging in gene flow frequency. Additionally, GM pollen grains were found in honey collected from honeybees foraging on both GM and non-GM oilseed rape cultivars. The phosphinothricin acetyltransferase protein was also detected in both unbroken pollen-containing and pollen-free honey by protein testing strips, suggesting that honeybee foraging on GM oilseed rape could lead to contamination with GM ingredients. Overall, the results provide a direct scientific basis for the ecological risk assessment and safety management of GM oilseed rape.
Previous studies showed that spermine could protect the organism from oxidative damage in vivo. However, in vivo information on the antioxidant-related underlying molecular mechanism of spermine is limited. In this experiment, we further evaluated the effects of spermine supplementation and extended spermine administration on the antioxidant status and antioxidant-related signaling molecules gene expression in the liver and longissimus dorsi of piglets. A total of 80 piglets were randomly distributed to two groups, that is, those with adequate nutrient intake administrated with spermine (0.4 mmol/kg BW) or those with restricted nutrient intake supplemented by saline. The piglets were fed in pairs for 7 h or 3, 6, or 9 days. The results are as follows: (1) spermine can promote the antioxidant capacity by increasing enzymatic antioxidant capacity, glutathione content and clearance of oxygen radicals; (2) spermine significantly increased the mRNA levels of enzymatic antioxidant substances, NF-E2-related nuclear factor 2, Kelch-like ECH-associated protein 1, and the mammalian target of rapamycin but decreased the mRNA levels of ribosomal p70 S6 kinase in the liver and longissimus dorsi of the piglets.
A study of ASP 30 steel surface modification with high intensity Ti:sapphire laser, operating at 804 nm wavelength and pulse duration of 60 fs, in vacuum ambient, is presented. ASP 30 steel surface variations were studied at laser intensities of 1014 and 1013 W/cm2. The steel target specific surface changes and phenomena observed are: (i) Creation of craters at 1014 W/cm2 intensity; (ii) formation of periodic surface structures only at the reduced intensity of 1013 W/cm2; (iii) chemical surface changes registered only at higher laser intensity, and (iv) occurrence of plasma in front of the surface, including its emission in X-ray region. It can be concluded from this study that the reported laser intensities can effectively be applied for ASP 30 steel surface modification. Careful choosing of laser intensity and pulse count can lead to precise superficial material removal, for example laser intensity ~1013 W/cm2 and low pulse count can lead to ultra-precise surface processing. Generally, femtosecond laser surface modification of ASP 30 steel is non-contact and very rapid compared with traditional modification methods.
Our calculations show that the cross section of the inverse Compton scattering in strong magnetic fields may be larger than that of Thompson scattering by sevaral orders of magnitude in the case of polar cap surface of pulsars. We can also see that when the energy of e± exceeds a certain value, their energy loss caused by the inverse Compton scattering may be larger than the energy gain from electric field in the inner gap, which implies that the e± could not be accelerated to γ = 106. Meanwhile, the electrostatic forces acting on the electrons will be balanced by the radiative pressure if temperature T > 108 K.
It is beleived that the surface temperarure for most of pulsars is less than 106 K, in that case the ions of iron can not be emitted from the surface of pulsars. However, the temperarure at the polar cap can be increased to 3×106 through the bombardment of electrons to the polar cap according to R-S model. This quasi-equilibrium state by self-regulating must make the coherent radio emission unstable on the contrary.