Field experiments were conducted at four locations in Kansas in 1999 and 2000 to evaluate grain sorghum response to simulated drift rates of four herbicides. Imazethapyr, glufosinate, glyphosate, and sethoxydim were applied at 1/3, 1/10, 1/33, and 1/100 of the use rate when plants were 10 to 20 cm tall. Visible crop injury increased as rates of each herbicide increased. Glyphosate and imazethapyr caused the most injury and glufosinate the least. Data show that some plants that were significantly injured 2 wk after treatment (WAT) recovered 8 WAT. However, some plants that received the highest rate of imazethapyr or glyphosate died. Grain sorghum yields were reduced only when injury was severe. This research showed that the potential for sorghum injury from off-target herbicide drift is greater from imazethapyr and glyphosate than from sethoxydim or glufosinate.