In this paper, synthesis of Cu2ZnSnSe4 (CZTSe) materials by using simple and cost-effective solid state reaction method from the elemental Cu, ZnO, SnO and elemental Se powders are carried out. The SEM images show spherical, non-uniform size with aggregation of nanopowders. The phase separation and thermal analysis of the milled powders suggested that most of the starting powders reacted because of a mechanical alloying effect during milling process. After the solid state reaction at above 500 °C, the nanopowders crystallized into stannite single phase, which are confirm by XRD spectra. The thermoelectric properties of synthesized powder are under study.