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1 results

  • Individual differences in schizophrenia
  • Edmund T. Rolls, Wenlian Lu, Lin Wan, Hao Yan, Chuanyue Wang, Fude Yang, Yunlong Tan, Lingjiang Li, Chinese Schizophrenia Collaboration Group, Hao Yu, Peter F. Liddle, Lena Palaniyappan, Dai Zhang, Weihua Yue, Jianfeng Feng
  • Journal: BJPsych Open / Volume 3 / Issue 6 / November 2017
  • Published online by Cambridge University Press: 02 January 2018, pp. 265-273
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  • View abstract
    Background

    Whether there are distinct subtypes of schizophrenia is an important issue to advance understanding and treatment of schizophrenia.

    Aims

    To understand and treat individuals with schizophrenia, the aim was to advance understanding of differences between individuals, whether there are discrete subtypes, and how fist-episode patients (FEP) may differ from multiple episode patients (MEP).

    Method

    These issues were analysed in 687 FEP and 1880 MEP with schizophrenia using the Positive and Negative Syndrome Scale for (PANSS) schizophrenia before and after antipsychotic medication for 6 weeks.

    Results

    The seven Negative Symptoms were correlated with each other and with P2 (conceptual disorganisation), G13 (disturbance of volition), and G7 (motor retardation). The main difference between individuals was in the cluster of seven negative symptoms, which had a continuous unimodal distribution. Medication decreased the PANSS scores for all the symptoms, which were similar in the FEP and MEP groups.

    Conclusions

    The negative symptoms are a major source of individual differences, and there are potential implications for treatment.