While our fascination with understanding the past is sufficient to warrant an increased focus on synthesis, solutions to important problems facing modern society require understandings based on data that only archaeology can provide. Yet, even as we use public monies to collect ever-greater amounts of data, modes of research that can stimulate emergent understandings of human behavior have lagged behind. Consequently, a substantial amount of archaeological inference remains at the level of the individual project. We can more effectively leverage these data and advance our understandings of the past in ways that contribute to solutions to contemporary problems if we adapt the model pioneered by the National Center for Ecological Analysis and Synthesis to foster synthetic collaborative research in archaeology. We propose the creation of the Coalition for Archaeological Synthesis coordinated through a U.S.-based National Center for Archaeological Synthesis. The coalition will be composed of established public and private organizations that provide essential scholarly, cultural heritage, computational, educational, and public engagement infrastructure. The center would seek and administer funding to support collaborative analysis and synthesis projects executed through coalition partners. This innovative structure will enable the discipline to address key challenges facing society through evidentially based, collaborative synthetic research.

Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for 147,315 and 143,056 twins respectively, from 28 twin cohorts (52% females; 38% MZ twins). Together, we had information on individual or parental education from 42 twin cohorts representing 19 countries. The original education classifications were transformed to education years and analyzed using linear regression models. Overall, MZ males had 0.26 (95% CI [0.21, 0.31]) years and MZ females 0.17 (95% CI [0.12, 0.21]) years longer education than DZ twins. The zygosity difference became smaller in more recent birth cohorts for both males and females. Parental education was somewhat longer for fathers of DZ twins in cohorts born in 1990–1999 (0.16 years, 95% CI [0.08, 0.25]) and 2000 or later (0.11 years, 95% CI [0.00, 0.22]), compared with fathers of MZ twins. The results show that the years of both individual and parental education are largely similar in MZ and DZ twins. We suggest that the socio-economic differences between MZ and DZ twins are so small that inferences based upon genetic modeling of twin data are not affected.

A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.

For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.

The development of anisotropy in an initially isotropie spectrum is studied numerically for two-dimensional magnetohydrodynamic turbulence. The anisotropy develops through the combined effects of an externally imposed d.c. magnetic field and viscous and resistive dissipation at high wavenumbers. The effect is most pronounced at high mechanical and magnetic Reynolds numbers. The anisotropy is greater at the higher wavenumbers.

The Strauss equations of reduced resistive magnetohydrodynamics are solved pseudo-spectrally, inside a cylinder of square cross-section. Conducting, free-slip, boundary conditions are imposed at the boundaries normal to the direction of the imposed d.c. magnetic field and net current, and periodic boundary conditions are imposed in the third direction. The emphasis is on the development of disruptions. Initial conditions are not analytical equilibria, and are characterized by wide-band noise perturbations in many Fourier modes. Typical spatial resolution is 32 × 32 × 16. At this resolution, the code takes approximately 0·7 seconds per time step on a CRAY-1 computer. Lundquist numbers are limited by the need to resolve the small-scale turbulence which develops. Disruptions are characterized by (i) a burst of kinetic fluid activity which is roughly equipartitioned with the magnetic fluctuations at the small scales, but which involves overall kinetic energies which are much less than the magnetic energies; (ii) a helical ‘m = l, n = 1’ current filament which develops out of the wide-band turbulent noise and wraps itself around the magnetic axis; and (iii) relatively mild disturbances of the magnetic field lines, at least at these low values of Lundquist number (S ≃ 100). The results are compared with those from similar codes which solve the linearized Strauss equations.

It is shown numerically, both for the two-dimensional Navier-Stokes (guidingcentre plasma) equations and for two-dimensional magnetohydrodynamics, that the long-time asymptotic state in a forced inverse-cascade situation is one in which the spectrum is completely dominated by its own fundamental. The growth continues until the fundamental is dissipatively limited by its own dissipation rate.

A pseudo-spectral three-dimensional Strauss-equations code is used to describe internal disruptions in a strongly magnetized, electrically-conducting fluid, with and without an externally applied, axial electric field. Rigid conducting walls form a square (x, y) boundary, and periodic boundary conditions are assumed in the axial (z) direction. Typical resolution is 64 × 64 × 32 and the maximum Lundquist number is approximately 400. The dynamics are dominated by a helical current filament which wraps itself around the axis of the cylinder; parts of this filament can sometimes become strongly negative. The ratio of turbulent kinetic energy to total poloidal magnetic energy rises from very small values to values of the order of a few hundredths, and executes ‘bounces’ as a function of time in the absence of the external electric field. In the presence of the external electric field, the first bounce is by far the largest, then the plasma settles into a non-uniform quasi-steady state characterized by a poloidal fluid velocity flow. At the large scales, this flow has the shape of a pair of counter-rotating bean-shaped vortices. The subsequent development of this fluid flow depends strongly upon whether or not a viscous term is added to the equation of motion. Inclusion of viscosity tends to damp the flow and leads to pronounced subsequent bounces suggestive of sawtooth oscillations, though the first bounce remains substantially the largest. By means of a three-mode (Lorenz-like) truncation of the Strauss equations, the evolution of the largest spatial scales alone may be examined. Some time-dependent solutions of the low-order truncation system suggest qualitative agreement with fully resolved solutions of the Strauss equations, while other solutions exhibit interesting dynamical-systems behaviour which is thus far unparalleled in the fully-resolved simulation results.

Accurate bedside assessment of the ratio of pulmonary to systemic flow (Qp/Qs ratio, referred to as “the flow ratio” or “the ratio”) plays an important role in the management of many congenital heart defects, especially the complexes unified by univentricular atrioventricular connections. Arterial oxygen saturation can be a misleading measure of the ratio, and may not reflect derangements until they are quite large. Theoretical analysis suggests that systemic venous oxygenation may be a better indicator of the ratio. To examine this, we created a widely patent atrial septal defect in neonatal piglets (weight =4–6.5 kg, n=6). Snares aruond the aorta and pulmonary trunk were adjusted to alter the flow ratio from 0.1 to 6.5. Venous oxygen saturations, measured in the mid-inferior caval vein, were at a maximum at a ratio about 1, and declined rapidly with increases or decreases in the ratio beyond a limited range. The venous oxygen saturation was found to vary much more than arterial oxygen saturation, with arterial oxygen saturation only falling when the ratio dropped below 0.5. Oxygen delivery (Oxygen Content x Cardiacoutput) was found to parallel closely systemic venous oxygen saturation, and was at a maximum at the same ratio that produced a maximum value of systemic venous oxygen saturation. The study suggests that systemic venous oxygen saturation provides a better estimate than does systemic arterial oxygen saturationof the flow ratio and oxygen delivery. Interventions that maximize systemic venous oxygen saturation should maximize oxygen delivery, and determination of systemic venous oxygen saturation should be a helpful addition in managing children with a number of congenital heart defects.

Ectopic and supernumerary teeth occur in a wide variety of sites. Those that have been reportedinclude the mandibular condyle, coronoid process, orbit, palate, nasal cavity and the maxillaryantrum. Eruption of teeth into these sites is rare, and easily overlooked. We present two casesin which eruption of teeth into the nose and paranasal sinuses was associated with significant morbidity and show how this was relieved by appropriate surgery.

Emergency Medical Services (EMS) have taken great strides toward the development of city and statewide programs. However, once a person embarks on a plane or on a ship for any extended period of time, the EMS are at times meager and at other times not coordinated well with ground EMS. The American Heart Association has developed a protocol for basic and advanced cardiac life support to exist in all major air terminals, and especially within aircraft of all types. Particularly important are those aircrafts carrying large numbers of people for extended periods of time.