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Microplastics are ubiquitous in our environment but their presence in air is less well understood. Homes are likely a key source of airborne microplastics and microfibres to the environment owing to the frequent use and storage of plastics and textiles within them. Studying their presence, concentration and distribution in these environments is difficult without the participation of citizens due to accessibility challenges. Few studies have examined the intricacies of the prevalence of indoor microplastics and microfibres or the link between indoor exposure and behavioural and regulatory approaches that could reduce their concentrations. The application of a quintuple innovation helix framework, within which a co-creative citizen science research methodology is applied, provides an opportunity for citizens to shape the scientific method, ensuring that methods are accessible and appropriate for widespread use and designed by the citizen, for the citizen. Exploring behaviours and motivations in plastic and textile use by citizens with industry may reduce the generation of these particles. Future studies should consider the importance of citizen inclusion when designing research strategies for measuring and reducing microplastic concentrations in homes, enabling a nuanced understanding of their generation and distribution and facilitating the development of appropriate behavioural, industrial and regulatory messaging and mitigative measures.
The first demonstration of laser action in ruby was made in 1960 by T. H. Maiman of Hughes Research Laboratories, USA. Many laboratories worldwide began the search for lasers using different materials, operating at different wavelengths. In the UK, academia, industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications. This historical review looks at the contribution the UK has made to the advancement of the technology, the development of systems and components and their exploitation over the last 60 years.
Dysfunctional impulsivity reflects ‘recklessness without deliberation and evaluation of consequences’ and has negative consequences whereas functional impulsivity reflects ‘rapid responding to situational demands in order to maximise one's circumstances’ and often has positive consequences (1).
Objective
To examine the functional brain basis of dysfunctional impulsivity in healthy people and in people with schizophrenia.
Methods
Thirteen healthy controls and 21 schizophrenia patients (10/21 with serious repetitive violence) underwent fMRI during a Go/ NoGo task. Dysfunctional impulsivity was indexed using the Impulsiveness subscale and functional impulsivity using the Venturesomeness subscale of the Impulsiveness-Venturesomeness-Empathy questionnaire (2).
Results
Violent patients had elevated Impulsiveness scores relative to non-violent patients and controls. Impulsiveness did not correlate significantly with task performance in healthy controls or patients. Impulsiveness, but not Venturesomeness, scores correlated during the NoGO condition with lower activity in the anterior cingulate (AC) in controls, and lower inferior temporal and hippocampal activity in patients.
Conclusions
These findings accord with previously reported associations between reduced hippocampal volume and dysfunctional impulsivity in schizophrenia (3) and, combined with our earlier observations of reduced AC activation during a working memory task in violent antisocial individuals (4), suggest that the influence of dysfunctional impulsivity in antisocial and criminal behaviour is mediated via deficient (inhibitory) functions of the AC and hippocampus.
Identifying risk factors of individuals in a clinical-high-risk state for psychosis are vital to prevention and early intervention efforts. Among prodromal abnormalities, cognitive functioning has shown intermediate levels of impairment in CHR relative to first-episode psychosis and healthy controls, highlighting a potential role as a risk factor for transition to psychosis and other negative clinical outcomes. The current study used the AX-CPT, a brief 15-min computerized task, to determine whether cognitive control impairments in CHR at baseline could predict clinical status at 12-month follow-up.
Methods
Baseline AX-CPT data were obtained from 117 CHR individuals participating in two studies, the Early Detection, Intervention, and Prevention of Psychosis Program (EDIPPP) and the Understanding Early Psychosis Programs (EP) and used to predict clinical status at 12-month follow-up. At 12 months, 19 individuals converted to a first episode of psychosis (CHR-C), 52 remitted (CHR-R), and 46 had persistent sub-threshold symptoms (CHR-P). Binary logistic regression and multinomial logistic regression were used to test prediction models.
Results
Baseline AX-CPT performance (d-prime context) was less impaired in CHR-R compared to CHR-P and CHR-C patient groups. AX-CPT predictive validity was robust (0.723) for discriminating converters v. non-converters, and even greater (0.771) when predicting CHR three subgroups.
Conclusions
These longitudinal outcome data indicate that cognitive control deficits as measured by AX-CPT d-prime context are a strong predictor of clinical outcome in CHR individuals. The AX-CPT is brief, easily implemented and cost-effective measure that may be valuable for large-scale prediction efforts.
Major depressive disorder (MDD) commonly co-occurs with clinically significant levels of anxiety. However, anxiety symptoms are varied and have been inconsistently associated with clinical, functional, and antidepressant treatment outcomes. We aimed to identify and characterise dimensions of anxiety in people with MDD and their use in predicting antidepressant treatment outcome.
Method
1008 adults with a current diagnosis of single-episode or recurrent, nonpsychotic, MDD were assessed at baseline on clinical features and cognitive/physiological functioning. Participants were then randomised to one of three commonly prescribed antidepressants and reassessed at 8 weeks regarding symptom change, as well as remission and response, on the 17-item Hamilton Rating Scale Depression (HRSD17) and the 16-item Quick Inventory of Depressive Symptomatology (QIDS-SR16). Exploratory factor analysis was used on items from scales assessing anxiety symptoms, and resulting factors were assessed against clinical features and cognitive/physiological functioning. Factors were also assessed on their ability to predict treatment outcome.
Results
Three factors emerged relating to stress, cognitive anxiety, and somatic anxiety. All factors showed high internal consistency, minimal cross-loadings, and unique clinical and functional profiles. Furthermore, only higher somatic anxiety was associated with poorer QIDS-SR16 remission, even after adjusting for covariates and multiple comparisons.
Conclusions
Anxiety symptoms in people with MDD can be separated onto distinct factors that differentially respond to treatment outcome. Furthermore, these factors do not align with subscales of established measures of anxiety. Future research should consider cognitive and somatic symptoms of anxiety separately when assessing anxiety in MDD and their use in predicting treatment outcome.
Salmonella is a leading cause of bacterial foodborne illness. We report the collaborative investigative efforts of US and Canadian public health officials during the 2013–2014 international outbreak of multiple Salmonella serotype infections linked to sprouted chia seed powder. The investigation included open-ended interviews of ill persons, traceback, product testing, facility inspections, and trace forward. Ninety-four persons infected with outbreak strains from 16 states and four provinces were identified; 21% were hospitalized and none died. Fifty-four (96%) of 56 persons who consumed chia seed powder, reported 13 different brands that traced back to a single Canadian firm, distributed by four US and eight Canadian companies. Laboratory testing yielded outbreak strains from leftover and intact product. Contaminated product was recalled. Although chia seed powder is a novel outbreak vehicle, sprouted seeds are recognized as an important cause of foodborne illness; firms should follow available guidance to reduce the risk of bacterial contamination during sprouting.
Discoloration of bermudagrass often results from application of MSMA herbicide used to control southern crabgrass and other weeds. However, when products containing iron sulfate (FeSO4) are tank-mixed with MSMA, this discoloration is reduced. Experiments investigated the effect of tank-mixing organic arsenical herbicides with FeSO4 or a chelated iron source (Sprint 330) in terms of southern crabgrass control and injury to bermudagrass. Tank-mixing MSMA with FeSO4 reduced bermudagrass injury. However, southern crabgrass control was also reduced by at least 50% with the addition of ≥0.38 kg Fe2+ ha−1. Neither antagonism nor safening of bermudagrass was observed when the chelated Fe2+ source was used. Applying FeSO4 as a separate treatment 1 to 4 d before or after MSMA application did not reduce visual burmudagrass injury 1 wk after treatment. Solution pH and FeSO4 concentration controlled the extent of complexation and level of antagonism observed in the field; inorganic Fe2+ reacted with MSMA to form a complex having reduced herbicidal activity. Potentiometric and spectrophotometric investigations found that methylarsonate, the parent acid of MSMA and other organic arsenical herbicides, reacts with inorganic Fe2+ to form a stable 1:1 Fe2+-methylarsonic acid chelate having two points of metal coordination and a stability constant log10 (β) = 2.77 ± 0.04. Tank-mixing MSMA with FeSO4 to protect against bermudagrass injury negates the benefit of applying the herbicide for weed control, and therefore is not a recommendable practice for turf managers.
Giant ragweed has been increasing as a major weed of row crops in the last
30 yr, but quantitative data regarding its pattern and mechanisms of spread
in crop fields are lacking. To address this gap, we conducted a Web-based
survey of certified crop advisors in the U.S. Corn Belt and Ontario, Canada.
Participants were asked questions regarding giant ragweed and crop
production practices for the county of their choice. Responses were mapped
and correlation analyses were conducted among the responses to determine
factors associated with giant ragweed populations. Respondents rated giant
ragweed as the most or one of the most difficult weeds to manage in 45% of
421 U.S. counties responding, and 57% of responding counties reported giant
ragweed populations with herbicide resistance to acetolactate synthase
inhibitors, glyphosate, or both herbicides. Results suggest that giant
ragweed is increasing in crop fields outward from the east-central U.S. Corn
Belt in most directions. Crop production practices associated with giant
ragweed populations included minimum tillage, continuous soybean, and
multiple-application herbicide programs; ecological factors included giant
ragweed presence in noncrop edge habitats, early and prolonged emergence,
and presence of the seed-burying common earthworm in crop fields. Managing
giant ragweed in noncrop areas could reduce giant ragweed migration from
noncrop habitats into crop fields and slow its spread. Where giant ragweed
is already established in crop fields, including a more diverse combination
of crop species, tillage practices, and herbicide sites of action will be
critical to reduce populations, disrupt emergence patterns, and select
against herbicide-resistant giant ragweed genotypes. Incorporation of a
cereal grain into the crop rotation may help suppress early giant ragweed
emergence and provide chemical or mechanical control options for
late-emerging giant ragweed.
Seed-oriented planting provides a manner to influence canopy structure. The purpose of this research was to improve maize light interception using seed-oriented planting to manipulate leaf azimuth across the row thereby minimizing leaf overlap. To achieve leaf azimuths oriented preferentially across the row, seeds were planted: (i) upright with caryopsis pointed down, parallel to the row (upright); and (ii) laying flat, embryo up, perpendicular to the row (flat). These treatments were compared to conventionally planted seeds with resulting random leaf azimuth distribution. Seed orientation effects were contrasted with three levels of plant population and two levels of hybrid specific canopy structures. Increased plant population resulted in greater light interception but yield tended to decrease as plant population increased. The planophile hybrid produced consistently greater yields than the erectophile hybrid. The difference between planophile and erectophile hybrids ranged from 283 to 903 kg ha−1. Overall, mean grain yield for upright and flat seed placement increased by 351 and 463 kg ha−1 compared to random seed placement. Greater cumulative intercepted photosynthetically active radiation (CIPAR) was found for oriented seeds rather than random-oriented seeds. At physiological maturity upright, flat and random-oriented seeds intercepted 555, 525 and 521 MJ m−2 of PAR, respectively. Maize yield responded positively to improved light interception and better radiation use efficiency. Under irrigated conditions, precision planting of maize increased yield by 9 to 14% compared to random-oriented seeds.
We present maps in the visible emission lines of [S II] and the infrared emission lines of H2, at 2.12μm, for several bipolar outflow complexes which exhibit jet structures. A comparison of the morphology of this infrared emission and that seen in visible emission lines shows both the visible and the H2 emission exhibit clumpy structure on similar scales. It appears that the brightest H2 emission occurs at the working surfaces of the jets. Virtually no H2 emission is associated with the jets themselves.
Velocity profiles are presented for several objects and possible emission mechanisms are discussed.
Dinoflagellates are a major component of the marine microplankton and, from fossil evidence, appear to have been so for the past 200 million years. In contrast, the pre-Triassic record contains only equivocal occurrences of dinoflagellates, despite the fact that comparative ultrastructural and molecular phylogenetic evidence indicates a Precambrian origin for the lineage. Thus, it has often been assumed that the dearth of Paleozoic fossil dinoflagellates was due to a lack of preservation or recognition and that the relatively sudden appearance of dinoflagellates in the Mesozoic is an artifact of the record. However, new evidence from a detailed analysis of the fossil record and from the biogeochemical record indicates that dinoflagellates did indeed undergo a major evolutionary radiation in the early Mesozoic.
Demonstrating the effectiveness of health care interventions requires valid measurement of the impact, or outcome of those interventions. It is increasingly suggested that Quality of Life (QoL) is the ‘gold standard’ outcome internationally (Bowling 1995) and in Australasia (Mordue & Parkin, 1997). Although a number of QoL measures are now available, questions remain about the definition of the concept itself and the psychometric properties of those measures. A consequence of major concern is that health services research or clinical studies of healthcare interventions using inadequately defined outcomes or invalid measures will in turn produce results that lack validity. This paper explores a number of such issues concerning the concept of QoL and the way it is measured.
Introduction: Effective management of major depressive disorder (MDD) continues to be a challenging task for psychiatrists and primary care physicians. This trial evaluated the efficacy and safety of adjunctive aripiprazole versus antidepressant monotherapy in patients with MDD and independently replicated the positive findings of two similar trials.
Methods: Patients (N=1, 147) with MDD experiencing a major depressive episode and a history of inadequate response to antidepressant monotherapy were enrolled (week 0); 827 received single-blind adjunctive placebo plus open-label antidepressant (escitalopram, fluoxetine, paroxetine controlled release, sertraline, or venlafaxine extended release) for 8 weeks to confirm inadequate response to antidepressants; 349 patients with inadequate response were randomized (1:1) to double-blind, adjunctive placebo (n=172) or adjunctive aripiprazole (n=177; 2–20 mg/day). Primary outcome was the mean change in Montgomery-Åsberg Depression Rating Scale (MADRS) Total score from baseline (week 8) to endpoint (week 14).
Results: Clinically significant improvements in depressive symptoms as assessed by decreases in the MADRS Total score were greater with adjunctive aripiprazole (−10.1) than placebo (−6.4; P<.001). Remission rates were greater for adjunctive aripiprazole than for adjunctive placebo (week 14, 36.8% vs 18.9%; P<.001). Completion rates with adjunctive aripiprazole and placebo were high (83% vs. 87%) and discontinuations due to adverse events were low (6.2% vs 1.7%).
Conclusion: For some patients with MDD who do not obtain adequate symptom relief with antidepressant monotherapy, adjunctive therapies can significantly improve depressive symptoms. As reported, adjunctive aripiprazole was associated with a two-fold higher remission rate than adjunctive placebo. This, and previous studies, have shown that discontinuations due to adverse events were low and completion rates were high, and has indicated that both antidepressant and aripiprazole in combination were relatively well-tolerated and safe. This is the third consecutive clinical trial, in the absence of a failed trial, to demonstrate that aripiprazole augmentation to antidepressants is an efficacious and well-tolerated treatment for patients with MDD who do not respond adequately to standard antidepressant monotherapy (ClinicalTrials.gov study NCT00105196).
To determine what factors are associated with parental motivation to change body weight in overweight children.
Design
Cross-sectional study.
Setting
Dunedin, New Zealand.
Subjects
Two hundred and seventy-one children aged 4–8 years, recruited in primary and secondary care, were identified as overweight (BMI≥85th percentile) after screening. Parents completed questionnaires on demographics; motivation to improve diet, physical activity and weight; perception and concern about weight; parenting; and social desirability, prior to being informed that their child was overweight. Additional measures of physical activity (accelerometry), dietary intake and child behaviour (questionnaire) were obtained after feedback.
Results
Although all children were overweight, only 42 % of parents perceived their child to be so, with 36 % indicating any concern. Very few parents (n 25, 8 %) were actively trying to change the child’s weight. Greater motivation to change weight was observed for girls compared with boys (P=0·001), despite no sex difference in BMI Z-score (P=0·374). Motivation was not associated with most demographic variables, social desirability, dietary intake, parenting or child behaviour. Increased motivation to change the child’s weight was observed for heavier children (P<0·001), those who were less physically active (P=0·002) and more sedentary (P<0·001), and in parents who were more concerned about their child’s weight (P<0·001) or who used greater food restriction (P<0·001).
Conclusions
Low levels of parental motivation to change overweight in young children highlight the urgent need to determine how best to improve motivation to initiate change.
Parents report that children’s eating behaviours are a major barrier to providing them with a healthy diet. Links between problem eating behaviours and parental feeding practices are not well established and have not previously been examined in overweight children. The aim of the present study was to assess associations between problem food behaviours, dietary intake and parental feeding practices of overweight children aged 4–8 years.
Design
Participants were recruited for a lifestyle intervention (n 203). At baseline, children’s BMI was measured and parents completed comprehensive questionnaires about the feeding practices they used, the problem food behaviours their children exhibited and the foods their child consumed. A fussy eating scale was developed and associations were determined using correlations and regression analysis, including interactions.
Setting
Dunedin, New Zealand.
Subjects
Overweight children aged 4–8 years.
Results
Healthy eating guidance and monitoring by parents were related to the consumption of fewer unhealthy foods (B=−0·4, P=0·001 and B=−0·4, P<0·001). Conversely, a lack of parental control (child control) was related to a higher intake of unhealthy foods (B = 0·5, P<0·001). Parents of children who were fussy eaters monitored their child’s food intake less (P<0·001) and allowed the child more freedom over what he/she ate (P<0·001). These children consumed fewer fruit and vegetables than those who were not fussy eaters (P<0·001). However, fussy eaters with food-restrictive parents ate more fruit and vegetables (B=2·9, P<0·001).
Conclusions
These results suggest that a more structured food environment might be beneficial for the diet and food behaviours of young overweight children.