Immiscible displacement in porous media is common in many practical applications. Under quasi-static conditions, the process is significantly affected by disorder of the porous media and the wettability of the pore surface. Previous studies have focused on wettability effects, but the impact of the interplay between disorder and contact angle is not well understood. Here, we combine microfluidic experiments and pore-scale simulations with theoretical analysis to study the impact of disorder on the quasi-static displacement from weak imbibition to strong drainage. We define the probability of overlap to link the menisci advancements to displacement patterns, and derive a theoretical model to describe the lower and upper bounds of the cross-over zone between compact displacement and capillary fingering for porous media with arbitrary flow geometry at a given disorder. The phase diagram predicted by the theoretical model shows that the cross-over zone, in terms of contact angle range, expands as the disorder increases. The diagram further identifies four zones to elucidate that the impact of disorder depends on wettability. In zone I, increasing disorder destabilizes the patterns, and in zone II, a stabilizing effect plays a role, which is less significant than that in zone I. In the other two zones, invasion morphologies are compact and fingering, respectively, independent of both contact angle and disorder. We evaluate the proposed diagram using pore-scale simulations, experiments in this work and in the literature, confirming that the diagram can capture the effect of disorder on displacement under different wetting conditions. Our work extends the classical phase diagrams and is also of practical significance for engineering applications.

A growing trend of aging population of China has brought tremendous pressure on the domestic care system, and community education is one of the important content for elderly services. Based on the framework of SAPAD, the community English class in Guangzhou City is taken for case study. Depth research on three stakeholeders-the elderly, social workers and volunteers are carried out by interview, user observation and field research. 6 levels (physical level, syntactic level, empirical level, semantic level, pragmatic level and social level) are extracted based on SAPAD framework, and the behavior- object-significance mapping is completed. Significant clusters of multiple users at different levels are analyzed, and 16 core significant clusters are jointly built. By linking with clustering results of the syntactic level, 6 new function modules are obtained. Finally, the community elderly education service system is built through personas, service blueprint, touch points and storyboard. The new service system will improve learning efficiency, satisfactions and emotional appeals for the elderly, and work efficiency of social workers and volunteers.

Paediatric Mycoplasma pneumoniae pneumonia (MPP) is a major cause of community-acquired pneumonia in China. Data on epidemiology of paediatric MPP from China are little known. This study retrospectively collected data from June 2006 to June 2016 in Beijing Children's Hospital, Capital Medical University of North China and aims to explore the epidemiological features of paediatric MPP and severe MPP (SMPP) in North China during the past 10 years. A total of 27 498 paediatric patients with pneumonia were enrolled. Among them, 37.5% of paediatric patients had MPP. In this area, an epidemic took place every 2–3 years at the peak, and the positive rate of MPP increased during these peak years over time. The peak age of MPP was between the ages of 6 and 10 years, accounting for 75.2%, significantly more compared with other age groups (χ2 = 1384.1, P < 0.0001). The epidemics peaked in September, October and November (χ2 = 904.9, P < 0.0001). Additionally, 13.0% of MPP paediatric patients were SMPP, but over time, the rate of SMPP increased, reaching 42.6% in 2016. The mean age of paediatric patients with SMPP (6.7 ± 3.0 years old) was younger than that of patients with non-SMPP (7.4 ± 3.2 years old) (t = 3.60, P = 0.0001). The prevalence of MPP and SMPP is common in China, especially in children from 6 to 10 years old. Paediatric patients with SMPP tend to be younger than those with non-SMPP. MPP outbreaks occur every 2–3 years in North China. September, October and November are the peak months, unlike in South China. Understanding the epidemiological characteristics of paediatric MPP can contribute to timely treatment and diagnosis, and may improve the prognosis of children with SMPP.

AlMgB14–TiB2 ceramic was successfully brazed to TC4 alloy with inactive AgCu filler alloy. X-ray diffractometer, SEM, and energy-dispersive spectrometer were used to study interfacial microstructure and shear strength of the joints under different brazing temperatures. The results indicated that the typical microstructure of the TC4/AlMgB14–TiB2 joint was TC4/Ti(s.s) + Ti2Cu/Ti2Cu/TiCu/TiCu2Al/Ag(s.s) + Cu(s.s)/TiB whiskers/TiB2 reaction layer/AMBT. By increasing the brazing temperature, the thickness of the TC4 diffusion layer was improved, whereas that of the brazing seam decreased remarkably. When the brazing temperature was increased to 880 °C, the brazing seam was composed of Ti–Cu intermetallic Ag(s.s) with a few Cu(s.s), TiCu2Al distributed. Meanwhile, the formation of a continuous TiB2 reaction layer at the interface of the AMBT and brazing filler facilitated the improvement of joint shear strength. The joint with the maximum shear strength of 46.7 MPa was obtained while brazing at 880 °C for 10 min.

Recently, we introduced an epoxy group to mebendazole by a reaction with epichlorohydrin and obtained two isoforms, mebendazole C1 (M-C1) and mebendazole C2 (M-C2). The in vitro effects of mebendazole derivatives at different concentrations on Echinococcus multilocularis protoscoleces and metacestodes as well as cytotoxicity in rat hepatoma (RH) cells were examined. The results demonstrated that the solubility of the two derivatives was greatly improved compared to mebendazole. The mortality of protoscoleces in vitro reached to 70–80% after 7 days of exposure to mebendazole or M-C2, and M-C2 showed higher parasiticidal effects than mebendazole (P > 0.05). The parasiticidal effect of M-C1 was low, even at a concentration of 30 µm. The percentage of damaged metacestodes that were treated with mebendazole and M-C2 in vitro at different concentrations were similar, and M-C1 exhibited insignificant effects on metacestodes. Significant morphological changes on protoscoleces and metacestodes were observed after treatment with mebendazole and M-C2. In addition, the introduction of an epoxy group to mebendazole also reduced its cytotoxicity in RH cells. Our results demonstrate that the introduction of an epoxy group not only improved the solubility of mebendazole, but also increased its parasiticidal effects on E. multilocularis and reduced its cytotoxicity in RH cells.

Capital allocation is of central importance in portfolio management and risk-based performance measurement. Capital allocations for univariate risk measures have been extensively studied in the finance literature. In contrast to this situation, few papers dealt with capital allocations for multivariate risk measures. In this paper, we propose an axiom system for capital allocation with multivariate risk measures. We first recall the class of the positively homogeneous and subadditive multivariate risk measures, and provide the corresponding representation results. Then it is shown that for a given positively homogeneous and subadditive multivariate risk measure, there exists a capital allocation principle. Furthermore, the uniqueness of the capital allocation principe is characterized. Finally, examples are also given to derive the explicit capital allocation principles for the multivariate risk measures based on mean and standard deviation, including the multivariate mean-standard-deviation risk measures.

We develop a series of small infinitary epistemic logics to study deductive inference involving intra-/interpersonal beliefs/knowledge such as common knowledge, common beliefs, and infinite regress of beliefs. Specifically, propositional epistemic logics GL (Lα) are presented for ordinal α up to a given αo (αo ≥ ω) so that GL(L0) is finitary KDn with n agents and GL(Lα) (α ≥ 1) allows conjunctions of certain countably infinite formulae. GL(Lα) is small in that the language is countable and can be constructive. The set of formulae Lα is increasing up to α = ω but stops at ω We present Kripke-completeness for GL(Lα) for each α ≤ ω, which is proved using the Rasiowa–Sikorski lemma and Tanaka–Ono lemma. GL(Lα) has a sufficient expressive power to discuss intra-/interpersonal beliefs with infinite lengths. As applications, we discuss the explicit definability of Axioms T (truthfulness), 4 (positive introspection), 5 (negative introspection), and of common knowledge in GL(Lα) Also, we discuss the rationalizability concept in game theory in our framework. We evaluate where these discussions are done in the series GL(Lα), α ≤ ω.

Approximation sequences and derived equivalences occur frequently in the research of mutation of tilting objects in representation theory, algebraic geometry and noncommutative geometry. In this paper, we introduce symmetric approximation sequences in additive categories and weakly n-angulated categories which include (higher) Auslander-Reiten sequences (triangles) and mutation sequences in algebra and geometry, and show that such sequences always give rise to derived equivalences between the quotient rings of endomorphism rings of objects in the sequences modulo some ghost and coghost ideals.

An all-fiberized and narrow-bandwidth master oscillator power amplification (MOPA) system with record output power of 4 kW level and slope efficiency of 78% is demonstrated. Tandem pumping strategy is tentatively introduced into the narrow-bandwidth MOPA system for thermally induced mode instability (TMI) suppression. The stimulated Brillouin scattering (SBS) effect is balanced by simply using one-stage phase modulation technique. With different phase modulation signals, SBS limited output powers of 336 W, 1.2 kW and 3.94 kW are respectively achieved with spectral bandwidths accounting for 90% power of ${\sim}$ 0.025, 0.17 and ${\sim}$ 0.89 nm. Compared with our previous 976 nm pumping system, TMI threshold is overall boosted to be ${>}$ 5 times in which tandem pumping increases the TMI threshold of ${>}$ 3 times. The beam quality ( $M^{2}$ factor) of the output laser is well within 1.5 below the TMI threshold while it is ultimately saturated to be 1.86 with the influence of TMI at maximal output power. Except for SBS and TMI, stimulated Raman scattering (SRS) effect will be another challenge for further power scaling. In such a high power MOPA system, multi-detrimental effects (SBS, SRS and TMI) will coexist and may be mutual-coupled, which could provide a well platform for further comprehensively investigating and optimizing the high power, narrow-bandwidth fiber amplifiers.

The relationship between multilingualism and tolerance of ambiguity (TA) has been examined in recent studies (e.g., Dewaele & Li, 2013; van Compernolle, 2016), which focus upon multilinguals with mixed nationalities in non-EFL contexts. Most of these studies regrettably reflect a failure to use effect sizes or provide information on the reliability and validity of the instruments used. The present study explored the relationship between multilingualism and TA by focusing upon 260 English-using multilinguals of one single nationality in an EFL context. Factor analysis revealed a three-factor solution, rather than a four-factor solution of the original TA scale, suggesting a need to re-examine the validity of such instruments when used outside of their native contexts. The results identified multilingualism, number of languages known and gender as important predictors for TA. Given the relative nature of effect-size benchmarks, a topic-specific effect-size benchmark system is proposed to (re-)interpret the present and previous findings.

Tokamak start-up is strongly dependent on the state of the initial plasma formed during plasma breakdown. We have investigated through numerical simulations the effects that the pre-filling pressure and induced electric field have on pure ohmic heating during the breakdown process. Three breakdown modes during the discharge are found, as a function of different initial parameters: no breakdown mode, successful breakdown mode and runaway mode. No breakdown mode often occurs with low electric field or high pre-filling pressure, while runaway electrons are usually easy to generate at high electric field or low pre-filling pressure ( ${<}1.33\times 10^{-4}$  Pa). The plasma behaviours and the physical mechanisms under the three breakdown modes are discussed. We have identified the electric field and pressure values at which the different modes occur. In particular, when the electric field is $0.3~\text{V}~\text{m}^{-1}$ (the value at which ITER operates), the pressure range for possible breakdown becomes narrow, which is consistent with Lloyd’s theoretical prediction. In addition, for $0.3~\text{V}~\text{m}^{-1}$ , the optimal pre-filling pressure range obtained from our simulations is $1.33\times 10^{-3}\sim 2.66\times 10^{-3}$  Pa, in good agreement with ITER’s design. Besides, we also find that the Townsend discharge model does not appropriately describe the plasma behaviour during tokamak breakdown due to the presence of a toroidal field. Furthermore, we suggest three possible operation mechanisms for general start-up scenarios which could better control the breakdown phase.

High power superfluorescent fiber sources (SFSs), which could find wide applications in many fields such as middle infrared laser generation, Raman fiber laser pumping and spectral beam combination, have experienced a flourishing time in recent years for its unique properties, such as short coherence length and high temporal stability. The challenge for performance scalability of powerful SFS mainly lies on the physical issues including parasitic laser oscillation and modal instability (MI). In this contribution, by employing in-band pumping avenue and high-order transverse-mode management, we explore a high power SFS with record power, near-diffraction-limited beam quality and spectral manipulation flexibility. An ultimate output power of 3.14 kW can be obtained with high temporal stability and a beam quality of $M^{2}=1.59$ for the amplified light. Furthermore, the dynamics of spectral evolutions, including red-shifting of central wavelength and unsymmetrical broadening in spectral wings, of the main amplifier with different seed linewidths are investigated contrastively. Benefiting from the unique high pump brightness and high MI threshold of in-band pumping scheme, the demonstrated system also manifests promising performance scaling potential.

Familial monozygotic (MZ) twinning reports are rare around the world, and we report a four-generation pedigree with seven recorded pairs of female MZ twins. Whole-genome sequencing of seven family members was performed to explore the featured genetic factors in MZ twins. For variations specific to MZ twins, five novel variants were observed in the X chromosome. These candidates were used to explain the seemingly X-linked dominant inheritance pattern, and only one variant was exonic, located at the 5′UTR region of ZCCHC12 (chrX: 117958597, G > A). Besides, consistent mitochondrial DNA composition in the maternal linage precluded roles of mitochondria for this trait. In this pedigree, autosomes also contain diverse variations specific to MZ twins. Pathway analysis revealed a significant enrichment of genes carrying novel SNVs in the epithelial adherens junction-signaling pathway (p = .011), contributed by FGFR1, TUBB6, and MYH7B. Meanwhile, TBC1D22A, TRIOBP, and TUBB6, also carrying similar SNVs, were involved in the GTPase family-mediated signal pathway. Furthermore, gene-set enrichment analysis for 533 genes covered by copy number variations specific to MZ twins illustrated that the tight junction-signaling pathway was significantly enriched (p < .001). Therefore, the novel changes in the X chromosome and the provided candidate variants across autosomes may be responsible for MZ twinning, giving clues to increase our understanding about the underlying mechanism.

Monosized spherical Cu–20% Sn (wt%) alloy particles with diameter ranging from 70.6 to 334.0 μm were prepared by the pulsated orifice ejection method (termed “POEM”). Fully dense without pores and bulk inclusions, the cross-sectional micrographs of the spherical alloy particles indicate an even distribution of Cu and Sn. These spherical Cu–Sn alloy particles exhibit a good spherical shape and a narrow size distribution, suggesting that the liquid Cu–Sn alloy can completely break the balance between the surface tension and the liquid static pressure in the crucible micropores and accurately control the volume of the droplets. Furthermore, the cooling rate of spherical Cu–20% Sn alloy particles is estimated by a Newton’s cooling model. The cooling rate of the Cu–20% Sn alloy particle decreases gradually with the particle diameter increasing. Smaller particles have higher cooling rates and when the particle diameter is less than 70 μm, the cooling rate of particles can reach more than 3.3 × 104 K/s. The secondary dendrite arm spacing has strong dependence on particle diameter which increases gradually with the increase of particle diameter. The results demonstrate that POEM is an effective route for fabrication of high-quality monosized Cu–20% Sn alloy particles.

OBJECTIVES/SPECIFIC AIMS: Characterize the expression kinetics of HIV-1 Envelope and their relationship to virus production at the cellular level. METHODS/STUDY POPULATION: In vitro and ex vivo laboratory analyses. RESULTS/ANTICIPATED RESULTS: Initial studies addressing the kinetics of cell surface. Envelope (Env) expression reveal that Env expression to peaks on day 2 post infection. Next steps include a series of experiments to compare the kinetics of Env cell surface expression with broadly neutralizing antibody (bNAb)-mediated ADCC and the characterization of virus production kinetics in this same context. To be maximally effective, ADCC elimination of infected cells should occur before peak Env expression. DISCUSSION/SIGNIFICANCE OF IMPACT: Potent bNAbs to HIV-1 recognize vulnerable sites on the HIV-1 Envelope (Env) protein and are of great clinical interest due to their potential use in the prevention and treatment of HIV-1 infection. Their effectiveness depends not only on the neutralization of viral infectivity, but also on the elimination of productively infected cells via antibody-dependent cellular cytotoxicity (ADCC). On a cellular level, ADCC dynamics are determined by the timing and level of Env expression on the surface of HIV-infected cells. This study aims to delineate the expression kinetics of HIV-1 Envelope and their relationship to virus production. We expect that it will provide new insights into the utility of bNAb-mediated ADCC in treating and possibly curing HIV-1 infection; therefore results might have substantial impact on future HIV treatment strategies.